CN108295200A - A kind of drug and preparation method thereof for treating appendicitis - Google Patents

Abstract

The invention discloses a kind of drugs and preparation method thereof for treating appendicitis, its be disappeared by rheum officinale, dandelion, waxgourd seed, peach kernel, moutan bark, spina gleditsiae, awns, radix paeoniae rubra, Patrinia scaniosaefolia, honeysuckle, root of Aucklandia lappa Decne, corydalis tuber, Radix Angelicae Sinensis, the tuber of pinellia, frankincense, myrrh, rhizoma anemarrhenae, caulis bambusae in taenian, gypsum are prepared according to a certain weight ratio, drug of the present invention, which has, to reinforce vital energy, prevent prolapse and engender liquid, blood-breaking, Xiao Ji Zhi Tong, it is clearing heat and detoxicating, sharp water dissipate-swelling, the function of dispersing swelling and dissipating binds, appendicitis is quick, good effect for treating, and does not recur.

Description

A kind of drug and preparation method thereof for treating appendicitis

Technical field

The present invention relates to a kind of drugs and preparation method thereof for treating appendicitis, belong to the field of Chinese medicines.

Background technology

Appendicitis refers to that the inflammatory that appendix is formed due to many factors changes, Abdominal Surgery.It is a kind of common Disease, prognosis depend on whether timely diagnosing and treating.Early stage diagnosis and treatment, patient mostly can rehabilitation in a short time, the death rate 0.1% One 0.2%；If delay diagnosis and treatment can cause serious complication, or even cause death.Clinically often there is right lower abdomen pain Bitterly, the performances such as body temperature raising, vomiting and neutrophilic leukocytosis.Since western medicine side effect is big, people are to effectively controlling There are great demands for the Chinese medicine for the treatment of appendicitis, up to now, it has not been found that the related report about the present invention.

Invention content

Repeatedly verification of the present inventor according to research and the clinical test of theory of traditional Chinese medical science has finally found effectively treatment appendix Scorching drug, so as to complete the present invention.

It is an object of the invention to provide a kind of Chinese medicine compositions of effective treatment appendicitis.

Another aim of the present invention is to provide the preparation methods of the Chinese medicine composition.

Drug of the present invention be selection rheum officinale, dandelion, waxgourd seed, peach kernel, moutan bark, spina gleditsiae, awns disappear, radix paeoniae rubra, Patrinia scaniosaefolia, Honeysuckle, root of Aucklandia lappa Decne, corydalis tuber, Radix Angelicae Sinensis, the tuber of pinellia, frankincense, myrrh, rhizoma anemarrhenae, caulis bambusae in taenian, gypsum, dried orange peel, Fructus Forsythiae, Fructus Aurantii, Fructus meliae toosendan into Prepared by row combination, make each efficacy of drugs generate synergistic effect these pharmaceutical compositions, so as to effectively treat appendicitis. It is to enter stomach, large intestine, liver diameter because its is bitter in taste, cold, there is the poison that purges heat wherein to select rheum officinale, breaks and stagnates, the function of row hemostasis is controlled Real heat constipation, delirious speech are gone mad, dyspepsia feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menopause Bi , lumps in the chest and abdomen, when the hot epidemic disease of row, sudden and violent eye Red pain is spitted blood, bleeding from five sense organs or subcutaneous tissue, yang jaundice, oedema, and stranguria with turbid discharge is urinated red, large carbuncle pyogenic infections, furunculosis, burn.It is because of its property to select dandelion Bitter but sweet flavor trembles with fear, enters liver, stomach, has clearing heat and detoxicating, and the function of diuresis dissipating bind controls acute mastitis, adenolymphitis, scrofula, serious case of furuncle Sore swells, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infections. Select waxgourd seed be because its nature and flavor it is sweet, it is cool, enter meridian of Foot-JUE YIN, there is moistening lung, resolving sputum, disappear carbuncle, and the function of Li Shui controls phlegm heat-syndrome cough It coughs, lung carbuncle, acute appendicitis, gonorrhoea, oedema, tinea pedis, hemorrhoid, nasal surface wine Zha.Select peach kernel be because of its sweet and neutral bitter in taste, enter the heart, Liver, large intestine channel have the blood-breaking row stasis of blood, moisturize the function of sliding warp, controlling through closing , Disorder lumps in the abdomen, and pyreticosis stores blood, blood-arthralgia, malaria, traumatic injury, Blood stasis and swelling pain, the dry constipation of blood.It selects moutan bark and is because its nature and flavor is arduous, it is cool, enter the heart, liver and kidney channel, there is a heat-clearing, cool blood, and Blood, the function of dispersing blood stasis control heat invading xuefen, and macular eruption , Jing Epilepsy is spat, is defeated in battle, has blood in stool, and hectic fever due to yin labor heat, Amenorrhea , Disorder lumps in the abdomen, large carbuncle flutters damage.Choosing It is to search wind because its nature and flavor is acrid in flavour and warm in nature with spina gleditsiae, detoxification, detumescence, the function of apocenosis controls carbuncle swells, sore, pestilential wind, tinea sore, Retention of afterbirth.It is to tremble with fear because of its property acrid,bitter and salty taste, enter stomach, large intestine channel, have and purge heat, moisturize, the function of softening hard masses is controlled to select awns to disappear Real heat is stagnant, abdominal distention constipation, stops phlegm accumulation, and hot eyes is hidden from view, erysipelas, carbuncle swells.Selecting radix paeoniae rubra is slightly cold, returns because its is bitter in taste Liver Channel has clearing heat and cooling blood, the function of removing blood stasis and analgesics to control epidemic heat syndrome and go mad, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, Amenorrhea pain Jing , Epilepsy lump in the abdomen abdominal pain, injury from falling down, carbuncle swells sore.It is to put down because its is bitter in taste, enter liver, stomach, large intestine channel, there is heat-clearing to select Patrinia scaniosaefolia Removing toxic substances, the function of apocenosis broken stasis of blood control acute appendicitis, diarrhea, leukorrhea with reddish discharge, postpartum stasis of blood, red eye, swell pain, carbuncle swells mange.It selects Honeysuckle is to tremble with fear because its nature and flavor is sweet, enter lung, stomach, there is a heat-clearing, the function of removing toxic substances, controls warm disease heating, toxic-heat and blood stasis, large carbuncle, Pyogenic infections, scrofula, anal fistula.It is because its nature and flavor is arduous to select root of Aucklandia lappa Decne, and temperature enters lung, liver, the spleen channel, there is promoting qi circulation and relieving pain, warming middle-JIAO for easing the stomach Function controls the syncope due to pathogenic cold stagnation of the circulation of vital energy, and chest and abdomen swelling and pain, vomiting, diarrhea, diarrhea is tenesmus, cold hernia.It is because its nature and flavor is pungent to select corydalis tuber Hardship, temperature, enters liver, stomach, there is promoting blood circulation, dissipates the stasis of blood, qi-regulating, and the function of analgesic controls all pains of trusted subordinate's waist and knee, and irregular menstruation , Disorder lumps in the abdomen collapse In, postpartum anemic fainting, lochiorrhagia, traumatic injury.It is to enter the heart, liver, the spleen channel because of its nature and flavor sweet, acrid, warm, enrich blood to select Radix Angelicae Sinensis And blood, menstruction regulating and pain relieving, the function of moisturize laxation, irregular menstruation is controlled, Amenorrhea abdominal pain , Disorder lump in the abdomen knots are poly-, uterine bleeding, headache due to deficiency of blood, dizziness, Impotence numbness, intestinal dryness difficulty is just, heavy after dysentery characterized by blood in the stool, ulcer sores, metal-inflicted wound, injury from falling down.Select the tuber of pinellia be because its nature and flavor it is acrid in flavour and warm in nature, it is toxic, Enter spleen, stomach, there is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass to control wet phlegm and cold drink, vomits, gastric disorder causing nausea, cough and phlegm, chest Diaphragm turgor, phlegm and headache, dizziness and sleepless, outer subduing inflammation.It is because its nature and flavor is arduous to select frankincense, and temperature enters the heart, liver, the spleen channel, has Regulating qi and activating blood, analgesic therapy, the function of chasing after poison control qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhoea, postpartum blood stasis Shouting pain.It is to put down because its is bitter in taste, enter Liver Channel, have scattered blood stasis eliminatings, the function of detumescence ding-tong to control and fall damage to select myrrh, metal-inflicted wound, Muscles and bones, all Tong , Disorder lumps in the abdomen of trusted subordinate, Amenorrhea, ulcer sore pain, anal fistula, mesh barrier.Selecting rhizoma anemarrhenae is trembled with fear because its is bitter in taste, enter lung, stomach, Kidney channel has nourishing yin and lessening fire, the function of moisturize laxation to control dysphoria with smothery sensation and quench one's thirst, and hectic fever due to yin labor heat, cough with lung heat, dry feces, urine is not Profit.It selects caulis bambusae in taenian and is because its nature and flavor is sweet, it is cool, enter stomach, gallbladder channel, there is a heat-clearing, cool blood, resolving sputum, the function of antiemetic controls dysphoria with smothery sensation and vomit It spits, hiccup, the asthma of phlegm heat-syndrome cough is spitted blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, vomiting during early pregnancy, movement of the foetus , Jing Epilepsy.Selecting gypsum is trembled with fear, enters because of its property acrid-sweet flavor Lung, stomach, raw with having expelling pathogenic factors from muscles for clearing heat, the function that relieving restlessness is quenched the thirst to control pyreticosis high fever and do not move back, vexed coma, delirious speech is gone mad, thirsty pharynx Dry, lung heat asthma is anxious, heatstroke spontaneous perspiration, stomach fire headache, toothache, and heat toxin, which is stopped up, contains, and spot dermexanthesis, aphthae forges deposited myogenic sore, outside Ulcer sores are controlled, bursts and does not withdraw, the burning hot wound of soup.It is to have qi-regulating strong because of its bitter in taste, acrid in flavour and warm in nature, return lung, the spleen channel to select dried orange peel Spleen, eliminating dampness and eliminating phlegm function control chest gastral cavity turgor, and deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.Select Fructus Forsythiae be because its is bitter in taste, it is cool, enter The heart, liver, gallbladder channel have heat-clearing, removing toxic substances, dissipating bind, and warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes are controlled in detumescence.It selects Fructus Aurantii be because of its nature and flavor toil, it is cool, enter lung, spleen, large intestine channel, there is a relieving stagnant Qi, row phlegm, the function of disperse accumulation, it is stagnant to control chest diaphragm phlegm, chest Ruffian coerces swollen, dyspepsia, and gas is vomitted inverse, weight, rectal prolapse, the prolapse of uterus after diarrhea.Selecting Fructus meliae toosendan is trembled with fear, has because its is bitter in taste Poison enters liver, stomach, small intestinl channel, has wet down heat, clearing away the liver-fire to relieve pain, the function of desinsection controls pyretic epigastralgia, hypochondriac pain, colic, malnutrition due to parasitic infestation abdomen Bitterly.

Specific implementation mode

The drug dose of instant component is also to be obtained by plenty of explorations of the inventor, and the dosage of each component is following heavy All tools have a better effect in amount range：

5-15 grams of rheum officinale, 5-15 grams of dandelion, 5-15 grams of waxgourd seed, 5-15 grams of peach kernel, 5-15 grams of moutan bark, spina gleditsiae 5-15 Gram, awns disappear 5-15 grams, 10-14 grams of radix paeoniae rubra, 15-25 grams of Patrinia scaniosaefolia, 15-25 grams of honeysuckle, 5-15 grams of root of Aucklandia lappa Decne, 5-15 grams of corydalis tuber, 15-25 grams of Radix Angelicae Sinensis, 10-14 grams of the tuber of pinellia, 5-15 grams of frankincense, 5-15 grams of myrrh, 10-14 grams of rhizoma anemarrhenae, 10-14 grams of caulis bambusae in taenian, gypsum 5- 15 grams, 5-15 grams of dried orange peel, 5-15 grams of Fructus Forsythiae, 5-15 grams of Fructus Aurantii, 10-20 grams of Fructus meliae toosendan.

Preferably：

10 grams of rheum officinale, 10 grams of dandelion, 10 grams of waxgourd seed, 10 grams of peach kernel, 10 grams of moutan bark, 10 grams of spina gleditsiae, awns disappear 10 grams, red 12 grams of Chinese herbaceous peony, 20 grams of Patrinia scaniosaefolia, 20 grams of honeysuckle, 10 grams of root of Aucklandia lappa Decne, 10 grams of corydalis tuber, 20 grams of Radix Angelicae Sinensis, 12 grams of the tuber of pinellia, 10 grams of frankincense do not have 10 grams of medicine, 12 grams of rhizoma anemarrhenae, 12 grams of caulis bambusae in taenian, 10 grams of gypsum, 10 grams of dried orange peel, 10 grams of Fructus Forsythiae, 10 grams of Fructus Aurantii, 15 grams of Fructus meliae toosendan.

The preparation method of drug of the present invention is as follows

One, it stocks up

1, rheum officinale：The raw rhubarb being cut into small pieces, active compound is taken to pick net impurity, size stepping is stewed to moisten to uniform humidity inside and outside, slice, It dries；

2, dandelion：Impurity is picked, soil is cleaned, segment is dried；

3, waxgourd seed：Net impurity is picked, the used time smashs to pieces, or with yellow-white is fried with slow fire, and sets dry place；

4, peach kernel：Hard shell impurity is removed, sets in boiling water pot and boils to crust microcreping, pull out, is immersed in cold water, kind of a skin is removed in stranding, dries, It winnows with a dustpan net；

5, moutan bark：Impurity is picked, core is removed, cleans, moisturizes, is sliced, dries；

6, spina gleditsiae：Impurity is picked, is soaked in water, is sliced, dries after moisturizing；

7, awns disappears：It takes the awns naturally produced to disappear, after boiling-off, filtering, cooling, the crystallization on upper layer is taken to disappear for awns；

8, radix paeoniae rubra：Crude drug is taken, impurity is removed, size stepping is cleaned, moisturized, shave, dry, weeds out clast；

9, Patrinia scaniosaefolia：Crude drug is taken, impurity is removed and is slightly dried in the air with water spray, segment is dry；

10, honeysuckle：Silt is weeded out, net impurity is picked；

11, root of Aucklandia lappa Decne：Crude drug in whole is put in clear water and is cleaned, is pulled out, bored profit makes soft for 12-24 hours, and slice dries；

12, corydalis tuber：Impurity is picked, is soaked in water, is cleaned, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is sliced or broken；

13, Radix Angelicae Sinensis：Impurity is picked, is cleaned, bored profit is slightly dried in the air, and slice dries；

14, the tuber of pinellia：Impurity is picked, grey bits are weeded out；

15, frankincense：Pick sand impurity；

16, myrrh：Impurity is picked, fragment is broken into；

17, rhizoma anemarrhenae：Net impurity is picked, is hit and is washed with water, is pulled out, is softened, slice dries；

18, caulis bambusae in taenian：Hard bamboo stick, impurity are removed, grey bits are shaked off, is kneaded into small group or segment；

19, gypsum：Miscellaneous stone is removed, soil is cleaned, is broken into fritter；

20, dried orange peel：Crude drug is taken, impurity and the pericarp of blackening are removed, wash quickly is net, softens, chopping, dry or low temperature dry, Weed out grey bits；

21, Fructus Forsythiae：Net impurity is picked, is rubbed open, discarding stalk is removed；

22, Fructus Aurantii：Flesh, core are removed, edulcoration is slightly soaked, pulled out, softens, and it is degree that can pinch doubling with hand, and slice dries；

23, Fructus meliae toosendan：Impurity is picked, is cleaned, drying or is split into two halves at grating.

Two, it prepares

1, the rheum officinale of the weight, dandelion, waxgourd seed, peach kernel, moutan bark, spina gleditsiae, awns are disappeared, radix paeoniae rubra, Patrinia scaniosaefolia, gold and silver Flower, root of Aucklandia lappa Decne, corydalis tuber, Radix Angelicae Sinensis, the tuber of pinellia, frankincense, myrrh, rhizoma anemarrhenae, caulis bambusae in taenian, gypsum, dried orange peel, Fructus Forsythiae, Fructus Aurantii, Fructus meliae toosendan are put into pan-fried In medicine container, add 7 times of amounts of water, after impregnating 120 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, filter for the first time Decoction liquor pours into first time decoction liquor in container；

2, the dregs of a decoction of filtering are added into 5 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；

3, it decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.

There is clearing heat and detoxicating dandelion, the function of diuresis dissipating bind is monarch drug in a prescription in prescription；Patrinia scaniosaefolia have it is clearing heat and detoxicating, apocenosis broken stasis of blood Function；Corydalis tuber has promoting blood circulation, dissipates the stasis of blood, qi-regulating, the function of analgesic, the two is ministerial drug, and three taste medicines play clearing heat and detoxicating, diuresis jointly Dissipating bind, apocenosis broken stasis of blood, promoting blood circulation to remove blood stasis, the effect of regulating qi-flowing for relieving pain, treatment appendicitis effect is comprehensive, and with clearing heat and detoxicating, and apocenosis is broken The stasis of blood, promoting blood circulation to remove blood stasis can effect a permanent cure based on regulating qi-flowing for relieving pain, and myrrh has scattered blood stasis eliminatings, and the function of detumescence ding-tong is adjutant, and rhizoma anemarrhenae has enriching yin Fall fire, the function of moisturize laxation are to make medicine, and all medicines are to take stopgap measures with being left.

Drug of the present invention have clearing heat and detoxicating, diuresis dissipating bind, apocenosis broken stasis of blood, promoting blood circulation to remove blood stasis, regulating qi-flowing for relieving pain, nourishing yin and lessening fire Function, for treating appendicitis, short treating period, quick, non-relapse after healing.

Carry out the advantageous effect of the present invention is further explained the drug below by way of test example, these test examples include this hair The animal toxicity test report of bright drug and clinical observation on the therapeutic effect data.

The animal toxicity test of [test example 1] drug of the present invention is reported：

Rabbit 30, male and female dual-purpose, 2.0-2.5kg of weight is taken to be divided to two groups, every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode gives for administration by gavage Medicine even served 7 days twice daily, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and drug is without bad Toxic side effect.

The clinical observation on the therapeutic effect of [test example 2] drug of the present invention

1, general information

Accept appendicitis out-patient totally 48 for medical treatment.

2, diagnostic criteria

Appendicitis clinically often has right lower abdomen pain, body temperature to increase, vomit and the performances such as neutrophilic leukocytosis.

3, therapy

Above-mentioned medicament is selected, is taken to patient, each taking 1 dose, early daily, evening respectively takes 1 time, and 7 days as a course for the treatment of, continuous to take With 5 courses for the treatment of.

4, efficacy assessment standard

It is effective：Appendicitis symptom disappears, recovery from illness；

It improves：The symptoms were significantly improved for appendicitis, and pain relief, constitution is gradually restored；

In vain：Improvement standard person is not achieved.

5, treatment results（It see the table below）

In above-mentioned treatment, with drug therapy Appendicitis Patients 48 of the present invention, as a result effective 42, obvious effective rate 87.5% is good Turn 4, improvement rate 8.3%, invalid 2, total effective rate 95.8%.

Claims (3)

1. a kind of drug for treating appendicitis, it is characterised in that：It is made of the bulk pharmaceutical chemicals in following weight range：

5-15 grams of rheum officinale, 5-15 grams of dandelion, 5-15 grams of waxgourd seed, 5-15 grams of peach kernel, 5-15 grams of moutan bark, spina gleditsiae 5-15 Gram, awns disappear 5-15 grams, 10-14 grams of radix paeoniae rubra, 15-25 grams of Patrinia scaniosaefolia, 15-25 grams of honeysuckle, 5-15 grams of root of Aucklandia lappa Decne, 5-15 grams of corydalis tuber, 15-25 grams of Radix Angelicae Sinensis, 10-14 grams of the tuber of pinellia, 5-15 grams of frankincense, 5-15 grams of myrrh, 10-14 grams of rhizoma anemarrhenae, 10-14 grams of caulis bambusae in taenian, gypsum 5- 15 grams, 5-15 grams of dried orange peel, 5-15 grams of Fructus Forsythiae, 5-15 grams of Fructus Aurantii, 10-20 grams of Fructus meliae toosendan.

2. drug according to claim 1, wherein the dosage of each bulk pharmaceutical chemicals is：

10 grams of rheum officinale, 10 grams of dandelion, 10 grams of waxgourd seed, 10 grams of peach kernel, 10 grams of moutan bark, 10 grams of spina gleditsiae, awns disappear 10 grams, red 12 grams of Chinese herbaceous peony, 20 grams of Patrinia scaniosaefolia, 20 grams of honeysuckle, 10 grams of root of Aucklandia lappa Decne, 10 grams of corydalis tuber, 20 grams of Radix Angelicae Sinensis, 12 grams of the tuber of pinellia, 10 grams of frankincense do not have 10 grams of medicine, 12 grams of rhizoma anemarrhenae, 12 grams of caulis bambusae in taenian, 10 grams of gypsum, 10 grams of dried orange peel, 10 grams of Fructus Forsythiae, 10 grams of Fructus Aurantii, 15 grams of Fructus meliae toosendan.

3. the preparation method of drug according to claim 1 or claim 2, it includes the following steps：

（One）Stock

（1）Rheum officinale：The raw rhubarb being cut into small pieces, active compound is taken to pick net impurity, size stepping is stewed to moisten to uniform humidity inside and outside, slice, It dries；

（2）Dandelion：Impurity is picked, soil is cleaned, segment is dried；

（3）Waxgourd seed：Net impurity is picked, the used time smashs to pieces, or with yellow-white is fried with slow fire, and sets dry place；

（4）Peach kernel：Hard shell impurity is removed, sets in boiling water pot and boils to crust microcreping, pull out, is immersed in cold water, kind of a skin is removed in stranding, shines It is dry, it winnows with a dustpan net；

（5）Moutan bark：Impurity is picked, core is removed, cleans, moisturizes, is sliced, dries；

（6）Spina gleditsiae：Impurity is picked, is soaked in water, is sliced, dries after moisturizing；

（7）Awns disappears：It takes the awns naturally produced to disappear, after boiling-off, filtering, cooling, the crystallization on upper layer is taken to disappear for awns；

（8）Radix paeoniae rubra：Crude drug is taken, impurity is removed, size stepping is cleaned, moisturized, shave, dry, weeds out clast；

（9）Patrinia scaniosaefolia：Crude drug is taken, impurity is removed and is slightly dried in the air with water spray, segment is dry；

（10）Honeysuckle：Silt is weeded out, net impurity is picked；

（11）Root of Aucklandia lappa Decne：Crude drug in whole is put in clear water and is cleaned, is pulled out, bored profit makes soft for 12-24 hours, and slice dries；

（12）Corydalis tuber：Impurity is picked, is soaked in water, is cleaned, solarization is dried in the air, and is moistened to uniform humidity inside and outside, is sliced or broken；

（13）Radix Angelicae Sinensis：Impurity is picked, is cleaned, bored profit is slightly dried in the air, and slice dries；

（14）The tuber of pinellia：Impurity is picked, grey bits are weeded out；

（15）Frankincense：Pick sand impurity；

（16）Myrrh：Impurity is picked, fragment is broken into；

（17）Rhizoma anemarrhenae：Net impurity is picked, is hit and is washed with water, is pulled out, is softened, slice dries；

（18）Caulis bambusae in taenian：Hard bamboo stick, impurity are removed, grey bits are shaked off, is kneaded into small group or segment；

（19）Gypsum：Miscellaneous stone is removed, soil is cleaned, is broken into fritter；

（20）Dried orange peel：Crude drug is taken, impurity and the pericarp of blackening are removed, wash quickly is net, softens, chopping, dry or low temperature dry, Weed out grey bits；

（21）Fructus Forsythiae：Net impurity is picked, is rubbed open, discarding stalk is removed；

（22）Fructus Aurantii：Flesh, core are removed, edulcoration is slightly soaked, pulled out, softens, and it is degree that can pinch doubling with hand, and slice dries；

（23）Fructus meliae toosendan：Impurity is picked, is cleaned, drying or is split into two halves at grating；

（Two）It prepares

（1）The rheum officinale of the weight, dandelion, waxgourd seed, peach kernel, moutan bark, spina gleditsiae, awns are disappeared, radix paeoniae rubra, Patrinia scaniosaefolia, gold and silver Flower, root of Aucklandia lappa Decne, corydalis tuber, Radix Angelicae Sinensis, the tuber of pinellia, frankincense, myrrh, rhizoma anemarrhenae, caulis bambusae in taenian, gypsum, dried orange peel, Fructus Forsythiae, Fructus Aurantii, Fructus meliae toosendan are put into pan-fried In medicine container, add 7 times of amounts of water, after impregnating 120 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, filter for the first time Decoction liquor pours into first time decoction liquor in container；

（2）The dregs of a decoction of filtering are added into 5 times of amounts of water, are boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；

（3）It decoction liquor will be mixed evenly twice, and be divided into 3 doses and take.