CN108785595A - A kind of Chinese medicine for treating alcoholic liver disease - Google Patents

Abstract

The present invention relates to a kind of Chinese medicines for treating alcoholic liver disease, it is prepared by the raw medicinal material of following weight proportion：10 parts of eve of the lunar New Year Huang, 30 parts of fund grass, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, 12 parts of common wrightia root or stem, 12 parts of Radix Curcumae.Clinical experiments have proved that the present invention can safely and effectively treat alcoholic liver disease.

Description

A kind of Chinese medicine for treating alcoholic liver disease

Technical field

The present invention relates to a kind of Chinese medicines, and in particular to a kind of Chinese medicine for treating alcoholic liver disease.

Background technology

Alcoholic liver disease is by ethyl alcohol and its metabolism product to caused by the breaking-up of liver cell and poisonous effect, with liver Metabolic disorder is that basic acute and chronic liver number is injured.3 types of alcoholic liver disease clinic point：Fatty liver, hepatitis, hepatic sclerosis.This three Often it is mixed.Alcoholic liver disease is in addition to general hepatic sclerosis, and also malnutrition, anaemia, spider angioma, liver palms, neuritis, flesh wither Contracting, parotid gland enlargement, gynecomasty, orchiatrophy etc..The interpretation of the cause, onset and process of an illness of alcoholic liver disease develops complicated, clinical symptoms change multiterminal, card Type overlapping interlocks, thus when dialectical, the course of disease of patient and degree of being addicted to drink, cautiously grasping pathogenesis must be combined to size up the current situation, shrewd void It is real, according to the different phase and syndrome characteristics of disease development, formulate the method for righting, eliminating evil.Righting is beneficial to irritability, nourishing hepatic yin, benefit The difference of spleen, kidney-nourishing, eliminating evil have relieving alcoholism, clearing damp heat, resolving sputum is turbid, qi-regulating, dissolving stasis it is different.In general, disease initial stage is preferably clear Dampness elimination heat, normalizing gallbladder to cure jaundice；The suitable promoting flow of qi and blood circulation of mid-term, the addiction that disappears resolving sputum；Later stage suitable strengthening vital QI to eliminate pathogenic factors, tonification and purgation in combination, accomplishes that qi-restoratives is not forgotten It is real, it lets out and does not forget void in fact.This right disease is damp and hot two property by wine, accumulates long-pending detoxification, and caused by thief kills internal organs, therefore it treats big method, when On the basis of diagnosis and treatment, coordinate the cytotoxic drug that relieves the effect of alcohol, it is damp and hot to distinguish.Dissolve wine poison when first weight taste, it made to be sent out thoroughly from flesh stock, Or it from urine point profit, excretes.

Medicinal material present Research involved in the present invention is as follows：

The eve of the lunar New Year is yellow【Alias】General, Huang Liang, fire ginseng, skin as, another name for Sichuan Province rheum officinale, Radixet Rhizoma Rhei, cow tongue rheum officinale, bright and beautiful line, raw army, Sichuan troops. 【Source】This product is the drying root and rhizome of polygonum rheum palmatum, Rheum tanguticum Maxim or Rheum officinale.Autumn end cauline leaf is withered Wither or secondary spring germination before excavation, remove radicula, scrape off crust, valve cutting or section, rope wears that bunchiness is dry or convection drying.【Nature and flavor】 It is bitter, cold.【Channel tropism】Returns spleen, stomach, large intestine, liver, pericardium channel.【Major function】Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For Real heat constipation, stagnate abdominal pain, and rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, hemostasis Amenorrhea, traumatic injury control scald outside；Upper gastrointestinal bleeding.Rheum palmatum (processed with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For hot eyes pharynx swelling, Gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, to be exerted oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding.There is the stasis of blood for blood-head Haemorrhage.【Usage and dosage】It is for oral administration：Decoction, 3~30g.【Pay attention to】Pregnant woman uses with caution.【It takes passages】《Chinese book on Chinese herbal medicine》.

Fund grass【Alias】Christina loosestrife herb, to seat grass, roadside yellow, everywhere Huang, copper coin grass, a string of money, very little bone seven.【Source】 This product is the drying herb of Ofthe Primulaceae Lysimachia christinae.Summer, the harvesting of two season of autumn, remove impurity, dry.【Nature and flavor】It is sweet, salty, it is micro- It is cold.【Channel tropism】Return liver, courage, kidney, bladder warp.【Major function】Eliminating dampness and heat, treating stranguria, detumescence.For heat gonorrhea, Sha Lin urinates puckery work Bitterly, jaundice, carbuncle swells furunculosis, venomous snake bite；Liver and bile stone, lithangiuria.【Usage and dosage】It is for oral administration：Decoction, 15~60g. 【Pay attention to】The all poison of all the moon subcutaneous ulcers, splenasthenic diarrhea person avoid and smash juice life clothes.【It takes passages】《Chinese book on Chinese herbal medicine》.

Rhizoma corydalis【Alias】Profound Hu Su, corydalis tuber prolong recklessly.【Source】This product is the dry tuber of papaveraceae plant corydalis. Early summer cauline leaf is excavated when withered, removes fibrous root, is cleaned, and is set when boiled in boiling water to proper without the white heart, is taken out, dry.【Nature and flavor】Pungent, Hardship, temperature.【Channel tropism】Return liver, the spleen channel.【Major function】Promoting blood circulation, sharp gas, analgesic.For chest side of body, epigastric pain, closed dysmenorrhea, production Stasis blocking afterwards, tumbling and swelling.【Usage and dosage】It is for oral administration：Decoction, 3-9g.【Pay attention to】Pregnant woman uses with caution.【It takes passages】《Chinese book on Chinese herbal medicine》.

Curcuma zedoary【Alias】Curcuma wenyujin, zedoary, radix zedoariae, Rhizoma Trillii Tschonoskii, smelly dung ginger.【Source】This product is zingiberaceous plant The dry rhizome of zedoary, Guangxi zedoary or RADIX CURCUMAE.The latter, which practises, claims " Curcuma wenyujin ".It excavates, cleans after winter cauline leaf is withered, It steams or boils to the saturating heart, fibrous root and impurity is removed after dry or low temperature dry.【Nature and flavor】It is pungent, bitter, temperature.【Channel tropism】Return liver, the spleen channel. 【Major function】Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.For Dan lump in the abdomen lump in the abdomens, blood stasis closed, dyspepsia distending pain；Early cervical carcinoma.【Usage is used Amount】It is for oral administration：Decoction, 6~12g.【Pay attention to】Pregnant woman disables.Qi-blood deficiency, weakness of spleen and stomach,the frail spleen and stomach is without the careful clothes of stagnant person.【It takes passages】《China Book on Chinese herbal medicine》.

Artemisia capillaris【Alias】Because dirt, Ma Xian, mattress Gall wormwood artemisias, oriental wormwood, because of old wormwood artemisia, capillary wormwood, suede wormwood artemisia, spire sweet wormwood, artemisia hedinii, An Lv Grass, grandmother wormwood artemisia, wild blue wormwood artemisia.【Source】For the young young stem and leaf of feverfew Artemisia capillaris.Spring seedling harvests when about three cun high, Impurity is removed, soil is removed, dries.【Nature and flavor】Toil, it is cool.【Channel tropism】Enter liver, spleen, bladder warp.【Major function】Heat-clearing profit It is wet.Control jaundice with damp-heat pathogen, difficult urination, pruritus sore scabies.Yang jaundice is controlled with cape jasmine, rheum officinale；Yin jaundice is controlled with monkshood, rhizoma zingiberis.【Pay attention to】Heat Very turn to be yellow, no moisture, the two disabling.【Usage and dosage】It is for oral administration：Decoction, 3~9g.【It takes passages】《Chinese book on Chinese herbal medicine》.

The seed of cowherb【Alias】SEMEN VACCARIAE, milk rice, king bull, barley ox.【Source】This product is that pinkwort wheat is blue The dry mature seed of dish.Summer fruit maturation, pericarp tap plant when not yet cracking, and dry, and lay seed, remove impurity, It dries again.【Nature and flavor】Hardship is put down.【Channel tropism】Hardship is put down.【Major function】Invigorate blood circulation, lower breast detumescence.For agalactia, warp It closes, dysmenorrhoea, acute mastitis swelling and pain.【Usage and dosage】It is for oral administration：Decoction, 4.5~9g.【Pay attention to】Pregnant woman uses with caution.Disease, uterine bleeding disease lose blood simultaneously It must be avoided.【It takes passages】《Chinese book on Chinese herbal medicine》.

Common wrightia root or stem【Alias】Mo Zhuguo, chapter table, Chang Zi, nine dense wood, branch paulownia wood, pig pine, angle's candle, handle of a knife, hardship Often, thin aunt's wood, Ma Ling, pig dish mother, bitter poplar.【Source】The root or stem branch of pen are hung upside down for apocynaceae plant.Harvesting and storage： Whole year can adopt, and clean, and slice dries.【Nature and flavor】It is sweet；It is light；It is mild-natured.【Channel tropism】Return liver, kidney, lung, small intestinl channel.【Major function】 Dispelling wind and removing obstruction in the meridians；Reducing phlegm and resolving masses；Dampness removing.Main arthralgia pain due to rheumatism；Lumbocrural pain；Traumatic injury；Scrofula；Chronic bronchitis；Icteric Hepatitis, cirrhotic ascites.【Usage and dosage】It is for oral administration：Decoction, 9~30g.【It takes passages】《Chinese book on Chinese herbal medicine》

Radix Curcumae【Alias】Radix curcumae, white silk Radix Curcumae.【Source】This product is zingiberaceous plant RADIX CURCUMAE, turmeric, Guangxi zedoary or zedoary Dried root.The above two practise title " RADIX CURCUMAE " and " Radix Curcuma " respectively, remaining is claimed " osmanthus Radix Curcumae " or " green by character difference habit Silk Radix Curcumae ".It is excavated after winter cauline leaf is withered, removes silt and radicula, steamed or boiled to the saturating heart, it is dry.【Nature and flavor】It is pungent, bitter, it trembles with fear. 【Channel tropism】Return liver, the heart, lung channel.【Major function】Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.For closed dysmenorrhea, chest and abdomen are swollen Bitterly, shouting pain, pyreticosis coma, epilepsy are gone mad, jaundice.【Usage and dosage】It is for oral administration：Decoction, 3~9g.【Pay attention to】The deficiency of Yin lose blood and No qi depression to blood stasis person avoids clothes, pregnant women should cautiously take.【It takes passages】《Chinese book on Chinese herbal medicine》.

Invention content

The present invention is intended to provide a kind of Chinese medicine for treating alcoholic liver disease, by selecting suitable medicinal material and its matching Than achieving the purpose that safely and effectively to cure alcoholic liver disease.

In order to achieve the above object, the present invention uses following technical scheme：

A kind of Chinese medicine for treating alcoholic liver disease, which is characterized in that it is prepared by the raw medicinal material of following weight proportion It forms：The eve of the lunar New Year is 10 parts yellow, 30 parts of fund grass, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, hangs upside down wax Candle 12 parts, 12 parts of Radix Curcumae.

The beneficial effects of the present invention will now be described with reference to clinical experimental data：

1, general information

Outpatient service and in hospital patients with alcoholic liver disease 74, man 71, female are collected between October altogether in inventor in October, 2012 ~ 2013 year 3, at 32~65 years old age, average age 46 years old is indulged in excessive drinking 5 ~ 22 years times.It is randomly divided into treatment group 51 and control group 23, 2 groups of genders, age and course of disease comparing difference are not statistically significant, are comparable.

Diagnostic criteria

Diagnostic criteria according to national alcoholic liver disease clinical speciality meeting：1. sign：（1）Alcoholic hepatitis：Symptom of digestive tract Heavier to have nausea, vomiting, anorexia is weak, becomes thin, and hepatic region pain aggravates etc..Severe patient is in acute severe hepatitis or liver function Failure；（2）Alcoholic cirrhosis：Outside general hepatocirrhosis symptoms, also malnutrition, anaemia, spider angioma, liver palms, neuritis, flesh Atrophy, parotid gland enlargement, gynecomasty, the symptoms such as orchiatrophy are common compared with posthepatitic cirrhosis, and visible Dupuytren slaps contraction Contracting, glossitis, when parotid gland enlargement, can be with pancreatitis.Early stage hepatomegaly, late period liver reduce, and splenomegaly is common not as good as posthepatitic cirrhosis.Abdomen Water appearance is more early, often merges canker.

2.B type ultrasonic examinations：（1) fatty liver：Showing that liver volume increases, there is uniform tiny echo in essence, and There is tiny luminous point intensive, " the bright liver " of acoustic beam decaying enhancing；(2) spleen enlargement is seen in alcoholic cirrhosis.Liver parenchyma echo Enhancing, caudal lobe is opposite to be increased.Splenic vein and portal vein diameter are significantly more than normal (the former is normal 1.0cm, the latter 1.5cm).

2, test method

2.1 therapy

The oral present invention for the treatment of group is according to capsule made from specific embodiment 3,3 times a day.36 days courses for the treatment of, two courses for the treatment of.

Control group takes orally the safe happy each 0.2g of piece, and each 0.2g of vitamin C takes orally 3 times a day, 36 days courses for the treatment of, two The course for the treatment of.

3, criterion of therapeutical effect and treatment results

3.1 criterion of therapeutical effect

Clinical cure：Clinical symptoms disappear.Liver function recovery is normal, and citrus orchards check normal；

Effectively：Clinical symptoms disappear substantially, and liver function is obviously restored, citrus orchards alcoholic liver disease disease

Change mitigation (including fatty liver switchs to mild or moderate by severe：Or moderate restores normal and liver

Lesion degree is hardened without exacerbation, ascites is substantially reduced or disappears)；

In vain：Clinical symptoms are without alleviation, even liver function is not restored to aggravate, citrus orchards lesion does not change

Become or aggravates.

3.2 treatment results are shown in Table 1.

1 two groups of curative effects of table compare

Group	n	Clinic control	Effectively	In vain	Total effective rate (%)	Serious adverse reaction example
							Treatment group	51	23	20	8	84.31%	0
Control group	23	2	10	11	52.17%	0

As it can be seen that drug produced by the present invention can safely and effectively treat alcoholic liver disease, there is promotional value.

Specific implementation mode

In order to better understand with the implementation present invention, further illustrated the present invention with reference to specific embodiment.

Embodiment 1

It weighs：The eve of the lunar New Year is 10 grams yellow, 30 grams of fund grass, 10 grams of rhizoma corydalis, 10 grams of curcuma zedoary, 12 grams of Artemisia capillaris, 12 grams of the seed of cowherb, falls Hang 12 grams of candle, 12 grams of Radix Curcumae；Add 8 times of amount water, decocts 1.5 hours, filtering；Filter residue adds 6 times of amount water, decocts 1 hour, filtering； Merging filtrate is concentrated into 120 grams to get the decoction of one day dosage of normal adult is met.

For treating alcoholic liver disease.It is oral, it is taken three times per bu Morning Afternoon Evening.

Embodiment 2

It weighs：The eve of the lunar New Year is 10 grams yellow, 30 grams of fund grass, 10 grams of rhizoma corydalis, 10 grams of curcuma zedoary, 12 grams of Artemisia capillaris, 12 grams of the seed of cowherb, falls Hang 12 grams of candle, 12 grams of Radix Curcumae；Add 10 times of amount water, decocts 2 hours, filtering；Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering； Merging filtrate concentrates, dry, packs to get the powder of one day dosage of normal adult is met.

For treating alcoholic liver disease.It is oral, it is taken three times per bu Morning Afternoon Evening.

Embodiment 3

It weighs：The eve of the lunar New Year is 10 grams yellow, 30 grams of fund grass, 10 grams of rhizoma corydalis, 10 grams of curcuma zedoary, 12 grams of Artemisia capillaris, 12 grams of the seed of cowherb, falls Hang 12 grams of candle, 12 grams of Radix Curcumae；Add 6 times of amount water, decocts 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, it is dry, it is packed into Capsule shells are to get meeting the capsule of one day dosage of normal adult.

For treating alcoholic liver disease.It is oral, it is taken three times per bu Morning Afternoon Evening.

Claims (4)

1. a kind of Chinese medicine for treating alcoholic liver disease, which is characterized in that it is by the raw medicinal material system of following weight proportion It is standby to form：The eve of the lunar New Year is 10 parts yellow, 30 parts of fund grass, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, hangs upside down 12 parts of candle, 12 parts of Radix Curcumae.

2. the Chinese medicine for treating alcoholic liver disease as described in claim 1, which is characterized in that preparation method is：It weighs： The eve of the lunar New Year is 10 parts yellow, fund is 30 parts careless, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, common wrightia root or stem 12 Part, 12 parts of Radix Curcumae；Add 8 times of amount water, decocts 1.5 hours, filtering；Filter residue adds 6 times of amount water, decocts 1 hour, filtering；Merging filtrate, 120 parts are concentrated into get decoction；Above-mentioned part each means parts by weight.

3. the Chinese medicine for treating alcoholic liver disease as described in claim 1, which is characterized in that preparation method is：It weighs： The eve of the lunar New Year is 10 parts yellow, fund is 30 parts careless, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, common wrightia root or stem 12 Part, 12 parts of Radix Curcumae；Add 10 times of amount water, decocts 2 hours, filtering；Filter residue adds 8 times of amount water, decocts 1.5 hours, filtering；Merge filter Liquid concentrates, dry, packs to get powder；Above-mentioned part each means parts by weight.

4. the Chinese medicine for treating alcoholic liver disease as described in claim 1, which is characterized in that preparation method is：It weighs： The eve of the lunar New Year is 10 parts yellow, fund is 30 parts careless, 10 parts of rhizoma corydalis, 10 parts of curcuma zedoary, 12 parts of Artemisia capillaris, 12 parts of the seed of cowherb, common wrightia root or stem 12 Part, 12 parts of Radix Curcumae；Add 6 times of amount water, decocts 3 times, decoct 1 hour every time, merge decoction liquor, concentrate, it is dry, capsule shells are packed into, Up to capsule；Above-mentioned part each means parts by weight.