CN107951964B - Peanut skin extract and grape seed extract compound capsule and production method thereof - Google Patents
Peanut skin extract and grape seed extract compound capsule and production method thereof Download PDFInfo
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Abstract
The invention belongs to the field of capsules, and discloses a compound capsule of peanut skin extract and grape seed extract and a production method thereof, wherein the compound capsule comprises the main components of 30-35% of grape seed extract, 30-35% of peanut skin extract, 30% of starch and 0.2-1% of magnesium stearate, and the preparation method comprises the steps of drying, sieving, mixing and encapsulating. The compound capsule of the peanut red skin extract and the grape seed extract is safe and nontoxic and has strong oxidation resistance.
Description
Technical Field
The invention belongs to the field of capsules, and particularly relates to a compound capsule of a peanut skin extract and a grape seed extract and a production method thereof.
Technical Field
The peanut skin is used as a byproduct with extremely low value in the production process of peanuts, and besides being used for animal feed, most of the peanut skin is used as waste, so that the resource waste is caused. Researches in recent years find that the peanut red skin is rich in polyphenols and has high nutritional and utilization values. The polyphenol substances in the peanut skin comprise procyanidine, resveratrol, phenolic acid and the like, wherein the procyanidine accounts for the highest specific weight, and about 50 percent of the polyphenol substances are oligomers with higher biological activity. Procyanidin is a polyphenol compound separated from grape seeds and formed by connecting monomer flavan-3-alcohols with different polymerization degrees. Procyanidins are a generic term for a large group of polyphenolic compounds that are widely found in the plant kingdom. Originally collectively referred to as condensed tannins or flavanols, with the continued development of separation and identification techniques and the continued research into such substances, they have become an independent large group of substances collectively referred to as procyanidins. The basic composition units of the compound are catechin and epicatechin, and the upper unit and the lower unit are connected by C-C bonds at 4-8 or 4-6 positions to form a mixture with different polymerization degrees. Procyanidin has strong antioxidant ability, can be used as main effective component of medicine for preventing cancer and preventing and treating cardiovascular diseases, and can be used as safe and nontoxic natural antioxidant. Resveratrol is also called as resveratrol, has a chemical name of 3, 4', 5-trihydroxy stilbene, and is a non-flavonoid polyphenol compound containing stilbene structure. In nature, resveratrol mainly exists in plants such as peanut, grape, giant knotweed, mulberry, gnetum montanum, Maackia amurensis and the like, has high content in seed coats, is phytoalexin and has important physiological functions. The research shows that the effects of inhibiting cancer cells, reducing blood fat, preventing and treating cardiovascular diseases, resisting oxidation, delaying senility and the like are obvious.
The content of grape seed polyphenols can reach about 8%, most of the grape seed polyphenols are procyanidins (generally accounting for 70% -85%), and then substances such as resveratrol and the like, and researches in recent years show that the procyanidins are strong antioxidants, have strong capability of scavenging oxygen free radicals, have activity 20 and 50 times stronger than VC and VE respectively, have various biological effects of resisting tumors, resisting viruses, protecting cardiovascular and the like, and become important raw materials of medicines and health-care products and important additives of foods and cosmetics.
The peanut red skin procyanidin has a large difference with grape seed procyanidin, and the literature research finds that 3 monomers, 14 dimers, 11 trimers and the like are identified in grape seed procyanidin, and 5 monomers, 10 dimers, 1 trimer and 1 tetramer and the like are identified in peanut red skin procyanidin at present. Most of procyanidine capsule products in the current market are procyanidine from grape seeds, and the effect of antioxidant products in the market is not obvious.
Disclosure of Invention
The invention aims to provide a peanut red skin extract and grape seed extract compound capsule and a production method thereof.
The invention is mainly realized by the following technical scheme:
the compound capsule of the peanut skin extract and the grape seed extract is characterized in that the capsule comprises the following components in percentage by weight: 30-35% of grape seed extract, 30-35% of peanut skin extract, 30% of starch and 0.2-1% of magnesium stearate.
Preferably, the first and second electrodes are formed of a metal,
the capsule comprises the following components in percentage by weight: 34.5% of grape seed extract, 34.5% of peanut skin extract, 30% of starch and 1% of magnesium stearate.
Preferably, the first and second electrodes are formed of a metal,
the peanut skin extract is prepared by the following process: removing shells of peanut, then placing the peanut in an oven, drying the peanut for 1h at a constant temperature of 50 ℃, taking out the peanut, and separating peanut skin from peanut kernels; performing high-voltage pulse electric field treatment on the peanut skin, then adding the peanut skin into 70% ethanol with the weight being 10 times that of the peanut skin, heating to 50 ℃, stirring for 30min at 100rpm under the condition of heat preservation, filtering and collecting filtrate, performing reduced pressure distillation on the filtrate to recover ethanol, collecting concentrated solution, and performing vacuum freeze drying on the concentrated solution to obtain the treated peanut skin.
Preferably, the first and second electrodes are formed of a metal,
the parameters of the electric field treatment are as follows: the field strength was 20kv/cm, the total treatment time was 400. mu.s, the pulse width was 4. mu.s, and the pulse frequency was 400 pps.
Preferably, the first and second electrodes are formed of a metal,
the grape seed extract is prepared by the following process: placing grape seeds in an oven, drying for 2h at a constant temperature of 50 ℃, then taking out, crushing into powder, sieving with a 50-mesh sieve, then carrying out high-voltage pulse electric field treatment, adding into 70% ethanol with the weight being 10 times of that of the grape seeds, heating to 50 ℃, carrying out stirring treatment for 60min at a speed of 100rpm under a heat preservation condition, filtering and collecting filtrate, carrying out reduced pressure distillation on the filtrate to recover ethanol, collecting concentrated solution, and carrying out vacuum freeze drying on the concentrated solution to obtain the grape seed extract.
Preferably, the first and second electrodes are formed of a metal,
the parameters of the electric field treatment are as follows: the field strength was 30kv/cm, the total treatment time was 600. mu.s, the pulse width was 4. mu.s, and the pulse frequency was 400 pps.
The invention also claims a production method of the compound capsule of the peanut skin extract and the grape seed extract, which comprises the following steps:
step (1): drying starch at 70 deg.C for 1-2 hr, and packaging into clean PE bag for cooling to prevent moisture absorption;
step (2): sieving grape seed extract, peanut skin extract, dried and cooled starch, and magnesium stearate with 60-80 mesh sieve respectively to obtain fine powder.
And (3): mixing the magnesium stearate and the starch obtained in the step (2) according to a ratio, adding the grape seed extract and the peanut red skin extract, and mixing for 20-40 minutes to obtain mixed powder;
and (4): and (4) performing capsule filling, finishing, polishing, bottling and boxing operations on the mixed powder obtained in the step (3).
Preferably, the first and second electrodes are formed of a metal,
in the step (1), the drying value of the starch is less than or equal to 6wt% of water.
Preferably, the first and second electrodes are formed of a metal,
in the step (2), the stainless steel screen mesh with 60 meshes is screened
The invention mainly includes but is not limited to the following aspects:
modern medical research finds that: the main reason for aging is that the excess of free radicals in vivo destroys the oxidation balance mechanism of the organism, firstly, the free radicals directly destroy the oxidation of protein and cause cross-linking denaturation, and also oxidize and cross-link nucleic acid, so that DNA is broken, and the like, thereby seriously affecting the normal transcription and translation process of protein genetic information, reducing or even eliminating the expression level of protein, or generating mutant protein, and the like. The invention is a health food prepared by selecting grape seed extract and peanut skin extract as main raw materials according to modern pharmacological research results.
Modern pharmacological research shows that the grape seed extract and the peanut skin extract are rich in polyphenols and can obviously reduce the level of free radicals. Therefore, the grape seed extract and the peanut red skin extract have extremely strong antioxidant activity, and the grape seed extract and the peanut red skin extract are selected as raw materials, so that the formula is scientific and reasonable, the synergistic performance is good, and the antioxidant function is clear.
The high-voltage pulse electric field is adopted to treat peanut red skins or grape seeds, the effect is better than that of conventional ultrasonic treatment, the content of polyphenol substances can be improved by more than 35%, and the operation mode is simpler and more convenient; aiming at the difference of polyphenols in peanut skin and grape seeds, the degree of aggregation of grape seed procyanidin is higher, and the ethanol extraction time is longer than that of peanut skin;
the invention adopts an alcohol extraction mode, the yield of the polyphenols is continuously improved along with the increase of the concentration of the ethanol, when the ethanol reaches 70 percent, the extraction rate of the polyphenols is the highest, and the polarity of the polyphenols in the extracting solution is closer to that of the 70 percent ethanol.
Compared with a model control group, the group in the example 1 and the control groups 1-2 can improve the content of SOD in red blood cells and liver, and compared with the control group 1 or 2 only added with one of peanut red skin extract or grape seed extract, the group in the example 1 has better effect of improving SOD, and suggests that the peanut red skin extract and the grape seed extract which are reasonably compatible have a certain synergistic effect and good oxidation resistance.
Drawings
FIG. 1: influence of ethanol concentration on the yield of polyphenols.
Detailed Description
In order to make those skilled in the art better understand the technical solutions of the present application, the present invention will be further described in detail with reference to the following specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. Based on the embodiments in the present application, other embodiments obtained by a person of ordinary skill in the art without any creative effort shall fall within the protection scope of the present invention.
Example 1
A compound capsule of peanut skin extract and grape seed extract comprises the following components (weight percentage):
34.5% of grape seed extract, 34.5% of peanut skin extract, 30% of starch and 1% of magnesium stearate.
The production method of the compound capsule of the peanut red skin extract and the grape seed extract comprises the following steps:
step (1): drying starch at 70 deg.C for 2 hr, drying, and packaging in clean PE bag for cooling. Moisture absorption is prevented;
step (2): sieving grape seed extract, peanut skin extract, dried and cooled starch, and magnesium stearate with 60 mesh sieve to obtain fine powder;
and (3): mixing the magnesium stearate and the starch obtained in the step (2) according to a ratio, and then adding the grape seed extract and the peanut skin extract for total mixing for 20 minutes to obtain mixed powder;
and (4): and (4) performing capsule filling, finishing, polishing, bottling and boxing operations on the mixed powder obtained in the step (3).
The peanut skin extract is prepared by the following process: removing shells of peanut, then placing the peanut in an oven, drying the peanut for 1h at a constant temperature of 50 ℃, taking out the peanut, and separating peanut skin from peanut kernels; carrying out high-voltage pulse electric field treatment on peanut skin, wherein the field intensity of an electric field is 20kv/cm, the total treatment time is 400 mus, the pulse width is 4 mus, and the pulse frequency is 400 pps; adding into 10 times of 70% ethanol, heating to 50 deg.C, stirring at 100rpm for 30min under heat preservation, filtering, collecting filtrate, distilling the filtrate under reduced pressure to recover ethanol, collecting concentrated solution, and vacuum freeze drying to obtain peanut skin treated product.
The grape seed extract is prepared by the following process:
placing grape seeds in a drying oven, drying for 2h at the constant temperature of 50 ℃, then taking out, crushing into powder, sieving with a 50-mesh sieve, and then carrying out high-voltage pulse electric field treatment, wherein the field intensity of an electric field is 30kv/cm, the total treatment time is 600 mus, the pulse width is 4 mus, and the pulse frequency is 400 pps; adding into 10 times of 70% ethanol, heating to 50 deg.C, stirring at 100rpm under heat preservation for 60min, filtering, collecting filtrate, distilling the filtrate under reduced pressure to recover ethanol, collecting concentrated solution, and vacuum freeze drying to obtain grape seed extract.
The above operations, from drying, crushing, mixing, and inclusion, were all performed in thirty thousand clean zones.
Example 2
A compound capsule of peanut skin extract and grape seed extract comprises the following components (weight percentage):
34.75 percent of grape seed extract, 34.75 percent of peanut skin extract, 30 percent of starch and 0.5 percent of magnesium stearate.
The compound capsule of the peanut red skin extract and the grape seed extract and the production method thereof comprise the following steps:
step (1): drying starch at 70 deg.C for 1 hr, drying, and packaging in clean PE bag for cooling. Preventing moisture absorption.
Step (2): sieving grape seed extract, peanut skin extract, dried and cooled starch, and magnesium stearate with 80 mesh sieve to obtain fine powder.
And (3): and (3) mixing the magnesium stearate and the starch obtained in the step (2) according to a ratio, adding the grape seed extract and the peanut skin extract, and mixing for 40 minutes to obtain mixed powder.
And (4): and (4) performing capsule filling, finishing, polishing, bottling and boxing operations on the mixed powder obtained in the step (3).
The peanut skin extract is prepared by the following process: removing shells of peanut, then placing the peanut in an oven, drying the peanut for 1h at a constant temperature of 50 ℃, taking out the peanut, and separating peanut skin from peanut kernels; carrying out high-voltage pulse electric field treatment on peanut skin, wherein the field intensity of an electric field is 20kv/cm, the total treatment time is 400 mus, the pulse width is 4 mus, and the pulse frequency is 400 pps; adding into 10 times of 70% ethanol, heating to 50 deg.C, stirring at 100rpm for 30min under heat preservation, filtering, collecting filtrate, distilling the filtrate under reduced pressure to recover ethanol, collecting concentrated solution, and vacuum freeze drying to obtain peanut skin treated product.
The grape seed extract is prepared by the following process:
placing grape seeds in a drying oven, drying for 2h at the constant temperature of 50 ℃, then taking out, crushing into powder, sieving with a 50-mesh sieve, and then carrying out high-voltage pulse electric field treatment, wherein the field intensity of an electric field is 30kv/cm, the total treatment time is 600 mus, the pulse width is 4 mus, and the pulse frequency is 400 pps; adding into 10 times of 70% ethanol, heating to 50 deg.C, stirring at 100rpm under heat preservation for 60min, filtering, collecting filtrate, distilling the filtrate under reduced pressure to recover ethanol, collecting concentrated solution, and vacuum freeze drying to obtain grape seed extract.
The above operations, from drying, crushing, mixing, and inclusion, were all performed in thirty thousand clean zones.
Example 3
The difference from example 1 lies in the preparation process of the peanut red skin extract and the grape seed extract, which is as follows:
the peanut skin extract is prepared by the following process: removing shells of peanut, then placing the peanut in an oven, drying the peanut for 1h at a constant temperature of 50 ℃, taking out the peanut, and separating peanut skin from peanut kernels; adding peanut skin into 10 times of 70% ethanol, heating to 50 deg.C, performing ultrasonic treatment at 25kHz for 30min under heat preservation, filtering, collecting filtrate, distilling the filtrate under reduced pressure to recover ethanol, collecting concentrated solution, and vacuum freeze drying the concentrated solution to obtain treated peanut skin.
The grape seed extract is prepared by the following process:
placing grape seeds in an oven, drying for 2h at the constant temperature of 50 ℃, then taking out, crushing into powder, sieving with a 50-mesh sieve, then adding into 70% ethanol with the weight of 10 times of the grape seeds, heating to 50 ℃, carrying out ultrasonic treatment for 60min under the heat preservation condition, wherein the ultrasonic intensity is 25kHz, filtering, collecting filtrate, carrying out reduced pressure distillation on the filtrate to recover ethanol, collecting concentrated solution, and carrying out vacuum freeze drying on the concentrated solution to obtain the grape seed extract.
Example 4
The content of polyphenols in the peanut red skin extract is detected by an absorptiometry method based on 1000g of peanut red skin, wherein the yield (%) = (mass of peanut red skin extract/mass of peanut red skin) × 100%, and the purity (%) = (mass of polyphenols in peanut red skin extract/mass of peanut red skin extract) × 100%. See table 1 specifically:
TABLE 1
| Group of | Example 1 | Example 3 |
| Peanut skin extract g | 196.8 | 191.8 |
| The yield is% | 19.68 | 19.18 |
| Purity% | 61.8 | 43.6 |
The content of polyphenols in the grape seed extract was measured by absorptiometry based on 1000g of grape seeds, wherein the yield (%) = (mass of grape seed extract/mass of grape seeds) × 100%, and the purity (%) = (mass of polyphenols in the grape seed extract/mass of grape seeds extract) × 100%. See table 2 specifically:
TABLE 2
| Group of | Example 1 | Example 3 |
| Grape seed extract g | 106.7 | 114.3 |
| The yield is% | 10.67 | 11.43 |
| Purity% | 68.5 | 49.3 |
And (4) conclusion: the high-voltage pulse electric field is adopted to treat peanut red skins or grape seeds, the effect is better than that of conventional ultrasonic treatment, the content of polyphenol substances is improved by more than 35%, and the operation mode is simpler and more convenient.
Example 5
Influence of ethanol concentration on yield of peanut red skin polyphenols:
taking example 1 as an example, the influence of ethanol concentration on the yield of polyphenols is detected, as shown in fig. 1, the yield of polyphenols is continuously improved with the increase of ethanol concentration, and when the ethanol concentration reaches 70%, the extraction rate of polyphenols is the highest, because the peanut red skin extract is a mixed solution of a series of organic substances, wherein the polyphenols mainly include procyanidins, resveratrol, phenolic acids, sterols and the like, and the polarity of the polyphenols is closer to that of 70% ethanol; the polyphenol substance content obtained by pure water extraction is about two thirds of that of 70% ethanol, and the absolute ethanol content is the lowest and is only one half of that of 70% ethanol.
Example 6
The compound capsule of the invention has the following oxidation resistance tests:
experimental animals: kunming mouse, male, 28-30g, 10 weeks old. Randomly dividing mice into 5 groups, namely a blank control group, a model control group, an example 1 group, a control group 1 and a control group 2, wherein each group comprises 10 mice, injecting a D-galactose solution (0.2 g/ml) with a dose of 10ml/KG into the neck and the back of each group except the blank control group, and simultaneously administering a compound capsule preparation with a dose of 50mg/KG, wherein the model control group is administered with a preparation without grape seed extract and peanut red skin extract, and the rest is the same as the example 1; example 1 group the formulation prepared in example 1 was administered; control 1 was given formulation 1 without added grape seed extract, replaced with an equal amount of peanut red skin extract, as in example 1; control 2 was given formulation 2, which was not added peanut skin extract, but replaced with an equal amount of grape seed extract, as in example 1. The blank control group was given the same quality of physiological saline. After 60 days, each physiological index was observed. Index measurement: blood was taken from the intraocular vein of the mouse for SOD measurement, then the animal was sacrificed by removing the cervical vertebrae, and the liver was taken and rapidly frozen for SOD measurement. Specific results are shown in table 3:
TABLE 3
| Group of | Number only | Erythrocyte extract NU/ml | Liver homogenate NU/mg |
| | 10 | 11768±1630 | 9.76±0.41 |
| | 10 | 9134±1012 | 8.37±0.59 |
| EXAMPLE 1 | 10 | 13019±1277 | 9.33±0.46 |
| Control group 1 | 10 | 12353±1429 | 9.12±0.54 |
| | 10 | 11978±1162 | 9.09±0.33 |
And (4) conclusion: compared with a model control group, the group of example 1 and the control groups 1-2 can improve the content of SOD in erythrocytes and livers, and compared with the control group 1 only added with the peanut red skin extract or the control group 2 only added with the grape seed extract, the group of example 1 has better effect of improving SOD, which indicates that the peanut red skin extract and the grape seed extract which are reasonably compatible have a certain synergistic effect and good oxidation resistance.
Although the invention has been described herein with reference to illustrative embodiments thereof, it is not intended to be limited thereto, but rather it is to be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the spirit and scope of the principles of this invention as disclosed in the appended claims.
Claims (5)
1. The compound capsule of the peanut skin extract and the grape seed extract is characterized in that the capsule comprises the following components in percentage by weight: 30-35% of grape seed extract, 30-35% of peanut red skin extract, 30% of starch and 0.2-1% of magnesium stearate;
the peanut skin extract is prepared by the following process: removing shells of peanut, then placing the peanut in an oven, drying the peanut for 1h at a constant temperature of 50 ℃, taking out the peanut, and separating peanut skin from peanut kernels; performing high-voltage pulse electric field treatment on peanut skin, adding the peanut skin into 10 times of 70% ethanol, heating to 50 ℃, stirring at 100rpm under the condition of heat preservation for 30min, filtering and collecting filtrate, performing reduced pressure distillation on the filtrate to recover ethanol, collecting concentrated solution, and performing vacuum freeze drying on the concentrated solution to obtain a treated peanut skin;
the parameters of the electric field treatment are as follows: the field intensity is 20kv/cm, the total processing time is 400 mus, the pulse width is 4 mus, and the pulse frequency is 400 pps;
the grape seed extract is prepared by the following process: placing grape seeds in an oven, drying for 2h at the constant temperature of 50 ℃, taking out, crushing into powder, sieving with a 50-mesh sieve, performing high-voltage pulse electric field treatment, adding into 10 times of 70% ethanol, heating to 50 ℃, stirring at 100rpm under the condition of heat preservation for 60min, filtering, collecting filtrate, performing reduced pressure distillation on the filtrate to recover ethanol, collecting concentrated solution, and performing vacuum freeze drying on the concentrated solution to obtain a grape seed extract;
the parameters of the electric field treatment are as follows: the field strength was 30kv/cm, the total treatment time was 600. mu.s, the pulse width was 4. mu.s, and the pulse frequency was 400 pps.
2. The peanut skin extract and grape seed extract compound capsule as claimed in claim 1, wherein the capsule comprises the following components by weight percent: 34.5% of grape seed extract, 34.5% of peanut skin extract, 30% of starch and 1% of magnesium stearate.
3. The peanut skin extract and grape seed extract compound capsule as claimed in claim 1, wherein the capsule comprises the following components by weight percent: 34.75 percent of grape seed extract, 34.75 percent of peanut skin extract, 30 percent of starch and 0.5 percent of magnesium stearate.
4. The production method of the peanut skin extract and grape seed extract compound capsule as claimed in claim 1, wherein the production method comprises the following steps:
step (1): drying starch at 70 deg.C for 1-2 hr, and packaging into clean PE bag for cooling to prevent moisture absorption;
step (2): respectively grinding grape seed extract, peanut skin extract, dried and cooled starch and magnesium stearate, and sieving with 60-80 mesh sieve to obtain fine powder;
and (3): mixing the magnesium stearate and the starch obtained in the step (2) according to a ratio, adding the grape seed extract and the peanut red skin extract, and mixing for 20-40 minutes to obtain mixed powder;
and (4): and (4) performing capsule filling, finishing, polishing, bottling and boxing operations on the mixed powder obtained in the step (3).
5. The production method according to claim 4, wherein in the step (2), a 60-mesh stainless steel screen is passed.
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| CN107951964A (en) | 2018-04-24 |
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Address after: 276600 west section of Chengnan Ring Road, Junan County, Linyi, Shandong Patentee after: Jinsheng Grain and Oil Group Co.,Ltd. Patentee after: SHANDONG JINPHARM CO.,LTD. Address before: 276600 west section of Chengnan Ring Road, Junan County, Linyi, Shandong Patentee before: SHANDONG JINSHENG CEREALS & OILS GROUP Co.,Ltd. Patentee before: SHANDONG JINPHARM CO.,LTD. |
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Effective date of registration: 20221214 Address after: 276600 building 6, No. 0000441, daxihuan Road, Junan County, Linyi City, Shandong Province Patentee after: SHANDONG JINPHARM CO.,LTD. Address before: 276600 west section of Chengnan Ring Road, Junan County, Linyi, Shandong Patentee before: Jinsheng Grain and Oil Group Co.,Ltd. Patentee before: SHANDONG JINPHARM CO.,LTD. |