CN107890547A - A kind of Chinese medicine for being used to treat AML - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine for being used to treat AML, it is prepared by the raw medicinal material of following weight proportion：10 parts of eve of the lunar New Year Huang, 30 parts of fund grass, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, 12 parts of common wrightia root or stem, 12 parts of root tuber of aromatic turmeric.Clinical experiments have proved that the present invention can safely and effectively treat AML.

Description

A kind of Chinese medicine for being used to treat AML

Technical field

The present invention relates to a kind of Chinese medicine, and in particular to a kind of Chinese medicine for being used to treat AML.

Background technology

AML is as caused by the breaking-up and poisonous effect of ethanol and its metabolism product to liver cell, with liver Metabolic disorder is injured for basic acute and chronic liver number.Clinical point of 3 types of AML：Fatty liver, hepatitis, hepatic sclerosis.This three Often it is mixed.AML also has malnutrition, anaemia, spider angioma, liver palms, neuritis, flesh to wither in addition to general hepatic sclerosis Contracting, parotid gland enlargement, gynecomasty, orchiatrophy etc..The interpretation of the cause, onset and process of an illness of AML develops complicated, clinical symptoms change multiterminal, card Type is overlapping staggeredly, thus when dialectical, must combine the course of disease of patient and degree of being addicted to drink, and cautiously grasping pathogenesis is sized up the current situation, shrewd void Different phase and syndrome characteristics real, developed according to disease, formulate righting, the method for eliminating evil.Righting is beneficial to irritability, nourishing hepatic yin, benefit The difference of spleen, kidney-nourishing, eliminating evil have relieving alcoholism, clearing damp heat, resolving sputum is turbid, qi-regulating, dissolving stasis it is different.In general, disease is preferably clear initial stage Dampness elimination heat, normalizing gallbladder to cure jaundice；The suitable promoting flow of qi and blood circulation of mid-term, the addiction that disappears resolving sputum；Later stage suitable strengthening vital QI to eliminate pathogenic factors, tonification and purgation in combination, accomplishes that qi-restoratives is not forgotten It is real, let out and do not forget void in fact.This right disease is damp and hot two property by wine, accumulates long-pending detoxification, and caused by thief kills internal organs, therefore it treats big method, when On the basis of diagnosis and treatment, coordinate the cytotoxic drug that relieves the effect of alcohol, it is damp and hot to distinguish.Dissolve wine poison and work as first weight taste, it is sent out thoroughly from flesh stock, Or from urine point profit, excrete.

Medicinal material present Research involved in the present invention is as follows：

The eve of the lunar New Year is yellow【Alias】General, Huang Liang, fire ginseng, skin as, another name for Sichuan Province rheum officinale, Radixet Rhizoma Rhei, cow tongue rheum officinale, bright and beautiful line, raw army, Sichuan troops. 【Source】This product is the drying root and rhizome of polygonum rheum palmatum, Rheum tanguticum Maxim or Rheum officinale.Autumn end cauline leaf is withered Wither or secondary spring germination before excavate, remove radicula, scrape off crust, valve cutting or section, rope wears that bunchiness is dry or convection drying.【Nature and flavor】 It is bitter, cold.【Channel tropism】Returns spleen, stomach, large intestine, liver, pericardium channel.【Major function】Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For Real heat constipation, stagnate stomachache, and rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, hemostasis Amenorrhea, traumatic injury, scald is controlled outside；UGB.Prepared RADIX ET RHIZOMA RHEI with wine is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, Gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, exerts oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.There is the stasis of blood for blood-head Haemorrhage.【Usage and dosage】It is for oral administration：Decoct soup, 3~30g.【Pay attention to】Pregnant woman uses with caution.【Take passages】《Chinese book on Chinese herbal medicine》.

Fund grass【Alias】Christina loosestrife herb, to seat grass, everywhere LUBIANHUANG, Huang, copper coin grass, a string of money, very little bone seven.【Source】 This product is the drying herb of Ofthe Primulaceae Lysimachia christinae.Summer, the harvesting of season in autumn two, remove impurity, dry.【Nature and flavor】It is sweet, salty, it is micro- It is cold.【Channel tropism】Return liver, courage, kidney, bladder warp.【Major function】Eliminating dampness and heat, treating stranguria, detumescence.For heat gonorrhea, Sha Lin, puckery work is urinated Bitterly, jaundice, carbuncle swells furunculosis, venomous snake bite；Liver and bile stone, lithangiuria.【Usage and dosage】It is for oral administration：Decoct soup, 15~60g. 【Pay attention to】All all poison of cloudy subcutaneous ulcer, splenasthenic diarrhea person, avoid and smash juice life clothes.【Take passages】《Chinese book on Chinese herbal medicine》.

Rhizoma corydalis【Alias】Profound Hu Su, corydalis tuber, prolong recklessly.【Source】This product is the dry tuber of papaveraceae plant corydalis. Early summer cauline leaf is excavated when withered, removes fibrous root, is cleaned, put boiled in boiling water to it is proper without the white heart when, take out, dry.【Nature and flavor】Pungent, Hardship, temperature.【Channel tropism】Return liver, the spleen channel.【Major function】Promoting blood circulation, sharp gas, analgesic.For chest side of body, epigastric pain, closed dysmenorrhea, production Stasis blocking afterwards, tumbling and swelling.【Usage and dosage】It is for oral administration：Decoct soup, 3-9g.【Pay attention to】Pregnant woman uses with caution.【Take passages】《Chinese book on Chinese herbal medicine》.

Curcuma zedoary【Alias】Curcuma wenyujin, zedoary, radix zedoariae, Rhizoma Trillii Tschonoskii, smelly dung ginger.【Source】This product is the fluffy cowherb of zingiberaceous plant The dry rhizome of art, Guangxi zedoary or RADIX CURCUMAE.The latter, which practises, claims " Curcuma wenyujin ".Excavate, clean after winter cauline leaf is withered, steam or Boil to the saturating heart, dry or low temperature drying after remove fibrous root and impurity.【Nature and flavor】It is pungent, bitter, temperature.【Channel tropism】Return liver, the spleen channel.【Function Cure mainly】Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.For Dan lump in the abdomen lump in the abdomens, blood stasis closed, dyspepsia distending pain；Early cervical carcinoma.【Usage and dosage】It is interior Clothes：Decoct soup, 6~12g.【Pay attention to】Pregnant woman disables.Qi-blood deficiency, weakness of spleen and stomach,the frail spleen and stomach is without the careful clothes of stagnant person.【Take passages】《Chinese book on Chinese herbal medicine》.

Artemisia capillaris【Alias】Because dirt, Ma Xian, mattress Gall wormwood artemisias, oriental wormwood, because of old wormwood artemisia, capillary wormwood, suede wormwood artemisia, spire sweet wormwood, smelly wormwood artemisia, An Lv Grass, grandmother wormwood artemisia, wild blue wormwood artemisia.【Source】For the young young stem and leaf of feverfew Artemisia capillaris.Spring seedling harvests when high about three cun, Impurity is removed, soil is removed, dries.【Nature and flavor】Toil, it is cool.【Channel tropism】Enter liver, spleen, bladder warp.【Major function】Heat-clearing profit It is wet.Control jaundice with damp-heat pathogen, difficult urination, pruritus sore scabies.Yang jaundice is controlled with cape jasmine, rheum officinale；Yin jaundice is controlled with monkshood, rhizoma zingiberis.【Pay attention to】Heat Very turn to be yellow, no moisture, the two disabling.【Usage and dosage】It is for oral administration：Decoct soup, 3~9g.【Take passages】《Chinese book on Chinese herbal medicine》.

The seed of cowherb【Alias】SEMEN VACCARIAE, milk rice, king bull, barley ox.【Source】This product is pinkwort cow-fat Dry mature seed.Summer fruit maturation, pericarp tap plant when not yet ftractureing, and dry, and lay seed, remove impurity, then Dry.【Nature and flavor】Hardship, put down.【Channel tropism】Hardship, put down.【Major function】Invigorate blood circulation, lower breast detumescence.For agalactia, Amenorrhea, Dysmenorrhoea, acute mastitis swelling and pain.【Usage and dosage】It is for oral administration：Decoct soup, 4.5~9g.【Pay attention to】Pregnant woman uses with caution.Disease, the uterine bleeding disease of losing blood must simultaneously avoid It.【Take passages】《Chinese book on Chinese herbal medicine》.

Common wrightia root or stem【Alias】Mo Zhuguo, chapter table, Chang Zi, nine dense wood, branch paulownia wood, pig pine, angle's candle, handle of a knife, hardship Often, thin aunt's wood, Ma Ling, pig dish mother, bitter poplar.【Source】The root or stem branch of pen are hung upside down for apocynaceae plant.Harvesting and storage： Whole year can adopt, and clean, and section, dry.【Nature and flavor】It is sweet；It is light；It is mild-natured.【Channel tropism】Return liver, kidney, lung, small intestinl channel.【Major function】 Dispelling wind and removing obstruction in the meridians；Reducing phlegm and resolving masses；Dampness removing.Main arthralgia pain due to rheumatism；Lumbocrural pain；Traumatic injury；Scrofula；Chronic bronchitis；Icteric Hepatitis, cirrhotic ascites.【Usage and dosage】It is for oral administration：Decoct soup, 9~30g.【Take passages】《Chinese book on Chinese herbal medicine》

Root tuber of aromatic turmeric【Alias】Radix curcumae, white silk root tuber of aromatic turmeric.【Source】This product is zingiberaceous plant RADIX CURCUMAE, turmeric, Guangxi zedoary or zedoary Dried root.The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, and remaining is claimed " osmanthus root tuber of aromatic turmeric " or " green by the different habits of character Silk root tuber of aromatic turmeric ".Excavated after winter cauline leaf is withered, remove silt and radicula, steamed or boil to the saturating heart, dry.【Nature and flavor】It is pungent, bitter, tremble with fear. 【Channel tropism】Return liver, the heart, lung channel.【Major function】Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.It is swollen for closed dysmenorrhea, chest and abdomen Bitterly, shouting pain, pyreticosis coma, epilepsy are gone mad, jaundice.【Usage and dosage】It is for oral administration：Decoct soup, 3~9g.【Pay attention to】The deficiency of Yin lose blood and Avoid clothes, pregnant women should cautiously take without qi depression to blood stasis person.【Take passages】《Chinese book on Chinese herbal medicine》.

The content of the invention

The present invention is intended to provide a kind of Chinese medicine for being used to treat AML, by selecting suitable medicinal material and its matching somebody with somebody Than reaching the purpose for safely and effectively curing AML.

In order to achieve the above object, the present invention uses following technical scheme：

A kind of Chinese medicine for being used to treat AML, it is characterised in that it is the raw medicinal material preparation by following weight proportion Form：The eve of the lunar New Year is yellow 10 parts, 30 parts of fund grass, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, hangs upside down wax Candle 12 parts, 12 parts of root tuber of aromatic turmeric.

The beneficial effects of the present invention will now be described with reference to clinical experimental data：

1st, general information

Outpatient service and in hospital patients with alcoholic liver disease 74, man 71, female are collected between October altogether in inventor in October, 2012 ~ 2013 year 3, at 32~65 years old age, average age 46 years old, indulge in excessive drinking 5 ~ 22 years times.Treatment group 51 and control group 23 are randomly divided into, 2 groups of sexes, age and course of disease comparing difference are not statistically significant, have comparativity.

Diagnostic criteria

Diagnostic criteria according to national AML clinical speciality meeting：1. sign：（1）Alcoholic hepatitis：Symptom of digestive tract Heavier to have nausea, vomiting, anorexia is weak, becomes thin, and hepatic region pain aggravates etc..Severe patient is in acute severe hepatitis or liver function Exhaustion；（2）Alcoholic cirrhosis：Outside general hepatocirrhosis symptoms, there are malnutrition, anaemia, spider angioma, liver palms, neuritis, flesh The symptoms such as atrophy, parotid gland enlargement, gynecomasty, orchiatrophy are common compared with posthepatitic cirrhosis, and visible Dupuytren palm contractions Contracting, glossitis, can be with pancreatitis during parotid gland enlargement.Early stage hepatomegaly, late period liver reduce, and splenomegaly is common not as posthepatitic cirrhosis.Abdomen Water appearance is more early, often merges canker.

2.B type ultrasonic examinations：（1) fatty liver：Liver volume increase is shown, the tiny echo of uniformity substantially occurs, and There is " the bright liver " that tiny luminous point is intensive, and acoustic beam decay strengthens；(2) spleen enlargement is seen in alcoholic cirrhosis.Liver parenchyma echo Enhancing, caudal lobe is relative to be increased.Splenic vein and portal vein diameter are significantly more than normal (the former is normal 1.0cm, the latter 1.5cm).

2nd, test method

2.1 treatment method

The oral present invention for the treatment of group is according to capsule made from specific embodiment 3,3 times a day.36 days courses for the treatment of, two courses for the treatment of.

The control group oral safe happy each 0.2g of piece, each 0.2g of vitamin C, 3 times a day orally, 36 days courses for the treatment of, two The course for the treatment of.

3rd, criterion of therapeutical effect and treatment results

3.1 criterion of therapeutical effect

Clinical cure：Clinical symptom disappearance.Liver function recovery is normal, and citrus orchards check normal；

Effectively：Clinical symptoms disappear substantially, and liver function is substantially recovered, citrus orchards AML disease

Change mitigation (including fatty liver switchs to mild or moderate by severe：Or moderate recovers normal and liver

Hardening lesion degree substantially mitigates or disappeared without exacerbation, ascites)；

It is invalid：Clinical symptoms are without alleviation, even liver function is not recovered to aggravate, citrus orchards lesion does not change

Become or aggravate.

3.2 treatment results are shown in Table 1.

1 two groups of curative effects of table compare

Group	n	Clinic control	Effectively	It is invalid	Total effective rate (%)	Serious adverse reaction example
							Treatment group	51	23	20	8	84.31%	0
Control group	23	2	10	11	52.17%	0

It can be seen that medicine produced by the present invention can safely and effectively treat AML, there is promotional value.

Embodiment

In order to more fully understand and implement the present invention, the present invention is further illustrated with reference to specific embodiment.

Embodiment 1

Weigh：The eve of the lunar New Year is yellow 10 grams, 30 grams of fund grass, 10 grams of rhizoma corydalis, 10 grams of curcuma zedoary, 12 grams of Artemisia capillaris, 12 grams of the seed of cowherb, falls Hang 12 grams of candle, 12 grams of root tuber of aromatic turmeric；Add 8 times of amount water, decoct 1.5 hours, filtering；Filter residue adds 6 times of amount water, decocts 1 hour, filtering； Merging filtrate, 120 grams are concentrated into, produce the decoction for meeting one day dosage of normal adult.

For treating AML.Orally, taken three times per bu Morning Afternoon Evening.

Embodiment 2

Weigh：The eve of the lunar New Year is yellow 10 grams, 30 grams of fund grass, 10 grams of rhizoma corydalis, 10 grams of curcuma zedoary, 12 grams of Artemisia capillaris, 12 grams of the seed of cowherb, falls Hang 12 grams of candle, 12 grams of root tuber of aromatic turmeric；Add 10 times of amount water, decoct 2 hours, filtering；Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering； Merging filtrate, concentrate, dry, packaging, produce the powder for meeting one day dosage of normal adult.

For treating AML.Orally, taken three times per bu Morning Afternoon Evening.

Embodiment 3

Weigh：The eve of the lunar New Year is yellow 10 grams, 30 grams of fund grass, 10 grams of rhizoma corydalis, 10 grams of curcuma zedoary, 12 grams of Artemisia capillaris, 12 grams of the seed of cowherb, falls Hang 12 grams of candle, 12 grams of root tuber of aromatic turmeric；Add 6 times of amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, dry, load Capsule shells, produce the capsule for meeting one day dosage of normal adult.

For treating AML.Orally, taken three times per bu Morning Afternoon Evening.

Claims (4)

1. a kind of Chinese medicine for being used to treat AML, it is characterised in that it is by the raw medicinal material system of following weight proportion It is standby to form：The eve of the lunar New Year is yellow 10 parts, 30 parts of fund grass, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, hangs upside down 12 parts of candle, 12 parts of root tuber of aromatic turmeric.

2. the as claimed in claim 1 Chinese medicine for being used to treat AML, it is characterised in that its preparation method is：Weigh： The eve of the lunar New Year is yellow 10 parts, fund is careless 30 parts, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, common wrightia root or stem 12 Part, 12 parts of root tuber of aromatic turmeric；Add 8 times of amount water, decoct 1.5 hours, filtering；Filter residue adds 6 times of amount water, decocts 1 hour, filtering；Merging filtrate, 120 parts are concentrated into, produces decoction；Above-mentioned part each means parts by weight.

3. the as claimed in claim 1 Chinese medicine for being used to treat AML, it is characterised in that its preparation method is：Weigh： The eve of the lunar New Year is yellow 10 parts, fund is careless 30 parts, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, common wrightia root or stem 12 Part, 12 parts of root tuber of aromatic turmeric；Add 10 times of amount water, decoct 2 hours, filtering；Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering；Merge filter Liquid, concentrate, dry, packaging, produce powder；Above-mentioned part each means parts by weight.

4. the as claimed in claim 1 Chinese medicine for being used to treat AML, it is characterised in that its preparation method is：Weigh： The eve of the lunar New Year is yellow 10 parts, fund is careless 30 parts, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, common wrightia root or stem 12 Part, 12 parts of root tuber of aromatic turmeric；Add 6 times of amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, dry, load capsule shells, Produce capsule；Above-mentioned part each means parts by weight.