CN107812051A - A kind of Chinese medicine for being used to treat acute cholecystitis - Google Patents

A kind of Chinese medicine for being used to treat acute cholecystitis Download PDF

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CN107812051A
CN107812051A CN201610821340.XA CN201610821340A CN107812051A CN 107812051 A CN107812051 A CN 107812051A CN 201610821340 A CN201610821340 A CN 201610821340A CN 107812051 A CN107812051 A CN 107812051A
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acute cholecystitis
chinese medicine
desmodium
decoct
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高忠青
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Zibo Kuake Pharmaceutical Technology Co Ltd
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Zibo Kuake Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285Aucklandia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
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    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The present invention relates to a kind of Chinese medicine for being used to treat acute cholecystitis, it is prepared by the raw medicinal material of following weight proportion:5 parts of rheum officinale, 30 parts of desmodium, 15 parts of oriental wormwood, 9 parts of cape jasmine, 9 parts of corydalis tuber, 9 parts of radix scutellariae, 6 parts of the banksia rose, 6 parts of radix bupleuri, 9 parts of the dried immature fruit of citron orange.Clinical experiments have proved that the present invention can safely and effectively treat acute cholecystitis.

Description

A kind of Chinese medicine for being used to treat acute cholecystitis
Technical field
The present invention relates to a kind of Chinese medicine, and in particular to a kind of Chinese medicine for being used to treat acute cholecystitis.
Background technology
Acute cholecystitis is due to gallbladder inflammation caused by gall-bladder pipe choking and bacteria attack, is the common disease of gall-bladder. Its incidence of disease is only second to appendicitis in abdominal surgery, and this disease is more common in a middle-aged person of 35~55 years old, and women morbidity is compared with male It is more, fat and multiple pregnancies women are more common in especially.The common complication hydrops of gallbladder, white bile, milk of lime bile, porcelain sample courage Capsule, perforation of gallbladder, Biliary-digestive fistula, hepatapostema.Acute cholecystitis illness:Many patients fall ill entering greasy dinner after midnight, because High fat diet can make gall-bladder strengthen shrinking, and prostrate is easy to small cholelith and slips into simultaneously incarceration cystic duct.It is mainly shown as upper right abdomen Rest pain, paroxysmal aggravation, can shoulder back of the body radiation to the right;Often occur together heat, nausea and vomiting, but it is rare to shiver with cold, and jaundice is light.Belly Check and find that upper right abdomen is full, gallbladder area tension of abdominal muscle, obvious tenderness, Blumberg's sign.
Medicinal material present Research involved in the present invention is as follows:
Rheum officinale【Source】This product is the drying root and rhizome of polygonum rheum palmatum, Rheum tanguticum Maxim or Rheum officinale.Qiu Mo Excavated before cauline leaf is withered or secondary spring is germinateed, remove radicula, scrape off crust, valve cutting or section, restricted and wear bunchiness drying or convection drying. 【Nature and flavor】Hardship, tremble with fear.【Channel tropism】Returns spleen, stomach, large intestine, liver, pericardium channel.【Major function】Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, leads to by the stasis of blood Through.For real heat constipation, stagnate stomachache, and rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells malignant boil Sore, blood stasis closed, traumatic injury, scald is controlled outside;UGB.Prepared RADIX ET RHIZOMA RHEI with wine is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For mesh Red pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, exerts oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.For Blood-head has stasis of blood haemorrhage.【Usage and dosage】It is for oral administration:Decoct soup, 3~30g.【Pay attention to】Pregnant woman uses with caution.【Take passages】《Chinese book on Chinese herbal medicine》
Desmodium【Alias】Christina loosestrife herb, to seat grass, everywhere LUBIANHUANG, Huang, copper coin grass, a string of money, very little bone seven.【Source】This product For the drying herb of Ofthe Primulaceae Lysimachia christinae.Summer, the harvesting of season in autumn two, remove impurity, dry.【Nature and flavor】It is sweet, salty, it is slightly cold. 【Channel tropism】Return liver, courage, kidney, bladder warp.【Major function】Eliminating dampness and heat, treating stranguria, detumescence.For heat gonorrhea, Sha Lin, urine is puckery to have a pain, Jaundice, carbuncle swells furunculosis, venomous snake bite;Liver and bile stone, lithangiuria.【Usage and dosage】It is for oral administration:Decoct soup, 15~60g.【Note Meaning】All all poison of cloudy subcutaneous ulcer, splenasthenic diarrhea person, avoid and smash juice life clothes.【Take passages】《Chinese book on Chinese herbal medicine》.
Oriental wormwood【Alias】Capillary wormwood, Artemisia capillaris, Artemisia stelleriana, suede wormwood artemisia, monkey hair.【Source】Product are feverfew artemisia scoparia or oriental wormwood The dry aerial parts of wormwood artemisia.Tapped when harvesting or autumn bud grow up to during spring seedling high 6~10cm, remove impurity and old stem, Dry.The spring habit of harvesting claims " capillary wormwood ", the title " Artemisia capillaris " that autumn taps.【Nature and flavor】It is bitter, pungent, it is slightly cold.【Channel tropism】Return Spleen, stomach, liver, gallbladder channel.【Major function】Clearing away damp-heat, removing jaundice subcutaneous ulcer.For jaundice oliguria, wet sore itch;Infectious jaundice type hepatitis. 【Usage and dosage】It is for oral administration:Decoct soup, 6~15g.【Take passages】《Chinese book on Chinese herbal medicine》.
Cape jasmine【Alias】Yellow Fructus Gardeniae, yellow fruit tree, fructus gardeniae, Fructus Gardeniae.【Source】This product is the dry of madder wort cape jasmine Dry ripening fruits, its root can also be used as medicine.9~November, fruit maturation was harvested when being in reddish yellow, removed carpopodium and impurity, was steamed supreme Vapour puts slightly boiling hot in boiling water, taking-up, drying.Root summer and autumn are excavated, and are cleaned and are dried.【Nature and flavor】Hardship, tremble with fear.【Channel tropism】The thoughts of returning home, lung, three Jiao Jing.【Major function】Fruit:Purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.It is puckery for Vexed, jaundice, blood strangury Bitterly, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles;Control bruise pain outside.【Usage and dosage】It is for oral administration:Decoct soup, 6~9g.【Pay attention to】Spleen Empty loose stool person avoids clothes.【Take passages】《Chinese book on Chinese herbal medicine》.
Corydalis tuber【Alias】Profound Hu Su, corydalis tuber, prolong recklessly.【Source】This product is the dry tuber of papaveraceae plant corydalis. Early summer cauline leaf is excavated when withered, removes fibrous root, is cleaned, put boiled in boiling water to it is proper without the white heart when, take out, dry.【Nature and flavor】Pungent, Hardship, temperature.【Channel tropism】Return liver, the spleen channel.【Major function】Promoting blood circulation, sharp gas, analgesic.For chest side of body, epigastric pain, closed dysmenorrhea, production Stasis blocking afterwards, tumbling and swelling.【Usage and dosage】It is for oral administration:Decoct soup, 3-9g.【Pay attention to】Pregnant woman uses with caution.【Take passages】《Chinese book on Chinese herbal medicine》.
Radix scutellariae【Alias】Radix Scutellariae, scutellaria tea, tsuchikane tea root.【Source】This product is the dry root of labiate radix scutellariae. Spring, the excavation of season in autumn two, remove fibrous root and silt, hit tertia after solarization, dry.【Nature and flavor】Hardship, tremble with fear.【Channel tropism】Return lung, courage, spleen, Large intestine, small intestinl channel.【Major function】Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis are antiabortive.It is damp and hot for damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest Feeling of fullness, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.【Usage and dosage】It is for oral administration:Decoct Soup, 3-9g.【Pay attention to】Fructus Corni, keel make for it.It is real to dislike green onion.Fear cinnabar, tree peony, black false hellebore.【Take passages】《Chinese book on Chinese herbal medicine》.
The banksia rose【Alias】Aplotaxis auriculata, costus root.【Source】This product is the dry root of the feverfew banksia rose.Autumn, season in winter two adopt Dig, remove silt and fibrous root, segment, big vertical profile again hits tertia into valve after drying.【Nature and flavor】It is pungent, bitter, temperature.【Channel tropism】Return Spleen, stomach, large intestine, three burnt, gallbladder channels.【Major function】Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.For chest gastral cavity distending pain, weight after rush down dysentery, dyspepsia Do not disappear, do not feel like eating.Roasted RADIX AUCKLANDIAE reality intestines antidiarrheal.For stomachache of having loose bowels.【Usage and dosage】It is for oral administration:Decoct soup, 1.5~6g.【Pay attention to】 The deficiency of Yin body fluid deficiency careful clothes of person.【Take passages】《Chinese book on Chinese herbal medicine》.
Radix bupleuri【Alias】Ground is smoked, Asia puecon Hu, mountain dish, eats grass, faggot.【Source】This product is umbelliferae bupleurum or narrow leaf bavin The dry root of Hu.It is different by character, practise claim " Bupleurum Chinese " and " RADIX BUPLEURI SCORZONERAEFOLII " respectively.Spring, the excavation of season in autumn two, remove cauline leaf and mud Sand, dry.【Nature and flavor】Hardship, it is slightly cold.【Channel tropism】Return liver, gallbladder channel.【Major function】It is soothing the liver in inducing diaphoresis, rising Yang.For catching a cold Heating, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, prolapse of the anus.【Usage and dosage】It is for oral administration:Decoct soup, 3~9g.【Note Meaning】The dry rhizome of bigleaf thorowax root, the dense link in surface is poisonous, can not work as radix bupleuri and use.【Take passages】《Chinese book on Chinese herbal medicine》.
The dried immature fruit of citron orange【Source】This product is rutaceae bitter orange and its drying young fruit of variety or sweet orange.5~June collects From the fruit fallen, impurity is removed, crosscutting from middle part is two halves, is dried or low temperature drying, and smaller directly dries or low temperature drying. 【Nature and flavor】It is bitter, pungent, sour, temperature.【Channel tropism】Returns spleen, stomach.【Major function】Relieving stagnant Qi disperse accumulations, resolving sputum dissipate ruffian.For internal stagnation, ruffian Full distending pain, weight after rush down dysentery, constipation, the phlegm stagnant gas resistance obstruction of qi in the chest, accumulation of pathogens in chest;Gastroptosis, prolapse of the anus, the prolapse of uterus.【Usage and dosage】It is interior Clothes:Decoct soup, 3~9g.【Pay attention to】Pregnant woman uses with caution.【Take passages】《Chinese book on Chinese herbal medicine》.
The content of the invention
The present invention is intended to provide a kind of Chinese medicine for being used to treat acute cholecystitis, by selecting suitable medicinal material and its matching somebody with somebody Than reaching the purpose for safely and effectively curing acute cholecystitis.
In order to achieve the above object, the present invention uses following technical scheme:
A kind of Chinese medicine for being used to treat acute cholecystitis, it is characterised in that it is the raw medicinal material preparation by following weight proportion Form:5 parts of rheum officinale, 30 parts of desmodium, 15 parts of oriental wormwood, 9 parts of cape jasmine, 9 parts of corydalis tuber, 9 parts of radix scutellariae, 6 parts of the banksia rose, 6 parts of radix bupleuri, trifoliate orange It is real 9 parts.
The beneficial effects of the present invention will now be described with reference to clinical experimental data:
1st, general information
Outpatient service and in hospital acute cholecystitis patient 60 are collected in inventor in October, 2012 ~ 2013 year altogether between October, are randomly divided into Treatment group 40 and control group 20, treatment group man 20, female 20, the course of disease 5 ~ 9 days, average age 42.15 years old;Control group man 12, female 8, the course of disease 3 ~ 8 days, average age 38.25 years old.2 groups of sexes, age and course of disease comparing difference are not statistically significant, With comparativity.
Diagnostic criteria
Diagnostic criteria according to national acute cholecystitis clinical speciality meeting:(1), fall ill hurried, right Upper abdominal pain, nausea, vomit Tell, can there is high fever or shiver with cold.(2), face of acute ill, it is seen that jaundice, the obvious tenderness of upper right abdomen, tension of abdominal muscle, Murphy sign sun Property, or the gall-bladder of accessible enlargement.(3), blood leukocytes number and neutrophil leucocyte ratio increase, shift to left or see toxic granulation. (4), B it is super be diagnosis Main Basiss, can show that gollbladder dilation degree, hydrops, empyema, peribiliary ooze out and sexually revise.
2nd, test method
2.1 treatment method
The oral present invention for the treatment of group is according to capsule made from specific embodiment 3,3 times a day.The course for the treatment of 10 days.
The oral JINDAN PIAN of control group, 4 tablets once, 3 times a day orally, the course for the treatment of 10 days.
3rd, criterion of therapeutical effect and treatment results
3.1 criterion of therapeutical effect
Integration × 100 before therapeutic index (n) one (integration one integrates after treating before treating)/treatment
Clinical cure:Symptom, sign therapeutic index are more than 90%, and blood picture is normal, and B ultrasound image is normal or the person of being obviously improved.
It is effective:Symptom, sign therapeutic index are more than 75%, and blood picture is normal, and B ultrasound gall-bladder image is obviously improved or improved Person.
Effectively:Symptom, sign therapeutic index are taken more than 50%, blood picture is normal, and B ultrasound image has improvement.
It is invalid:Symptom, sign therapeutic index are less than 50%, and blood picture, B ultrasound gall-bladder image are without improver.
3.2 treatment results are shown in Table 1.
1 two groups of curative effects of table compare
Group n Clinic control It is effective Effectively It is invalid Total effective rate (%) Serious adverse reaction example
Treatment group 40 10 21 7 2 95% 0
Control group 20 2 9 7 2 90% 0
It can be seen that medicine produced by the present invention can safely and effectively treat acute cholecystitis, there is promotional value.
Embodiment
In order to more fully understand and implement the present invention, the present invention is further illustrated with reference to specific embodiment.
Embodiment 1
Weigh:5 grams of rheum officinale, 30 grams of desmodium, 15 grams of oriental wormwood, 9 grams of cape jasmine, 9 grams of corydalis tuber, 9 grams of radix scutellariae, 6 grams of the banksia rose, radix bupleuri 6 Gram, 9 grams of the dried immature fruit of citron orange;Add 8 times of amount water, decoct 1.5 hours, filtering;Filter residue adds 6 times of amount water, decocts 1 hour, filtering;Merging filtrate, 120 grams are concentrated into, produces the decoction for meeting one day dosage of normal adult.
For treating acute cholecystitis.Orally, taken three times per bu Morning Afternoon Evening.
Embodiment 2
Weigh:5 grams of rheum officinale, 30 grams of desmodium, 15 grams of oriental wormwood, 9 grams of cape jasmine, 9 grams of corydalis tuber, 9 grams of radix scutellariae, 6 grams of the banksia rose, radix bupleuri 6 Gram, 9 grams of the dried immature fruit of citron orange;Add 10 times of amount water, decoct 2 hours, filtering;Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering;Merging filtrate, Concentration, dry, packaging, produce the powder for meeting one day dosage of normal adult.
For treating acute cholecystitis.Orally, taken three times per bu Morning Afternoon Evening.
Embodiment 3
Weigh:5 grams of rheum officinale, 30 grams of desmodium, 15 grams of oriental wormwood, 9 grams of cape jasmine, 9 grams of corydalis tuber, 9 grams of radix scutellariae, 6 grams of the banksia rose, radix bupleuri 6 Gram, 9 grams of the dried immature fruit of citron orange;Add 6 times of amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, dry, load capsule shells, i.e., The capsule of one day dosage of normal adult must be met.
For treating acute cholecystitis.Orally, taken three times per bu Morning Afternoon Evening.

Claims (4)

1. a kind of Chinese medicine for being used to treat acute cholecystitis, it is characterised in that it is by the raw medicinal material system of following weight proportion It is standby to form:5 parts of rheum officinale, 30 parts of desmodium, 15 parts of oriental wormwood, 9 parts of cape jasmine, 9 parts of corydalis tuber, 9 parts of radix scutellariae, 6 parts of the banksia rose, 6 parts of radix bupleuri, 9 parts of the dried immature fruit of citron orange.
2. it is used for the Chinese medicine of acute cholecystitis as claimed in claim 1, it is characterised in that its preparation method is:Weigh:Rheum officinale 5 parts, 30 parts of desmodium, 15 parts of oriental wormwood, 9 parts of cape jasmine, 9 parts of corydalis tuber, 9 parts of radix scutellariae, 6 parts of the banksia rose, 6 parts of radix bupleuri, 9 parts of the dried immature fruit of citron orange;Add 8 Amount water again, decoct 1.5 hours, filtering;Filter residue adds 6 times of amount water, decocts 1 hour, filtering;Merging filtrate, 120 parts are concentrated into, i.e., Obtain decoction;Above-mentioned part each means parts by weight.
3. the as claimed in claim 1 Chinese medicine for being used to treat acute cholecystitis, it is characterised in that its preparation method is:Weigh: 5 parts of rheum officinale, 30 parts of desmodium, 15 parts of oriental wormwood, 9 parts of cape jasmine, 9 parts of corydalis tuber, 9 parts of radix scutellariae, 6 parts of the banksia rose, 6 parts of radix bupleuri, the dried immature fruit of citron orange 9 Part;Add 10 times of amount water, decoct 2 hours, filtering;Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering;Merging filtrate, concentrate, do It is dry, packaging, produce powder;Above-mentioned part each means parts by weight.
4. the as claimed in claim 1 Chinese medicine for being used to treat acute cholecystitis, it is characterised in that its preparation method is:Weigh: 5 parts of car rheum officinale, 30 parts of desmodium, 15 parts of oriental wormwood, 9 parts of cape jasmine, 9 parts of corydalis tuber, 9 parts of radix scutellariae, 6 parts of the banksia rose, 6 parts of radix bupleuri, the dried immature fruit of citron orange 9 Part;Add 6 times of amount water, decoct 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, dry, load capsule shells, produce capsule Agent;Above-mentioned part each means parts by weight.
CN201610821340.XA 2016-09-14 2016-09-14 A kind of Chinese medicine for being used to treat acute cholecystitis Pending CN107812051A (en)

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