CN107903296A - 羟基积雪草苷的提取方法 - Google Patents
羟基积雪草苷的提取方法 Download PDFInfo
- Publication number
- CN107903296A CN107903296A CN201711229398.6A CN201711229398A CN107903296A CN 107903296 A CN107903296 A CN 107903296A CN 201711229398 A CN201711229398 A CN 201711229398A CN 107903296 A CN107903296 A CN 107903296A
- Authority
- CN
- China
- Prior art keywords
- madecassoside
- ethanol
- extracting method
- crude extract
- xad
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 title claims abstract description 41
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 title claims abstract description 34
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 title claims abstract description 34
- 229940090813 madecassoside Drugs 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 84
- 238000010828 elution Methods 0.000 claims abstract description 34
- 239000011347 resin Substances 0.000 claims abstract description 23
- 229920005989 resin Polymers 0.000 claims abstract description 23
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims abstract description 22
- 239000000287 crude extract Substances 0.000 claims abstract description 20
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims abstract description 18
- 241000167550 Centella Species 0.000 claims abstract description 17
- 239000002253 acid Substances 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 239000000706 filtrate Substances 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 238000001514 detection method Methods 0.000 claims abstract description 10
- 238000004809 thin layer chromatography Methods 0.000 claims abstract description 10
- 238000010992 reflux Methods 0.000 claims abstract description 9
- 239000003480 eluent Substances 0.000 claims abstract description 8
- 238000005267 amalgamation Methods 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 7
- -1 hydroxyl asiaticosid Chemical compound 0.000 claims abstract description 7
- 235000021110 pickles Nutrition 0.000 claims abstract description 6
- 229940022757 asiaticoside Drugs 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 239000000284 extract Substances 0.000 abstract description 2
- 229930182490 saponin Natural products 0.000 description 6
- 235000017709 saponins Nutrition 0.000 description 6
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 5
- 150000007949 saponins Chemical class 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 244000146462 Centella asiatica Species 0.000 description 2
- 235000004032 Centella asiatica Nutrition 0.000 description 2
- 208000028990 Skin injury Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000010148 water-pollination Effects 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 1
- 229930182573 Centellasaponin Natural products 0.000 description 1
- 241000288570 Chionochloa conspicua Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005554 pickling Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201711229398.6A CN107903296B (zh) | 2017-11-29 | 2017-11-29 | 羟基积雪草苷的提取方法 |
Applications Claiming Priority (1)
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CN201711229398.6A CN107903296B (zh) | 2017-11-29 | 2017-11-29 | 羟基积雪草苷的提取方法 |
Publications (2)
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CN107903296A true CN107903296A (zh) | 2018-04-13 |
CN107903296B CN107903296B (zh) | 2021-01-26 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115894597A (zh) * | 2022-11-03 | 2023-04-04 | 广州好肌肤科技有限公司 | 一种具有多重修护功效的羟基积雪草苷的提取工艺及应用 |
CN115998652A (zh) * | 2022-08-29 | 2023-04-25 | 广州好肌肤科技有限公司 | 一种具有舒缓修护功效的积雪草提取工艺 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1774257A (zh) * | 2002-12-10 | 2006-05-17 | 拜尔消费者保健股份公司 | 制备富含羟基积雪草苷和特米诺苷的积雪草酸提取物的方法 |
CN104592341A (zh) * | 2014-12-30 | 2015-05-06 | 广州白云山汉方现代药业有限公司 | 一种从积雪草中提取积雪草苷、羟基积雪草苷的方法 |
CN106380504A (zh) * | 2016-08-25 | 2017-02-08 | 桂林益天成生物科技有限公司 | 从积雪草中提取羟基积雪草苷的方法 |
-
2017
- 2017-11-29 CN CN201711229398.6A patent/CN107903296B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1774257A (zh) * | 2002-12-10 | 2006-05-17 | 拜尔消费者保健股份公司 | 制备富含羟基积雪草苷和特米诺苷的积雪草酸提取物的方法 |
CN104592341A (zh) * | 2014-12-30 | 2015-05-06 | 广州白云山汉方现代药业有限公司 | 一种从积雪草中提取积雪草苷、羟基积雪草苷的方法 |
CN106380504A (zh) * | 2016-08-25 | 2017-02-08 | 桂林益天成生物科技有限公司 | 从积雪草中提取羟基积雪草苷的方法 |
Non-Patent Citations (1)
Title |
---|
卢茂芳等: "积雪草提取纯化工艺的研究", 《湖南中医药大学学报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115998652A (zh) * | 2022-08-29 | 2023-04-25 | 广州好肌肤科技有限公司 | 一种具有舒缓修护功效的积雪草提取工艺 |
CN115894597A (zh) * | 2022-11-03 | 2023-04-04 | 广州好肌肤科技有限公司 | 一种具有多重修护功效的羟基积雪草苷的提取工艺及应用 |
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CN107903296B (zh) | 2021-01-26 |
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PB01 | Publication | ||
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Effective date of registration: 20210104 Address after: 541004 pavement 1-4 and 2-4, 1 Tung ring new village, Putuo Road, East Ring Road, Qixing District, Guilin, the Guangxi Zhuang Autonomous Region Applicant after: GUILIN RONGTONG TECHNOLOGY Co.,Ltd. Address before: 541004 No.2, pengjialing new village, Qixing District, Guilin City, Guangxi Zhuang Autonomous Region Applicant before: Tao Kunxiu |
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GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20211013 Address after: 510440 Room 706, Kaiying International Science Park Area A, 44 Qixing Gang Road, Luogang Village, Junhe Street, Baiyun District, Guangzhou City, Guangdong Province Patentee after: Zhenghe (Guangzhou) Biotechnology Co.,Ltd. Address before: 541004 pavement 1-4 and 2-4, 1 Tung ring new village, Putuo Road, East Ring Road, Qixing District, Guilin, the Guangxi Zhuang Autonomous Region Patentee before: GUILIN RONGTONG TECHNOLOGY Co.,Ltd. |
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TR01 | Transfer of patent right |