CN107982354A - 一种治疗腹痛吐泻的中药有效部位组合物及其制备方法 - Google Patents
一种治疗腹痛吐泻的中药有效部位组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开一种治疗腹痛吐泻的中药有效部位组合物,由如下按质量份数计的组分组成:广霍香50‑100、丁香50‑100、肉桂50‑100、木香50‑100、细辛20‑40、沉香50‑100、甘草30‑70、白芷20‑40。并依次取原料,制备完全后出料。可用于治疗夏伤暑热,头目眩晕等症,特别适用于治疗小儿的肚痛、腹泻等症。
Description
技术领域
本发明涉及中药领域,具体涉及一种治疗腹痛吐泻的中药有效部位组合物及其制备方法。
背景技术
目前,虽然用于腹痛吐泻的药物种类繁多,但却没有安全有效的特效药,临床应用化学药物治疗较为普遍,药物多以抗生素、消炎为主,但临床用药的副作用大,危险性较高,与其它药物联合用药,更加大了患者的临床用药风险,特别是儿童患者,因此,开发安全有效的治疗腹痛吐泻药物具有较好的社会效益和经济效益。
发明内容
本发明的目的在于针对现有治疗腹痛吐泻药物中存在的不足,提供一种具有治疗腹痛吐泻功效的药物组合物,该组合物还可用于制备治疗夏伤暑热,头目眩晕等症,特别适用于治疗小儿的肚痛、腹泻等症。
本发明的另一目的在于提供上述药物组合物的制备方法,该方法操作简单,便于实施,药物收得率高,最大程度的保持了药物的有效成分。
本发明目的通过以下方案予以实现:
本发明的治疗腹痛吐泻的中药有效部位组合物,由如下按质量份数计的组分组成:广霍香50-100、丁香50-100、肉桂50-100、木香50-100、细辛20-40、沉香50-100、甘草30-70、白芷20-40。
其中,该组合物优选为由如下按质量份数计的组分组成:广霍香60-80、丁香60-80、肉桂60-80、木香60-80、细辛25-35、沉香60-80、甘草40-60、白芷30-35。
该组合物最优选为由如下按质量份数计的组分组成:
广霍香71、丁香71、肉桂71、木香71、细辛25、沉香71、甘草48、白芷35。
广藿香(Pogostemon cablin):唇形科植物,多年生草本直立植物,有香气。原产菲律宾,东南亚各地栽培较多,中国南方地区也有大量栽培。全草含挥发油,可用作强刺激药与芳香料,是香水常见成分。广藿香的功能主治主要是芳香化湿、和胃止呕、祛暑解表。主湿阻中焦之脘腹痞闵、食欲不振、呕吐、泄泻、外感暑湿之寒热头痛、湿温初起的发热身困、胸闵恶心、鼻渊、手足癣。
丁香:为桃金娘科植物丁香的花蕾。温中,暖肾,降逆。治呃逆,呕吐,反胃,泻痢,心腹冷痛,痃癖,疝气,癣疾。
肉桂:为樟科常绿乔木植物肉桂Cinnamomum cassia Presl的干皮和粗枝皮。干皮去表皮者称肉桂心, 采自粗枝条或幼树干皮 者称官桂。主产于广东、广西等地。主治:用于阳痿、宫冷、心腹冷痛、虚寒吐泻、经闭、痛经、温经通脉。
木香:木香是菊科植物云木香和川木香的通称。云木香(学名:Saussureacostus),又名广木香或青木香,属菊科风毛菊属。川木香(学名:Dolomiaea souliei)是菊科川木香属的植物,均是中国的特有植物。分布在中国大陆的四川、云南、西藏等地,多生长在高山草地和灌丛中,为野生植物,尚未由人工引种栽培。这两种植物的根茎都是重要的中草药。木香功能主治:行气止痛,健脾消食。用于胸脘胀痛,泻痢后重,食积不消,不思饮食。
细辛:别名:华细辛、盆草细辛,拉丁文名:Asarum sieboldii Miq. 马兜铃科、细辛属多年生草本。根茎入药,用为解热、利尿、镇痛、镇静药。(由于细辛双叶中含马兜铃酸等毒性成分,05版药典规定细辛入药部位沿用古法,恢复用根及根茎入药。)细辛具有祛风散寒,通窍止痛,温肺化饮的功效。根据十八反的药性,细辛不能与藜芦同用。
沉香:沉香的来源为双子叶植物药瑞香科乔木植物沉香Aquilaria agallocha(Lour.) Roxb 或白木香A. sinensis (Lour.) Gilg 在受到自然界的伤害,(如雷击,风折,虫蛀等)或受到人为破坏以后在自我修复的过程中分泌出的油脂受到真菌的感染,所凝结成的分泌物就是沉香。琼脂【海南沉香别名】、白木香【国内沉香树种】、莞香【广东、广西、香港产沉香统称】、其名称因结香的地域性不同,木香种类不同,因而名称不同。主要治气逆喘息、呕吐呃逆、脘腹胀痛、腰膝虚冷、大肠虚秘、小便气淋,男子精冷。
甘草:甘草(学名:Glycyrrhiza uralensis Fisch)别名:国老、甜草、乌拉尔甘草、甜根子。豆科、甘草属多年生草本,根与根状茎粗壮,是一种补益中草药。对人体很好的一种药,药用部位是根及根茎,药材性状根呈圆柱形,长25-100厘米,直径0.6-3.5厘米。外皮松紧不一,表面红棕色或灰棕色。根茎呈圆柱形,表面有芽痕,断面中部有髓。喜阴暗潮湿,日照长气温低的干燥气候。甘草多生长在干旱、半干旱的荒漠草原、沙漠边缘和黄土丘陵地带。甘草功能主治用于心气虚、心悸怔忡、脉结代、以及脾胃气虚、倦怠乏力、痈疽疮疡、咽喉肿痛、用于调和某些药物的烈性。
白芷:根呈圆锥形,长10-20cm,直径2-2.5cm。表面灰棕色,有横向突起的皮孔,顶端有凹陷的茎痕。质硬,断面白色,粉性足,皮部密布棕色油点。白芷的功能主治:祛风湿、活血排脓、生肌止痛。用于头痛、牙痛、鼻渊、肠风痔漏、赤白带下、痈疽疮疡、皮肤瘙痒。白芷还有美容功效,挑选大而色纯白无霉迹的白芷,取其根部,碾为极细末,掺入到一小瓶普通护肤品中,充分搅拌和匀,坚持使用,有一定的增白效果。
上述组合物的制备方法步骤如下:
(1) 取广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷加水煎煮,将煎液滤过,浓缩、醇沉、再浓缩,得到浓缩液;
(2) 取上述浓缩液,按常规制剂工艺加入适宜辅料,加工制成相应剂型。
其中,该组合物的制备方法优选为:
(1) 取广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷粉碎成粗粉,加9-13倍量水煎煮1-3次,每次1-3小时,煎液滤过,滤液合并,减压浓缩至相对密度为1.10-1.15的清膏,加乙醇使含醇量为65%,静置24小时,过滤,回收乙醇、浓缩,得到浓缩液;
(2)取上述浓缩液,按常规制剂工艺加入适宜辅料,加工制成相应剂型。
该组合物的制备方法最优选为:
(1) 取广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷粉碎成粗粉,加10倍量水煎煮2次,每次1.5小时,煎液滤过,滤液合并,减压浓缩至相对密度为1.10-1.15的清膏,加乙醇使含醇量为65%,静置24小时,过滤,回收乙醇、浓缩,得到浓缩液;
(2) 取上述浓缩液,按常规制剂工艺加入适宜辅料,加工制成相应剂型。
通过上述配方及制备方法所得含有广霍香的组合物具有如下疗效:
(1)归脾、胃、肺经。具有芳香化湿、和胃止呕、祛暑解表。肚泻腹绞、肚痛腹胀、寒胃吐酸、胸膈闷塞、寒痰咳嗽、食欲不振、呕吐、泄泻、山风瘴气、眩车晕船;
(2)治疗小儿肚泻腹绞,肚痛腹胀等症,不会伤及小儿脏腑肠胃。
与现有技术相比,本发明组合物具有如下技术效果:
本发明组合物配伍新颖合理,用于治疗腹痛吐泻等症疗效快,效果明显,服用简单,用药量少,无毒副作用。
具体实施方式
以下就用实施例来进一步解释本发明,但实施例并不对本发明做任何限定。
实施例1
取广霍香71克、丁香71克、肉桂71克、木香71克、细辛25克、沉香71克、甘草48克、白芷35克。将上述原料粉碎成粗粉,加8倍量水煎煮1.5小时,过滤药液,减压浓缩至相对密度为1.13的清膏,加乙醇使含醇量为65%,静置过夜,过滤,回收乙醇,浓缩,得到浓缩液1000ml。通过鼓风干燥后,进行超微粉碎,粒径控制在30μm以下,碎至全部通过65目-80目筛,分装于50克的玻璃瓶中,包装即得。
本品为黄棕色粉末,应色泽均匀,无花纹与色斑。在105℃干燥至恒重,减失重量不得过2.0%。可直接用水送服。
实施例2
1.临床观察600例病人均有明显临床症状,并经临床医师确诊。其中年龄最大80岁,最小八个月,病程最长10天,最短3天。
2.把患者按年龄分为儿童组(16岁以下),成人组(17-55岁),老年组(55岁以上)。口服实施例1中得到的中药组合物,成人量每日二次,每次0.3-0.9克,并以保济口服液为对照,口服保济口服液,成人量每日三次,每次10ml。
3.治愈:腹泻、吐泻、肚胀基本消失,功能恢复正常。显效:症状明显好转,腹泻、吐泻、肚胀明显减少。好转:症状减轻,腹泻、吐泻、肚胀减轻。无效:用药前后症状无改变。
4.各年龄组服用含有广霍香的中药组合物的散剂与服用保济口服液的治疗效对比。
通过对比可知,实施例1得到的含广霍香的中药组合物的散剂在治疗腹痛吐泻有特效,且优于保济口服液,在治疗儿童腹痛吐泻中疗效尤为明显。此外,治疗组的患者在用药后,睡眠状况均有显著好转。
实施例3
1.实验动物:ICR小鼠,体重22.5-26.5g,雌雄各半。
2.实验方法:经预试,实施例1中得到的中药组合物的毒性很低,测不出LD50,故对小鼠进行一日最大给药量测定。最大给药量为36克,为成年人临床口服剂量的20倍,7天后观察无一例中毒死亡,全部健康存活。
以上所述实施例的各技术特征可以进行任意的组合,为使描述简洁,未对上述实施例中的各个技术特征所有可能的组合都进行描述,然而,只要这些技术特征的组合不存在矛盾,都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (8)
1.一种治疗腹痛吐泻的中药有效部位组合物,其特征在于该组合物由广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷组成。
2.如权利要求1所述的组合物,其特征在于该组合物由如下按质量份数计的组分组成:广霍香50-100、丁香50-100、肉桂50-100、木香50-100、细辛20-40、沉香50-100、甘草30-70、白芷20-40组成。
3.如权利要求2所述的组合物,其特征在于该组合物由如下按质量份数计的组分组成:广霍香60-80、丁香60-80、肉桂60-80、木香60-80、细辛25-35、沉香60-80、甘草40-60、白芷30-35组成。
4.如权利要求3所述的组合物,其特征在于该组合物由如下按质量份数计的组分组成:广霍香71、丁香71、肉桂71、木香71、细辛25、沉香71、甘草48、白芷35组成。
5.如权利要求1-4所述的组合物,可加工制成散剂、颗粒剂、片剂、口服液、糖浆剂、胶囊。
6.权利要求1所述组合物的制备方法,其特征在于包括如下步骤:
(1)取广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷加水煎煮,将煎液滤过,浓缩、醇沉、再浓缩,得到浓缩液;
(2)取上述浓缩液,按常规制剂工艺加入适宜辅料,加工制成相应剂型。
7.如权利要求6所述组合物的制备方法,其特征在于包括如下步骤:
(1)取广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷粉碎成粗粉,加9-13倍量水煎煮1-3次,每次1-3小时,煎液滤过,滤液合并,减压浓缩至相对密度为1.10-1.15的清膏,加乙醇使含醇量为65%,静置24小时,过滤,回收乙醇、浓缩,得到浓缩液;
(2)取上述浓缩液,按常规制剂工艺加入适宜辅料,加工制成相应剂型。
8.如权利要求7所述组合物的制备方法,其特征在于包括如下步骤:
(1)取广霍香、丁香、肉桂、木香、细辛、沉香、甘草、白芷粉碎成粗粉,加10倍量水煎煮2次,每次1.5小时,煎液滤过,滤液合并,减压浓缩至相对密度为1.10-1.15的清膏,加乙醇使含醇量为65%,静置24小时,过滤,回收乙醇、浓缩,得到浓缩液;
(2)取上述浓缩液,按常规制剂工艺加入适宜辅料,加工制成相应剂型。
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