CN107929410A - Application of the white sand syrup preparation in the medicine of prophylactic treatment arthritis and complication is prepared - Google Patents
Application of the white sand syrup preparation in the medicine of prophylactic treatment arthritis and complication is prepared Download PDFInfo
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- CN107929410A CN107929410A CN201711296056.6A CN201711296056A CN107929410A CN 107929410 A CN107929410 A CN 107929410A CN 201711296056 A CN201711296056 A CN 201711296056A CN 107929410 A CN107929410 A CN 107929410A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Natural Medicines & Medicinal Plants (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides application of the white sand syrup preparation in the medicine for the treatment of of arthritis and its complication is prepared.The white sand syrup preparation is prepared by white poplar, pedunculate acronychia wood, Sculellaria barbata and kuh-seng, and the white sand syrup preparation can effectively treatment of arthritis and its complication.
Description
Invention field
The present invention relates to the application of white sand syrup preparation, more particularly to white sand syrup preparation is preparing prevention or treatment joint
Application in scorching and its complication medicine.
Background technology
Arthritis (arthritis) refers to generation in human synovial and its surrounding tissue, by inflammation, infection, degeneration, wound
Or inflammatory disease caused by other factors, tens of kinds can be divided into.The arthritic in China has more than 100,000,000, and number is continuous
Increase.Clinical manifestation is the red, swollen, hot of joint, pain, dysfunction and joint deformity, and severe patient causes joint deformity, influences to suffer from
Person's quality of life.Half suffers from osteoarthritis in more than the 50 years old crowd in China according to statistics, in over-65s crowd.
For arthritis, doctor trained in Western medicine is undesirable using medicine, therapeutic effects such as glucocorticoids, immunodepressant at present；
And toxic side effect, it is impossible to long-time service.
The content of the invention
It is an object of the invention to provide white sand syrup preparation to prepare prevention or the medicine for the treatment of of arthritis and its complication
Application in thing.
What the present invention was achieved through the following technical solutions.White sand syrup preparation is in preparation prevention or treatment of arthritis and its simultaneously
Send out the application in the medicine of disease.
In foregoing application, the complication includes rheumatism or gout.
In foregoing application, the white sand syrup is made of with the raw material of following weight proportions：20-40 parts of white poplar, granulated sugar
6-12 parts of 20-40 parts wooden, 10-20 parts of Sculellaria barbata and kuh-seng.
In foregoing application, the white sand syrup is made of with the raw material of following weight proportions：25-35 parts of white poplar, granulated sugar
8-10 parts of 25-35 parts wooden, 12-18 parts of Sculellaria barbata and kuh-seng.
In foregoing application, the white sand syrup is made of with the raw material of following weight proportions：30 parts of white poplar, pedunculate acronychia wood 30
9 parts of part, 15 parts of Sculellaria barbata and kuh-seng.
In foregoing application, the white sand syrup is prepared:White poplar, pedunculate acronychia wood add water to cook 1h, add Sculellaria barbata,
Kuh-seng, adds water to cook secondary, each 2h, collecting decoction, filtration, it is 1.25- that filtrate decompression, which is concentrated into relative density at 60 DEG C,
1.26 clear cream, adds one or more pharmaceutically acceptable carriers, according still further to the conventional method of pharmaceutical field, is prepared into
Acceptable formulation in field of medicaments.
In foregoing application, the carrier includes diluent, excipient, filler, disintegrant, wetting agent, adhesive, table
Face activating agent, sorbefacient or lubricant.
In foregoing application, the formulation includes oral formulations, ejection preparation or external preparation.
In foregoing application, the oral formulations include syrup, capsule, granule, tablet, pill or oral liquid.
In foregoing application, the syrup is prepared：White poplar, pedunculate acronychia wood add water to cook 1h, add Sculellaria barbata, hardship
Ginseng, adds water to cook secondary, each 2h, collecting decoction, filtration, it is 1.25-1.26 that filtrate decompression, which is concentrated into relative density at 60 DEG C,
Clear cream, separately take the sucrose of 65 parts by weight, add 1-2 times to measure the boil-off solution of boiling, merge with above-mentioned clear cream, add 0.02 parts by weight sweet tea
The potassium sorbate of chrysanthemum element and 0.2 parts by weight, mixes, and stands 48h, filtration, adds the orange essence of 1 parts by volume and add water to 1000 bodies
Product part, stirs evenly, and stands 48h, filtration is filling, sterilizing, to obtain the final product.
In order to make those of ordinary skill in the art be better understood from the present invention, come below by way of experiment and embodiment further
Illustrate the purposes of the present invention：
1. pharmacological experiment study of experimental example
1 experiment material
1.1 medicine
1.1.1 medicine of the present invention, with embodiment 1.
1.1.2 numbness of dispelling soup, it is commercially available.
1.2 health Thirty male rats 60, weight 250-300g, by Heilongjiang University of Chinese Medicine experimental animal
The heart provides.
2 experimental methods and result
2.1 analgesic activity
30 rats are divided into 3 groups, every group 10, set physiological saline, numbness of dispelling soup group and of the present invention group respectively.Numbness of dispelling soup group
Gavage is dispelled numbness soup, is being administered once a day, continuous 7 days, 1.1g/kg was administered in every rat every time, is prepared before use with distilled water
Into suspension；The present invention organizes gavage medicine of the present invention in the same way；Physiological saline group gavage 10ml physiological saline；Last
30min after administration, every group of 0.7% glacial acetic acid 10ml/kg of intraperitoneal injection, record rat writhing number, the results are shown in Table 2.
Table 2 to the analgesic activity of rat (N=10)
Note：Compared with physiological saline group*P ＜ 0.05,**P ＜ 0.01；
Compared with numbness soup group of dispelling+P ＜ 0.05.
Numbness of dispelling soup group and present invention group can resist the pain reaction caused by acetic acid stimulates, and mouse writhing number is substantially subtracted
It is few, and present invention group effect is better than numbness soup group of dispelling.
2.2 anti-inflammatories are tested
30 rats are divided into 3 groups by mice ear experiment, every group 10, set physiological saline, numbness of dispelling soup group and sheet respectively
Invention medicine group.Numbness of dispelling soup group gavage is dispelled numbness soup, is being administered once a day, and continuous 7 days, 1.1g/kg was administered in every rat every time,
The suspension being configured to before use with distilled water；The present invention organizes gavage medicine of the present invention in the same way；Physiological saline group fills
Stomach 10ml physiological saline；7th day, every mouse right ear one side is smeared into 20 μ L dimethylbenzene, another side smears 10 μ L.After 30min
Animal is put to death, is beaten with 8mm card punch and takes the same position disk of left and right ear, weighed, calculates swelling rate=(auris dextra weight-left ear weight
Amount)/left ear weight × 100%.It the results are shown in Table 3.
3 mouse of table turn round auricle edema rate compare (N=10)
Note：Compared with physiological saline group*P ＜ 0.05,**P ＜ 0.01；
Compared with numbness soup group of dispelling+P ＜ 0.05.
The result shows that：Numbness of dispelling soup group and present invention group can reduce mouse and turn round auricle edema rate.And present invention group effect is excellent
In numbness soup group of dispelling (+P ＜ 0.05)
Compared with prior art, white sand syrup preparation of the present invention has arthritis and its complication certain treatment to make
With.
Embodiment
Embodiment 1：
Polygonum capitatum is taken, segment, adds boiling secondary, each 1.5h, collecting decoction, stands, and filtration, filtrate is condensed into thick paste,
It dry, pulverize, the starch of the amount of being made 10-20%, mix, load capsule, to obtain the final product.
Usage and dosage：It is oral, one time 4-6,3 times a day.
Specification：0.3g/.
Function is with curing mainly：Treatment of arthritis and its complication.
Claims (10)
1. application of the white sand syrup preparation in prevention or the medicine for the treatment of of arthritis and its complication is prepared.
2. application as claimed in claim 1, it is characterised in that：The complication includes rheumatism or gout.
3. application as claimed in claim 1 or 2, it is characterised in that：The white sand syrup is with the raw material of following weight proportions
It is made：6-12 parts of 20-40 parts of white poplar, 20-40 parts of pedunculate acronychia wood, 10-20 parts of Sculellaria barbata and kuh-seng.
4. application as claimed in claim 3, it is characterised in that：The white sand syrup is with the raw material system of following weight proportions
Into：8-10 parts of 25-35 parts of white poplar, 25-35 parts of pedunculate acronychia wood, 12-18 parts of Sculellaria barbata and kuh-seng.
5. application as claimed in claim 4, it is characterised in that：The white sand syrup is with the raw material system of following weight proportions
Into：9 parts of 30 parts of white poplar, 30 parts of pedunculate acronychia wood, 15 parts of Sculellaria barbata and kuh-seng.
6. apply as described in claim 4 or 5, it is characterised in that:The white sand syrup is prepared:White poplar, pedunculate acronychia wood add
Water decocts 1h, adds Sculellaria barbata, kuh-seng, adds water to cook secondary, each 2h, and collecting decoction filters, and filtrate decompression is concentrated into 60
Relative density is the clear cream of 1.25-1.26 at DEG C, adds one or more pharmaceutically acceptable carriers, is led according still further to pharmacy
The conventional method in domain, is prepared into acceptable formulation in field of medicaments.
7. application as claimed in claim 6, it is characterised in that：The carrier includes diluent, excipient, filler, disintegration
Agent, wetting agent, adhesive, surfactant, sorbefacient or lubricant.
8. application as claimed in claim 7, it is characterised in that：The formulation includes oral formulations, ejection preparation or external application system
Agent.
9. the application described in claim 8, it is characterised in that：The oral formulations include syrup, capsule, granule, piece
Agent, pill or oral liquid.
10. application as claimed in claim 8, it is characterised in that：The syrup is prepared：White poplar, pedunculate acronychia wood add decocting
1h is boiled, adds Sculellaria barbata, kuh-seng, adds water to cook secondary, each 2h, collecting decoction filters, and filtrate decompression is concentrated at 60 DEG C
Relative density is the clear cream of 1.25-1.26, separately takes the sucrose of 65 parts by weight, adds 1-2 times to measure the boil-off solution of boiling, is closed with above-mentioned clear cream
And 0.02 parts by weight Steviosin and the potassium sorbate of 0.2 parts by weight are added, mix, stand 48h, filter, add the tangerine of 1 parts by volume
Sub- essence simultaneously adds water to 1000 parts by volume, stirs evenly, and stands 48h, filtration is filling, sterilizing, to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711296056.6A CN107929410A (en) | 2017-12-08 | 2017-12-08 | Application of the white sand syrup preparation in the medicine of prophylactic treatment arthritis and complication is prepared |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711296056.6A CN107929410A (en) | 2017-12-08 | 2017-12-08 | Application of the white sand syrup preparation in the medicine of prophylactic treatment arthritis and complication is prepared |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107929410A true CN107929410A (en) | 2018-04-20 |
Family
ID=61946254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711296056.6A Withdrawn CN107929410A (en) | 2017-12-08 | 2017-12-08 | Application of the white sand syrup preparation in the medicine of prophylactic treatment arthritis and complication is prepared |
Country Status (1)
| Country | Link |
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| CN (1) | CN107929410A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120085601A (en) * | 2011-01-24 | 2012-08-01 | 정현석 | Treating method for degenerative arthritis using baekjeolyusintang and its active component |
-
2017
- 2017-12-08 CN CN201711296056.6A patent/CN107929410A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120085601A (en) * | 2011-01-24 | 2012-08-01 | 정현석 | Treating method for degenerative arthritis using baekjeolyusintang and its active component |
Non-Patent Citations (3)
| Title |
|---|
| 惠永正: "《中药天然产物大全》", 31 January 2011, 上海科学技术出版社 * |
| 郭举鹏等: "《中国非处方药完全手册》", 31 May 2005, 陕西科学技术出版社 * |
| 郭俊铨: "《中兽医药物学》", 30 April 1987, 四川科学技术出版社 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180420 |