CN101455858A - Biology collagen brown medical soft suture-thread manufacture method - Google Patents
Biology collagen brown medical soft suture-thread manufacture method Download PDFInfo
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- CN101455858A CN101455858A CNA2009100136087A CN200910013608A CN101455858A CN 101455858 A CN101455858 A CN 101455858A CN A2009100136087 A CNA2009100136087 A CN A2009100136087A CN 200910013608 A CN200910013608 A CN 200910013608A CN 101455858 A CN101455858 A CN 101455858A
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 26
- 108010035532 Collagen Proteins 0.000 title claims abstract description 26
- 229920001436 collagen Polymers 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims abstract description 8
- 238000005406 washing Methods 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000032798 delamination Effects 0.000 claims abstract description 5
- 201000010099 disease Diseases 0.000 claims abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 5
- 239000002657 fibrous material Substances 0.000 claims abstract description 5
- 210000000713 mesentery Anatomy 0.000 claims abstract description 5
- 238000000227 grinding Methods 0.000 claims abstract description 4
- 238000005498 polishing Methods 0.000 claims abstract description 4
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 4
- 238000002791 soaking Methods 0.000 claims abstract description 4
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 12
- 239000004744 fabric Substances 0.000 claims description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000004067 bulking agent Substances 0.000 claims description 5
- 239000003995 emulsifying agent Substances 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- JHWIEAWILPSRMU-UHFFFAOYSA-N 2-methyl-3-pyrimidin-4-ylpropanoic acid Chemical compound OC(=O)C(C)CC1=CC=NC=N1 JHWIEAWILPSRMU-UHFFFAOYSA-N 0.000 claims description 4
- 241000283690 Bos taurus Species 0.000 claims description 4
- ZQOMKIOQTCAGCM-UHFFFAOYSA-L [Na+].[Na+].OS(O)(=O)=O.[O-]S([O-])(=O)=O Chemical compound [Na+].[Na+].OS(O)(=O)=O.[O-]S([O-])(=O)=O ZQOMKIOQTCAGCM-UHFFFAOYSA-L 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 4
- 229960004543 anhydrous citric acid Drugs 0.000 claims description 4
- 238000004061 bleaching Methods 0.000 claims description 4
- 210000000845 cartilage Anatomy 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000010413 mother solution Substances 0.000 claims description 4
- 210000004877 mucosa Anatomy 0.000 claims description 4
- 239000008234 soft water Substances 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 3
- 239000013527 degreasing agent Substances 0.000 claims description 3
- 238000005237 degreasing agent Methods 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 230000000704 physical effect Effects 0.000 claims description 3
- 238000007790 scraping Methods 0.000 claims description 3
- 235000019155 vitamin A Nutrition 0.000 claims description 3
- 239000011719 vitamin A Substances 0.000 claims description 3
- 229940045997 vitamin a Drugs 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 239000000835 fiber Substances 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 230000029663 wound healing Effects 0.000 abstract description 2
- 210000000936 intestine Anatomy 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003925 fat Substances 0.000 abstract 1
- 235000010855 food raising agent Nutrition 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 210000002151 serous membrane Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- -1 sucrose ester Chemical class 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 102000004882 Lipase Human genes 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000010417 needlework Methods 0.000 description 3
- 241000256852 Aculeata Species 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000019832 sodium triphosphate Nutrition 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 238000009954 braiding Methods 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- JOPOVCBBYLSVDA-UHFFFAOYSA-N chromium(6+) Chemical compound [Cr+6] JOPOVCBBYLSVDA-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000012779 reinforcing material Substances 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- Materials For Medical Uses (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
The invention discloses a method for manufacturing a medical apparatus, in particular to a method for manufacturing a soft brown biological collagen medical suture. The method for manufacturing the soft brown biological collagen medical suture is characterized by comprising the following steps: firstly, washing the inner wall of a fresh intestine and casing which has no disease after quarantine to be clean, performing coarse scrapping processing and delamination treatment on mucous membranes, serous membranes and mesenteries in the intestine and casing, and using a raising agent to perform loosening treatment; secondly, separating and cutting off fats in smooth muscle fibers and collagen fibers; thirdly, adding pyro into softened water, soaking fiber materials into the softened water for washing, and performing polymerization processing and setting treatment; and fourthly, using an automatic coreless grinding machine to perform processing and polishing, and performing suture and needle connection. The soft brown biological collagen medical suture has soft line body, easy operation, good positioning performance, high tensile strength and knotting strength and smooth suture-needle connection, reduces inflammation reaction during wound healing, and achieves perfect combination of the suture and a stitching needle.
Description
(1) technical field
The present invention relates to a kind of medical apparatus and instruments manufacture method, particularly a kind of biology collagen brown medical soft suture-thread manufacture method.
(2) background technology
At present, clinical in widely used absorbable medical suture, its quality good or not is directly connected to the rehabilitation of postoperative patient, indicates the manufacturing technology level of product in the contemporary medical instruments field.The import that use in the clinical operation present age can absorb chemosynthesis stitching thread (PGA), belongs to the multiply braiding structure, exists certain defective: easily hide foreign body, dead thalline in the line body structure slit, rough surface is big to human tissue injury.The chemical substance of line body and ethylene oxide residue thing have potential side effects patient's rehabilitation; The chemosynthesis line shelf-life is short, preserves the environmental requirement strictness, and preservation has a big risk.Since the eighties, widely used Bioabsorbable slit zygonema in clinical, line body constitution is hard, knotting is unstable, knot and easily slide, chemical residue has rejection to tissue in its manufacture process, easily produces inflammation between healing stage, directly affect the operation quality, and increase patient's misery; Ordinary sewing pin needlework connect the employing punch ram, fluting envelope curve pin, and Aculeata easily produces different forms such as flat mouth, ellipse, rib shape, and the connecting portion rough surface is big to the towing wound of tissue.
(3) summary of the invention
The present invention is in order to remedy the deficiencies in the prior art, a kind of biology collagen brown medical soft suture-thread manufacture method is provided, this method is reasonable in design, technology is advanced, easy to operate, properties of product are superior, the line system is made the defective of having abandoned the protozoa line in the process, and interpolation can promote that human tissue cell is synthetic, the effective element of repair function.
The present invention is achieved through the following technical solutions:
A kind of biology collagen brown medical soft suture-thread manufacture method, its special character is: comprise the steps: that following concentration is all weight percent concentration: (1) at first selects the collagen fabric in fresh QINGSHANYANG casing, cattle casing or the cartilage for use; Fresh casing through the no disease of quarantine is cleaned inwall, and the mucosa in the casing, serous coat, mesentery are slightly scraped processing delamination processing, with the bulking agent processing of loosening; (2) separate the fat that excises in smooth muscle fiber, the collagen fabric then: in 3%-5% sodium bicarbonate solution, add 6% degreasing agent and 2% food emulsifying agent, in 30-40 ℃ of temperature, pH value 7-10 scope, carry out ungrease treatment, alcoholic solution with 75% concentration, put into 3-4% anhydrous sodium sodium bisulfate and carry out anticorrosion, sterilization, bleaching was soaked 2-3 hour; Soak after 1 hour with medical glycerol and to clean, collagen fabric, smooth muscle fiber are squeezed and shut out dissolving and absorb the unnecessary medicinal liquid in back with carefully scraping machined automatically with soft water; (3) above fibrous material is put into 0.1-0.3 ‰ pyrogallic acid with demineralized water earlier, after soaking washing in 4 hours, again 0.1-0.3 ‰ sodium dichromate mother solution is added anhydrous citric acid 0.1-0.5% and dilute, behind adding vitamin A, the C element, carry out the polymerization process setting treatment again; (4), carry out suture again and be connected with pin with automatic coreless grinding machine processing and polishing; After the physical property detection is qualified, add and preserve the solution packaging sterilizing, promptly make biology collagen brown medical soft suture-thread.
Biology collagen brown medical soft suture-thread manufacture method of the present invention, described step (4) carries out suture and pin is connected to: at first select for use the afterbody perforating needle that suture is inserted in the pin hole, the degree of depth is the 2-3 millimeter, with automatic extruding lathe or hydraulic machine, adopt extruding or roll compacting marching method fixed processing.
Described bulking agent is NaHCO
3Or NH
4HCO
3Degreasing agent is that sodium tripolyphosphate or lipase are Triacylglycerol acylhydrolase, and its catalysis natural biological grease hydrolysis generates fatty acid and glycerol; Food emulsifying agent is a fatty glyceride, perhaps sucrose ester, sorbose alcohol ester, methyl glycol fatty acid ester etc.
Advantage of the present invention: line body softness, easy operating, positioning performance is good; Tensile strength and knot strength height; In prescription, add medical, edible additive and vitamin, the harm of having avoided chemical residue that human body is produced, biocompatibility is good, has reduced the inflammatory reaction in the wound healing; Adopt the suture needle of afterbody laser boring not damaged, needlework connect along sliding, firm, are that present biology line is incomparable, reach the perfect adaptation of suture and suture needle, and it is suitable that needlework connect the garden, and the operation resistance is little, and towing is slight, damages minimum.
(4) specific embodiment
Embodiment 1:
The preparation method of this embodiment following (following concentration is all weight percent concentration):
At first select the collagen fabric in fresh QINGSHANYANG casing, cattle casing or the cartilage for use.Fresh casing through the no disease of quarantine is cleaned inwall, the mucosa in the casing, serous coat, mesentery is slightly scraped the processing delamination handle, and uses bulking agent NaHCO
3The processing of loosening; In order to separate the excision smooth muscle fiber; fat in the collagen fabric; adopt unique technology to be: (many in 3% sodium bicarbonate solution owing to producing acid in the organism metabolism process; so sodium bicarbonate plays an important role in the buffering blood pH; therefore blood and material intermiscibility are good); add 6% lipase Triacylglycerol acylhydrolase and 2% food emulsifying agent fatty glyceride 30 ℃ of temperature; pH value is to carry out ungrease treatment in 7 scopes; alcoholic solution with 75% concentration; put into 4% anhydrous sodium sodium bisulfate and carry out anticorrosion; sterilization; bleaching was soaked 2-3 hour; eliminate the harmful substance in the fiber; soak after 1 hour with medical glycerol then and clean, with collagen fabric with soft water; the Special Automatic crowded unnecessary medicinal liquid in dissolving absorption back that shuts out of machined of carefully scraping of smooth muscle fiber reuse.Above fibrous material is put into 0.3 ‰ pyrogallic acids with demineralized water earlier, after soaking washing in 4 hours, reach the corrosion-resistant effect of effective sterilization, and then 0.3 ‰ sodium dichromate mother solutions are added anhydrous citric acid 0.5% dilute, make hexavalent chromium be converted into trivalent chromium, reduce the toxicity of chromium, the anti-degradability of reinforcing material, the purpose of delayed absorption behind adding vitamin A, the C element, is carried out the polymerization process setting treatment again.Use automatic coreless grinding machine processing and polishing then, carrying out suture again is connected with pin, its process is: at first select afterbody perforating needle (laser beam perforating needle or drill bit perforating needle) for use, suture is inserted in the pin hole, the degree of depth is the 2-3 millimeter, with automatic extruding lathe or hydraulic machine, after adopting advanced " extruding or roll compacting " marching method fixed processing, Aculeata is sliding suitable, and resistance is little, and shape is round, novel structure, little to tissue towing damage, alleviate patient's misery, really reach the effect that not damaged is sewed up.After the physical property detection is qualified, adds and preserve solution packaging sterilizing, the biology collagen brown medical soft suture-thread of promptly making.
Embodiment 2:
The preparation method of this embodiment following (following concentration is all weight percent concentration):
At first select for use the collagen fabric in fresh QINGSHANYANG casing, cattle casing or the cartilage to clean inwall, the mucosa in the casing, serous coat, mesentery are slightly scraped processing delamination processing, with the bulking agent NH4HCO3 processing of loosening through the fresh casing of the no disease of quarantine; In 5% sodium bicarbonate solution, add 6% sodium tripolyphosphate and 2% food emulsifying agent sucrose ester, 35 ℃ of temperature, pH value is to carry out ungrease treatment in 10 scopes, alcoholic solution with 75% concentration, put into 3% anhydrous sodium sodium bisulfate and carry out anticorrosion, sterilization, bleaching was soaked 2-3 hour, eliminate the harmful substance in the fiber, soak after 1 hour with medical glycerol then and clean, carefully scrape machined and squeeze and shut out dissolving and absorb the unnecessary medicinal liquid in back collagen fabric, smooth muscle fiber reuse are Special Automatic with soft water.Above fibrous material is put into 0.1 ‰ pyrogallic acids with demineralized water earlier, soaks washing in 4 hours after, reach the corrosion-resistant effect of effective sterilization, and then 0.1 ‰ sodium dichromate mother solutions adding anhydrous citric acid 0.1% diluted.Other is identical with embodiment 1.
Claims (2)
1. biology collagen brown medical soft suture-thread manufacture method, it is characterized in that: comprise the steps: that following concentration is all weight percent concentration: (1) at first selects the collagen fabric in fresh QINGSHANYANG casing, cattle casing or the cartilage for use; Fresh casing through the no disease of quarantine is cleaned inwall, and the mucosa in the casing, serous coat, mesentery are slightly scraped processing delamination processing, with the bulking agent processing of loosening; (2) separate the fat that excises in smooth muscle fiber, the collagen fabric then: in 3%-5% sodium bicarbonate solution, add 6% degreasing agent and 2% food emulsifying agent, in 30-40 ℃ of temperature, pH value 7-10 scope, carry out ungrease treatment, alcoholic solution with 75% concentration, put into 3-4% anhydrous sodium sodium bisulfate and carry out anticorrosion, sterilization, bleaching was soaked 2-3 hour; Soak after 1 hour with medical glycerol and to clean, collagen fabric, smooth muscle fiber are squeezed and shut out dissolving and absorb the unnecessary medicinal liquid in back with carefully scraping machined automatically with soft water; (3) above fibrous material is put into 0.1-0.3 ‰ pyrogallic acid with demineralized water earlier, after soaking washing in 4 hours, again 0.1-0.3 ‰ sodium dichromate mother solution is added anhydrous citric acid 0.1-0.5% and dilute, behind adding vitamin A, the C element, carry out the polymerization process setting treatment again; (4), carry out suture again and be connected with pin with automatic coreless grinding machine processing and polishing; After the physical property detection is qualified, add and preserve the solution packaging sterilizing, promptly make biology collagen brown medical soft suture-thread.
2. biology collagen brown medical soft suture-thread manufacture method according to claim 1, it is characterized in that: described step (4) carries out suture and pin is connected to: at first select for use the afterbody perforating needle that suture is inserted in the pin hole, the degree of depth is the 2-3 millimeter, with automatic extruding lathe or hydraulic machine, adopt extruding or roll compacting marching method fixed processing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100136087A CN101455858B (en) | 2009-01-04 | 2009-01-04 | Biology collagen brown medical soft suture-thread manufacture method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100136087A CN101455858B (en) | 2009-01-04 | 2009-01-04 | Biology collagen brown medical soft suture-thread manufacture method |
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| Publication Number | Publication Date |
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| CN101455858A true CN101455858A (en) | 2009-06-17 |
| CN101455858B CN101455858B (en) | 2012-05-23 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638552A (en) * | 2013-12-12 | 2014-03-19 | 董新义 | Preparation method of biochemical complexing off-white medical absorbable suture line |
| CN104069541A (en) * | 2013-12-04 | 2014-10-01 | 江西龙腾生物高科技有限公司 | Preparation method of collagen suture line |
| CN104491920A (en) * | 2014-12-19 | 2015-04-08 | 山东博达医疗用品有限公司 | Method for preparing absorbable suture |
| CN104524626A (en) * | 2014-12-19 | 2015-04-22 | 山东博达医疗用品有限公司 | Absorbable collagen protein snare line and preparation method thereof |
| CN105288716A (en) * | 2015-12-02 | 2016-02-03 | 单县华宇缝合制品有限公司 | Dye for preparing brown catgut capable of quickening wound healing speed |
| CN105381498A (en) * | 2015-12-02 | 2016-03-09 | 单县华宇缝合制品有限公司 | Dye for preparing brown catgut suture |
| CN106215224A (en) * | 2016-08-29 | 2016-12-14 | 刘畅 | A kind of chrome liquor of chromic suture |
| CN107875435A (en) * | 2017-11-21 | 2018-04-06 | 菏泽海诺知识产权服务有限公司 | A kind of preparation technology of absorbability medical catgut |
| CN110025819A (en) * | 2019-05-24 | 2019-07-19 | 山东省科学院新材料研究所 | A kind of technique removing catgut fat |
| CN113663115A (en) * | 2021-08-23 | 2021-11-19 | 山东博达医疗用品股份有限公司 | Preparation method of collagen-coated absorbable medical suture |
| WO2022095028A1 (en) * | 2020-11-07 | 2022-05-12 | 单县华宇缝合制品有限公司 | High-strength biological suture line and preparation method therefor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE18445T1 (en) * | 1981-11-13 | 1986-03-15 | Chemokol Ges Kollagenprod | PROCESS FOR THE PREPARATION OF COLLAGEN MATERIAL FOR SURGICAL PURPOSES. |
| CN1183971C (en) * | 2001-06-20 | 2005-01-12 | 任晓艳 | Medicinal catgut |
| CN1425473A (en) * | 2001-12-10 | 2003-06-25 | 王桂法 | Process for producing medical absorptive animal protein fibre net |
| CN1363397A (en) * | 2002-01-08 | 2002-08-14 | 江西龙腾实业有限公司 | Process for preparing medical suture bio-silk from goat intestines |
-
2009
- 2009-01-04 CN CN2009100136087A patent/CN101455858B/en active Active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069541A (en) * | 2013-12-04 | 2014-10-01 | 江西龙腾生物高科技有限公司 | Preparation method of collagen suture line |
| CN103638552A (en) * | 2013-12-12 | 2014-03-19 | 董新义 | Preparation method of biochemical complexing off-white medical absorbable suture line |
| CN104491920A (en) * | 2014-12-19 | 2015-04-08 | 山东博达医疗用品有限公司 | Method for preparing absorbable suture |
| CN104524626A (en) * | 2014-12-19 | 2015-04-22 | 山东博达医疗用品有限公司 | Absorbable collagen protein snare line and preparation method thereof |
| CN105288716A (en) * | 2015-12-02 | 2016-02-03 | 单县华宇缝合制品有限公司 | Dye for preparing brown catgut capable of quickening wound healing speed |
| CN105381498A (en) * | 2015-12-02 | 2016-03-09 | 单县华宇缝合制品有限公司 | Dye for preparing brown catgut suture |
| CN106215224A (en) * | 2016-08-29 | 2016-12-14 | 刘畅 | A kind of chrome liquor of chromic suture |
| CN107875435A (en) * | 2017-11-21 | 2018-04-06 | 菏泽海诺知识产权服务有限公司 | A kind of preparation technology of absorbability medical catgut |
| CN110025819A (en) * | 2019-05-24 | 2019-07-19 | 山东省科学院新材料研究所 | A kind of technique removing catgut fat |
| CN110025819B (en) * | 2019-05-24 | 2021-09-07 | 山东省科学院新材料研究所 | Process for removing catgut fat |
| WO2022095028A1 (en) * | 2020-11-07 | 2022-05-12 | 单县华宇缝合制品有限公司 | High-strength biological suture line and preparation method therefor |
| CN113663115A (en) * | 2021-08-23 | 2021-11-19 | 山东博达医疗用品股份有限公司 | Preparation method of collagen-coated absorbable medical suture |
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| Publication number | Publication date |
|---|---|
| CN101455858B (en) | 2012-05-23 |
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