CN107912043B - 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物 - Google Patents

用于食管癌和其他癌症免疫治疗的新型肽和肽组合物 Download PDF

Info

Publication number
CN107912043B
CN107912043B CN201680038852.7A CN201680038852A CN107912043B CN 107912043 B CN107912043 B CN 107912043B CN 201680038852 A CN201680038852 A CN 201680038852A CN 107912043 B CN107912043 B CN 107912043B
Authority
CN
China
Prior art keywords
peptide
cancer
cell
cells
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680038852.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN107912043A (zh
Inventor
安德烈·马尔
托尼·温斯切尼克
科莱特·宋
奥利弗·施尔
延斯·弗里切
哈普瑞特·辛格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immatics Biotechnologies GmbH
Original Assignee
Immatics Biotechnologies GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1511792.2A external-priority patent/GB201511792D0/en
Application filed by Immatics Biotechnologies GmbH filed Critical Immatics Biotechnologies GmbH
Priority to CN202110826163.5A priority Critical patent/CN113880938B/zh
Publication of CN107912043A publication Critical patent/CN107912043A/zh
Application granted granted Critical
Publication of CN107912043B publication Critical patent/CN107912043B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001152Transcription factors, e.g. SOX or c-MYC
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0638Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
CN201680038852.7A 2015-07-06 2016-07-05 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物 Active CN107912043B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110826163.5A CN113880938B (zh) 2015-07-06 2016-07-05 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562188870P 2015-07-06 2015-07-06
US62/188,870 2015-07-06
GB1511792.2 2015-07-06
GBGB1511792.2A GB201511792D0 (en) 2015-07-06 2015-07-06 Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers
PCT/EP2016/065812 WO2017005733A2 (en) 2015-07-06 2016-07-05 Novel peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110826163.5A Division CN113880938B (zh) 2015-07-06 2016-07-05 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物

Publications (2)

Publication Number Publication Date
CN107912043A CN107912043A (zh) 2018-04-13
CN107912043B true CN107912043B (zh) 2022-02-18

Family

ID=56368954

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680038852.7A Active CN107912043B (zh) 2015-07-06 2016-07-05 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物
CN202110826163.5A Active CN113880938B (zh) 2015-07-06 2016-07-05 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202110826163.5A Active CN113880938B (zh) 2015-07-06 2016-07-05 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物

Country Status (32)

Country Link
US (21) US10487132B2 (enExample)
EP (2) EP3736283A1 (enExample)
JP (3) JP6944382B2 (enExample)
KR (1) KR102890065B1 (enExample)
CN (2) CN107912043B (enExample)
AU (3) AU2016289754B2 (enExample)
BR (1) BR112017028363A2 (enExample)
CA (2) CA3221001A1 (enExample)
CL (7) CL2017003361A1 (enExample)
CO (1) CO2017012886A2 (enExample)
CR (3) CR20230563A (enExample)
DK (1) DK3319985T3 (enExample)
EA (1) EA201792671A1 (enExample)
ES (1) ES2841507T3 (enExample)
HR (1) HRP20210076T1 (enExample)
HU (1) HUE052628T2 (enExample)
IL (2) IL313594A (enExample)
LT (1) LT3319985T (enExample)
MA (1) MA51531A (enExample)
MD (1) MD3319985T2 (enExample)
MX (2) MX2017017148A (enExample)
MY (2) MY188354A (enExample)
PE (3) PE20180259A1 (enExample)
PH (1) PH12018500004A1 (enExample)
PL (1) PL3319985T3 (enExample)
PT (1) PT3319985T (enExample)
RS (1) RS61203B1 (enExample)
SG (1) SG10202001668PA (enExample)
SI (1) SI3319985T1 (enExample)
TW (2) TWI776332B (enExample)
UA (1) UA124411C2 (enExample)
ZA (1) ZA201707810B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107912043B (zh) 2015-07-06 2022-02-18 伊玛提克斯生物技术有限公司 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物
MY198087A (en) 2015-10-05 2023-07-31 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
CN109628591B (zh) * 2018-12-04 2022-04-15 南方医科大学南方医院 用于肺腺癌预后预测的标志物
CN112007167B (zh) * 2020-08-29 2023-01-24 南京中医药大学 蟾酥多肽在作为蟾蜍甾烯促渗剂中的应用
CN112812197B (zh) * 2021-01-11 2022-05-31 中国药科大学 一种兰州百合多糖及其制备方法和应用
CN114057860B (zh) * 2021-11-09 2023-10-20 中国科学技术大学 特定组氨酸甲基化修饰的s100a9蛋白免疫原、多克隆抗体及其制备方法
CN114717191B (zh) * 2022-04-26 2023-06-16 兰州大学第一医院 一株人肝内胆管癌细胞株icc-x3及其应用
CN115322967B (zh) * 2022-06-13 2023-08-08 浙江省人民医院 一种永生化人甲状腺乳头状癌成纤维细胞株及其构建方法和应用
CN114957399B (zh) * 2022-06-29 2023-05-09 湖北工业大学 一种多肽、多肽衍生物及其在制备抗肿瘤药物中的应用
CN115261471A (zh) * 2022-07-18 2022-11-01 武汉儿童医院 与胶质母细胞瘤预后显著相关的抗原及其应用
CN116449015A (zh) * 2022-08-26 2023-07-18 成都益安博生物技术有限公司 一种胃癌的外周血tcr标志物序列及其检测试剂盒和应用
CN116183920B (zh) * 2022-09-22 2023-10-20 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 用于检测鼻咽癌预后的抗体组合、系统及应用
CN116144772B (zh) * 2022-11-18 2023-08-25 昆明医科大学第一附属医院 一种Hsa_circ_0006117在制备治疗肺腺癌药物中的应用
CN115737619A (zh) * 2022-11-21 2023-03-07 深圳承启生物科技有限公司 一种用于抑制肿瘤的药物靶点、用途及口服药物
CN115831228B (zh) * 2022-12-08 2025-05-16 西北工业大学 一种基于线性混合模型的基因调控网络推断方法
CN116676334B (zh) * 2023-02-08 2025-05-27 深圳大学 抑郁症动物模型的构建方法
CN117106910B (zh) * 2023-08-10 2025-03-11 杭州师范大学 外周血白细胞rna联合标志物在制备检测或诊断早期原发性胆囊癌试剂盒中的应用
CN117843721B (zh) * 2024-03-07 2024-05-10 鲁东大学 一种扇贝源抗氧化肽及其制备方法与应用
CN119307618B (zh) * 2024-12-13 2025-03-14 浙江大学医学院附属邵逸夫医院 肝内胆管癌发生与发展过程中的关键分子的创新筛选方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007028573A1 (en) * 2005-09-05 2007-03-15 Immatics Biotechnologies Gmbh Tumor-associated peptides binding to human leukocyte antigen (hla) class i or ii molecules and related anti-cancer vaccine
WO2008013934A2 (en) * 2006-07-27 2008-01-31 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
CN102170900A (zh) * 2008-10-01 2011-08-31 伊玛提克斯生物技术有限公司 抗神经元和脑肿瘤等几种肿瘤的新型免疫疗法
CN102971003A (zh) * 2010-06-02 2013-03-13 伊玛提克斯生物技术有限公司 基于细胞周期素d1衍生的肿瘤相关抗原的癌症改进疗法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440859A (en) 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
IN151589B (enExample) 1978-12-22 1983-05-28 Biogen Nv
US4530901A (en) 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4678751A (en) 1981-09-25 1987-07-07 Genentech, Inc. Hybrid human leukocyte interferons
US4766075A (en) 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4810648A (en) 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
US4897445A (en) 1986-06-27 1990-01-30 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide bond
AU6852594A (en) 1993-06-03 1995-01-03 Therapeutic Antibodies Inc. Production of antibody fragments
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
CA2243235C (en) 1996-01-17 2010-08-10 Imperial College Innovations Limited Immunotherapy using cytotoxic t lymphocytes (ctl)
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
WO1998047921A1 (en) * 1997-04-21 1998-10-29 Schering Corporation Mammalian cytokines; related reagents and methods
US7393663B2 (en) * 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
JP2001512013A (ja) 1997-08-01 2001-08-21 ジェンセット 前立腺に発現される分泌タンパク質の5’est
EP2319929A1 (en) 1998-12-23 2011-05-11 Genentech, Inc. IL-1 related polypeptides
EP1237564A4 (en) * 1999-12-10 2005-05-04 Epimmune Inc TRIGGERING OF CELLULAR IMMUNE RESPONSES AGAINST P53 USING NUCLEIC ACID AND PEPTIDE COMPOSITIONS
US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
DE60142475D1 (de) 2000-03-27 2010-08-12 Technion Res And Dev Of Founda Einkettige haupthistokompatibilitätskomplexe der klasse i (mhc-i), kodierende konstrukte und methoden ihrer erzeugung
US20030144474A1 (en) 2000-06-05 2003-07-31 Sunol Molecular Corporation T cell receptor fusions and conjugates and methods of use thereof
AU2000275748A1 (en) * 2000-09-01 2002-03-22 Epimmune, Inc. Hla-a2.1 binding peptides and their uses
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
CA2476625A1 (en) 2002-02-20 2003-08-28 Dyax Corp. Mhc-peptide complex binding ligands
US7569664B2 (en) 2002-10-09 2009-08-04 Immunocore Limited Single chain recombinant T cell receptors
US7378495B2 (en) * 2002-10-21 2008-05-27 Pevion Biotech, Ltd. PTH-rP related peptide cancer therapeutics
PT1558643E (pt) 2002-11-09 2009-08-24 Immunocore Ltd Apresentação de um receptor das células t
GB0304068D0 (en) 2003-02-22 2003-03-26 Avidex Ltd Substances
US20040220094A1 (en) 2003-05-01 2004-11-04 Skinner Keith K. Inverse agonist and agonist peptides that stimulate/inhibit hair growth
US8053183B2 (en) * 2005-07-27 2011-11-08 Oncotherapy Science, Inc. Method of diagnosing esophageal cancer
PL1760088T3 (pl) 2005-09-05 2008-10-31 Immatics Biotechnologies Gmbh Związane z nowotworem peptydy wiążące się w sposób niedyskryminujący z cząsteczkami antygenu ludzkiego leukocytu klasy II (HLA)
ES2438444T3 (es) * 2006-09-08 2014-01-16 Amgen, Inc Variantes de la familia de IL-1
BRPI0813621A2 (pt) 2007-07-27 2017-05-09 Immatics Biotechnologies Gmbh imunoterapia contra tumores neuronais e cerebrais
CN105566450A (zh) 2007-07-27 2016-05-11 伊玛提克斯生物技术有限公司 免疫疗法的新型免疫抗原表位
US20090263574A1 (en) 2008-04-21 2009-10-22 Quinn Daniel E Method of restoring an article
PT2119726E (pt) * 2008-05-14 2015-03-30 Immatics Biotechnologies Gmbh Novos e poderosos peptídeos para mhc classe ii derivados de survinina e neurocano
US20110318380A1 (en) * 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
WO2010120554A1 (en) * 2009-04-01 2010-10-21 The Regents Of The University Of California Detecting and treating breast cancer resistance to egfr inhibitors
GB201004575D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
US20120225954A1 (en) 2010-09-05 2012-09-06 University Health Network Methods and compositions for the classification of non-small cell lung carcinoma
WO2012056407A1 (en) 2010-10-26 2012-05-03 Technion Research & Development Foundation Ltd. Antibodies which bind soluble t-cell receptor ligands
WO2013057586A1 (en) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions and methods for producing soluble t - cell receptors
JP2015226468A (ja) 2012-08-27 2015-12-17 北海道公立大学法人 札幌医科大学 p53ファミリーキメラ分子およびその使用
ES2603589T3 (es) 2012-11-08 2017-02-28 F. Hoffmann-La Roche Ag Ácidos nucleicos que codifican polipéptidos quiméricos para la identificación sistemática de bibliotecas
EP2808392A1 (en) 2013-05-28 2014-12-03 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamers and use of the aptamers in the diagnosis and treatment of cancer
TWI819228B (zh) 2013-08-05 2023-10-21 德商伊瑪提克斯生物科技有限公司 新穎肽類,細胞及其用於治療多種腫瘤的用途,其製造方法及包含其等之醫藥組成物(八)
GB201319446D0 (en) 2013-11-04 2013-12-18 Immatics Biotechnologies Gmbh Personalized immunotherapy against several neuronal and brain tumors
CN107912043B (zh) 2015-07-06 2022-02-18 伊玛提克斯生物技术有限公司 用于食管癌和其他癌症免疫治疗的新型肽和肽组合物
GB201511792D0 (en) 2015-07-06 2015-08-19 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers
TWI796299B (zh) 2016-08-26 2023-03-21 德商英麥提克生物技術股份有限公司 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007028573A1 (en) * 2005-09-05 2007-03-15 Immatics Biotechnologies Gmbh Tumor-associated peptides binding to human leukocyte antigen (hla) class i or ii molecules and related anti-cancer vaccine
WO2008013934A2 (en) * 2006-07-27 2008-01-31 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
CN102170900A (zh) * 2008-10-01 2011-08-31 伊玛提克斯生物技术有限公司 抗神经元和脑肿瘤等几种肿瘤的新型免疫疗法
CN102971003A (zh) * 2010-06-02 2013-03-13 伊玛提克斯生物技术有限公司 基于细胞周期素d1衍生的肿瘤相关抗原的癌症改进疗法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1–34)NH2;Fabio Rizzolo 等;《Journal of Peptide Science》;20110801;第708-714页 *

Also Published As

Publication number Publication date
EA201792671A1 (ru) 2018-06-29
EP4321172A2 (en) 2024-02-14
ZA201707810B (en) 2018-11-28
US10703795B2 (en) 2020-07-07
US10487132B2 (en) 2019-11-26
ES2841507T3 (es) 2021-07-08
US20220106380A1 (en) 2022-04-07
US20220119486A1 (en) 2022-04-21
MX2017017148A (es) 2018-02-23
EP3736283A1 (en) 2020-11-11
HUE052628T2 (hu) 2021-05-28
CA2991396A1 (en) 2017-01-12
CN113880938A (zh) 2022-01-04
JP2022020614A (ja) 2022-02-01
CL2021000982A1 (es) 2021-09-10
US11359003B2 (en) 2022-06-14
PE20231014A1 (es) 2023-07-05
IL256303B1 (en) 2024-10-01
MY188354A (en) 2021-12-02
TW202124430A (zh) 2021-07-01
JP6944382B2 (ja) 2021-10-06
US20200010531A1 (en) 2020-01-09
CL2023000706A1 (es) 2023-08-18
US20200291088A1 (en) 2020-09-17
TWI776332B (zh) 2022-09-01
MA51531A (fr) 2020-11-11
BR112017028363A2 (pt) 2018-08-28
US20210024609A1 (en) 2021-01-28
CL2021000981A1 (es) 2021-09-10
PH12018500004A1 (en) 2018-07-09
CR20170579A (es) 2018-05-25
MY198784A (en) 2023-09-27
US20220119487A1 (en) 2022-04-21
US20220112266A1 (en) 2022-04-14
SI3319985T1 (sl) 2021-01-29
CO2017012886A2 (es) 2018-03-09
IL256303B2 (en) 2025-02-01
CR20230563A (es) 2024-01-22
US20200157176A1 (en) 2020-05-21
MD3319985T2 (ro) 2021-01-31
CR20230562A (es) 2024-01-22
IL313594A (en) 2024-08-01
US20210277086A1 (en) 2021-09-09
US20220098275A1 (en) 2022-03-31
US11999774B2 (en) 2024-06-04
US20220135648A1 (en) 2022-05-05
CL2021000980A1 (es) 2021-09-10
JP2018519825A (ja) 2018-07-26
US20220135647A1 (en) 2022-05-05
US12351616B2 (en) 2025-07-08
US10626162B2 (en) 2020-04-21
US11401319B2 (en) 2022-08-02
DK3319985T3 (da) 2021-01-04
US20220098276A1 (en) 2022-03-31
US20190315832A1 (en) 2019-10-17
PE20240778A1 (es) 2024-04-17
CN113880938B (zh) 2025-09-05
HK1255542A1 (en) 2019-08-23
AU2022205209B2 (en) 2024-05-09
IL256303A (en) 2018-02-28
HRP20210076T1 (hr) 2021-05-14
SG10202001668PA (en) 2020-04-29
US20220106379A1 (en) 2022-04-07
KR20180026758A (ko) 2018-03-13
LT3319985T (lt) 2020-12-28
AU2016289754B2 (en) 2021-02-18
TW202222825A (zh) 2022-06-16
US11608370B2 (en) 2023-03-21
CL2023000708A1 (es) 2023-08-18
EP4321172A3 (en) 2024-08-21
AU2021200800A1 (en) 2021-03-04
RS61203B1 (sr) 2021-01-29
US20220098277A1 (en) 2022-03-31
US20210277088A1 (en) 2021-09-09
US20220135646A1 (en) 2022-05-05
US12297254B2 (en) 2025-05-13
CL2021000979A1 (es) 2021-09-10
JP2024041841A (ja) 2024-03-27
US10829537B2 (en) 2020-11-10
US20210277087A1 (en) 2021-09-09
KR102890065B1 (ko) 2025-11-21
AU2021200800B2 (en) 2022-08-18
CL2017003361A1 (es) 2018-05-04
PL3319985T3 (pl) 2021-05-04
MX2021013003A (es) 2022-01-18
US12258382B2 (en) 2025-03-25
US20220119484A1 (en) 2022-04-21
US11932678B2 (en) 2024-03-19
CN107912043A (zh) 2018-04-13
AU2016289754A1 (en) 2017-11-30
PT3319985T (pt) 2021-01-06
AU2022205209A1 (en) 2022-08-04
US20220119485A1 (en) 2022-04-21
UA124411C2 (uk) 2021-09-15
CA3221001A1 (en) 2017-01-12
PE20180259A1 (es) 2018-02-05
US11939366B2 (en) 2024-03-26

Similar Documents

Publication Publication Date Title
US11608370B2 (en) Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
US10364282B2 (en) Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
EA048702B1 (ru) Новые пептиды и комбинации пептидов для применения в иммунотерапии рака пищевода и других видов рака

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant