CN107951964A - A kind of peanut red coat extract and grape seed extract compounding capsule and its production method - Google Patents
A kind of peanut red coat extract and grape seed extract compounding capsule and its production method Download PDFInfo
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- CN107951964A CN107951964A CN201711319309.7A CN201711319309A CN107951964A CN 107951964 A CN107951964 A CN 107951964A CN 201711319309 A CN201711319309 A CN 201711319309A CN 107951964 A CN107951964 A CN 107951964A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention belongs to capsule field, disclose a kind of peanut red coat extract and grape seed extract compounding capsule and its production method, it is grape seed extract 30% 35% including its main constituents, peanut red coat extract 30 35%, starch 30%, magnesium stearate 0.2% 1%, preparation method include dry, sieving, mixing, dress capsule to obtain the final product.Product peanut red coat extract and grape seed extract of the present invention compound capsule, safe and non-toxic, have very strong oxidation resistance.
Description
Technical field
The invention belongs to capsule field, and in particular to a kind of peanut red coat extract and grape seed extract compound capsule
And its production method.
Technical background
Peanut red coat is as extremely low accessory substance is worth during peanut production, in addition to for animal feed, largely
It is taken as discarded object and causes the wasting of resources.Recent researches are found, polyphenols is rich in peanut red coat, are had very high
Nutrition and utility value.Polyphenols includes the materials such as procyanidine, resveratrol, phenolic acid, its Central Plains flower in peanut red coat
Blue or green element accounting weight highest, there are about 50% as the higher oligomer of bioactivity.Procyanidine is one separated from grape pip
The polyphenol compound that class is formed by connecting by monomeric flavan -3- alcohols materials with different polymerization degree.Procyanidine is in plant kingdom
The general name for the major class polyphenolic substance being widely present.Originally condensed tannin or flavanol compound are referred to as, as skill is identified in separation
The continuous development of art and deepen continuously to such material research, be referred to as original as an independent major class material, system
Anthocyanidin.The basic component units of this kind of compound are catechin and epicatechin, with 4-8 or 4-6 C-C between upper lower unit
Key is connected, and forms the mixture with different polymerization degree.Procyanidine has stronger oxidation resistance, can be used as anti-cancer, prevent
The principle active component of cardiovascular disease medicine is controlled, can be used as safe and non-toxic new type natural antioxidant.Resveratrol is also known as
Resvertrol, 3,4 ', 5 one trihydroxy talan of chemical name, is the non-flavonoids polyphenolic substance containing stilbene class formation.
In nature, resveratrol is primarily present in the plants such as peanut, grape, giant knotweed, mulberry fruit, sweetberry jointfir, Maackia amurensis Rupr et Maxim, is especially being planted
Content is higher in skin, is a kind of phytoalexin, has important physiological function.Some researches show that it suppresses cancer cell, reduces
Blood fat, prevention and cure of cardiovascular disease, anti-oxidant, anti-aging etc. play a role clearly.
Grape seed polyphenols class content of material can reach 8% or so, be procyanidine (typically constitute from 70% one 85%) mostly, its
Secondary is the materials such as resveratrol, and research in recent years shows, procyanidine is a kind of powerful antioxidant, has stronger removing oxygen certainly
It is 20 and 50 times stronger than VC and VE difference by the ability of base, its activity, there are a variety of lifes such as antitumor, antiviral, protection angiocarpy
Thing effect, has become medicine, the important source material of health products and food, the important additives of cosmetics.
Peanut red coat procyanidine and grape pip procyanidin differ greatly, and literature survey is found at present in grape
Identify 3 kinds of monomers in seed procyanidine, 14 kinds of dimers, 11 kinds of tripolymers etc., identify 5 in peanut red coat procyanidine
Kind of monomer, 10 kinds of dimers, a kind of tripolymer, a kind of tetramer etc..Procyanidine capsule product is largely Portugal currently on the market
The procyanidine in grape seed source, and oxidation resistant product effect unobvious on the market.
The content of the invention
The purpose of the present invention is a kind of peanut red coat extract and grape seed extract compounding capsule and its production method, sheet
Invent the peanut red coat extract prepared and grape seed extract compounding capsule contains grape seed extract and peanut red coat extraction
Thing, the two compatibility is reasonable, mutually collaboration, has obvious anti-oxidation function so that this product has more compared with other categories
Obvious anti-oxidation efficacy.
It is of the invention main to realize by following technical solution：
A kind of peanut red coat extract and grape seed extract compound capsule, it is characterised in that the weight of each component in the capsule
It is as follows to measure percentage：Grape seed extract 30%-35%, peanut red coat extract 30-35%, starch 30%, magnesium stearate 0.2%-
1%。
Preferably,
The percentage by weight of each component is as follows in the capsule：Grape seed extract 34.5%, peanut red coat extract 34.5%, forms sediment
Powder 30%, magnesium stearate 1%.
Preferably,
The peanut red coat extract is prepared according to following technique：Peanut is shelled, is subsequently placed in baking oven, 50 DEG C of constant temperature
Under the conditions of dry 1h, take out, peanut red coat and shelled peanut separated；Peanut red coat is subjected to high-pressure pulse electric processing, then
It is added in 70% ethanol of 10 times of weight, is heated to 50 DEG C, 100rpm stir process 30min under heat-retaining condition, is collected by filtration filter
Liquid, carries out vacuum distillation recycling ethanol by filtrate, collects concentrate, concentrate is used vacuum freeze drying, it is red that peanut is made
Clothing processed material.
Preferably,
The parameter of the electric field treatment is：Field strength is 20kv/cm, and total processing time is 400 μ s, and pulse width is 4 μ s, pulse frequency
Rate is 400pps.
Preferably,
The grape seed extract is prepared according to following technique：Grape pip is placed in baking oven, is dried under 50 DEG C of constant temperatures
2h, then takes out, and is ground into powder, crosses 50 mesh sieves, then carries out high-pressure pulse electric processing, is then added to 10 times of weight
In 70% ethanol, 50 DEG C are heated to, 100rpm stir process 60min, is collected by filtration filtrate under heat-retaining condition, and filtrate is subtracted
Pressure is distilled to recover ethanol, collects concentrate, concentrate is carried out vacuum freeze drying, and grape seed extract is made.
Preferably,
The parameter of the electric field treatment is：Field strength is 30kv/cm, and total processing time is 600 μ s, and pulse width is 4 μ s, pulse frequency
Rate is 400pps.
A kind of producer of above-mentioned peanut red coat extract and grape seed extract compounding capsule is also claimed in the present invention
Method, it comprises the following steps：
Step（1）：Starch is dried, when drying temperature is 70 DEG C, drying time is 1-2 small, loaded after dry clean
Cooled down in PE bags, prevent the moisture absorption；
Step（2）：Grape seed extract, peanut red coat extract, drying starch after cooling, magnesium stearate are crossed into 60- respectively
80 mesh sieves, obtain fine powder.
Step（3）：By step（2）The magnesium stearate and starch of gained are proportionally mixed, and are added grape pip and are carried
Thing and peanut red coat extract is taken always to be mixed, incorporation time is 20-40 minutes, obtains mixed powder；
Step（4）：By step（3）The mixed powder of gained carries out filling capsule, arrangement, polishing, bottling, incasement operation, to obtain the final product.
Preferably,
The step（1）In, starch drying values moisture≤6wt%.
Preferably,
The step（2）In, cross 60 mesh stainless steel mesh
The foothold of the present invention and beneficial effect mainly include but is not limited to the following aspects：
Modern medicine study is found：The main reason for body aging is interior free yl content surplus, destroys the oxidation of body
Oxidative demage directly to protein of balancing, first free radical and caused crosslinking denaturation, also the oxidation to nucleic acid and
Crosslinking, makes DNA that fracture etc. occur, so as to seriously affect the normal transcription of protein hereditary information, translation process, makes protein
Expression quantity, which reduces, even to disappear, or produces mutein etc..The present invention is exactly according to modern pharmacological research achievement, chooses Portugal
Grape seed extract and peanut red coat extract are health food made of primary raw material.
Modern pharmacological studies have shown that polyphenols is rich in grape seed extract and peanut red coat extract, can be significantly
Reduce Free Radical Level.It can be seen that grape seed extract and peanut red coat extract are respectively provided with extremely strong antioxidation activity, this product
Grape seed extract and peanut red coat extract are chosen as raw material, scientific formulation is reasonable, and synergisticing performance is good, and anti-oxidation function is bright
Really.
Peanut red coat or grape pip are handled using high-pressure pulse electric, it is more better than conventional ultrasonication, it is more
Aldehydes matter content can improve more than 35%, and mode of operation is easier；For Polyphenols thing in peanut red coat and grape pip
The aggressiveness degree of the difference of matter, wherein grape pip procyanidin is higher, and ethanol extraction time is compared with peanut red coat increase；
The present invention is by the way of alcohol extracting, and with the increase of concentration of alcohol, polyphenols yield is continuously improved, when ethanol reaches
When 70%, the recovery rate highest of polyphenols, the polarity of polyphenols and 70% ethanol in extracting solution is closer to.
Compared with model control group, 1 group of embodiment, control group 1-2 can improve containing for SOD in red blood cell and liver
Amount, compared with only adding a kind of control group 1 or 2 of material in peanut red coat extract or grape seed extract, 1 group of embodiment
More preferable to the effect of raising SOD, the peanut red coat extract and grape seed extract for prompting reasonable compatibility possess certain collaboration
Effect, antioxygenic property are good.
Brief description of the drawings
Fig. 1：Influence of the concentration of alcohol to polyphenols yield.
Embodiment
In order to make those skilled in the art be better understood from the technical solution of the application, below in conjunction with real in detail below
Example is applied, the present invention is further described in detail, it is clear that described embodiment is only that the application part is implemented
Example, instead of all the embodiments.Based on the embodiment in the application, those of ordinary skill in the art are not making creativeness
It is being obtained under the premise of work so other embodiment, should all belong to the scope of protection of the invention.
Embodiment 1
A kind of peanut red coat extract and grape seed extract compound capsule, its component is as follows（Percentage by weight）：
Grape seed extract 34.5%, peanut red coat extract 34.5%, starch 30%, magnesium stearate 1%.
The production method of above-mentioned peanut red coat extract and grape seed extract compounding capsule, includes the following steps：
Step（1）：Starch is dried, when drying temperature is 70 DEG C, drying time is 2 small, loads clean PE after dry
Cooled down in bag.Prevent the moisture absorption；
Step（2）：By grape seed extract, peanut red coat extract, drying starch after cooling, 60 mesh sieve mistake of magnesium stearate
Sieve, obtains its fine powder；
Step（3）：By step（2）The magnesium stearate and starch of gained are proportionally mixed, and add grape seed extract
Always mixed with peanut red coat extract, incorporation time is 20 minutes, obtains mixed powder；
Step（4）：By step（3）The mixed powder of gained carries out filling capsule, arrangement, polishing, bottling, incasement operation.
The peanut red coat extract is prepared according to following technique：Peanut is shelled, is subsequently placed in baking oven, 50 DEG C
1h is dried under constant temperature, is taken out, peanut red coat and shelled peanut are separated；Peanut red coat is subjected to high-pressure pulse electric processing,
The field strength 20kv/cm of electric field, total processing time are 400 μ s, and pulse width is 4 μ s, pulse frequency 400pps；It is then added to
In 70% ethanol of 10 times of weight, 50 DEG C are heated to, 100rpm stir process 30min under heat-retaining condition, is collected by filtration filtrate, will
Filtrate carries out vacuum distillation recycling ethanol, collects concentrate, concentrate is used vacuum freeze drying, and peanut red coat processing is made
Thing.
The grape seed extract is prepared according to following technique：
Grape pip is placed in baking oven, 2h is dried under 50 DEG C of constant temperatures, then takes out, is ground into powder, crosses 50 mesh sieves, then
High-pressure pulse electric processing is carried out, the field strength 30kv/cm of electric field, total processing time is 600 μ s, and pulse width is 4 μ s, pulse frequency
Rate is 400pps；It is then added in 70% ethanol of 10 times of weight, is heated to 50 DEG C, 100rpm stir process under heat-retaining condition
60min, is collected by filtration filtrate, and filtrate is carried out vacuum distillation recycling ethanol, concentrate is collected, concentrate is carried out vacuum refrigeration
It is dry, grape seed extract is made.
Aforesaid operations are carried out from drying, crushing, mixing, the operation of interior bag in 300,000 clean areas.
Embodiment 2
A kind of peanut red coat extract and grape seed extract compound capsule, its component is as follows（Percentage by weight）：
Grape seed extract 34.75%, peanut red coat extract 34.75%, starch 30%, magnesium stearate 0.5%.
Above-mentioned peanut red coat extract and grape seed extract compounding capsule and its production method, include the following steps：
Step（1）：Starch is dried, when drying temperature is 70 DEG C, drying time is 1 small, loads clean PE after dry
Cooled down in bag.Prevent the moisture absorption.
Step（2）：By grape seed extract, peanut red coat extract, drying starch after cooling, 80 mesh sieve of magnesium stearate
Sieving, obtains its fine powder.
Step（3）：By step（2）The magnesium stearate and starch of gained are proportionally mixed, and are added grape pip and are carried
Thing and peanut red coat extract is taken always to be mixed, incorporation time is 40 minutes, obtains mixed powder.
Step（4）：By step（3）The mixed powder of gained carries out filling capsule, arrangement, polishing, bottling, incasement operation.
The peanut red coat extract is prepared according to following technique：Peanut is shelled, is subsequently placed in baking oven, 50 DEG C
1h is dried under constant temperature, is taken out, peanut red coat and shelled peanut are separated；Peanut red coat is subjected to high-pressure pulse electric processing,
The field strength 20kv/cm of electric field, total processing time are 400 μ s, and pulse width is 4 μ s, pulse frequency 400pps；It is then added to
In 70% ethanol of 10 times of weight, 50 DEG C are heated to, 100rpm stir process 30min under heat-retaining condition, is collected by filtration filtrate, will
Filtrate carries out vacuum distillation recycling ethanol, collects concentrate, concentrate is used vacuum freeze drying, and peanut red coat processing is made
Thing.
The grape seed extract is prepared according to following technique：
Grape pip is placed in baking oven, 2h is dried under 50 DEG C of constant temperatures, then takes out, is ground into powder, crosses 50 mesh sieves, then
High-pressure pulse electric processing is carried out, the field strength 30kv/cm of electric field, total processing time is 600 μ s, and pulse width is 4 μ s, pulse frequency
Rate is 400pps；It is then added in 70% ethanol of 10 times of weight, is heated to 50 DEG C, 100rpm stir process under heat-retaining condition
60min, is collected by filtration filtrate, and filtrate is carried out vacuum distillation recycling ethanol, concentrate is collected, concentrate is carried out vacuum refrigeration
It is dry, grape seed extract is made.
Aforesaid operations are carried out from drying, crushing, mixing, the operation of interior bag in 300,000 clean areas.
Embodiment 3
With embodiment 1, difference is that peanut red coat extract is different with the preparation process of grape seed extract, specifically such as
Under：
The peanut red coat extract is prepared according to following technique：Peanut is shelled, is subsequently placed in baking oven, 50 DEG C of constant temperature
Under the conditions of dry 1h, take out, peanut red coat and shelled peanut separated；By peanut red coat into 70% ethanol for being added to 10 times of weight
In, 50 DEG C are heated to, 30min is ultrasonically treated under heat-retaining condition, ultrasound intensity 25kHz, is collected by filtration filtrate, and filtrate is carried out
Vacuum distillation recycling ethanol, collects concentrate, concentrate is used vacuum freeze drying, peanut red coat processed material is made.
The grape seed extract is prepared according to following technique：
Grape pip is placed in baking oven, 2h is dried under 50 DEG C of constant temperatures, then takes out, is ground into powder, crosses 50 mesh sieves, then
It is added in 70% ethanol of 10 times of weight, is heated to 50 DEG C, 60min, ultrasound intensity 25kHz is ultrasonically treated under heat-retaining condition,
Filtrate is collected by filtration, filtrate is subjected to vacuum distillation recycling ethanol, concentrate is collected, concentrate is subjected to vacuum freeze drying,
Grape seed extract is made.
Embodiment 4
In terms of 1000g peanut red coats, the content of polyphenols in absorption photometry detection peanut red coat extract, wherein, obtain
Rate（%）=（Peanut red coat extract quality/peanut red coat quality）× 100%, purity（%）=（Polyphenols in peanut red coat extract
Material mass/peanut red coat extract quality）×100%.Specifically it is shown in Table 1：
Table 1
| Group | Embodiment 1 | Embodiment 3 |
| Peanut red coat extract g | 196.8 | 191.8 |
| Yield % | 19.68 | 19.18 |
| Purity % | 61.8 | 43.6 |
In terms of 1000g grape pips, the content of polyphenols in absorption photometry detection grape seed extract, wherein, yield（%）
=（Grape seed extract quality/grape pip quality）× 100%, purity（%）=（Polyphenols quality/Portugal in grape seed extract
Grape seed extract quality）×100%.Specifically it is shown in Table 2：
Table 2
| Group | Embodiment 1 | Embodiment 3 |
| Grape seed extract g | 106.7 | 114.3 |
| Yield % | 10.67 | 11.43 |
| Purity % | 68.5 | 49.3 |
Conclusion：Peanut red coat or grape pip are handled using high-pressure pulse electric, it is more better than conventional ultrasonication, it is more
Aldehydes matter content improves more than 35%, and mode of operation is easier.
Embodiment 5
Influence of the concentration of alcohol to peanut red coat polyphenols yield：
By taking embodiment 1 as an example, influence of the concentration of alcohol to polyphenols yield is have detected, as shown in Figure 1, with concentration of alcohol
Increase, polyphenols yield be continuously improved, when ethanol reaches 70%, the recovery rate highest of polyphenols, because peanut
Scarlet extracting solution is a series of mixed solution of organic substances, wherein, polyphenols mainly includes procyanidine, white black false hellebore
The materials such as alcohol, phenolic acid and sterol, are closer to the polarity of 70% ethanol；The polyphenols obtained using Aqua pure extract
Content is 2/3rds or so of 70% ethanol, and absolute ethyl alcohol content is minimum, is only the half of 70% ethanol.
Embodiment 6
Present invention compounding capsule antioxygenic property test：
Experimental animal：Kunming mice, male, 28-30g, 10 week old.Mouse is randomly divided into 5 groups, blank control group, model pair
According to group, 1 group of embodiment, control group 1 and control group 2, every group 10, in addition to blank control group, each group difference nape is noted
Penetrate the D- galactose solutions of 10ml/KG dosage（0.2g/ml）, while give the compounding capsule preparations of 50mg/KG dosage, wherein mould
Type control group gives the preparation for not adding grape seed extract and peanut red coat extract, remaining is the same as embodiment 1；1 group of embodiment
Give the preparation of the preparation of embodiment 1；Control group 1 gives preparation 1, and said preparation does not add grape seed extract, using equivalent peanut
Scarlet extract substitutes, remaining is the same as embodiment 1；Control group 2 gives preparation 2, and said preparation is adopted not add peanut red coat extract
Substituted with equivalent grape seed extract, remaining is the same as embodiment 1.Blank control group gives the physiological saline of phase homogenous quantities.After 60 days
Observe each physical signs.Index determining：Mouse intraocular venous blood sampling, measures for SOD, and then cervical dislocation puts to death animal, takes liver
Dirty, snap frozen is measured for SOD.Concrete outcome is shown in Table 3：
Table 3
| Group | Number of elements | Red blood cell extract NU/ml | Liver homogenate NU/mg |
| Blank control group | 10 | 11768±1630 | 9.76±0.41 |
| Model control group | 10 | 9134±1012 | 8.37±0.59 |
| 1 group of embodiment | 10 | 13019±1277 | 9.33±0.46 |
| Control group 1 | 10 | 12353±1429 | 9.12±0.54 |
| Control group 2 | 10 | 11978±1162 | 9.09±0.33 |
Conclusion：Compared with model control group, 1 group of embodiment, control group 1-2 can improve SOD in red blood cell and liver
Content, the control group 1 with only adding peanut red coat extract, or the control group 2 of only addition grape seed extract are compared, embodiment
The effect of 1 group of raising SOD is more preferable, prompts, the peanut red coat extract and grape seed extract of reasonable compatibility possess certain association
Same-action, antioxygenic property are good.
Although reference be made herein to invention has been described for explanatory embodiment of the invention, but is not intended to limit the invention,
It should be understood that those skilled in the art can be designed that a lot of other modifications and embodiment, these modifications and embodiment
It will belong within spirit disclosed in the present patent application and spirit.
Claims (10)
1. a kind of peanut red coat extract and grape seed extract compounding capsule, it is characterised in that each component in the capsule
Percentage by weight is as follows：Grape seed extract 30%-35%, peanut red coat extract 30-35%, starch 30%, magnesium stearate 0.2%-
1%。
2. peanut red coat extract and grape seed extract compounding capsule according to claims 1, it is characterised in that institute
The percentage by weight for stating each component in capsule is as follows：Grape seed extract 34.5%, peanut red coat extract 34.5%, starch 30%,
Magnesium stearate 1%.
3. peanut red coat extract and grape seed extract compounding capsule according to claims 1, it is characterised in that institute
The percentage by weight for stating each component in capsule is as follows：Grape seed extract 34.75%, peanut red coat extract 34.75%, starch
30%, magnesium stearate 0.5%.
4. peanut red coat extract and grape seed extract compounding capsule according to claim 1-3 is allowed to one, its feature
It is,
The peanut red coat extract is prepared according to following technique：Peanut is shelled, is subsequently placed in baking oven, 50 DEG C of constant temperature
Under the conditions of dry 1h, take out, peanut red coat and shelled peanut separated；Peanut red coat is subjected to high-pressure pulse electric processing, then
It is added in 70% ethanol of 10 times of weight, is heated to 50 DEG C, 100rpm stir process 30min under heat-retaining condition, is collected by filtration filter
Liquid, carries out vacuum distillation recycling ethanol by filtrate, collects concentrate, concentrate is used vacuum freeze drying, it is red that peanut is made
Clothing processed material.
5. peanut red coat extract according to claim 4 and grape seed extract compounding capsule, it is characterised in that described
The parameter of electric field treatment is：Field strength is 20kv/cm, and total processing time is 400 μ s, and pulse width is 4 μ s, and pulse frequency is
400pps。
6. peanut red coat extract and grape seed extract compounding capsule according to claim 1-3 is allowed to one, its feature
It is,
The grape seed extract is prepared according to following technique：Grape pip is placed in baking oven, is dried under 50 DEG C of constant temperatures
2h, then takes out, and is ground into powder, crosses 50 mesh sieves, then carries out high-pressure pulse electric processing, is then added to 10 times of weight
In 70% ethanol, 50 DEG C are heated to, 100rpm stir process 60min, is collected by filtration filtrate under heat-retaining condition, and filtrate is subtracted
Pressure is distilled to recover ethanol, collects concentrate, concentrate is carried out vacuum freeze drying, and grape seed extract is made.
7. peanut red coat extract according to claim 6 and grape seed extract compounding capsule, it is characterised in that described
The parameter of electric field treatment is：Field strength is 30kv/cm, and total processing time is 600 μ s, and pulse width is 4 μ s, and pulse frequency is
400pps。
8. the producer of a kind of peanut red coat extract and grape seed extract the compounding capsule according to claim 1-7
Method, it is characterised in that the production method comprises the following steps：
Step（1）：Starch is dried, when drying temperature is 70 DEG C, drying time is 1-2 small, is loaded totally after dry
Cooled down in PE bags, prevent the moisture absorption；
Step（2）：Grape seed extract, peanut red coat extract, drying starch after cooling, magnesium stearate are ground respectively,
60-80 mesh sieves are crossed, obtain fine powder；
Step（3）：By step（2）The magnesium stearate and starch of gained are proportionally mixed, and add grape seed extract
Always mixed with peanut red coat extract, incorporation time is 20-40 minutes, obtains mixed powder；
Step（4）：By step（3）The mixed powder of gained carries out filling capsule, arrangement, polishing, bottling, incasement operation, to obtain the final product.
9. a kind of peanut red coat extract according to claim 8 and grape seed extract compounding capsule and its producer
Method, it is characterised in that the step（1）In, starch drying values moisture≤6wt%.
10. a kind of peanut red coat extract according to claim 8 and grape seed extract compounding capsule and its producer
Method, it is characterised in that the step（2）In, cross 60 mesh stainless steel mesh.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108634181A (en) * | 2018-05-04 | 2018-10-12 | 安徽燕之坊食品有限公司 | A kind of grape seed extract flour additive and preparation method thereof |
| CN110651942A (en) * | 2019-10-29 | 2020-01-07 | 江苏神华药业有限公司 | Lycopene composition solid beverage and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108634181A (en) * | 2018-05-04 | 2018-10-12 | 安徽燕之坊食品有限公司 | A kind of grape seed extract flour additive and preparation method thereof |
| CN110651942A (en) * | 2019-10-29 | 2020-01-07 | 江苏神华药业有限公司 | Lycopene composition solid beverage and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107951964B (en) | 2021-02-09 |
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