CN107922352B - 制备蛋白质脱乙酰酶抑制剂的方法 - Google Patents

制备蛋白质脱乙酰酶抑制剂的方法 Download PDF

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CN107922352B
CN107922352B CN201680046553.8A CN201680046553A CN107922352B CN 107922352 B CN107922352 B CN 107922352B CN 201680046553 A CN201680046553 A CN 201680046553A CN 107922352 B CN107922352 B CN 107922352B
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acid
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CN107922352A (zh
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F·塞伊迪
J·H·范杜泽尔
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Acetylon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201680046553.8A 2015-06-08 2016-06-08 制备蛋白质脱乙酰酶抑制剂的方法 Active CN107922352B (zh)

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US201562172624P 2015-06-08 2015-06-08
US62/172,624 2015-06-08
PCT/US2016/036434 WO2016200930A1 (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors

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CN107922352A CN107922352A (zh) 2018-04-17
CN107922352B true CN107922352B (zh) 2021-08-06

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US (1) US10144714B2 (https=)
EP (1) EP3303304B1 (https=)
JP (1) JP6873053B2 (https=)
CN (1) CN107922352B (https=)
AR (1) AR105812A1 (https=)
AU (2) AU2016276573A1 (https=)
CA (1) CA2988594C (https=)
ES (1) ES2769255T3 (https=)
MX (1) MX369349B (https=)
TW (1) TWI706937B (https=)
WO (1) WO2016200930A1 (https=)

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TW201803594A (zh) * 2016-06-09 2018-02-01 達納-法伯癌症協會 Hdac抑制劑與bet抑制劑之使用方法及醫藥組合
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US11497746B2 (en) 2016-11-23 2022-11-15 Acetylon Pharmaceuticals, Inc. Pharmaceutical combinations comprising a histone deacetylase inhibitor and a programmed death-ligand 1 (PD-L1) inhibitor and methods of use thereof

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WO2016200930A9 (en) 2017-02-23
WO2016200930A1 (en) 2016-12-15
MX369349B (es) 2019-11-06
EP3303304B1 (en) 2019-11-20
AR105812A1 (es) 2017-11-15
AU2020267299A1 (en) 2020-12-10
JP2018518486A (ja) 2018-07-12
CN107922352A (zh) 2018-04-17
US20160355486A1 (en) 2016-12-08
TW201718517A (zh) 2017-06-01
TWI706937B (zh) 2020-10-11
AU2016276573A1 (en) 2018-01-04
CA2988594C (en) 2023-08-15
JP6873053B2 (ja) 2021-05-19
AU2020267299B2 (en) 2022-07-07
ES2769255T3 (es) 2020-06-25
US10144714B2 (en) 2018-12-04
CA2988594A1 (en) 2016-12-15
EP3303304A1 (en) 2018-04-11
MX2017015900A (es) 2018-11-09

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