CN107982132A - A kind of radioresistance isolation breast - Google Patents
A kind of radioresistance isolation breast Download PDFInfo
- Publication number
- CN107982132A CN107982132A CN201711412439.5A CN201711412439A CN107982132A CN 107982132 A CN107982132 A CN 107982132A CN 201711412439 A CN201711412439 A CN 201711412439A CN 107982132 A CN107982132 A CN 107982132A
- Authority
- CN
- China
- Prior art keywords
- cistanche
- naringenin
- glycosides
- isolation breast
- digicitrine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
Abstract
The invention discloses a kind of radioresistance isolation breast, including components such as Glycosides of Cistanche 0.15%, digicitrine 0.3%, naringenin 0.04%, Gotu Kola P.Es 1.8%, addition Glycosides of Cistanche can strengthen cell SOD activity, reduce MDA contents, lipid peroxidation inhibition effect is played, and the recovery of SOD activity after raying irradiation damage can be obviously promoted;Digicitrine, which has, to be removed free radical and reaches radioresistance, oxidation resistant effect, moreover it is possible to suppresses the lipid oxidation after gamma-ray irradiation;Naringenin can protect cells from radiating caused DNA damage; alleviate stimulation of the environment to skin; several component synergistic effects; by removing free radical, anti peroxidation of lipid, enhancing cell SOD activity; reduce the approach of MDA contents; significant radiation protection can be played, and mitigates skin radiation injury, makes the more pale high resilience of skin.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of radioresistance isolation breast.
Background technology
People are generally computer office now, with also having brought radiation problem.It is prolonged to be subject to radiate shadow
Ring, cause scaly dry skin, long spot, the problems such as colour of skin is obscure.In addition, with industrialized development, increasing environmental pollution, atmosphere
Middle harmful substance increase, with the destruction of ozone layer, the radiation intensity of solar ultraviolet is also increasing, and ultraviolet is as cancer
Major incentive attracted people's attention, the cosmetics such as radioresistance, isolation in cosmetics play more and more important work
With.The aerial skin of exposure is even more that easy ultraviolet irradiation causes erythema, oedema, freckle of skin etc., UV resistance
Product is mainly used in summer, and still, with living-pattern preservation, while more and more people recognize the evil of ultraviolet radioactive
Place, and sun care preparations eliminates the ability of skin disease hidden danger that ultraviolet is brought and is also increasingly taken seriously, therefore in 1 year
Radioresistance, the product demand increase of isolation, the wide market of such product are used in the four seasons.
The prior art lays claim to that radioresistance, the product of isolating function are very much, but largely add preservative, anti-inflammatory
Medicine, pigment, the application content of spices are higher, do not play the role of not only protecting cell, have on the contrary to Skin Cell certain stimulation,
Toxic side effect, sun-proof result is also undesirable, or even effectively sun-prevention component is to utilize the compound with sensitization risk of synthesis, meeting
Skin is made to cast off a skin, the adverse reaction such as burning sensation.
The content of the invention
, can be by removing free radical, anti peroxidation of lipid, increasing it is an object of the invention to provide a kind of radioresistance isolation breast
Strong cell SOD activity, reduces the approach of MDA contents, effectively has the function that radioresistance, isolation.
To achieve the above object, the present invention provides following technical solution:
A kind of radioresistance isolation breast includes the component of following mass percent:
Glycosides of Cistanche 0.05 ~ 0.25%
Digicitrine 0.1 ~ 0.5%
Naringenin 0.01 ~ 0.06%
Gotu Kola P.E 0.5 ~ 3%
Further the isolation breast includes the component of following mass percent:
Glycosides of Cistanche 0.07 ~ 0.22%
Digicitrine 0.2 ~ 0.4%
Naringenin 0.02 ~ 0.05%
Gotu Kola P.E 1.1 ~ 2.7%
Further, the isolation breast includes the component of following mass percent:
Glycosides of Cistanche 0.15%
Digicitrine 0.3%
Naringenin 0.04%
Gotu Kola P.E 1.8%
In addition, the Glycosides of Cistanche is by being obtained after ethanol extraction drying with the saline cistanche after crushing;The hair
Glutinous rehmannia flavones is obtained by filtration after being extracted after digitalis is soaked with boiling water boiling;The naringenin is by crushing drying
Pomelo peel, is extracted with hot water;The Gotu Kola P.E is from the centella herb cleaned up, is steamed with high pressure
Vapour carries out what water raised.
The isolation breast of the present invention further includes the component of following mass percent:
Glycerine 3 ~ 6%, titanium dioxide 8 ~ 15%, dimethyl silicone polymer 3 ~ 6%, cetyl PEG/PPG-10/1 poly dimethyl silicon
Oxygen alkane 1 ~ 2%, the methyl of polyglycereol -3 distearate 0.5 ~ 1.5%, carbomer 0.1 ~ 0.3%, triethanolamine 0.1 ~ 0.3%,
0.2 ~ 0.5 part of Phenoxyethanol, Chlorphenesin 0.05 ~ 0.15%, diethyl hexylcarbonate 1 ~ 3%, caprylic/capric triglyceride 3 ~
5%th, Sodium Hyaluronate 0.01 ~ 0.03%, dipotassium glycyrrhizinate 0.05 ~ 0.15%, deionized water surplus.
In addition, this invention also provides a kind of preparation method of radioresistance isolation breast, include the following steps:
(1)By dimethyl silicone polymer, cetyl PEG/PPG-10/1 dimethyl silicone polymers, the methyl of polyglycereol -3 two
Stearate, diethyl hexylcarbonate, caprylic/capric triglyceride, titanium dioxide are uniformly mixed, and are heated to 80 ~ 85 DEG C, are made
A phases;
(2)Glycerine, carbomer, Chlorphenesin, Sodium Hyaluronate, dipotassium glycyrrhizinate, deionized water are uniformly mixed, are heated to 80
~ 85 DEG C, B phases are made;
(3)B phases are stirred and add A phases, 3 ~ 4min of emulsifying homogeneous, is made C phases;
(4)The C phases that cool add naringenin, Glycosides of Cistanche, digicitrine, Gotu Kola P.E, three ethanol to 50 DEG C
Amine, Phenoxyethanol are uniformly mixed, and radioresistance isolation breast is made.
Compared with prior art, it is the device have the advantages that as follows:
Addition Glycosides of Cistanche can strengthen cell SOD activity in the isolation breast of the present invention, reduce MDA contents, play anti-grease matter oxygen
Change acts on, and can be obviously promoted the recovery of SOD activity after raying irradiation damage;Digicitrine, which has, to be removed free radical and reaches
To radioresistance, oxidation resistant effect, moreover it is possible to suppress the lipid oxidation after gamma-ray irradiation;Naringenin can protect cells from radiating
Caused DNA damage, alleviates stimulation of the environment to skin, several component synergistic effects, by removing free radical, anti-lipid peroxy
Change, enhancing cell SOD activity, reduce the approach of MDA contents, significant radiation protection can be played, and mitigate skin radiation damage
Wound, makes the more pale high resilience of skin.
Embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated:
The all the components title occurred in text is INCI(International Nomenclature Cosmetic
Ingredient), i.e., international cosmetic raw material name institute is to defined title.
The newborn embodiment 1 ~ 5 of radioresistance isolation of the present invention is formulated, and is shown in Table 1.
Table 1
The Glycosides of Cistanche of the present invention is by being obtained after ethanol extraction drying with the saline cistanche after crushing.
The digicitrine of the present invention is obtained by filtration after being extracted after digitalis is soaked with boiling water boiling.
The naringenin of the present invention is by crushing dry pomelo peel, being extracted with hot water.
The Gotu Kola P.E of the present invention is from the centella herb cleaned up, carries out water with high steam and raises
's.
The preparation method of 1 ~ 5 radioresistance of above-described embodiment isolation breast comprises the following steps:
(1)By dimethyl silicone polymer, cetyl PEG/PPG-10/1 dimethyl silicone polymers, the methyl of polyglycereol -3 two
Stearate, diethyl hexylcarbonate, caprylic/capric triglyceride, titanium dioxide are uniformly mixed, and are heated to 85 DEG C, and A is made
Phase;
(2)Glycerine, carbomer, Chlorphenesin, Sodium Hyaluronate, dipotassium glycyrrhizinate, deionized water are uniformly mixed, are heated to 85
DEG C, B phases are made;
(3)B phases are stirred and add A phases, emulsifying homogeneous 4min, is made C phases;
(4)The C phases that cool add naringenin, Glycosides of Cistanche, digicitrine, Gotu Kola P.E, three ethanol to 50 DEG C
Amine, Phenoxyethanol are uniformly mixed, and radioresistance isolation breast is made.
Comparative example 1
Difference lies in be not added with Glycosides of Cistanche, other preparation methods and condition are same as Example 1 with embodiment 1.
Comparative example 2
Difference lies in be not added with digicitrine, other preparation methods and condition are same as Example 1 with embodiment 1.
Comparative example 3
Difference lies in be not added with naringenin, other preparation methods and condition are same as Example 1 with embodiment 1.
Comparative example 4
Difference lies in be not added with Gotu Kola P.E, other preparation methods and condition are same as Example 1 with embodiment 1.
Comparative example 5
With embodiment 1 difference lies in, be not added with Glycosides of Cistanche, digicitrine, naringenin, Gotu Kola P.E, other
Preparation method and condition are same as Example 1.
Embodiment 6
Radioresistance is tested:
Using QB/T2410-98《Assay method-ultraviolet absorptivity method of sunlight screening skin-protecting product UVB sun-proof skin care effects》Measure, its
Related data such as table 2 below:
Table 2
It can be seen that the newborn rejection rate to ultraviolet of radioresistance isolation of the present invention apparently higher than TiO from 2 data of table2, ZnO is to ultraviolet
Rejection rate, show the present invention there is excellent anti-radiation effect.
Embodiment 7
Oxidation Resistance Test
Experimental animal:The kunming mice 55 of health is taken, weight is 18~22g, is randomly divided into 11 groups, every group of 5 mouse:One
Group is blank group (do not apply radioresistance isolation breast), and five groups are contrast groups (the radioresistance isolation breast for smearing comparative example 1 ~ 5 respectively), five
Group is experimental group (the radioresistance isolation breast for smearing embodiment 1~5 respectively).
Experimental method:Each group mouse carries out back depilation with 0.8% sodium sulphate, leaks the test section of 4cm × 4cm cruelly.Apply
Skin first is cleaned with warm water before smearing radioresistance isolation breast, the mouse for being coated with radioresistance isolation breast is placed on sunlight simulated experiment case
Middle 1h, is carried out continuously 3 months, during which shaves off the mouse hair newly grown in time.Finally, clip mouse test section skin, prepares skin
Tissue homogenate, with superoxide dismutase (SOD) vigor in kit measurement mouse skin and malonaldehyde (MDA) content.It is real
Test as a result, see the table below 3:
Table 3
Group | SOD(U/mg) | MDA(nmol/mg) |
Blank group | 118.5±10.6 | 4.6±0.4 |
Embodiment 1 | 167.7±10.5 | 2.1±0.4 |
Embodiment 2 | 165.3±9.6 | 2.2±0.2 |
Embodiment 3 | 164.1±9.8 | 2.5±0.3 |
Embodiment 4 | 164.5±10.2 | 2.3±0.5 |
Embodiment 5 | 162.8±12.3 | 2.8±0.5 |
Comparative example 1 | 140.4±9.2 | 3.7±0.2 |
Comparative example 2 | 138±10.1 | 3.9±0.4 |
Comparative example 3 | 137±11.5 | 3.8±0.4 |
Comparative example 4 | 138±10.6 | 3.5±0.5 |
Comparative example 5 | 120.2±11.2 | 4.1±0.8 |
From table 3 it can be seen that embodiment 5 is not much different with blank group, the effect of illustrating the present invention component be Glycosides of Cistanche, hair
Glutinous rehmannia flavones, naringenin, Gotu Kola P.E.Comparative example 1 ~ 4 and embodiment 1~5 increase the content and drop of reducing agent SOD
The content of suboxides product MDA, but the positive effect of embodiment is higher than comparative example, illustrates Glycosides of Cistanche, the Mao Di of the present invention
Flavones, naringenin, Gotu Kola P.E synergistic effect, can play stronger antioxidation activity.
Above example only illustrates embodiment of the present invention, does not there is limitation in any form to the present invention;Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes or modification using the technology contents disclosed, becomes equivalent
The equivalent embodiment of change, technical spirit, carries out simple modification, equivalent change and modification to the present invention, belongs to according to the present invention
In the range of technical solution of the present invention.
Claims (9)
1. a kind of radioresistance isolation breast, it is characterised in that its component includes with content:
Glycosides of Cistanche 0.05 ~ 0.25%
Digicitrine 0.1 ~ 0.5%
Naringenin 0.01 ~ 0.06%
Gotu Kola P.E 0.5 ~ 3%
It is the mass percent that each component accounts for total raw material above.
2. isolation breast as claimed in claim 1, it is characterised in that its component includes with content:
Glycosides of Cistanche 0.07 ~ 0.22%
Digicitrine 0.2 ~ 0.4%
Naringenin 0.02 ~ 0.05%
Gotu Kola P.E 1.1 ~ 2.7%
It is the mass percent that each component accounts for total raw material above.
3. isolation breast as claimed in claim 2, it is characterised in that its component includes with content:
Glycosides of Cistanche 0.15%
Digicitrine 0.3%
Naringenin 0.04%
Gotu Kola P.E 1.8%
It is the mass percent that each component accounts for total raw material above.
4. such as claim 1 ~ 3 any one of them isolation breast, it is characterised in that after the Glycosides of Cistanche crushes
Saline cistanche is obtained by ethanol extraction after dry.
5. such as claim 1 ~ 3 any one of them isolation breast, it is characterised in that the digicitrine is to soak digitalis
It is obtained by filtration after being extracted after bubble with boiling water boiling.
6. such as claim 1 ~ 3 any one of them isolation breast, it is characterised in that the naringenin is by crushing dry shaddock
Sub- skin, is extracted with hot water.
7. such as claim 1 ~ 3 any one of them isolation breast, it is characterised in that the Gotu Kola P.E is dry from cleaning
In net centella herb, carry out what water raised with high steam.
8. such as claim 1 ~ 3 any one of them isolation breast, it is characterised in that the isolation breast formula further includes following matter
Measure the component of percentage:
Glycerine 3 ~ 6%, titanium dioxide 8 ~ 15%, dimethyl silicone polymer 3 ~ 6%, cetyl PEG/PPG-10/1 poly dimethyl silicon
Oxygen alkane 1 ~ 2%, the methyl of polyglycereol -3 distearate 0.5 ~ 1.5%, carbomer 0.1 ~ 0.3%, triethanolamine 0.1 ~ 0.3%,
0.2 ~ 0.5 part of Phenoxyethanol, Chlorphenesin 0.05 ~ 0.15%, diethyl hexylcarbonate 1 ~ 3%, caprylic/capric triglyceride 3 ~
5%th, Sodium Hyaluronate 0.01 ~ 0.03%, dipotassium glycyrrhizinate 0.05 ~ 0.15%, deionized water surplus.
9. prepare such as the method for claim 1 ~ 3 any one of them isolation breast, it is characterised in that the preparation method includes
Following steps:
(1)By dimethyl silicone polymer, cetyl PEG/PPG-10/1 dimethyl silicone polymers, the methyl of polyglycereol -3 two
Stearate, diethyl hexylcarbonate, caprylic/capric triglyceride, titanium dioxide are uniformly mixed, and are heated to 80 ~ 85 DEG C, are made
A phases;
(2)Glycerine, carbomer, Chlorphenesin, Sodium Hyaluronate, dipotassium glycyrrhizinate, deionized water are uniformly mixed, are heated to 80
~ 85 DEG C, B phases are made;
(3)B phases are stirred and add A phases, 3 ~ 4min of emulsifying homogeneous, is made C phases;
(4)The C phases that cool add naringenin, Glycosides of Cistanche, digicitrine, Gotu Kola P.E, three ethanol to 50 DEG C
Amine, Phenoxyethanol are uniformly mixed, and radioresistance isolation breast is made.
Priority Applications (1)
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CN201711412439.5A CN107982132A (en) | 2017-12-24 | 2017-12-24 | A kind of radioresistance isolation breast |
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CN201711412439.5A CN107982132A (en) | 2017-12-24 | 2017-12-24 | A kind of radioresistance isolation breast |
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CN107982132A true CN107982132A (en) | 2018-05-04 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274831A (en) * | 2013-07-10 | 2015-01-14 | 苏德培 | Composition based on naturally derived peptide and inflammation inhibitor and/or anti-oxidation compound |
CN105106024A (en) * | 2015-09-11 | 2015-12-02 | 新疆医科大学第一附属医院 | Flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides and preparation method thereof |
CN105287272A (en) * | 2015-06-17 | 2016-02-03 | 新疆医科大学第一附属医院 | Cosmetic composition with active components which are phenylethanoid glycosides of cistanche deserticola extract |
-
2017
- 2017-12-24 CN CN201711412439.5A patent/CN107982132A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274831A (en) * | 2013-07-10 | 2015-01-14 | 苏德培 | Composition based on naturally derived peptide and inflammation inhibitor and/or anti-oxidation compound |
CN105287272A (en) * | 2015-06-17 | 2016-02-03 | 新疆医科大学第一附属医院 | Cosmetic composition with active components which are phenylethanoid glycosides of cistanche deserticola extract |
CN105106024A (en) * | 2015-09-11 | 2015-12-02 | 新疆医科大学第一附属医院 | Flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides and preparation method thereof |
Non-Patent Citations (3)
Title |
---|
吕畅等: "木犀草素抗氧化作用研究进展", 《黑龙江医药》 * |
宋效庆等: "柚皮素抗炎和抗氧化作用的研究进展", 《中国科技期刊数据库》 * |
王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
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