WO2022095028A1

WO2022095028A1 - High-strength biological suture line and preparation method therefor

Info

Publication number: WO2022095028A1
Application number: PCT/CN2020/127519
Authority: WO
Inventors: 张萌
Original assignee: 单县华宇缝合制品有限公司
Priority date: 2020-11-07
Filing date: 2020-11-09
Publication date: 2022-05-12
Also published as: CN112336395B; CN112336395A

Abstract

A preparation process for a high-strength biological suture line, especially a high-strength biological suture line and a preparation method therefor. The high-strength biological suture line comprises a main material and auxiliary materials. The main material is an enteric line, and the auxiliary materials comprise a vitamin C solution, beewax and collagen. The main material and the auxiliary materials are treated independently and then mixed, and the auxiliary materials permeate into the enteric line. According to the biological suture line, the enteric line is used as the main body, the overall high strength of the biological suture line can be guaranteed by means of secondary toughening, the tensile strength is guaranteed, and the use effect is good. The vitamin C can be fully fused into the suture line in a soaking and rolling mode, it is guaranteed that the vitamin C can be effectively and slowly released to a wound part when the suture line is used, and the wound healing effect is improved.

Description

High-strength biological suture and preparation method thereof

technical field

The invention relates to the technical field of suture preparation, in particular to a preparation process of a high-strength biological suture, in particular to a high-strength biological suture and a preparation method thereof.

Background technique

Biological suture materials (such as catgut) can be absorbed by the human body and do not need to be removed after the wound is sutured. This is different from ordinary sutures that require suture removal. Because of this, biological sutures have been widely used in clinical applications. , Can be widely used in gynecology, obstetrics, surgery, plastic surgery, urology, pediatrics, stomatology, otolaryngology, ophthalmology and other operations and intradermal soft tissue suture.

As a biological suture material, in terms of physical properties, the tensile strength of the material has an important influence in use, which mainly determines the suture strength to the wound. If the tensile strength of the material is insufficient, it is easy to cause muscle tension at the suture site. Excessive size will cause the suture to be pulled and broken. Therefore, how to improve the strength of the biological suture under the premise of ensuring rapid absorption has an important impact on its clinical application.

SUMMARY OF THE INVENTION

In order to solve one of the above-mentioned technical problems, the technical solution adopted in the present invention is: a high-strength biological suture, including the following components: a main material and an auxiliary material, the main material is an enteric-coated thread, and the auxiliary material includes the following components: Vitamin C solution, beeswax, collagen.

Preferably, the main material and the auxiliary material are separately processed and then mixed, and each of the auxiliary materials penetrates into the inside of the enteric coating line.

Preferably, the vitamin C solution is a vitamin C solution with a concentration of 20%.

The preparation method of high-strength biological suture comprises the following steps:

S1: Prepare main ingredients:

After preparing the duck casings, wash them and cut the duck casings into enteric lines;

S2: Enteric line pretreatment:

The enteric-coated thread is placed in the high-strength biological suture preparation device for ultraviolet irradiation and disinfection to obtain sterile enteric-coated thread;

S3: toughening treatment:

The above-mentioned sterile enteric-coated thread is rinsed with low-temperature sterile water in the high-strength biological suture preparation device for 1-2 hours to obtain a toughened enteric-coated thread;

S4: Immersion rolling treatment:

The toughened enteric-coated thread obtained above is placed in a high-strength biological suture preparation device and soaked in a 20% vitamin C solution. During the soaking process, it is necessary to perform repeated rolling treatment for 2-3 hours to obtain the first product. Enteric line;

S5: Secondary toughening treatment:

Washing the above-obtained primary product enteric-coated wire with a low-temperature 20% vitamin C solution for 1-2 hours to obtain a secondary toughened enteric-coated wire;

S6: Drying treatment:

The obtained secondary toughened enteric-coated thread is dried inside the high-strength biological suture preparation device to obtain the first-grade enteric-coated thread;

S7: Apply collagen;

Apply collagen on the uniform surface of the obtained first-grade enteric-coated wire to obtain a middle-grade enteric-coated wire;

S8: Beeswax Wrap:

The surface of the above-obtained mid-grade enteric-coated thread is covered with beeswax and the surface is smoothed to obtain the final suture.

Preferably, the ultraviolet irradiation time is 15-20 min.

Preferably, the disinfection treatment adopts 5% NaOH solution.

Preferably, the temperature of the low-temperature 20% vitamin C solution in the secondary toughening treatment step of S5 is 0-4°C.

Preferably, the high-strength biological suture preparation device includes an aseptic processing chamber, an operating table is installed in the aseptic processing chamber, and an ultraviolet irradiation assembly and a sterile liquid spraying assembly are installed in the aseptic processing chamber , a suture comprehensive processing chamber is arranged on one side of the aseptic processing chamber, and a preliminary toughening component, an infiltration rolling component, a secondary toughening component, A drying assembly is provided with a brushing and dressing assembly in the drying assembly.

Preferably, the ultraviolet irradiation assembly includes a plurality of ultraviolet lamps fixedly arranged above the operation table in the aseptic processing chamber, each of the ultraviolet lamps adopts a liftable structure, and each of the ultraviolet lamps is used to realize the The enteric-coated wire placed on the sterile operating table is initially irradiated. During the irradiation process, the enteric-coated wire needs to be periodically turned over to make it uniformly irradiated.

Preferably, the aseptic liquid spray assembly includes a liquid spray pipe fixed on the top of the aseptic processing chamber, and a mist spray head is arranged at the bottom of the liquid spray pipe, and the mist spray head faces the operation The station sprays mist-like sterile liquid, the inlet end of the liquid spray pipe is connected to an external sterile liquid container, and a liquid spray pump is installed on the liquid spray pipe.

Preferably, the preliminary toughening assembly includes a first toughening pool, a first high-pressure spray head is fixedly arranged above the first toughening pool, and the first high-pressure spray head communicates with external high-pressure cold water through a first pipeline connected to the source, a first water filter screen plate is installed in the inner middle of the first toughening pool, and the first water filter screen plate is used to place the sterile enteric line, at the lower end of the first toughening pool A first drain pipe with a valve is provided in communication.

The center of the first water filter screen plate is recessed downward, mainly for the convenience that the sterile enteric line placed on it can be kept in the center position and not move substantially under the impact of high-pressure water flow, so as to ensure the impact of the impact. Toughening effect.

Preferably, the secondary toughening assembly includes a second toughening pool, a second high-pressure spray head is fixedly arranged above the second toughening pool, and the second high-pressure spray head communicates with the external high pressure through the second pipeline. The low-temperature 20% vitamin C solution is connected to the source, and a second filter screen plate is installed in the inner middle of the second toughening tank, and the second water filter screen plate is used to place the first product enteric coating line. The lower end of the second toughening pool is communicated with a second liquid drain pipe with a valve.

Preferably, the center of the second water filter screen plate is recessed downward, mainly for the convenience that the initial enteric coating line placed on it can be kept in the center position without large movement under the impact of high-pressure water flow , to ensure the impact toughening effect.

The use of two cold liquid impact toughening treatments can effectively improve the overall toughness, thereby improving its tensile strength and ensuring the high-strength characteristics of the overall obtained suture.

Preferably, the soaking roller pressing assembly includes an soaking pool, the soaking pool is filled with vitamin C solution, a positioning frame is fixedly installed above the soaking pool, and two side-by-side spacers are arranged at the bottom of the positioning frame In the horizontal cylinder provided, a moving block is fixedly connected to the front ends of the piston rods of the two horizontal cylinders. Two vertical cylinders are installed at intervals at the front end of the vertical cylinder, a roller frame is fixedly installed at the bottom of the two vertical cylinders, and a pressing roller is movably clamped in the roller frame. The toughened enteric line at the bottom is subjected to repeated pressure rolling.

Preferably, the two horizontal cylinders move synchronously, and the two vertical cylinders move synchronously.

Preferably, the drying assembly includes a drying bin, and several drying fans are installed in the drying bin, and the drying fans are used to realize the hot air drying of the secondary toughened enteric-coated wire. The center of the drying bin is provided with a vertically arranged tensioning frame, and a vertical tensioning screw is installed in the inner frame of the tensioning frame, and the two ends of the vertical tensioning screw are respectively passed through the inner frame of the tensioning frame. The stepped shaft section at the end is movably clamped in the corresponding through hole, and the stepped shaft section at the upper end of the vertical tensioning screw penetrates the top of the tensioning frame and is fixedly connected with the motor shaft of a servo tensioning motor , the motor housing of the servo tensioning motor is fixedly installed on the tensioning frame, the thread rotation directions of the upper and lower sections of the vertical tensioning screw are opposite, and the upper and lower sections of the vertical tensioning screw are in opposite directions. A lifting slider is symmetrically installed on the lower part of the lead screw, and the side walls of the two lifting sliders are respectively abutted and tightly matched with the inner frame of the tensioning frame, and are respectively fixed on the outer end surfaces of the two lifting sliders. A horizontal beam is connected, and a rotatable tensioning hook is movably installed in the hanging holes at the opposite ends of the two horizontal beams, and the two tensioning hooks are respectively matched to realize the tension of the secondary toughened enteric-coated thread. Tight tensioning knots are provided with the brushing and dressing assemblies on opposite sides of the tensioning frame, respectively.

Preferably, the brushing and dressing assembly is a spraying machine, and the powder spraying machine is used for spraying the collagen and beeswax onto the surface of the enteric thread.

The beneficial effects of the present invention are embodied in:

1. This biological suture uses enteric-coated thread as the main body. After secondary toughening, it can ensure its overall high strength, ensure tensile strength and good use effect;

2. The suture is soaked and rolled to fully integrate the vitamin C component into its interior, ensuring that the vitamin C can be effectively and slowly released to the wound site during use and improve the effect of wound healing;

3. Coating collagen and beeswax on the surface of the suture can further ensure that the collagen and beeswax can promote the healing of the wound after the biological suture is used for suture, and the use effect is good.

Description of drawings

In order to illustrate the specific embodiments of the present invention or the technical solutions in the prior art more clearly, the following briefly introduces the accompanying drawings that are required to be used in the description of the specific embodiments or the prior art. Similar elements or components are generally identified by similar reference numerals throughout the drawings. In the drawings, each element or component is not necessarily drawn to actual scale.

FIG. 1 is a schematic structural diagram of the present invention.

In the figure, 1. Aseptic processing room; 2. Operating table; 3. Ultraviolet irradiation component; 4. Aseptic liquid spray component; 5. Preliminary toughening component; 6. Immersion rolling component; 7. Secondary toughening Components; 8. Drying components; 9. Brushing and dressing components; 91. Spraying machine; 10. Suture comprehensive treatment room; 11. Ultraviolet lamp; 12. Liquid spray pipe; 13. Mist spray head; 14. Liquid spray pump ; 15, the first toughening pool; 16, the first high pressure nozzle; 17, the first filter screen plate; 18, the first drain pipe; 19, the second toughening tank; 20, the second high pressure nozzle; 21, The second pipeline; 22, the second filter screen plate; 23, the second drain pipe; 24, the infiltration tank; 25, the positioning frame; 26, the horizontal cylinder; 27, the moving block; 28, the slider; 29, the vertical cylinder; 30, roller frame; 31, pressing roller; 32, drying bin; 33, drying fan; 34, tension frame; 35, vertical tension screw; 36, servo tension motor; 37, lift Slider; 38, horizontal beam; 39, tensioning hook; 40, first pipe; 41, suture.

Detailed ways

Embodiments of the technical solutions of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only used to more clearly illustrate the technical solutions of the present invention, and are therefore only used as examples, and cannot be used to limit the protection scope of the present invention.

As shown in FIG. 1 , the high-strength biological suture includes the following components: a main material and an auxiliary material, the main material is an enteric thread, and the auxiliary material includes the following components: vitamin C solution, beeswax, and collagen.

The adjuvant preparation process set here can effectively ensure that the adjuvant penetrates into the enteric-coated thread, so that the enteric-coated thread can have a suturing effect and at the same time achieve a good effect of improving the wound treatment effect.

After soaking in the vitamin C solution, the internal vitamin C components can enter the intestinal solution, so that the vitamin C solution can gradually penetrate into the wound site after the suture in the later stage.

S1: Prepare main ingredients:

S2: Enteric line pretreatment:

The enteric-coated thread is placed on the operating table 2 of the high-strength biological suture preparation device, and the sterile intestine is obtained by turning on the ultraviolet lamp 11 for ultraviolet irradiation and by turning on the mist nozzle 13 of the sterile liquid spray assembly 4 for disinfection. melt line;

S3: toughening treatment:

The above-mentioned sterile enteric-coated thread is preliminarily toughened component 5 in the high-strength biological suture preparation device to be rinsed with low-temperature sterile water for 1-2 hours to obtain a toughened enteric-coated thread;

Through preliminary low-temperature sterile water washing, the toughness reinforcement of the sterile enteric-coated wire can be achieved to ensure its tensile strength.

S4: Immersion rolling treatment:

The above-mentioned toughened enteric-coated thread is placed in the soaking tank 24 of the soaking roller pressing assembly 6 in the high-strength biological suture preparation device and soaked in a 20% vitamin C solution. During soaking, 2- After 3 hours of repeated rolling treatment, the first product enteric-coated line was obtained;

The purpose of the repeated rolling by the pressing roller 31 is to promote the entry of the vitamin C component into the interior of the toughened enteric-coated wire, so that the interior is sufficiently infiltrated by the vitamin C solution.

S5: Secondary toughening treatment:

Washing the above-obtained primary enteric-coated wire with a low-temperature 20% vitamin C solution in the secondary toughening component 7 for 1-2 hours to obtain a secondary toughened enteric-coated wire;

Secondary toughening can more effectively improve its tensile strength and ensure its toughness in use.

S6: Drying treatment:

The obtained secondary toughened enteric-coated thread is dried in the drying bin 32 inside the high-strength biological suture preparation device by turning on each drying fan 33 to obtain the first-grade enteric-coated thread;

S7: Apply collagen;

S8: Beeswax Wrap:

Preferably, the ultraviolet irradiation time is 15-20min.

Preferably, the disinfection treatment adopts 5% NaOH solution.

Preferably, the high-strength biological suture preparation device includes an aseptic processing chamber 1 , an operating table 2 is installed in the aseptic processing chamber 1 , and an ultraviolet irradiation assembly 3 is installed in the aseptic processing chamber 1 And the aseptic liquid spray assembly 4, a suture comprehensive processing chamber 10 is provided on one side of the sterile processing chamber 1, and a preliminary toughening assembly is sequentially installed in the suture comprehensive processing chamber 10 from upstream to downstream. 5. Wetting and rolling components 6 , secondary toughening components 7 , and drying components 8 , in which drying components 8 are provided with brushing and dressing components 9 .

Preferably, the ultraviolet irradiation assembly 3 includes a plurality of ultraviolet lamps 11 fixedly arranged above the operation table 2 in the aseptic processing chamber 1 , and each of the ultraviolet lamps 11 adopts a liftable structure. The ultraviolet lamp 11 is used to realize the preliminary irradiation of the enteric-coated wire placed on the sterile operating table 2 , and during the irradiation process, the enteric-coated wire needs to be periodically turned over to make it uniformly irradiated.

The ultraviolet lamp 11 adopts a liftable structure, which can sterilize and irradiate the enteric line in a more targeted manner. At the same time, after spraying the NaOH solution for disinfection, the upper NaOH solution needs to be washed with clean water.

Preferably, the sterile liquid spray assembly 4 includes a liquid spray pipe 12 fixed on the top of the aseptic processing chamber 1 , and a mist spray head 13 is arranged at the bottom of the liquid spray pipe 12 . The spray head 13 sprays a mist of sterile liquid toward the operating table 2 , the inlet end of the liquid spray pipe 12 is connected to an external sterile liquid container, and a liquid spray pump 14 is installed on the liquid spray pipe 12 .

The spraying effect can be effectively improved by using the mist spray head 13 .

Preferably, the preliminary toughening assembly 5 includes a first toughening pool 15 , a first high-pressure spray head 16 is fixed above the first toughening pool 15 , and the first high-pressure spray head 16 passes through a first pipeline 40 is connected to an external high-pressure cold water source, and a first water filter screen plate 17 is installed in the inner middle of the first toughening pool 15, and the first water filter screen plate 17 is used to place the sterile enteric coating line. The lower end of the first toughening pool 15 is communicated with a first drain pipe 18 with a valve.

The center of the first water filter screen plate 17 is recessed downward, mainly for the convenience that the sterile enteric line placed on it can be kept in the center position and not move substantially under the impact of high-pressure water flow, so as to ensure Impact toughening effect.

Preferably, the secondary toughening assembly 7 includes a second toughening pool 19 , a second high-pressure spray head 20 is fixed above the second toughening pool 19 , and the second high-pressure spray head 20 passes through the second toughening pool 19 . The pipeline 21 is connected to the external source of high-pressure and low-temperature 20% vitamin C solution, and a second water filter screen plate 22 is installed in the inner middle of the second toughening tank 19, and the second water filter screen plate 22 is used for placing For the first-product enteric-coated line, a second drain pipe 23 with a valve is communicated and arranged at the lower end of the second toughening tank 19 .

Preferably, the center of the second water filter screen plate 22 is recessed downward, mainly for the convenience that the initial enteric-coated line placed on it can be kept in the center without a large amount under the impact of high-pressure water flow. Movement to ensure impact toughening effect.

Preferably, the soaking roller pressing assembly 6 includes an soaking pool 24, the soaking pool 24 is filled with vitamin C solution, a positioning frame 25 is fixedly installed above the soaking pool 24, and the positioning frame 25 There are two horizontal cylinders 26 arranged side by side and spaced at the bottom of the cylinder. The front ends of the piston rods of the two horizontal cylinders 26 are fixedly connected with a moving block 27. In the chute at the bottom of the frame 25, two vertical cylinders 29 are installed at intervals at the front end of the moving block 27, and a roller frame 30 is fixedly installed at the bottom of the two vertical cylinders 29. The roller frame 30 A pressing roller 31 is movably clamped inside, and the pressing roller 31 is used to achieve repeated pressing and rolling of the toughened enteric-coated line at the bottom of the infiltration pool 24 .

When the enteric-coated line is pressed by the pressing roller 31, the extension length of the two vertical cylinders 29 can be controlled to achieve different pressing degrees, and the back-and-forth rolling can be realized by controlling the movement of the horizontal cylinder 26, so as to improve the rolling effect and promote the solution. The effect of entering the inside of the enteric line.

Preferably, the two horizontal cylinders 26 move synchronously, and the two vertical cylinders 29 move synchronously.

Preferably, the drying assembly 8 includes a drying bin 32, and a plurality of drying fans 33 are installed in the drying bin 32, and the drying fans 33 are used to realize the drying of the secondary toughened enteric-coated wire. For hot air drying, a vertical tensioning frame 34 is installed in the center of the drying bin 32, and a vertical tensioning screw 35 is installed in the inner frame of the tensioning frame 34. The vertical tensioning Both ends of the tensioning screw 35 are movably clamped in the corresponding through holes through the stepped shaft sections at the ends thereof, and the stepped shaft section at the upper end of the vertical tensioning screw 35 passes through the top of the tensioning frame 34 and passes through the top of the tensioning frame 34. It is fixedly connected with the motor shaft of a servo tensioning motor 36, the motor shell of the servo tensioning motor 36 is fixedly installed on the tensioning frame 34, and the upper and lower sections of the vertical tensioning screw 35 are The threads are rotated in opposite directions, and a lifting slider 37 is symmetrically installed on the upper and lower leads of the vertical tensioning lead screw 35 , and the side walls of the two lifting sliders 37 are respectively connected to the tensioning frame 34 . A horizontal beam 38 is fixed on the outer end surfaces of the two lifting sliders 37, and a rotatable Tensioning hooks 39 , the two tensioning hooks 39 are respectively matched to realize the tensioning and tensioning of the secondary toughened enteric-coated thread, and the brushing and dressing assemblies 9 are respectively provided on the opposite sides of the tensioning frame 34 .

The vertical tensioning screw 35 provided here can drive the two lifting sliders 37 to approach or move away from each other when rotating, so as to realize the control of the two tensioning hooks 39, thereby driving the enteric-coated thread to achieve different tensioning The effect can not only play a tensioning effect but also play a role in testing its tensile strength. After the enteric-coated thread is tensioned, since the two tensioning hooks 39 provided can be rotated slowly, the entire tensioning hook 39 can be rotated slowly. The tight enteric-coated thread can also be rotated, so that it is convenient to spray collagen and beeswax on the surface of the rotatable enteric-coated thread by the spraying machine 91, and finally the desired biological suture 41 is obtained.

Preferably, the brushing and dressing assembly 9 is a spraying machine 91, and the powder spraying machine 91 is used for spraying collagen and beeswax onto the surface of the enteric thread.

The above embodiments are only used to illustrate the technical solutions of the present invention, but not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that the foregoing embodiments can still be used for The technical solutions described in the examples are modified, or some or all of the technical features thereof are equivalently replaced; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention. Within the scope of the claims and description of the present invention; for those skilled in the art, any alternative improvements or transformations made to the embodiments of the present invention fall within the protection scope of the present invention.

The parts that are not described in detail in the present invention are the well-known technologies of those skilled in the art.

Claims

The high-strength biological suture is characterized in that it includes the following components: a main material and an auxiliary material, the main material is an enteric thread, and the auxiliary material includes the following components: a vitamin C solution, beeswax, and collagen.
The high-strength biological suture thread according to claim 1, wherein the main material and the auxiliary material are separately processed and then mixed, and each of the auxiliary materials penetrates into the enteric-coated thread.
The high-strength biological suture thread according to claim 1, wherein the vitamin C solution is a vitamin C solution with a concentration of 20%.
4. the preparation method of high-strength biological suture is characterized in that: comprises the following steps:

S1: Prepare main ingredients:

After preparing the duck casings, wash them and cut the duck casings into enteric lines;

S2: Enteric line pretreatment:

The enteric-coated thread is placed in the high-strength biological suture preparation device for ultraviolet irradiation and disinfection to obtain sterile enteric-coated thread;

S3: toughening treatment:

The above-mentioned sterile enteric-coated thread is rinsed with low-temperature sterile water in the high-strength biological suture preparation device for 1-2 hours to obtain a toughened enteric-coated thread;

S4: Immersion rolling treatment:

The toughened enteric-coated thread obtained above is placed in a high-strength biological suture preparation device and soaked in a 20% vitamin C solution. During the soaking process, it is necessary to perform repeated rolling treatment for 2-3 hours to obtain the first product. Enteric line;

S5: Secondary toughening treatment:

Washing the above-obtained primary product enteric-coated wire with a low-temperature 20% vitamin C solution for 1-2 hours to obtain a secondary toughened enteric-coated wire;

S6: Drying treatment:

The obtained secondary toughened enteric-coated thread is dried inside the high-strength biological suture preparation device to obtain the first-grade enteric-coated thread;

S7: Apply collagen;

Apply collagen on the uniform surface of the obtained first-grade enteric-coated wire to obtain a middle-grade enteric-coated wire;

S8: Beeswax Wrap:

The surface of the above-obtained mid-grade enteric-coated thread is covered with beeswax and the surface is smoothed to obtain the final suture.
The method for preparing a high-strength biological suture thread according to claim 1, wherein the ultraviolet irradiation time is 15-20 min.
The method for preparing a high-strength biological suture according to claim 1, wherein the disinfection treatment adopts a 5% NaOH solution.
The method for preparing a high-strength biological suture according to claim 1, wherein the temperature of the low-temperature 20% vitamin C solution in the secondary toughening treatment step of S5 is 0-4°C.
The method for preparing high-strength biological sutures according to claim 1, wherein the device for preparing high-strength biological sutures comprises an aseptic processing chamber, and an operating table is installed in the aseptic processing chamber, where the An ultraviolet irradiation component and a sterile liquid spray component are installed in the aseptic processing chamber, a suture comprehensive processing chamber is arranged on one side of the sterile processing chamber, and the suture comprehensive processing chamber is installed in sequence from upstream to downstream in the suture comprehensive processing chamber. There are a preliminary toughening component, an immersion rolling component, a secondary toughening component, and a drying component, and a brushing and dressing component is arranged in the drying component.
The method for preparing a high-strength biological suture according to claim 8, wherein the ultraviolet irradiation assembly comprises a plurality of ultraviolet lamps fixedly arranged above the operating table in the aseptic processing chamber, and each of the ultraviolet lamps They all adopt a liftable structure, and each of the ultraviolet lamps is used to initially irradiate the enteric-coated line placed on the sterile operating table. During the irradiation process, the enteric-coated line needs to be turned regularly to make it uniform. irradiated.
The method for preparing a high-strength biological suture according to claim 9, wherein the aseptic liquid spraying assembly comprises a liquid spraying pipe fixed on the top of the aseptic processing chamber. The bottom is provided with a mist-like spray head, the mist-like spray head sprays mist-like sterile liquid toward the operating table, the inlet end of the liquid spray pipe is connected to an external sterile liquid container, and is installed on the liquid spray pipe There is a spray pump.