CN107898955A - A kind of medicine, its preparation method and application for promoting pig growth and development - Google Patents

A kind of medicine, its preparation method and application for promoting pig growth and development Download PDF

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CN107898955A
CN107898955A CN201711391752.5A CN201711391752A CN107898955A CN 107898955 A CN107898955 A CN 107898955A CN 201711391752 A CN201711391752 A CN 201711391752A CN 107898955 A CN107898955 A CN 107898955A
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medicine
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radix
chinese
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CN107898955B (en
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汪安国
刘文利
李丽
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SHANDONG XUNDAKANG BIOTECHNOLOGY CO.,LTD.
Shandong xundakang Veterinary Medicine Co., Ltd
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Shandong Xundakang Biological Science & Technology Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a kind of medicine, its preparation method and application for promoting pig growth and development, belong to livestock and poultry technical field of pharmaceuticals.The medicine of the present invention is made of the Chinese medicine composition of 99%~99.5% weight and the bacillus subtilis of 0.5%~1% weight, the Chinese medicine composition is that charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4 15: 25: 4 10: 38: 28: 26: 14: 14: 25: 0.1 2 compositions by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam.The medicine of the present invention can strengthen gastrointestinal function, improve food conversion ratio, excrement is few, reduces the discharge of exhaust gas.Excite immune organ function, improve active immunity level.Promote reparation and the secondary development of internal organs, increase premunition, reduce morbidity and death.

Description

A kind of medicine, its preparation method and application for promoting pig growth and development
Technical field
The invention belongs to livestock and poultry technical field of pharmaceuticals, and in particular to a kind of medicine for promoting pig growth and development, its preparation side Method and application.
Background technology
It is higher and higher to the quality requirement of poultry with the development of China's poultry farming, and various birds streams in recent years Sense and disease of digestive tract it is popular on a large scale, the growth of poultry receives serious influence, also influenced poultry quality, weight with And the economic benefit of farm；At present, people generally in animal and fowl fodder add antibiotic, hormone, chemical synthetic drug to prevent Control or mitigate bird flu.But the long-time service of these materials, causes pathogenic microorganism to develop immunity to drugs, in livestock products and environment Residual etc., serious threat human health.Therefore, there is an urgent need to develop it is a kind of have enhancing immune and premunition, resisting stress, Enhancing development, improve meat, while can reduce drug cost again, reduces feedstuff-meat ratio, shortens the green safe of breeding cycle Herbal medicine.
The content of the invention
In view of the deficiencies of the prior art, it is an object of the invention to provide piglet development is promoted, animal immune is improved Power, improves meat, while can reduce drug cost again, reduces feedstuff-meat ratio, shorten breeding cycle it is green safe it is non-harmful in Veterinary drug.
It is a kind of promote pig growth and development Chinese medicine composition, be by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4-15: 2-5: 4-10: 3-8: 2-8: 2-6: 1-4: 1-4: 2-5: 0.1-2 is formed.
On the basis of such scheme, the preparation method of the Chinese medicine composition for promoting pig growth and development, step is as follows：
1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
4. the thick paste in 3. is dried in vacuo, crush, cross 80-120 mesh sieves；
5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 80-120 mesh sieves are crushed respectively, then with 4. mixing It is even, to obtain the final product.
A kind of medicine for promoting pig growth and development, is by the Chinese medicine composition of 99%~99.5% weight and 0.5%~1% The bacillus subtilis composition of weight, the Chinese medicine composition are by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Jiao Hawthorn, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4-15: 2-5: 4-10: 3-8: 2-8: 2-6: 1-4: 1-4: 2-5: 0.1-2 is formed.
On the basis of such scheme, the medicine for promoting pig growth and development, is by the Chinese medicine composition of 99% weight Formed with the bacillus subtilis of 1% weight, the Chinese medicine composition is by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, mountain Medicine, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 15: 2: 4: 8: 2: 5: 1: 1: 5: 0.5 composition.
On the basis of such scheme, the medicine for promoting pig growth and development, is by the Chinese traditional medicine composition of 99.5% weight The bacillus subtilis of thing and 0.5% weight forms, and the Chinese medicine composition is by radix astragali, eucommia leaf extract, Radix Codonopsis, white Art, Chinese yam, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 12: 3: 5: 3: 8: 6: 4: 4: 2: 0.1 composition.
On the basis of such scheme, the medicine for promoting pig growth and development, is by the Chinese traditional medicine composition of 99.2% weight The bacillus subtilis of thing and 0.8% weight forms, and the Chinese medicine composition is by radix astragali, eucommia leaf extract, Radix Codonopsis, white Art, Chinese yam, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4: 5: 10: 8: 2: 2: 4: 4: 5: 2 compositions.
On the basis of such scheme, the preparation method of the Chinese medicine composition, step is as follows：
1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
4. the thick paste in 3. is dried in vacuo, crush, cross 80-120 mesh sieves；
5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 80-120 mesh sieves are crushed respectively, then with 4. mixing It is even, to obtain the final product.
On the basis of such scheme, the preparation method of the medicine for promoting pig growth and development, step is as follows：By Chinese medicine The powder of composition is mixed with bacillus subtilis to obtain the final product.
The medicinal application of promotion pig growth and development prepared by the above method is in enhancing development, raising immunity, enhancing Digestion and absorption function.
A kind of enhancing development, the pig's feed for improving immunity, strengthening digestion and absorption function, are added in feed Medicine prepared by the above method, additive amount 1kg/t.It can be added from weaning to any stage is delivered for sale, whole using effect is most It is good.
The monarch relation of Chinese prescription of the present invention is as follows：
We are using tonifying Qi and lifting yang, the stagnant scattered stasis of blood of row, strengthening the spleen and stomach as the rules for the treatment of, and wherein radix astragali tonifying Qi and lifting yang, blood-nourishing of promoting the production of body fluid, row are stagnant Logical numbness, orange peel regulating the flow of QI to ease the stomach, charred FRUCTUS CRATAEGI scattered stasis, melanoidin malt promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, Rhizoma Atractylodis Macrocephalae strengthening the spleen and replenishing qi is monarch drug in a prescription； In stir-baked MASSA FERMENTATA MEDICI-NALIS strengthening the spleen and stomach, the tune that helps digestion, Chinese yam tonifying spleen nourishing the stomach, Radix Codonopsis strengthening spleen and tonifying lung, is ministerial drug；Folium cortex eucommiae filling liver kidney, strengthening the bones and muscles For adjutant；Radix glycyrrhizae coordinating the drug actions of a prescription is to make medicine；Above Ten Herbs play tonifying Qi and lifting yang, the stagnant scattered stasis of blood of row, the rules for the treatment of of strengthening the spleen and stomach altogether.
The medicine of the present invention can strengthen gastrointestinal function, improve food conversion ratio, excrement is few, reduces the discharge of exhaust gas.Swash Send out immune organ function, improve active immunity level.Promote reparation and the secondary development of internal organs, increase premunition, reduce Morbidity and death.
Eucommia leaf extract, orange peel in medicine of the present invention, have effects that filling liver kidney, strengthening the bones and muscles, and can remove in vivo Rubbish, strengthens metabolism；Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, invigorating the spleen tonifying Qi；Charred Triplet (charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS)：With disappearing Food is led stagnant, the effect of invigorating the spleen and stomach, and can be increased protein synthesis, be improved trace element, promotes digestion.Chinese yam rhizome, promotes bone Bone is developed, albumen synthesis), promote child care pig to develop, stretch skeleton, suppress fat deposition, promote albumen generation, strong kidney controlling nocturnal emission with astringent drugs； Eucommia leaf extract, having strengthens immune and premunition, resisting stress, promotes the unique effects such as growth, improvement meat, can improve and exempt from Epidemic disease power, improves carcass quality.
Beneficial effects of the present invention：
1st, medicine strengthening the spleen and stomach of the invention, promotes enteron aisle allelotaxis, improves the viscosity of intestinal contents, suppress to disappear Change road pathogenic microorganism growth and breeding.
2nd, medicine of the present invention can promote appetite, and increase colony feed intake, promotes Fatty synthesis protein, activate digestive enzyme Property, augment nutritional material absorbing.
3rd, medicine of the invention increase animal disease resistant power, improves the weather-proof antistress function of pig, overall swinery is reduced anti- The use of raw element.
4th, medicine of the present invention can reduce drug cost, reduce feedstuff-meat ratio, shorten breeding cycle；Promote growth hormone release, Strengthen Calcium and phosphorous absorption, promote skeleton development, elongate skeleton；The same period feeds, and the same period, which delivers for sale, can increase weight 20 jin -30 jin；The same period raises Hello, same amount is delivered for sale, it can shift to an earlier date 15 days or so and deliver for sale.
5th, medicine of the invention uses genunie medicinal materials, traditional processing procedure, and a variety of rare traditional Chinese medicines are modulated meticulously；It can improve Feed conversion rate, growth promotion；Green and healthy, highly effective and safe.
Bacillus subtilis, manufacturer：Weifang Yi Hao Bioisystech Co., Ltd, goods number：014.
Embodiment
Used term in the present invention, it is unless otherwise specified, generally usual with those of ordinary skill in the art The implication of understanding.
With reference to specific embodiment, and with reference to the data further detailed description present invention.Following embodiments simply be Illustrate the present invention, rather than limit the scope of the invention in any way.
Embodiment 1
A kind of pharmaceutical composition of enhancing development, by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Jiaoshan Hill Short, bristly hair or beard, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 15: 2: 4: 8：2: 5: 1: 1: 5: 0.1 composition.
Specifically preparation method is：
1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
4. the thick paste in 3. is dried in vacuo, crush, cross 80 mesh sieves；
5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 80 mesh sieves are crushed respectively, then with 4. mixing, Bacillus subtilis is added according to 1% weight, to obtain the final product.
Embodiment 2
A kind of pharmaceutical composition of enhancing development, by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Jiaoshan Hill Short, bristly hair or beard, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 12: 3: 5: 3: 8: 6: 4: 4: 2: 0.1 composition
Specifically preparation method is：
1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
4. the thick paste in 3. is dried in vacuo, crush, cross 100 mesh sieves；
5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 100 mesh sieves are crushed respectively, then with 4. mixing, Bacillus subtilis is added according to 0.5% weight, to obtain the final product.
Embodiment 3
A kind of pharmaceutical composition of enhancing development, by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Jiaoshan Hill Short, bristly hair or beard, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4: 5: 10: 8: 2: 2: 4: 4: 5: 2 compositions.
Specifically preparation method is：
1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
4. the thick paste in 3. is dried in vacuo, crush, cross 120 mesh sieves；
5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 120 mesh sieves are crushed respectively, then with 4. mixing, Bacillus subtilis is added according to 0.8% weight, to obtain the final product.
Embodiment 4
A kind of pharmaceutical composition of enhancing development, by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Jiaoshan Hill Short, bristly hair or beard, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 8: 4: 7: 3: 7: 5: 3: 1: 2: 1 composition.
Preparation method is the same as embodiment 2.
Embodiment 5
A kind of pharmaceutical composition of enhancing development, by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, Jiaoshan Hill Short, bristly hair or beard, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 12: 4: 5: 3: 8: 5: 4: 2: 2: 1.5 compositions.
Preparation method is the same as embodiment 2.
First, the test of pesticide effectiveness
1.1 experiment packets
1.1.1 the medicine of embodiment 1
1.1.2 the medicine of embodiment 2；
1.1.3 the medicine of embodiment 3；
1.1.4 embodiment 2 does not contain medicine prepared by radix astragali, orange peel, charred FRUCTUS CRATAEGI, melanoidin malt, Rhizoma Atractylodis Macrocephalae；
1.1.5 using sealwort, the root of three-nerved spicebush, rose, rice sprout, the radix astragali in rhizoma atractylodis alternative embodiment 2, orange peel, charred FRUCTUS CRATAEGI, Jiao Medicine prepared by malt, Rhizoma Atractylodis Macrocephalae；
1.1.6 embodiment 2 does not contain medicine prepared by Radix Codonopsis, Chinese yam, stir-baked MASSA FERMENTATA MEDICI-NALIS；
1.1.7 the medicine prepared using the membrane of a chicken's gizzard, humus flava usta, the Radix Codonopsis in radix polygonati officinalis alternative embodiment 2, Chinese yam, stir-baked MASSA FERMENTATA MEDICI-NALIS；
1.1.8 embodiment 2 does not contain the medicine of eucommia leaf extract preparation；
1.1.9 the medicine that in cortex acanthopanacis alternative embodiment 2 prepared by eucommia leaf extract is used；
1.1.10 embodiment 2 does not contain the medicine of radix glycyrrhizae preparation；
1.1.11 the medicine that in jujube alternative embodiment 2 prepared by radix glycyrrhizae is used；
1.1.12 embodiment 2 does not contain the medicine of bacillus subtilis preparation；
1.1.13 blank control group.
1.2 zooperies design
1.2.1 1 is tested
Test pig factory：Weifang farm
Test period：On 2 24th, 2017 --- March 25
Unit：(jin)
Weanling pig similar in 195 monthly age weight is divided into 13 groups, every group 15 at random；1~4 group exists respectively The medicine of 1.1.1~1.1.3 is added in basal diet, 3 groups of 1~embodiment of embodiment is denoted as respectively, according to 1000kg feeds 1kg The amount addition of medicine；4~12 groups respectively in basal diet add 1.1.2~1.1.12 medicines, be denoted as respectively control group 1~ 9, added according to the amount of 1000kg feed 1kg medicines；Blank control group does not add any medicine, other experimental conditions are consistent.
Weight is surveyed in experiment after 30 days, observe diarrhea situation, calculates average daily gain amount, feedstuff-meat ratio, diarrhea rate (being shown in Table 2).
1 basal diet of table and trophic level
Raw material Content % Trophic level2) Content %
Corn 54.50 Digestible energy DE/ (MJ/kg)2) 14.90
Dregs of beans 22.00 Thick protein 19.70
Whey powder 9.00 Lysine 0.15
Expanded soybean 4.00 Methionine 0.15
Fish meal 5.00 Calcium 0.89
Soya-bean oil 2.00 Total phosphorus 0.57
Calcium monohydrogen phosphate CaHPO4 1.00
NaCl salt 0.30
Mountain flour 0.90
L lysine HCL 0.15
DL- METHIONINE 0.15
Premix1) 1.00
It is total 100.00
Note：1)Premix provides VA5512IU, VD 640IU, VK for every kilogram of diet32.2IU, VE20IU, VB1227.6μ G, VB25.5mg, VB62.2mg, D-VB5 14.8mg, nicotinic acid 30.3mg, biotin 0.05mg, choline 500mg, Cu 50mg, Fe 100mg, Mn 40mg, Zn 90mg, I 0.85mg, Se 0.35mg.
2)Digestible energy is calculated value, remaining is measured value.
2 weanling pig of table feeds indices of each medicine after 30 days
Result of the test shows that under the same conditions, medicine of the present invention is added in feeding to the weanling pig that original body mass is not much different Feed after thing, the average daily gain of piglet are significantly higher than other control groups, and feedstuff-meat ratio is substantially less than other control groups, illness rate It is significantly reduced；The medicine of this explanation present invention can increase the immunity of piglet, strengthen abilities of digestive and absorption, reduce disease Incidence, accelerates growth and development, shortens breeding cycle.
1.2.2 2 are tested
Test pig factory：Pizhou City Zou Bu Du Jun it
Test period：On 2 13rd, 2017 --- March 18
Unit：(jin)
Weanling pig similar in 20 first monthly age weight is divided into 2 groups, every group 10 at random；One of which is on basis Medicine prepared by embodiment 4 is added in daily ration, is denoted as 4 groups of embodiment respectively, is added according to the amount of 1000kg feed 1kg medicines； Any medicine is not added in another set basal diet, is denoted as blank control group, basal diet component is the same as table 1, other test bars Part is consistent.
Test period 30 days, statistical test original body mass, terminate weight；Counterpoise and feedstuff-meat ratio are calculated, observes diarrhea situation. The results are shown in Table 3.
3 weanling pig of table feeds indices of 4 medicine of embodiment after 30 days
1.2.3 3 are tested
Test pig factory：Big Tian Xingjun containing mountain village
Test period：On 2 27th, 2017 --- March 19
Unit：(jin)
Weanling pig similar in 30 first monthly age weight is divided into 2 groups, every group 15 at random；One of which is on basis The medicine of embodiment 5 is added in daily ration, is denoted as 5 groups of embodiment respectively, is added according to the amount of 1000kg feed 1kg medicines；In addition Any medicine is not added in one group of basal diet, is denoted as blank control group, basal diet component is the same as table 1, other experimental conditions one Cause.
Weight is surveyed in experiment after 20 days, statistical test original body mass, terminate weight；Counterpoise and feedstuff-meat ratio are calculated, observes diarrhea Situation.The results are shown in Table 4.
4 weanling pig of table feeds indices of 6 medicine of embodiment after 20 days
Drawn the abdomen using the medicine of the embodiment of the present invention 6 after 20 days, there is " back of the body ditch " in back, and build improves, build to length, Width extends, build bodybuilding.
1.2.4 4 are tested
Test pig factory：Reed toothed oak East Village Pan Zhao is refined
Test period：On March 1st, 2017 --- March 23
Unit：(jin)
Weanling pig similar in 22 first monthly age weight is divided into 2 groups, every group 11 at random；One of which is on basis The medicine of embodiment 5 is added in daily ration, is denoted as 5 groups of embodiment respectively, is added according to the amount of 1000kg feed 1kg medicines；In addition Any medicine is not added in one group of basal diet, is denoted as blank control group, basal diet component is the same as table 1, other experimental conditions one Cause.
Weight is surveyed in experiment after 22 days, statistical test original body mass, terminate weight；Counterpoise and feedstuff-meat ratio are calculated, observes diarrhea Situation.The results are shown in Table 5.
5 weanling pig of table feeds indices of 6 medicine of embodiment after 22 days
Experiment 2-4 result of the tests display that, after the feed of medicine of the present invention is added in raising, the average daily gain of weanling pig Increase, feedstuff-meat ratio and diarrhea rate reduce.The medicine of the present invention can promote appetite, and increase colony feed intake, promotes Fatty synthesis Protein, improves production performance, reduces emergency reaction, reduces the infection probability of disease.
2nd, influence of the medicine of the present invention to economic benefits of raising pigs
Experiment select 30 first 50 age in days weight similar in piglet, be randomly divided into test group and control group, every group 15, experimental period Totally 100 days, wherein pre-feeding period was 10 days, and 90 days are formal test period.One of which adds the medicine of embodiment 2 in basal diet Thing, is denoted as test group, is added according to the amount of 1000kg feed 1kg medicines；Any medicine is not added in another set basal diet, Blank control group is denoted as, other experimental conditions are consistent.
Small sample blood drawing, which is carried out, when testing and completing measures corresponding data.In stage on-test, all raw materials according to After proportioning mixing, 80 mesh sieves are crossed.Then it is sealed.
1st, weightening and economic benefit
In order to ensure drug effect, electronic scale weighs the Chinese medicine quantity needed daily in daily feeding process, feeds Foster forage volume is weighed, the same time weighing pig weight after feeding in 100 days.
Table 6 feed 10 days, 100 days when Body Mass Index (N=15)
7 Economic Benefit Accounting table of table
2nd, weanling pig blood parameters are analyzed
Before medicine of the present invention is fed, glucose content, Human Serum Albumin and total protein in each group piglet blood are measured The content of content, thyroxine (T4) and urinary nitrogen, it turns out that：The basic phase of the These parameters of test group and blank control group When containing feeding to add pharmaceutical feed of the present invention 100 days and measure Glucose in Blood by Cyclic, Human Serum Albumin and total protein The content of amount, thyroxine (T4) and urinary nitrogen.
Table 8 feed 100 days when blood in index (N=15)
*：Compared with control group, p<0.05, there is significant difference.
Result of the test is shown
(1), the content of glucose in blood
The content test group of glucose in serum is 2.47 ± 0.12, higher than the 2.13 ± 0.74 of control group, Portugal in serum Grape sugar shows that pig starter feed conversion ratio improves, and is more advantageous to the absorption of the nutriment of piglet higher than control group；
(2) total protein and albumin content
In test group, total protein is 62.63 ± 4.16 in serum, higher than control group 56.65 ± 8.84, albumin 31.23 ± 2.20, higher than control group 20.65 ± 9.88, the raising of Human Serum Albumin and total protein enhances the resistance of body, institute With medicine of the invention has the function that to improve weanling pig immunity and premunition, and promotes appetite, the feeding of increase colony Amount, promotes Fatty synthesis protein.
(3) content of thyroxine (T4) and urinary nitrogen
In test group, the content of thyroxine (T4) is higher than control group 25.64 ± 5.03, thyroid gland for 31.84 ± 4.47 The synthesis of plain (T4) to DNA and protein plays an important roll, and improves the disease resistance of body, the reinforcement of T4 secretions, illustrates machine Body metabolism it is vigorous, increase feed intake, absorb more nutriment meeting the enhancing of organism metabolism and cause physiology On needs.In test group, the content of urea nitrogen is less than the 5.03 ± 0.48 of control group for 3.88 ± 0.41, urea nitrogen in blood It is one of leading indicator of renal function, blood urea nitrogen raises during renal insufficiency, and urea nitrogen is less than control group in test group, says Bright medicine of the present invention has the function that to improve body function.
Blood parameters show medicine main function of the present invention be enhancing development influence each other with Immune-enhancing effect, phase Mutually promote, increase, the raising for being conducive to immune function of growth of the feed intake of pig, pig cell is immunized, humoral immunity work( The enhancing of energy promotes the reinforcement of organism metabolism function and the quickening of the speed of growth again in turn.
Use the effect after medicine of the present invention：
Using the obvious increase of feeding in 3 days, the 5th day nutrition high conversion rate digests incomplete phenomenon and disappears, and excrement is smelly within the 7th day Taste is opposite to be mitigated.
3rd, pharmacological toxicity is tested
3.1 test method
The ICR mouse 120 that weight is 18~22g are chosen, after 3 days adaptability is raised, being divided into 6 groups at random, (male and female are each Half), 5 groups of 1 group~embodiment of embodiment and blank control group, every group each 20；Blank control group gavage physiological saline, embodiment 1 group~embodiment, 5 groups of medicines for respectively preparing each embodiment are soluble in water to be gavaged, and each group medicine additive amount is 0.1g/mL, 0.3mL/ times, three times a day, continuous 7 days.
3.2 testing indexs and method
(1) clinicing symptom observation：The state of mind, the diet situation of daily viewing test mouse, dead feelings of falling ill per day entry Condition.
(2) pathological observation：Dissect observation internal organ change is carried out for dead mouse.
(3) growth indexes are observed：Routine weighing is carried out to experiment mouse；Off-test, slaughter mouse weigh in, internal organs weight it is dirty Device assessment of indices：Dissect rat, core dirty, spleen, liver, kidney, testis, ovary, weighs, and calculates internal organs according to the following formula and refers to Number：Organ index=internal organs weight/weight × 100.
(4) change in liver function is observed：After the test, mouse is slaughtered, takes blood to separate serum, measures AST, ALT.
3.3 data process＆analysis
All gathered datas carry out processing early period using Excel softwares, then carry out statistical analysis, LSD with SPSS 19.0 Multiple range test is carried out, is as a result represented using mean+SD.
3.3.1 clinicing symptom observation
Control group and test group mouse, the state of mind and diet are intended to, have no obvious exception to extraneous respond.Each group mouse Do not occur falling ill and death condition.
3.3.2 pathological observation：Control group and test group, progress dissect, which is observed, after mouse is slaughtered has no that observation internal organs are bright Aobvious pathological change.
3.3.3 growth indexes are observed：Off-test, slaughters that mouse weighs in, internal organs weight analysis are shown in Table 9.
9 each organ index of table is analyzed
Packet Liver index Cardiac index Renal index Lungs index Index and spleen index
1 group of embodiment 51.88±1.45a 4.54±0.21a 13.24±0.23a 6.47±0.39a 4.35±0.54a
2 groups of embodiment 51.85±1.51a 4.58±0.19a 13.27±0.21a 6.50±0.45a 4.39±0.49a
3 groups of embodiment 51.79±1.49a 4.51±0.22a 13.25±0.22a 6.45±0.51a 4.37±0.52a
4 groups of embodiment 51.83±1.45a 4.49±0.17a 13.19±0.28a 6.51±0.49a 4.33±0.50a
5 groups of embodiment 51.75±1.57a 4.55±0.20a 13.22±0.24a 6.50±0.44a 4.38±0.53a
Blank control group 51.32±1.50a 4.42±0.24a 13.17±0.27a 6.43±0.50a 4.33±0.52a
Note：Same column shoulder mark same letter represents difference not significantly (P>0.05), shoulder mark difference lowercase letter indication difference is shown Write (P<0.05).
As shown in Table 9, each organ index analysis, there was no significant difference between each test group and control group (P>0.05).
3.3.4 change in liver function is observed
After the test, mouse is slaughtered, takes blood to separate serum, measure AST (glutamic-oxalacetic transaminease), ALT (third turn of ammonia of paddy Enzyme) it is shown in Table 10.
Table 10 AST and ALT are measured
Packet Sum ALT AST
1 group of embodiment 20 35.21±2.05a 107.11±4.38a
2 groups of embodiment 20 35.33±2.11a 107.21±4.25a
3 groups of embodiment 20 35.27±2.09a 107.19±4.30a
4 groups of embodiment 20 35.35±2.01a 107.24±4.33a
5 groups of embodiment 20 35.24±2.14a 107.22±4.28a
Blank control group 20 35.27±2.17a 107.18±4.35a
Note：Same column shoulder mark same letter represents difference not significantly (P>0.05), shoulder mark difference lowercase letter indication difference is shown Write (P<0.05).
As shown in Table 10, each group of data difference compared with blank control group is not notable, all in normal range (NR).
3.4 long term toxicity test data
Healthy SPF grades of SD rat 96, half male and half female, is randomly divided into 4 groups, and respectively control group, the embodiment of the present invention 2 are made Standby medicine low dose group (15g/kg), middle dose group (30g/kg) and high dose group (90g/kg), every group 24.Ig is administered, Once a day, common 30d, in administration 30d and each execution 10 of every group of drug withdrawal 15d, abdominal aorta blood sampling.
Observation and testing index 1. behavior, appearance, hair color, urine color, excrement, active situation, drinking-water and dietary amount and detection Weight etc. weekly.2. administration the 30th day and drug withdrawal 15d takes a blood sample through abdominal aorta measure every blood biochemical analysis index and blood respectively As index include hemoglobin (Hgb), red blood cell (RBC) number, leucocyte (WBC) number, packed cell volume (HCT), be averaged it is red carefully Extracellular hemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) (MCHC), lymphocyte (LYM) number, monocyte (MON) number, neutrophil leucocyte (NEUT) number, eosinophil (EOS) number, basophilic granulocyte (BAS) number and blood platelet (PLT) number；Blood parameters include alanine aminotransferase (ALT), total bilirubin (T- BIL), total protein (TP), urea nitrogen (BUN), creatinine (CREA), albumin (ALB), glucose (GLU), alkaline phosphatase (ALP), gamma glutamyltransferase (GGT), triacylglycerol (TG), T-CHOL (CHOL), potassium (K), sodium (Na), chlorine (Cl)；The heart Creatase index includes：Aspartate amino transferase (AST), creatine kinase (CK), creatine kinase isozyme (CKMB), lactic acid Dehydrogenase (LDH)；Coagulation indexes include：Prothrombin time (PT), international standardization ratio (INR), thrombin time (TT), Partial prothrombin time (APTT), fibrinogen (FIB)；Core, liver, spleen, lung, kidney, adrenal gland, brain, stomach, large intestine, Small intestine, tracheae, oesophagus, reproductive organs (female：Uterus, ovary, male：Testis, epididymis) visually observe and weigh, extract control Group and each 4 of administration group male and female, put to death, dissection, visually observe each internal organs whether there is obvious lesion, and tissue block is fixed with 4% formaldehyde, Through paraffin embedding, microsection (4~6 μ m-thick), dewaxing aquation, HE dyeing, gradient alcohol dehydration, dimethylbenzene is transparent, neutral tree After glue sealing, histological observation is carried out under light microscope.Observation main organs tissue whether there is cell degeneration, inflammation and tumour The pathological changes such as generation, and film recording is given to typical cytopathic.
Result of the test shows that the medicine for preparing embodiment 2,15g/kg, 30g/kg, 90g/kg are big to SPF grades of SD of health Mouse continuous gavage is administered 1 month, the fur of animal, the colour of skin, ingest, activity, urine, feces etc. it is without exception；The blood routine of animal, The blood parameters such as Liver and kidney function and the main organs index of animal are in normal range (NR), and normal kinetic indifference；Pathology Histological examination shows that the important organ such as the heart, liver, spleen, lung, kidney, adrenal gland, tracheae, testis, ovary is without pathological change.It is discontinued Check that above indices are reacted without overt toxicity, show no cumulative toxicity after 15d.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc. Imitate embodiment.But it is every without departing from technical solution of the present invention content, the technical spirit according to the present invention is to above example institute Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.

Claims (10)

  1. A kind of 1. Chinese medicine composition for promoting pig growth and development, it is characterised in that：By radix astragali, eucommia leaf extract, Radix Codonopsis, white Art, Chinese yam, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4-15: 2-5: 4-10: 3-8: 2-8: 2-6: 1-4: 1-4: 2-5: 0.1-2 composition.
  2. 2. the preparation method of the Chinese medicine composition of the promotion pig growth and development according to claim 1, it is characterised in that step It is rapid as follows：
    1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
    2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
    3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
    4. the thick paste in 3. is dried in vacuo, crush, cross 80-120 mesh sieves；
    5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 80-120 mesh sieves are crushed respectively, then with 4. mixing, To obtain the final product.
  3. A kind of 3. medicine for promoting pig growth and development, it is characterised in that：By 99%~99.5% weight Chinese medicine composition and The bacillus subtilis composition of 0.5%~1% weight, the Chinese medicine composition are by radix astragali, eucommia leaf extract, Radix Codonopsis, white Art, Chinese yam, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4-15: 2-5: 4-10: 3-8: 2-8: 2-6: 1-4: 1-4: 2-5: 0.1-2 composition.
  4. 4. promote the medicine of pig growth and development according to claim 3, it is characterised in that：By the Chinese medicine composition of 99% weight Formed with the bacillus subtilis of 1% weight, the Chinese medicine composition is by radix astragali, eucommia leaf extract, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, mountain Medicine, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 15: 2: 4: 8: 2: 5: 1: 1: 5: 0.5 composition.
  5. 5. promote the medicine of pig growth and development according to claim 3, it is characterised in that：By the Chinese traditional medicine composition of 99.5% weight The bacillus subtilis of thing and 0.5% weight forms, and the Chinese medicine composition is by radix astragali, eucommia leaf extract, Radix Codonopsis, white Art, Chinese yam, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 12: 3: 5: 3: 8: 6: 4: 4: 2: 0.1 composition.
  6. 6. promote the medicine of pig growth and development according to claim 3, it is characterised in that：By the Chinese traditional medicine composition of 99.2% weight The bacillus subtilis of thing and 0.8% weight forms, and the Chinese medicine composition is by radix astragali, eucommia leaf extract, Radix Codonopsis, white Art, Chinese yam, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, orange peel, radix glycyrrhizae are by weight 4: 5: 10: 8: 2: 2: 4: 4: 5: 2 compositions.
  7. 7. according to any one of claim 3~6 medicine for promoting pig growth and development, it is characterised in that：The Chinese traditional medicine composition The preparation method of thing, step are as follows：
    1. weighing radix astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Chinese yam, orange peel, radix glycyrrhizae, 10 times of weight waters are added, boil extraction 2h, filtration；
    2. adding 8 times of weight waters into above-mentioned filter residue, extraction 2h, filtration are boiled；
    3. merge 1. 2. in filtrate, be concentrated into the paste of 1/8 weight；
    4. the thick paste in 3. is dried in vacuo, crush, cross 80-120 mesh sieves；
    5. by eucommia leaf extract, charred FRUCTUS CRATAEGI, melanoidin malt, stir-baked MASSA FERMENTATA MEDICI-NALIS, 80-120 mesh sieves are crushed respectively, then with 4. mixing, To obtain the final product.
  8. It is 8. as follows according to the preparation method of the medicine of any one of the claim 3~7 promotion pig growth and development, step：By in The powder of drug composition is mixed with bacillus subtilis to obtain the final product.
  9. 9. the medicine of promotion pig growth and development prepared by claim 8 the method is promoting piglet development, is improving to be immunized Application in terms of power, enhancing digestion and absorption function.
  10. A kind of 10. pig's feed for promoting piglet development, improving immunity, strengthening digestion and absorption function, it is characterised in that： Medicine prepared by claim 8 the method is added in feed, additive amount is 1kg/ tons.
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