CN107982367A - A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken and preparation method thereof - Google Patents

A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken and preparation method thereof Download PDF

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Publication number
CN107982367A
CN107982367A CN201711489980.6A CN201711489980A CN107982367A CN 107982367 A CN107982367 A CN 107982367A CN 201711489980 A CN201711489980 A CN 201711489980A CN 107982367 A CN107982367 A CN 107982367A
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chicken
oral liquid
preparation
traditional chinese
chinese medicine
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CN201711489980.6A
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Inventor
刘鼎阔
王立红
董惠峰
刘芳
李源
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Dingzheng Animal Pharmaceutical Tianjin Co Ltd
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Dingzheng Animal Pharmaceutical Tianjin Co Ltd
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Priority to CN201711489980.6A priority Critical patent/CN107982367A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to a kind of preparation method for the traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, including honeysuckle flower, Radix Isatidis, dandelion, Fructus Forsythiae, platycodon flower, blackberry lily, dried orange peel, radix glycyrrhizae.In the present invention, each component is weighed by metering, high temperature reflux extracts twice plus after water, after extracting solution filtering, merge extracting solution, be concentrated under reduced pressure into relative density and concentrate is made for 1.15, extracting in water again, collects distillate, oral liquid will be made after distillate hyperfiltration, sterilizing, constant volume.After continuously taking this medicine 3~5 days, compared with not carrying out medication therapy groups, mouth breathing is had no, when snore is small, feed intake increase, temperature recovery is normal, and laying rate is apparently higher than non-administered group, and without dead chicken.

Description

A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken and preparation method thereof
Technical field
The invention belongs to infectious laryngotracheitis of chicken disease treatment technical field, especially one kind to treat chicken infectivity throat gas Traditional Chinese medicine oral liquid of Guan Yan and preparation method thereof.
Background technology
Infectious laryngotracheitis is a kind of acute respiratory disease of the chicken as caused by herpesviral.The serious danger of winter morbidity Evil is larger.Each age in days chicken can infect, and young chicken and Adult Chicken are in the majority, and the band viral disease chicken after diseased chicken or rehabilitation is main infection Source.The immunity caused by chronic disease such as henhouse density is excessive, crowded, improper ventilation, hypovitaminosis, parasite reduce Cause this disease.
Non-immunized chicken group, often often loses symptom die by visitation of God, suffering from chicken has nose liquid initial stage, semi-transparent in acute, initial stage Bright shape, eye are shed tears, with conjunctivitis.It is depressed that full group's diseased chicken spirit is spread quickly, anorexia or useless exhausted, cockscomb meat hair worn in a bun or coil cyanosis, Expiratory dyspnea, stretches neck, mouth breathing, spasmodic cough, get rid of the mucus of head, expectoration sometimes with blood, is adhered to ground, sink, chicken On cage, often have chicken caused since clot, mucus, cheese thing block asphyxia and death of struggling suddenly, initial stage egg drop reduction unobvious, Decreased later 10-50% is differed.Immunized chicken group, in chronic process, frequent jumpbogroup symptom is good, cough out of the ordinary, fragmentary dead Die, the course of disease length, if any stress, resistance decline can break out.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide scientific formula, compatibility is reasonable, therapeutic effect is good, A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken having no toxic side effect.
The present invention adopts the technical scheme that：
A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, it is characterised in that：Including what is mixed in parts by weight Following components：
Moreover, including the following components mixed in parts by weight：
It is a further object to provide a kind of preparation side for the traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken Method, it is characterised in that：Comprise the following steps：
(1) by weighing balance extracting honeysuckle, Radix Isatidis, dandelion, Fructus Forsythiae, platycodon flower, blackberry lily, dried orange peel, radix glycyrrhizae, it is put into reflux In extractor, high temperature reflux extracts after adding water, spare after extracting solution filtering；
(2) dregs of a decoction are added in refluxing extraction tank, second of refluxing extraction is carried out after adding water, it is spare after extracting solution filtering；
(3) extracting solution of step (1) and (2) is merged, is concentrated under reduced pressure into relative density and concentrate is made for 1.15；
(4) dregs of a decoction are added in refluxing extraction tank, carries out second of extraction after adding water, collect distillate；
(5) oral liquid will be made after distillate hyperfiltration, sterilizing, constant volume.
(6) step distillate (4) and (5) is merged, then the concentrate with step (3) merge after (0.45 micron of hyperfiltration Filter membrane), sterilizing (121 degrees Celsius, 15min) after, add water to be settled to 1000ml and oral liquid be made.
The advantages and positive effects of the present invention are：
In the present invention, by weighing balance extracting honeysuckle, Radix Isatidis, dandelion, Fructus Forsythiae, platycodon flower, blackberry lily, dried orange peel, radix glycyrrhizae, two Secondary plus water high temperature reflux, extraction filtering, is concentrated under reduced pressure, and after second extraction, by the distillate hyperfiltration of collection, sterilize constant volume. Medicine each component cooperate, synergistic effect, have virus suppression kill, Immunity regulation, inducement interferon, to antitoxic work( Effect, can effectively treat viral disease, drug residue free, has no toxic side effect, will not produce drug resistance.Continuously take this medicine After 3~5 days, compared with not carrying out medication therapy groups, mouth breathing is had no, when snore is small, feed intake increase, temperature recovery is just Often, laying rate is apparently higher than non-administered group, and without dead chicken.
Embodiment
With reference to embodiment, the present invention is further described, and following embodiments are illustrative, be not it is limited, Protection scope of the present invention cannot be limited with following embodiments.
A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, innovation of the invention are：Including in parts by weight The following components of mixing：
Preferred scheme is：Including the following components mixed in parts by weight：
In the present invention, honeysuckle energy dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases；Radix Isatidis is usually used in temperature It is malicious during epidemic disease, pharyngalgia, febrile virulent maculae etc. of generating heat；Dandelion is clearing heat and detoxicating, diuresis dissipating bind；Fructus Forsythiae is clearing heat and detoxicating, mass dissipating and swelling eliminating；Campanulaceae Flower open the inhibited lung-energy, expelling phlegm and arresting coughing, relieving sore-throat dissipating bind, wide griskin purulence, has the effect such as Antipyretic, anti-inflammatory antiallergy；Blackberry lily heat-clearing Removing toxic substances, dissipating bind anti-inflammatory, swelling and pain relieving is relieving cough and reducing sputum；Dried orange peel regulating qi-flowing for strengthening spleen, it is eliminating dampness and eliminating phlegm, abdominal fullness and distention is cured mainly, deficiency of food is vomited and diarrhoea, Coughing with a lot of sputum；Radix glycyrrhizae cures mainly clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen.
Embodiment 1
A kind of preparation method for the traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, is made of following component：
10 parts of honeysuckle, 10 parts of Radix Isatidis, 10 parts of dandelion, Fructus Forsythiae are 10 parts clear, 4 parts of platycodon flower, 3 parts of blackberry lily, dried orange peel 3 Part, 3 parts of radix glycyrrhizae.
(1) by weighing balance extracting honeysuckle, Radix Isatidis, dandelion, Fructus Forsythiae, platycodon flower, blackberry lily, dried orange peel, radix glycyrrhizae, it is put into reflux In extractor, high temperature reflux extracts after adding water, spare after extracting solution filtering；
(2) dregs of a decoction are added in refluxing extraction tank, second of refluxing extraction is carried out after adding water, it is spare after extracting solution filtering；
(3) extracting solution of step (1) and (2) is merged, is concentrated under reduced pressure into relative density and concentrate is made for 1.15；
(4) dregs of a decoction are added in refluxing extraction tank, carries out second of extraction after adding water, collect distillate；
(5) oral liquid will be made after distillate hyperfiltration, sterilizing, constant volume.
(6) step distillate (4) and (5) is merged, then the concentrate with step (3) merge after (0.45 micron of hyperfiltration Filter membrane), sterilizing (121 degrees Celsius, 15min) after, add water to be settled to 1000ml and oral liquid be made.
Embodiment 2
A kind of preparation method for the traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, is made of following component：
11 parts of honeysuckle, 11 parts of Radix Isatidis, 8 parts of dandelion, Fructus Forsythiae are 8 parts clear, 4 parts of platycodon flower, 3 parts of blackberry lily, 3 parts of dried orange peel, 3 parts of radix glycyrrhizae.
Prepared by step in embodiment 1.
Embodiment 3
A kind of preparation method for the traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, is made of following component：
11 parts of honeysuckle, 10 parts of Radix Isatidis, 6 parts of dandelion, Fructus Forsythiae are 6 parts clear, 4 parts of platycodon flower, 3 parts of blackberry lily, 3 parts of dried orange peel, 3 parts of radix glycyrrhizae.
Prepared by step in embodiment 3.
Clinical test：
Administering mode：Drinking water administration, 2.5g, per 1kg feeds, is used continuously 3~5 days.
Such as：In July, 2011,5500 laying hens of certain farm are had difficulty in breathing, and mouth breathing, breathe, have rale, cough When coughing can mucus of the expectoration with blood, have head air-breathing posture forward and up.Feed intake declines, and part chicken is gone on a hunger strike, and drinking-water is significantly increased； Apathetic, activity is reduced, and part chicken crouches in cage bottom；Cockscomb meat hair worn in a bun or coil cyanosis, fever is slow-growing up to more than 45 DEG C, lays eggs Rate reduces, and death occurs.Dissect death chicken tracheae is in Catarrhal and hemorrhagic inflammation lesion.Flowed out from chicken mouthful translucent Clear liquid, and the mucus quantity is very big, and nasal sinus swelling, inside there is mucus.There is mucus in esophagus, larynx tracheal strips have haemal strand mucus, tracheae Inside equally there is blood sample mucus, enteron aisle has slight oedema, there is viral plaque in duodenum, and lymphonodi caecales bleeding is obvious.Make a definite diagnosis Infectious laryngotracheitis, then with 3 medicine of embodiment, after medication 3~5 days, compared with not carrying out medication therapy groups, has no and dehisces to exhale Inhale, when snore is small, feed intake increase, temperature recovery is normal, and laying rate is apparently higher than non-administered group, and without dead chicken.
In the present invention, by weighing balance extracting honeysuckle, Radix Isatidis, dandelion, Fructus Forsythiae, platycodon flower, blackberry lily, dried orange peel, radix glycyrrhizae, add Water decocts twice, is stood after merging filtrate, concentrates, is crushed after drying, adds sucrose, is dried after being granulated sieving, crosses sieve series again Obtain finished product.Mix with feed during use, then eaten for diseased chicken by a certain percentage, continuous use for a period of time after, diseased chicken is adopted Appetite rises, and amount of drinking water declines, and spirit and mobility are recovered, and body temperature also recovers normal, growth and development and laying rate after healing It is very normal, prepare and medication is very convenient, storage, convenient transportation, noresidue after medication, have no toxic side effect.

Claims (3)

  1. A kind of 1. preparation method for the traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken, it is characterised in that：Including by weight The following components of number mixing：
  2. 2. a kind of preparation method of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken according to claim 1, it is special Sign is：Including the following components mixed in parts by weight：
  3. 3. a kind of preparation method of Chinese herbal granules for being used to treat pig blue-ear disease according to claim 1 or 2, its feature It is：Comprise the following steps：
    (1) by weighing balance extracting honeysuckle, Radix Isatidis, dandelion, Fructus Forsythiae, platycodon flower, blackberry lily, dried orange peel, radix glycyrrhizae, it is put into refluxing extraction In tank, high temperature reflux extracts after adding water, spare after extracting solution filtering；
    (2) dregs of a decoction are added in refluxing extraction tank, second of refluxing extraction is carried out after adding water, it is spare after extracting solution filtering；
    (3) extracting solution of step (1) and (2) is merged, is concentrated under reduced pressure into relative density and concentrate is made for 1.15；
    (4) dregs of a decoction are added in refluxing extraction tank, carries out second of extraction after adding water, collect distillate；
    (5) oral liquid will be made after distillate hyperfiltration, sterilizing, constant volume.
    (6) step distillate (4) and (5) is merged, then the concentrate with step (3) merges after hyperfiltration (0.45 micron is filtered Film), sterilizing (121 degrees Celsius, 15min) after, add water to be settled to 1000ml and oral liquid be made.
CN201711489980.6A 2017-12-29 2017-12-29 A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken and preparation method thereof Pending CN107982367A (en)

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CN201711489980.6A CN107982367A (en) 2017-12-29 2017-12-29 A kind of traditional Chinese medicine oral liquid for treating infectious laryngotracheitis of chicken and preparation method thereof

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Application publication date: 20180504