CN107929224A - A kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition and preparation method thereof - Google Patents
A kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition and preparation method thereof Download PDFInfo
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- CN107929224A CN107929224A CN201711334350.1A CN201711334350A CN107929224A CN 107929224 A CN107929224 A CN 107929224A CN 201711334350 A CN201711334350 A CN 201711334350A CN 107929224 A CN107929224 A CN 107929224A
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- China
- Prior art keywords
- stem cell
- sweet osmanthus
- wrinkle
- moisture
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
The present invention provides a kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition, include the component of following parts by weight：10 20 parts of sweet osmanthus stem cell extract, black cohosh extract 10 20,5 10 parts of butter berry extract.Said composition can not only substantially reduce skin roughness, reach anti-wrinkle effect, also with preferable moistening effect, and it is safe and non-stimulating.
Description
Technical field
The present invention relates to a kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition and preparation method thereof.
Background technology
Moisturizing Journal of Sex Research is current cosmetics and the hot spot of dermatology research.Environmental pollution, Seasonal conversion so that because of angle
Dry skin caused by matter break water and the skin problem that thus caused skin is itched, furfur etc. is common are more and more tighter
Weight, moisturizing are very urgent.Moisturizer is added in cosmetics, it is therefore intended that the water content of keratoderma is maintained or increases, with
Phase, which improves, solves these common skin problems.Moisturizer can be divided into natural moisture preserving agent and synthesis moisturizer by its source, wherein
Natural moisture preserving agent can effectively prevent skin allergy, the phenomenon of the infringement skin such as erythema occurs, therefore natural moisture preserving agent is increasingly
Favored be subject to consumer.
Wrinkle and pigmentation are avoiding greatly in the primary outer feature of skin aging, and numerous woman eye.The skin of people
Skin was put into ageing state from 25 years old or so：Lipid is also reduced between sebum secretion amount and horn cell, in percutaneous moisture loss
Rise；Epidermal cell differentiation capability reduces, and cuticula is thinning, and atrophy of epidermis produces fine wrinkle.Corium produces insoluble collagen, elasticity
Reduce, hyaluronic acid also increases and reduces with the age, causes corium moisture content to reduce, and produces deeper wrinkle.
Furthermore under ultraviolet irradiation, active oxygen and lipid peroxide are produced in skin, lipid peroxide is made in oxidizing ferment
The materials such as malonaldehyde are resolved under, with albumen qualitative response, form brown plain spot, chromogenesis is calm.
Anti-aging cosmetics are dazzling currently on the market, and the main active of common light spot anti-wrinkle wrinkle has：Antioxygen
Change class；Steroids；Microelement kind；Anti-aging biochemical preparation and anti-aging natural extract class.These active ingredients, it is most of
For chemical synthesis preparation, skin care item are applied to, short time interior energy plays the effect of light spot anti-wrinkle, but use for a long time can be to skin
Skin brings injury, accelerates the aging of skin.
Stem cell is a kind of seed cell of not yet differentiation and development, has unlimited self-renewing duplication and differentiation potential, this
It is the basis that stem cell is used for beauty product.Plant stem cell is one be present in shoot apical meristem and Root apical meristem
Class special cells group, has self-renewal capacity, and can produce the daughter cell with lasting splitting ability, these special cells are
The source of the generation of the organs such as plant roots, stem, leaf and flower.Plant stem cell technology is the wound recovery mechanisms using plant as base
Plinth, Schilling plant form wound and restore histiocytic formation so as to induce, and it is i.e. dry that recovery tissue contains undifferentiated cell
Cell, these recovery histocytes are collected and are cultivated in nutrient solution.Stem cell beautifying technique and its Related product are near
2 years extensive concerns for being subject to beauty circle expert and insider.
The content of the invention
It is an object of the present invention to provide a kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition, the combination
Thing not only has preferable moisture-keeping functions, but also can play the role of anti-wrinkle.
To achieve the above object, the technical solution used in the present invention：A kind of anti-wrinkle containing sweet osmanthus stem cell extract,
Moisture-keeping composition, includes the component of following parts by weight：10-20 parts of sweet osmanthus stem cell extract, black cohosh extract 10-20,
5-10 parts of butter berry extract.
Single extract is usually used in the prior art and carries out moisturizing or anti-wrinkle, but its effect is not as far as possible preferable,
Present inventor has found by numerous studies, sweet osmanthus stem cell extract, black cohosh extract is compounded, its moisturizing
Significant effect is better than independent extract；Sweet osmanthus stem cell extract, butter berry extract are compounded, its anti-wrinkle significant effect
Better than independent extract；
Preferably, the weight ratio of the sweet osmanthus stem cell extract and black cohosh extract is 1:1.By sweet osmanthus stem cell
Extract, black cohosh extract are compounded according to said ratio, its moistening effect is best.
Preferably, the weight ratio of the sweet osmanthus stem cell extract and butter berry extract is 2:1.Sweet osmanthus stem cell is carried
Thing, butter berry extract is taken to be compounded according to said ratio, its anti-wrinkle effect is best.
Preferably, the composition further includes preservative, emulsifying agent, emollient, skin moisturizer, essence and water.It is preferred that
Ground, the emulsifying agent are selected from ceteareth -6, ceteareth -25, glycerin monostearate.The moisturizing
Agent is selected from White Mineral Oil, stearic acid, cetostearyl alcohol, olive oil, octanoic acid/certain herbaceous plants with big flowers acid triglyceride, shea butter, jojoba oil, silicon
Oil.The skin moisturizer is selected from glycerine, propane diols, 1,3 butanediols.
Preferably, the preparation method of the sweet osmanthus stem cell extract comprises the following steps：
1) isolation and culture of sweet osmanthus forming layer stem cell：By sweet osmanthus blade after disinfecting, aseptically,
Sweet osmanthus blade after disinfection is cut into 0.5cm*0.5cm sizes, is seeded on WPM culture mediums, leaf back is connect with WPM culture mediums
Touch, the dark culturing at 25 DEG C；Forming layer stem cell is transferred in subculture medium after two weeks and is cultivated, every two weeks subculture one
It is secondary, obtain sweet osmanthus forming layer stem cell；
2) culture medium after culture sweet osmanthus forming layer stem cell is collected, through ultrafiltration membrance filter, filtrate is concentrated, removes culture medium
In it is phenol red, retain culture medium in active ingredient；Culture medium and the lysate of sweet osmanthus forming layer stem cell are freeze-dried, obtained
To sweet osmanthus stem cell extract.
The present invention provides a kind of preparation method of composition described above, the preparation method is by each component raw material
Precise by weight ratio, is sufficiently mixed and stirs evenly, that is, obtains the composition.
Preferably, the formulation of the composition is solution, spray, powdery, paste or emulsion.
The present invention provides a kind of anti-wrinkle, Moisturizer, including oil phase, water phase, the water mutually includes described above
Composition.
Preferably, the anti-wrinkle, Moisturizer further include essence and preservative.
The beneficial effects of the present invention are：The present invention provides a kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisturizing
Composition, said composition can not only substantially reduce skin roughness, reach anti-wrinkle effect, also with preferable moistening effect,
It is and safe and non-stimulating.
Embodiment
Each raw material involved by following embodiments is the commercially available universal product unless otherwise instructed.
The preparation method of sweet osmanthus stem cell extract of the present invention comprises the following steps：
1) isolation and culture of sweet osmanthus forming layer stem cell：By sweet osmanthus blade after disinfecting, aseptically,
Sweet osmanthus blade after disinfection is cut into 0.5cm*0.5cm sizes, is seeded on WPM culture mediums, leaf back is connect with WPM culture mediums
Touch, the dark culturing at 25 DEG C；Forming layer stem cell is transferred in subculture medium after two weeks and is cultivated, every two weeks subculture one
It is secondary, obtain sweet osmanthus forming layer stem cell；
2) culture medium after culture sweet osmanthus forming layer stem cell is collected, through ultrafiltration membrance filter, filtrate is concentrated, removes culture medium
In it is phenol red, retain culture medium in active ingredient；Culture medium and the lysate of sweet osmanthus forming layer stem cell are freeze-dried, obtained
To sweet osmanthus stem cell extract.
Embodiment 1
Anti-wrinkle of the present invention, a kind of embodiment of moisture-keeping composition, the composition include the component of following parts by weight：
15 parts of sweet osmanthus stem cell extract, 15 parts of black cohosh extract, 7.5 parts of butter berry extract.
Embodiment 2
Anti-wrinkle of the present invention, a kind of embodiment of moisture-keeping composition, the composition include the component of following parts by weight：
10 parts of sweet osmanthus stem cell extract, 20 parts of black cohosh extract, 7.5 parts of butter berry extract.
Embodiment 3
Anti-wrinkle of the present invention, a kind of embodiment of moisture-keeping composition, the composition include the component of following parts by weight：
20 parts of sweet osmanthus stem cell extract, 10 parts of black cohosh extract, 7.5 parts of butter berry extract.
Comparative example 1
The formula of comparative example 1 is：30 parts of sweet osmanthus stem cell extract, 7.5 parts of butter berry extract.
Comparative example 2
The formula of comparative example 2 is：30 parts of black cohosh extract, 7.5 parts of butter berry extract.
The preparation method of embodiment 1-3 and documents 1-2：Each component raw material is accurately claimed by above-mentioned weight proportion
Amount, is sufficiently mixed and stirs evenly, you can.
First, 1-3 of embodiment of the present invention moisture-keeping efficacies evaluation test
Moisturizing rate assay method：The composition of above-described embodiment 1-3 and comparative example 1-3 after drying accurately are weighed respectively
0.5g adds the deionized water that mass fraction is sample 10%, is placed in the drier equipped with dry silica gel in diameter 3cm measuring cups
In, when standing time is respectively 3,6,12,24,36,48,60,72 small, its moisturizing rate, moisturizing rate %=H are calculated respectively2/H1×
100%, wherein, H1To add moisture content amount, H2For moisture content amount after placement.
Table 1 is the result that above-mentioned each composition moisturizing rate changes over time under silica gel environment, the results showed that different moisturizings
The order of agent moisturizing rate is：1 composition of the embodiment of the present invention>>2 composition of the embodiment of the present invention>3 composition of the embodiment of the present invention
>>The composition of comparative example 2>The composition of comparative example 1.From the results shown in Table 1, by sweet osmanthus stem cell extract, total shape
Cimicifuga foetida extract is compounded, synergistic, its moistening effect is significantly better than independent extract；The group of 1-3 of the embodiment of the present invention
Compound can keep high moisturizing rate in a long time, and the moisture retention effect of wherein embodiment 1 is best.
The result that the moisturizing rate of 1 1-3 products of the embodiment of the present invention of table changes over time
Embodiment 4
Anti-wrinkle of the present invention, moisturizing composition a kind of embodiment, the composition includes the group of following parts by weight
Point：15 parts of sweet osmanthus stem cell extract, 15 parts of black cohosh extract, 7.5 parts of butter berry extract.
Embodiment 5
Anti-wrinkle of the present invention, moisturizing composition a kind of embodiment, the composition includes the group of following parts by weight
Point：20 parts of sweet osmanthus stem cell extract, 15 parts of black cohosh extract, 5 parts of butter berry extract.
Embodiment 6
Anti-wrinkle of the present invention, moisturizing composition a kind of embodiment, the composition includes the group of following parts by weight
Point：10 parts of sweet osmanthus stem cell extract, 15 parts of black cohosh extract, 10 parts of butter berry extract.
Comparative example 3
The formula of comparative example 3 is：22.5 parts by weight of sweet osmanthus stem cell extract, 15 parts by weight of black cohosh extract.
Comparative example 4
The formula of comparative example 4 is：15 parts by weight of black cohosh extract, 22.5 parts by weight of butter berry extract.
The preparation method of embodiment 4-6 and comparative example 3-4：Each component raw material is pressed into above-mentioned weight proportion precise,
It is sufficiently mixed and stirs evenly, you can.
2nd, 4-6 of embodiment of the present invention anti-wrinkle efficacy assessments are tested
Method：
Subject amounts to 40 people.Specific sex composition determines at random.If period there are 2 people adverse reaction occur, terminate and survey
Examination；As a result adverse reaction is not found.After subject has smeared composition made from 4-6 of the embodiment of the present invention, the roughness of skin
Have clear improvement.
1. the left and right eye of subject is selected as tested region.Every subject's left eye smears given the test agent, and (present invention is real
Apply composition made from a 4-6) sample sets are used as, right eye smears documents 4,5 and does not smear any sample as control
Group.
2. before smearing cosmetics using skin lens image analysis system and moisture content of skin tester determination experiment position
Dermatoglyph degree.
3. smear in the tested area (the same area) cleaned by clear water sooner or later daily and detect product, during the experiment, by
Examination person cannot apply the other any cosmetics erased outside tested sample in Test sites.
4. subject is after continuous use given the test agent one week, two weeks, three weeks and four weeks, weekly same time subject general
Smear position to clean, number positional is smeared using skin lens image analysis system and moisture content of skin tester measure by tester
Value.
5. the numerical value that statistics subject position measures every time, the change rule of analyzing skin texture and moisture
Rule.
As a result：
(1) dermatoglyph situation of change：
Change rate=(number of sets of sample is according to Tn-initial value T0)/initial value T0× 100%
Relative change rate=(number of sets of sample is according to Tn-blank control group data Tn)/blank control group data Tn × 100%
T0It is subjects skin's measured value before testing, Tn is skin measured value when each subject tests at each time point every time.
1st, skin roughness (Skin Roughness SR)
Skin roughness is in all sections of skin, with the difference on straight line between maximum gray scale peak value and minimal gray peak value
Value.The parameter is the maximum height of skin surface unevenness.
The difference of 2 recipient site skin roughness of table and initial value
Within 4 weeks test periods, after recipient site uses present composition sample, its skin roughness is always in reduction
Trend, and be negative value, relative change rate is negative value always, and is in reduction trend；It can be seen that from the data of table 2 by sweet osmanthus
Stem cell extract, butter berry extract are compounded according to said ratio, can synergistic anti-wrinkle, use present invention combination
After thing 4 weeks, skin roughness substantially reduces, and the anti-wrinkle effect of wherein embodiment 4 is best.
3rd, safety testing
Test material and method
Animal：Regular grade large ear rabbit 4,2.3-2.7 kilograms of weight, body looks into animal no abnormality seen.
Environmental condition：Room temperature：22 DEG C -26 DEG C, relative humidity：65% -69%；
Test method：
Foundation《Cosmetics health specification》(version in 2007) acute skin irritation test, before experiment 24 it is small when, will test
Back part of animal backbone diamond wool is cut, 3 centimetres of 3 cm x of unhairing scope.Tested 0.5 gram of no originality is taken directly to be applied to right side skin
On skin, with clean gauze cover, with nonirritant immobilization with adhesive tape 2 it is small when.Other side is negative control.After removing tested material
1 it is small when, 24 it is small when, 48 it is small when 72 it is small when observe and animal subject contact site dermoreaction and keep a record.
Under this experimental condition, 1-6 of embodiment of the present invention compositions press White Rabbit acute skin irritation test skin thorn
It is nonirritant to swash strength grading.
The Security test of 1-6 compositions of the embodiment of the present invention：
1-6 of embodiment of the present invention compositions safety, the examination of human body patch are demonstrated by zoopery and human body patch test
Test and carried out by our company professional.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, those of ordinary skill in the art should
Understand, can be to technical scheme technical scheme is modified or replaced equivalently, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition, it is characterised in that include the group of following parts by weight
Point：10-20 parts of sweet osmanthus stem cell extract, black cohosh extract 10-20,5-10 parts of butter berry extract.
2. anti-wrinkle according to claim 1, moisture-keeping composition, it is characterised in that the sweet osmanthus stem cell extract and total
The weight ratio of shape cimicifuga foetida extract is 1:1.
3. anti-wrinkle according to claim 1, moisture-keeping composition, it is characterised in that the sweet osmanthus stem cell extract and ox
The weight ratio of oily berry extract is 2:1.
4. anti-wrinkle according to claim 1, moisture-keeping composition, it is characterised in that the anti-aging, moisture-keeping composition also wrap
Include preservative, pH adjusting agent, thickener, emulsifying agent, essence, pigment and water.
5. anti-wrinkle according to claim 1, moisture-keeping composition, it is characterised in that the emulsifying agent is selected from cetostearyl alcohol
Polyethers -6, ceteareth -25, glycerin monostearate, the emollient are selected from White Mineral Oil, stearic acid, cetearyl alcohol
Alcohol, olive oil, octanoic acid/certain herbaceous plants with big flowers acid triglyceride, shea butter, jojoba oil, silicone oil, the skin moisturizer are selected from glycerine, third
Glycol, 1,3 butanediols.
6. anti-wrinkle according to claim 1, moisture-keeping composition, it is characterised in that the system of the sweet osmanthus stem cell extract
Preparation Method comprises the following steps：
1) isolation and culture of sweet osmanthus forming layer stem cell：By sweet osmanthus blade after disinfecting, aseptically, it will disappear
Sweet osmanthus blade after poison is cut into 0.5cm*0.5cm sizes, is seeded on WPM culture mediums, leaf back is contacted with WPM culture mediums,
The dark culturing at 25 DEG C；Forming layer stem cell is transferred in subculture medium after two weeks and is cultivated, subculture once, obtains every two weeks
To sweet osmanthus forming layer stem cell；
2) culture medium after culture sweet osmanthus forming layer stem cell is collected, through ultrafiltration membrance filter, filtrate is concentrated, removes in culture medium
It is phenol red, retain the active ingredient in culture medium；Culture medium and the lysate of sweet osmanthus forming layer stem cell are freeze-dried, obtain osmanthus
Flower stem cell extract.
A kind of 7. anti-wrinkle, preparation method of moisture-keeping composition as described in claim 1-6 is any, it is characterised in that the system
Preparation Method is by each component raw material precise by weight ratio, is sufficiently mixed and stirs evenly, that is, obtains the composition.
8. anti-wrinkle according to claim 1, moisture-keeping composition, it is characterised in that the anti-wrinkle, the formulation of moisture-keeping composition
For aqua, creme, finish, washing lotion or emulsion.
9. a kind of anti-wrinkle, Moisturizer, it is characterised in that including oil phase, water phase, the water mutually includes such as claim 1-6
Any anti-wrinkle, moisture-keeping composition.
10. anti-wrinkle according to claim 9, Moisturizer, it is characterised in that the anti-wrinkle, Moisturizer also wrap
Include essence and preservative.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711334350.1A CN107929224A (en) | 2017-12-12 | 2017-12-12 | A kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711334350.1A CN107929224A (en) | 2017-12-12 | 2017-12-12 | A kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107929224A true CN107929224A (en) | 2018-04-20 |
Family
ID=61943117
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| CN201711334350.1A Withdrawn CN107929224A (en) | 2017-12-12 | 2017-12-12 | A kind of anti-wrinkle containing sweet osmanthus stem cell extract, moisture-keeping composition and preparation method thereof |
Country Status (1)
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104920227A (en) * | 2015-07-15 | 2015-09-23 | 广东融和生态农业有限公司 | Stem cell tissue culture seedling raising technique |
| CN105748343A (en) * | 2016-02-25 | 2016-07-13 | 广州市科玮生物技术有限公司 | Natural plant extract composition and application thereof in cosmetics |
-
2017
- 2017-12-12 CN CN201711334350.1A patent/CN107929224A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104920227A (en) * | 2015-07-15 | 2015-09-23 | 广东融和生态农业有限公司 | Stem cell tissue culture seedling raising technique |
| CN105748343A (en) * | 2016-02-25 | 2016-07-13 | 广州市科玮生物技术有限公司 | Natural plant extract composition and application thereof in cosmetics |
Non-Patent Citations (1)
| Title |
|---|
| 王建新 等: "《化妆品植物原料大全》", 30 June 2012 * |
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