CN107875435A - A kind of preparation technology of absorbability medical catgut - Google Patents
A kind of preparation technology of absorbability medical catgut Download PDFInfo
- Publication number
- CN107875435A CN107875435A CN201711167540.9A CN201711167540A CN107875435A CN 107875435 A CN107875435 A CN 107875435A CN 201711167540 A CN201711167540 A CN 201711167540A CN 107875435 A CN107875435 A CN 107875435A
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- CN
- China
- Prior art keywords
- catgut
- preparation technology
- sheep casing
- casing
- sheep
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of preparation technology of absorbability medical catgut, comprise the concrete steps that：Extract sheep casing, sheep casing is divided equally and becomes band and carries out loose processing with leavening agent, sheep casing is subjected to ungrease treatment and bleaching again, it is freeze-dried after sheep casing drafting plying is twisted into twine afterwards, dried catgut is polished by polishing machine again, chitosan collagen gel is prepared afterwards and it is formed film layer on polished catgut surface.Compared with existing common catgut, the casing suture prepared by preparation technology provided by the invention has splendid biocompatibility and cylinder block strength, fully meets the requirements at the higher level that market proposes to catgut.
Description
Technical field
The present invention relates to the fabricating technology field of medical catgut, and in particular to a kind of absorbability medical catgut
Preparation technology.
Background technology
Catgut is clinically to use more absorbability suture, and the quality of its quality directly affects the health of patient
Multiple situation.
Existing catgut because processing technology relatively falls behind, there is wire body is hard, ultimate strength and knotting ultimate strength difference and
The problems such as biocompatibility is bad, these problems seriously constrain the development of catgut, especially with it is external it is various it is emerging can
The appearance of absorbable suture line so that existing catgut industry have received very big impact.Therefore, how to overcome existing catgut
Above-mentioned be not enough to improve its market competitiveness and turn into a great problem of the pendulum in face of the sector.
The content of the invention
The present invention is directed to the deficiency of existing catgut preparation technology, and spy provides a kind of system of absorbability medical catgut
Standby technique.
Technical scheme is as follows.
A kind of preparation technology of absorbability medical catgut, it is characterised in that there are following steps：
The small intestine of healthy Grey Goats is chosen, sheep casing is made after removing its mucous membrane, serous coat, mesenterium；
By sheep casing longitudinal direction, uniformly decile becomes band and carries out loose processing with leavening agent, to improve its pliability；
Sheep casing is immersed in sodium hydroxide solution and carries out ungrease treatment, is washed with water after taking-up clean；
Sheep casing is soaked in the solution containing hydrogen peroxide and carries out bleaching, is washed with water after taking-up clean；
Sheep casing drafting plying after bleaching is twisted twine；
Catgut uses freeze-drying to ensure its tension intensity and knot strength；
Dried catgut is polished by polishing machine, to improve its surface smoothness；
Prepare chitosan collagen gel and it is formed film layer on polished catgut surface, this has ensured that it has
Preferable biocompatibility, improves cylinder block strength again.
Beneficial effects of the present invention：Compared with existing common catgut, prepared by preparation technology provided by the invention
Casing suture has splendid cylinder block strength and biocompatibility, fully meet that market proposes to catgut it is higher will
Ask.
Brief description of the drawings
Fig. 1 is the preparation technology flow chart of embodiment 1.
Embodiment
Preparation technology of the present invention is described in detail below with reference to specific embodiment.
Embodiment 1
This embodiment offers a kind of preparation technology of the medical casing suture of absorbability, its step are as shown in Figure 1：
S1, the small intestine for choosing healthy Grey Goats, sheep casing is made after removing its mucous membrane, serous coat, mesenterium；
S2, by sheep casing longitudinal direction, uniformly decile becomes band and carries out loose processing with NaHCO3；
S3, sheep casing is immersed in sodium hydroxide solution carries out ungrease treatment, be washed with water after taking-up clean；
S4, sheep casing is soaked in the solution containing hydrogen peroxide carries out bleaching, be washed with water after taking-up clean；
S5, the sheep casing drafting after bleaching, which is pooled capital, is twisted twine；
S6, catgut is freeze-dried；
S7, by polishing machine dried catgut is polished；
S8, it is sequentially placed into by distilled water dissolved gum original protein solution after carbomer and chitosan shell is made through stirring deaeration
Glycan collagen gel, chitosan collagen gel overlay film form film layer on catgut.
Above-described embodiment only listing property illustrates the principle and effect of the present invention, not for the limitation present invention.It is any to be familiar with
The personnel of technique can modify according to the principle of the present invention.Therefore, all modifications made according to the principle of the invention,
It all should cover among scope of the presently claimed invention.
Claims (3)
1. a kind of preparation technology of absorbability medical catgut, it is characterised in that there are following steps：
The small intestine of healthy Grey Goats is chosen, sheep casing is made after removing its mucous membrane, serous coat, mesenterium；
By sheep casing longitudinal direction, uniformly decile becomes band and carries out loose processing with leavening agent；
Sheep casing is immersed in sodium hydroxide solution and carries out ungrease treatment, is washed with water after taking-up clean；
Sheep casing is soaked in the solution containing hydrogen peroxide and carries out bleaching, is washed with water after taking-up clean；
Sheep casing drafting plying after bleaching is twisted twine；
Catgut is freeze-dried；
Dried catgut is polished by polishing machine；
Prepare chitosan collagen gel and it is formed film layer on polished catgut surface.
2. the preparation technology of absorbability medical catgut according to claim 1, it is characterised in that：Described leavening agent
For NaHCO3.
3. the preparation technology of absorbability medical catgut according to claim 1, it is characterised in that：Described chitosan
Collagen gel is to be taken off after carbomer and chitosan are sequentially placed into by distilled water dissolved gum original protein solution through stirring
Bubble forms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711167540.9A CN107875435A (en) | 2017-11-21 | 2017-11-21 | A kind of preparation technology of absorbability medical catgut |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711167540.9A CN107875435A (en) | 2017-11-21 | 2017-11-21 | A kind of preparation technology of absorbability medical catgut |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107875435A true CN107875435A (en) | 2018-04-06 |
Family
ID=61778330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711167540.9A Pending CN107875435A (en) | 2017-11-21 | 2017-11-21 | A kind of preparation technology of absorbability medical catgut |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107875435A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110665046A (en) * | 2019-11-19 | 2020-01-10 | 山东省科学院新材料研究所 | Decolouring process for preparing sheepskin casing in sheepskin operation suture |
| CN111905140A (en) * | 2020-05-26 | 2020-11-10 | 山东省科学院新材料研究所 | Multifunctional absorbable collagen medical suture and preparation method thereof |
| WO2022095028A1 (en) * | 2020-11-07 | 2022-05-12 | 单县华宇缝合制品有限公司 | High-strength biological suture line and preparation method therefor |
| CN114917395A (en) * | 2022-05-24 | 2022-08-19 | 单县华宇缝合制品有限公司 | Enteric thread processing system |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB176679A (en) * | 1921-03-19 | 1922-03-16 | Shunzo Uyama | Improved process for preparing catgut |
| CN1202380A (en) * | 1998-06-12 | 1998-12-23 | 王桂法 | Process for producing medical absorbable suture of ox gut |
| CN1284385A (en) * | 1999-08-16 | 2001-02-21 | 王桂发 | Munufacture of medical absorbable soft suture |
| CN1284384A (en) * | 1999-08-16 | 2001-02-21 | 王桂发 | Manufacture of medical absorbable soft bone suture |
| CN1363397A (en) * | 2002-01-08 | 2002-08-14 | 江西龙腾实业有限公司 | Process for preparing medical suture bio-silk from goat intestines |
| CN101332310A (en) * | 2007-06-27 | 2008-12-31 | 冷劲松 | Biodegradable shape memory stitched wire |
| CN101455858A (en) * | 2009-01-04 | 2009-06-17 | 张玉福 | Biology collagen brown medical soft suture-thread manufacture method |
| CN103638552A (en) * | 2013-12-12 | 2014-03-19 | 董新义 | Preparation method of biochemical complexing off-white medical absorbable suture line |
| CN104491920A (en) * | 2014-12-19 | 2015-04-08 | 山东博达医疗用品有限公司 | Method for preparing absorbable suture |
-
2017
- 2017-11-21 CN CN201711167540.9A patent/CN107875435A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB176679A (en) * | 1921-03-19 | 1922-03-16 | Shunzo Uyama | Improved process for preparing catgut |
| CN1202380A (en) * | 1998-06-12 | 1998-12-23 | 王桂法 | Process for producing medical absorbable suture of ox gut |
| CN1284385A (en) * | 1999-08-16 | 2001-02-21 | 王桂发 | Munufacture of medical absorbable soft suture |
| CN1284384A (en) * | 1999-08-16 | 2001-02-21 | 王桂发 | Manufacture of medical absorbable soft bone suture |
| CN1363397A (en) * | 2002-01-08 | 2002-08-14 | 江西龙腾实业有限公司 | Process for preparing medical suture bio-silk from goat intestines |
| CN101332310A (en) * | 2007-06-27 | 2008-12-31 | 冷劲松 | Biodegradable shape memory stitched wire |
| CN101455858A (en) * | 2009-01-04 | 2009-06-17 | 张玉福 | Biology collagen brown medical soft suture-thread manufacture method |
| CN103638552A (en) * | 2013-12-12 | 2014-03-19 | 董新义 | Preparation method of biochemical complexing off-white medical absorbable suture line |
| CN104491920A (en) * | 2014-12-19 | 2015-04-08 | 山东博达医疗用品有限公司 | Method for preparing absorbable suture |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110665046A (en) * | 2019-11-19 | 2020-01-10 | 山东省科学院新材料研究所 | Decolouring process for preparing sheepskin casing in sheepskin operation suture |
| CN111905140A (en) * | 2020-05-26 | 2020-11-10 | 山东省科学院新材料研究所 | Multifunctional absorbable collagen medical suture and preparation method thereof |
| WO2022095028A1 (en) * | 2020-11-07 | 2022-05-12 | 单县华宇缝合制品有限公司 | High-strength biological suture line and preparation method therefor |
| CN114917395A (en) * | 2022-05-24 | 2022-08-19 | 单县华宇缝合制品有限公司 | Enteric thread processing system |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180406 |