CN109276745A - A kind of cellulose combine dressing of high wet strength and preparation method thereof - Google Patents
A kind of cellulose combine dressing of high wet strength and preparation method thereof Download PDFInfo
- Publication number
- CN109276745A CN109276745A CN201811495331.1A CN201811495331A CN109276745A CN 109276745 A CN109276745 A CN 109276745A CN 201811495331 A CN201811495331 A CN 201811495331A CN 109276745 A CN109276745 A CN 109276745A
- Authority
- CN
- China
- Prior art keywords
- cellulose
- aqueous solution
- dressing
- wet strength
- high wet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002678 cellulose Polymers 0.000 title claims abstract description 73
- 239000001913 cellulose Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000000243 solution Substances 0.000 claims abstract description 62
- 239000007864 aqueous solution Substances 0.000 claims abstract description 43
- 238000006243 chemical reaction Methods 0.000 claims abstract description 26
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 21
- 239000013066 combination product Substances 0.000 claims abstract description 14
- 229940127555 combination product Drugs 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 14
- 230000002378 acidificating effect Effects 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000004132 cross linking Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 238000004108 freeze drying Methods 0.000 claims abstract description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 11
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 10
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 10
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 239000000835 fiber Substances 0.000 claims description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
- 230000035484 reaction time Effects 0.000 claims description 7
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 239000004593 Epoxy Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- -1 hydroxypropyl Chemical group 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 37
- 238000005213 imbibition Methods 0.000 abstract description 7
- 230000007547 defect Effects 0.000 abstract description 6
- 239000004971 Cross linker Substances 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 51
- 208000027418 Wounds and injury Diseases 0.000 description 51
- 239000010410 layer Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 24
- 230000035876 healing Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 10
- 239000002994 raw material Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- 238000001879 gelation Methods 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000001684 chronic effect Effects 0.000 description 7
- 230000000474 nursing effect Effects 0.000 description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 6
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 6
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 6
- 229920002643 polyglutamic acid Polymers 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000007710 freezing Methods 0.000 description 5
- 230000008014 freezing Effects 0.000 description 5
- 239000008273 gelatin Substances 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 235000011852 gelatine desserts Nutrition 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- LFKLPJRVSHJZPL-UHFFFAOYSA-N 1,2:7,8-diepoxyoctane Chemical compound C1OC1CCCCC1CO1 LFKLPJRVSHJZPL-UHFFFAOYSA-N 0.000 description 4
- 206010070834 Sensitisation Diseases 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 229910001385 heavy metal Inorganic materials 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 244000309715 mini pig Species 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000008313 sensitization Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 231100000135 cytotoxicity Toxicity 0.000 description 3
- 230000003013 cytotoxicity Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229940015043 glyoxal Drugs 0.000 description 3
- 230000036074 healthy skin Effects 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 210000004969 inflammatory cell Anatomy 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010007269 Carcinogenicity Diseases 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 101710112752 Cytotoxin Proteins 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001071864 Lethrinus laticaudis Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 229920001954 Restylane Polymers 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 231100000260 carcinogenicity Toxicity 0.000 description 1
- 230000007670 carcinogenicity Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 description 1
- 229940005991 chloric acid Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 229940091173 hydantoin Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000012783 reinforcing fiber Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000009724 venous congestion Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
Abstract
The invention discloses a kind of cellulose combine dressing of high wet strength, the dressing is from top to bottom respectively cellulose sponge layer, sterile gauze layer, cellulose sponge layer；The cellulose sponge layer is made using cellulose and its derivates aqueous solution, acidic aqueous solution or alkaline aqueous solution, crosslinking agent mixing crosslinking；The dressing is in spongy.In addition, including the following steps: to be sequentially added into acidic aqueous solution or alkaline aqueous solution in the aqueous solution of cellulose and its derivates the invention also discloses the preparation method of the cellulose combine dressing of the high wet strength, crosslinking agent, water-bath cross-linking reaction is carried out；By sterile gauze single berth on mold, crosslinker solution progress pre-freeze is poured into, freeze-drying obtains combination product；Combination product is cut, is dispensed, sterilize to get.The present invention efficiently solves the insufficient defect of bio-sponge mechanical property, and effectively reduces cost；The flexibility and water imbibition of cellulosic material are remained, and significantly improves product wet strength.
Description
Technical field
The present invention relates to biomedical materials fields, the porous absorbent dressing suitable for body surface for hemostasis, especially
It is related to a kind of cellulose combine dressing of high wet strength；Moreover, it relates to the preparation side of the cellulose combine dressing
Method.
Background technique
Chronic wounds, as venous congestion ulcer, pressure ulcer, diabetic foot ulcers and other chronic ulcers are hurt
Mouthful, including cave type or umbilicate type ulcer wound, a large amount of diffusates can be generated in agglutination, some wounds can be at 24 hours
Interior exudation is up to the diffusate of 50ml.Therefore the dressing with high liquid absorption amount is needed to absorb diffusate, clinically to prevent bacterium
It breeds and infects, the most ideal situation is that after wound dressing absorbs diffusate, it can be by full wafer for the surface wound of large area
Removal, and then can entirely taking away for chamber hole type wound, while wet strength is lower after will not absorbing diffusate because of wound dressing
And it is damaged.In general wound dressing of the wet strength lower than 0.1N/cm cracky in removal process, to aggravate wound care
The degree of difficulty of work, or even the possibility for having damaged wound dressing to remain in wound surface, can cause wound and surrounding skin
Accompanying infection.
In recent years, with the further investigation of biomedical material, people increasingly pay attention to the safety of nursing class product,
It is required that it is also higher and higher, it can such as be absorbed degradation with the contact material of the surface of a wound, can be metabolized in vivo, is non-toxic, it is clinical right
The demand of biological species material is very vigorous, but biological species material have the defects that one it is common be exactly that mechanical strength is poor, replacement of products
Fracture is easily caused in the process.
Aquacel wound dressing is most common Wound care dressing, and products characteristics are as follows: 1) having very strong suction
Receipts ability, imbibition rate are up to 15 times of own wt；2) clear gel is formed after absorbent solution；3) there is lower lateral hair
Thin characteristic；4) in absorbing wound exudate after-contraction.Afterwards two for chronic wounds processing it is especially important, at chronic wounds
In reason mostly undesired situation first is that the dipping of wound fluid, i.e. wound fluid bleed around until periphery healthy skin
Skin, dipping is likely to result in the infection or damage of periphery healthy skin frequent occurrence.Most of other kinds of wound dressings
Wound fluid can be caused to spread to the healthy skin of surrounding due to lateral capillarity, but there is low-down lateral capillary
Characteristic, it is possible to reduce the generation of such case.In addition, reducing after water suction, this will reduce the weight of the skin and wound dressing of surrounding
A possibility that folding, further reduced dipping.Another is plastic in the advantages of clinical application, during wound healing, wound
The few fibers of dressing " are sticked to " on wound sometimes and are not easy to remove.Using plastic characteristic, can first be soaked with physiological saline deposited
Expect the fiber plastic after-tack for making these " viscous " on wound or washed away by physiological saline, so that wound removal be made no longer to be one
The process of pain, improves the quality of life of patient during wound care.
The structure of existing wound dressing generally uses whole spongelike structure, but it has following defects that polymeric hydantoin
Continuous (polyvinyl alcohol, polyurethane etc.) because its hardness is relatively high, brittleness is larger, is not suitable for winding and uses；Bio-sponge (gelatin sea
Silk floss, collagen protein sponge, chitosan etc.) because of its preparation process complexity, so production higher cost, and it is used alone
Poor mechanical property, nursing process are easily broken off, so clinic needs a kind of i.e. economical and practical and mechanical strength higher while flexible
The preferable sponge dressing of property.
Chinese utility model patent CN201520871794 discloses a kind of dedicated wrapping dressing of limbs war wound emergency treatment, specially
Sharp product design mainly solves the case where war wound emergency treatment big bleeding, and major function design inclination is in quick-acting haemostatic powder, quick drainage,
The big feature of liquid absorption amount, the polyvinyl formal spongy layer that middle layer uses, major function are exactly imbibition expansion while oppressing
Hemostasis, but the generally existing hardness of macromolecule sponge is high, the feature of flexibility difference, so the design of middle layer macromolecule sponge will lead to
Entire product applicating property is poor.
Chinese invention patent application CN201711166122.8 discloses a kind of biologically active composite sponge auxiliary material
And the preparation method and application thereof.Its object is to develop a kind of cellulose casting product of promoting healing, by adding γ-polyglutamic
Acid and epoxychloropropane are reacted, and wherein experimental example can clearly find out the addition with gamma-polyglutamic acid, promoting healing effect
Fruit is obvious, and the effect of gamma-polyglutamic acid additive is promoting healing, but due to gamma-polyglutamic acid and epichlorohydrin crosslinker,
It uses toxicologic study still immature in human body, so to develop into medical supplies, still needs to carry out material toxicity, internal generation
It thanks, the further research such as carcinogenicity.And it is using traditional whole spongelike structure, however it remains poor mechanical property,
The problems such as nursing process is easily broken off.
United States Patent (USP) US3096228 discloses a kind of method of reinforcing fiber product wet strength.It is in cellulose fibre
A kind of reagent for being named as glyoxal is introduced, cellulosic molecule can be made more closely with the radical polymerisations such as the hydroxyl of cellulose, crosslinking
It links together, so as to while keeping this substance high-hygroscopicity and at colloidality, keep higher wet strong
Degree.However the glyoxal toxicity of this method addition is higher.
Therefore, so far, it is still necessary to which developing a kind of highly-safe can either have absorbability and gelation and can also
It is enough that the wound dressing of bigger wet strength is provided.
Summary of the invention
One of the technical problem to be solved in the present invention is to provide a kind of high humidity strength element combine dressing, effectively solve
Bio-sponge mechanical property insufficient defect, and effectively reduce cost；Retain the comfort of cellulose material itself and soft
It is soft, while increasing gelation and high wet strength of the product in use process, enhance clinical applicability, such as the burning of large area
When scald and chronic wounds processing, removing for full wafer is may be implemented in when dressing, brings convenience to nursing, while product gelation can
The secondary damage to wound is avoided, and highly-safe.
The second technical problem to be solved by the present invention is to provide a kind of preparation side of high humidity strength element combine dressing
Method, this method simple process, easy to operate, feasibility is strong.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is that:
In one aspect of the invention, a kind of cellulose combine dressing of high wet strength is provided, the dressing is from top to bottom distinguished
For cellulose sponge layer, sterile gauze layer, cellulose sponge layer；The cellulose sponge layer uses cellulose and its derivates water
Solution, acidic aqueous solution or alkaline aqueous solution, crosslinking agent mixing crosslinking are made；The dressing is in spongy.
As currently preferred technical solution, the dressing is from top to bottom respectively the cellulose sponge of 1-4cm thickness
The cellulose sponge layer of layer, the sterile gauze layer of 0.01mm thickness, 1-4cm thickness.
As currently preferred technical solution, the porosity of the cellulose sponge layer reaches 80% or more, and micropore is big
Small is 10-50 μm.
In another aspect of this invention, a kind of preparation method of the cellulose combine dressing of high wet strength is provided, including such as
Lower step:
(1) certain density cellulose and its derivates aqueous solution is prepared, stirs evenly and makes it completely dissolved；
(2) acidic aqueous solution or alkaline aqueous solution will be sequentially added in order in solution, crosslinking agent stirs evenly；
(3) mixed liquor of step (2) is subjected to water-bath cross-linking reaction at a certain temperature；
(4) by sterile gauze single berth on mold, the reaction solution for pouring into step (3) carries out pre-freeze, freeze-drying obtains sponge
Shape combine dressing；
(5) the spongy combine dressing that step (4) obtains cut, dispensed, sterilized, obtain a kind of fiber of high wet strength
Plain combine dressing.This is used for cellulose combine dressing for wound care, hemostasis.
As currently preferred technical solution, in step (1), the cellulose and its derivates aqueous solution, including
And the one or more for being not limited to carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPMC) etc.
Mixture, the concentration of solution about 1-5%.
As currently preferred technical solution, the brookfield viscosity of the cellulose and its derivates is about 150-
6500mPa.s。
As currently preferred technical solution, in step (2), the alkaline aqueous solution is sodium hydroxide, carbonic acid
Any one in hydrogen sodium, calcium bicarbonate, the concentration of the alkaline aqueous solution are 0.2-0.8mol/L, the alkaline aqueous solution with
The volume ratio of reaction solution is 2:100-6:100；The acidic aqueous solution is acetic acid, malic acid, citric acid, any in hydrochloric acid
One kind, the concentration of the acidic aqueous solution are 0.1-1.0mol/L, and the volume ratio of the acidic aqueous solution and reaction solution is 2:
100-8:100.
As currently preferred technical solution, in step (2), the crosslinking agent, including 1,4-butanediol two are shunk
Glycerin ether (BDDE) or 1, diepoxides or 1- (3- dimethylamino-propyl) -3- ethyl of 2,7,8- diepoxyoctanes
Carbodiimide (EDC)；The mass ratio of the crosslinking agent and material is 1:0.1-1:0.8.
As currently preferred technical solution, in step (3), the bath temperature of the water-bath cross-linking reaction is 30-
90 DEG C, reaction time 2-12h.
As currently preferred technical solution, in step (4), the temperature of the pre-freeze is -20 DEG C, freeze-drying temperature
Degree is -50 DEG C.
Compared with prior art, the beneficial effects of the present invention are:
Compared with the existing general traditional dressing using whole spongelike structure, the present invention is added single layer sterile gauze and answers
It closes, efficiently solves the insufficient defect of bio-sponge mechanical property, and effectively reduce cost.
Compared with Chinese utility model patent CN201520871794, present invention design continues mainly for chronic wounds
Sepage and oozing of blood, product design is simple, and the flexibility for remaining cellulose material is good, stick close advantage, inhale simultaneously
Gelation easily removes and noresidue after liquid, and Chinese utility model patent CN201520871794 and the internal layer of skin contact are shells
Glycan fiber filament may result in undesirable infection easily with wound adhesion when nursing is replaced.
Compared with Chinese patent application CN201711166122.8 and United States Patent (USP) US3096228, Chinese patent application
The safety of CN201711166122.8 additive gamma-polyglutamic acid is not confirmed, the friendship that the glyoxal toxicity present invention uses
Connection agent has successful application case in medical instruments field, what Q-med company of Sweden beauty and shaping product Restylane was used
It is exactly that diepoxides is crosslinked, Seprafilm biological absorbable anti-adhesion membrane in the U.S. uses EDC crosslinking agent, faces
Bed safety has been approved, and safety is higher.Gamma-polyglutamic acid adds in Chinese patent application CN201711166122.8
The effect of agent is promoting healing, and the effect of acidic aqueous solution or alkaline aqueous solution is to form ester bond or ehter bond must be anti-in the present invention
Condition is answered, to maintain the gelation of sponge, therefore, the effect of the two is different.
High humidity strength element combine dressing of the present invention retains the flexibility and water imbibition, comfort of cellulose material itself
And flexibility, while increasing gelation and high wet strength of the product in use process, enhance clinical applicability.By cellulose and
Its derivative aqueous solution (for example, HPMC and HEC) carries out crosslinking and is made the form of sponge, the space three-dimensional porous structure of intersection,
Make product have high-absorbable and gelation, while be added single layer sterile gauze carry out it is compound, efficiently solve bio-sponge power
Learn the insufficient defect of performance.In practical applications, when for example the burn and scald of large area and chronic wounds handle, when dressing, can be real
Removing for existing full wafer, brings convenience to nursing, while product gelation can avoid the secondary damage to wound.In addition, of the invention
High humidity strength element combine dressing detects through determining heavy metals, aseptic experiment, endotoxin detection, vitro cytotoxicity, is intradermal
Stimulation, sensitization test (STT) verifying prove that its toxicity is lower, securely and reliably.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the cellulose combine dressing of high wet strength of the present invention.
Fig. 2 is the micro-structure diagram of cellulose combine dressing spongy layer in the embodiment of the present invention 2.
Fig. 3 is the healing photo of the small porcine skin surface of a wound in experimental example 8 of the present invention, wherein 1 to represent cellulose of the present invention compound
Casting product group；2 represent absorbability gelatin foam group；3 represent sterile gauze group.
Fig. 4 is the dyeing schematic diagram of the full cortex healing skin of pig in experimental example 8 of the present invention, and wherein Fig. 4 (a) represents the present invention
Cellulose combine dressing product group；Fig. 4 (b) represents absorbability gelatin foam group；Fig. 4 (c) represents sterile gauze group.
Specific embodiment
The present invention will be described in the following with reference to the drawings and specific embodiments, involved in technical method such as in this hair
It is not illustrated in bright, is then this field convenient technical process, therefore repeat no more.
As shown in Figure 1, a kind of cellulose combine dressing of high wet strength of the present invention is from top to bottom respectively cellulose sponge
Layer A, sterile gauze layer B, cellulose sponge layer C；The cellulose sponge layer A and cellulose sponge layer C using cellulose and its
Derivative aqueous solution, acidic aqueous solution or alkaline aqueous solution, the mixing crosslinking of diepoxides crosslinking agent are made；The dressing
In spongy.The thickness of cellulose sponge layer A is about 1-4cm, and the thickness of sterile gauze layer B is about 0.01mm, cellulose sponge
The thickness of layer C is about 1-4cm.The porosity of cellulose sponge layer A and cellulose sponge layer C reach 80% or more, and micropore size is
10-50μm。
It is to prepare embodiment below:
Embodiment 1
A kind of cellulose combine dressing of high wet strength and preparation method thereof, includes the following steps:
It (1) is the ratio (body of 1% HPMC aqueous solution and 4% HEC aqueous solution in 1:1 by prepared mass percent concentration
Product ratio) mixing 600mL, and stir evenly；
(2) by the mixed liquor of step (1) sequentially add in proportion 0.2mol/L sodium bicarbonate solution and a certain amount of bis-epoxy
1,2,7,8-diepoxyoctane 3g of compound crosslink agent, stirs evenly；
(3) reaction solution of step (2) is subjected to water-bath, 60 DEG C of bath temperature, reaction time 3h；
(4) by sterile gauze single berth on mold, the reaction solution of step (3) is poured into, carries out -20 DEG C of pre-freezes, -50 DEG C of freezings are dry
It is dry to obtain combination product；
(5) the spongy combination product that step (4) obtains cut, dispensed, sterilized, obtained for the compound of wound care
Dressing.
The raw material HPMC solution viscosity is 150-400mPa.s, and the HEC solution viscosity is 1500-
2500mPa.s。
In the reaction mixture, the mass ratio of 1,2,7,8-diepoxyoctane of raw material and crosslinking agent is 1:0.1
(W/W), the volume ratio of lye sodium bicarbonate solution and reaction solution is 6:100(V:V).
Embodiment 2
A kind of cellulose combine dressing of high wet strength and preparation method thereof, includes the following steps:
(1) the HEC aqueous solution 600mL that prepared mass percent concentration is 2% is stirred evenly；
(2) by the solution of step (1) sequentially add in proportion 0.8mol/L NaOH solution and a certain amount of diepoxides
Crosslinking agent 1,4-butanediol diglycidyl ether 3.6g, stirs evenly；
(3) reaction solution of step (2) is subjected to water-bath, 45 DEG C of bath temperature, reaction time 4h；
(4) by sterile gauze single berth on mold, the reaction solution of step (3) is poured into, carries out -20 DEG C of pre-freezes, -50 DEG C of freezings are dry
It is dry to obtain combination product；
(5) the spongy combination product that step (4) obtains cut, dispensed, sterilized, obtained for the compound of wound care
The microstructure of dressing, gained cellulose combine dressing spongy layer is as shown in Figure 2.
The raw material HEC solution viscosity is 1500-2500mPa.s.
In the reaction mixture, the mass ratio of raw material and crosslinking agent 1,4-butanediol diglycidyl ether is 1:0.3
(W/W), lye NaOH solution and the volume ratio of reaction solution are 2:100(V:V).
Embodiment 3
A kind of cellulose combine dressing of high wet strength and preparation method thereof, includes the following steps:
(1) the CMC aqueous solution 600mL for being 1% by prepared mass percent concentration, stirs evenly；
(2) solution of step (1) is sequentially added to the citric acid solution and a certain amount of bis-epoxy chemical combination of 0.5mol/L in proportion
1,2,7,8- diepoxyoctane 4.8g of object crosslinking agent, stirs evenly；
(3) reaction solution of step (2) is subjected to water-bath, 90 DEG C of bath temperature, reaction time 2h；
(4) by sterile gauze single berth on mold, the reaction solution of step (3) is poured into, carries out -20 DEG C of pre-freezes, -50 DEG C of freezings are dry
It is dry to obtain combination product；
(5) the spongy combination product that step (4) obtains cut, dispensed, sterilized, obtained for the compound of wound care
Dressing.
The raw material CMC solution viscosity is 4000-6500mPa.s
In the reaction mixture, the mass ratio of 1,2,7,8- diepoxyoctane of raw material and crosslinking agent is 1:0.8(W/W),
The volume ratio of acid solution citric acid solution and reaction solution is 8:100(V:V).
Embodiment 4
A kind of cellulose combine dressing of high wet strength and preparation method thereof, includes the following steps:
It (1) is the ratio of 2.5% CMC aqueous solution and 2.5% HEC aqueous solution in 1:1 by prepared mass percent concentration
(volume ratio) mixes 600mL, and stirs evenly；
(2) mixed liquor of step (1) is sequentially added to the acetum and a certain amount of bis-epoxy chemical combination of 1.0mol/L in proportion
Object crosslinking agent 1,4-butanediol diglycidyl ether 7.5g, stirs evenly；
(3) reaction solution of step (2) is subjected to water-bath, 60 DEG C of bath temperature, reaction time 4h；
(4) by sterile gauze single berth on mold, the reaction solution of step (3) is poured into, carries out -20 DEG C of pre-freezes, -50 DEG C of freezings are dry
It is dry to obtain combination product；
(5) the spongy combination product that step (4) obtains cut, dispensed, sterilized, obtained for the compound of wound care
Dressing.
The raw material CMC solution viscosity is 4000-6500mPa.s, and the HEC solution viscosity is 4700-
5500mPa.s。
In the reaction mixture, raw material and crosslinking agent 1,4-butanediol diglycidyl ether mass ratio are 1:0.5(W/
W), the volume ratio of acid solution acetum and reaction solution is 2:100(V:V).
Embodiment 5
A kind of cellulose combine dressing of high wet strength and preparation method thereof, includes the following steps:
It (1) is ratio mixing (volume ratio) of the 5%CMC and 1%HPMC solution in 1:5 by prepared mass percent concentration
600mL is stirred evenly；
(2) aqueous solution of step (1) is sequentially added to the hydrochloric acid solution and a certain amount of bis-epoxy chemical combination of 0.1mol/L in proportion
Object crosslinking agent 1- (3- dimethylamino-propyl) -3- ethyl carbodiimide (EDC) 5g, stirs evenly；
(3) reaction solution of step (2) is subjected to water-bath, 65 DEG C of bath temperature, reaction time 4h；
(4) by sterile gauze single berth on mold, the reaction solution of step (3) is poured into, carries out -20 DEG C of pre-freezes, -50 DEG C of freezings are dry
It is dry to obtain combination product；
(5) the spongy combination product that step (4) obtains cut, dispensed, sterilized, obtained for the compound of wound care
Dressing.
The raw material CMC solution viscosity is 1500-2500mPa.s, and HPMC solution viscosity is 150-
400mPa.s
In the reaction mixture, raw material and crosslinking agent 1- (3- dimethylamino-propyl) -3- ethyl carbodiimide (EDC) quality
Than for 1:0.5(W/W), the volume ratio of acid solution hydrochloric acid solution and reaction solution is 5:100(V:V).
Experimental example
Effect of the invention is further elaborated below by way of experimental example:
The measurement of 1 water absorption rate of experimental example
Water absorption rate indicates the weight of every gram of product imbibition.The sponge sample for taking the present invention dry, thickness is identical, cut out rectangle,
It is each 3 pieces round and irregular shape, respective weight W1 is weighed, is immersed in 37 DEG C of physiological saline respectively, 5min is impregnated and sufficiently inhales
Water gently clamps one jiao with pincet, leaves the water, drain after moisture (aerial to stop about 1min) afterwards weigh its weight W2.It presses
It is calculated according to water absorption rate calculation formula, water absorption rate (g/g)=[W2(g)-W1(g)]/W1(g) averaged.It the results are shown in Table 1.
The test of 2 wet strength of experimental example
Wound dressing sample of the present invention is cut into the strip sample of 5.5cm wide, length is at least 8cm.Sample doubling is put into Sheng
Have in the container of physiological saline, solution height about 2cm, sample infiltration after take out, guarantee both ends there are about 1cm at be drying regime,
Specimen holder is gone out into container, its both ends is put into the fixture of imported electronic fabric strength tester, clamps the top and bottom of sample respectively, is surveyed
The two jaws distance for trying instrument is 5cm, and the speed of service that jaw is arranged is 10cm/ min, and the maximum that record destroys sample is exerted oneself
(N), same wound dressing is repeated above-mentioned experiment at least 5 times, obtains 5 wet strength values, and calculate average value, as a result sees
Table 1.
The comparison of the water absorption rate, dry strength and wet strength of 1 sample of table
Remarks: the sample before not combining does not add the sponge products of sterile gauze；Product after combination is to load sterile gauze
Joint product.
As can be seen from Table 1, combination front and back only slightly increases the change of product liquid absorption amount, and dry strength can be enhanced
To original at least 7 times or more, wet strength be can be enhanced to original 20 times or more, hence it is evident that increase product in use process
Gelation and high wet strength, provide convenience to clinical nursing procedure.
3 determining heavy metals of experimental example
The joint product 1g of Example 1 ~ 5 is surveyed according to the Residue on ignition check method of " Chinese Pharmacopoeia 2015 editions " the 4th 0841
Fixed (blazing temperature is 500 ~ 600 DEG C).According to " Chinese Pharmacopoeia 2015 editions " the 4th 0821 heavy metal inspection technique measurement, heavy metal
Testing result < 20ppm.
4 aseptic experiment of experimental example
It is carried out according to method as defined in GB/T 14233.2-2005, the joint product obtained to embodiment 1 ~ 5 detects, and ties
Fruit shows sterile.
The detection of 5 endotoxin of experimental example
It is carried out according to test according to method as defined in GB/T 14233.2-2005.Endogenous toxic material is carried out to the joint product of embodiment 1 ~ 5
Element detection, as the result is shown endotoxin all≤0.5Eu/ml.
The detection of 6 vitro cytotoxicity of experimental example
According to GB/T 16886.5-2003 BiologicalEvaluationofMedicalDevice: vitro cytotoxicity test obtains embodiment 1 ~ 5
The joint product obtained carries out cytotoxin detection, takes leaching liquor, and testing result shows cytotoxicity≤2 grade.
The intradermal stimulation of experimental example 7, sensitization test (STT)
Picosecond laser pulse: carrying out according to method as defined in GB/T 16886.10-2005, obtains to embodiment 1 ~ 5 compound
Product is detected, as the result is shown without skin wound repair；Sensitization of skin: according to side as defined in GB/T 16886.10-2005
Method carries out, and the joint product obtained to embodiment 1 ~ 5 detects, and reacts as the result is shown without sensitization of skin.
The test of 8 piggy skin healing of experimental example
Healthy miniature pig 10 is randomly divided into negative control group (sterile gauze), positive controls (the auspicious grace absorbability in Jiangxi
Gelfoam), product group (cellulose combine dressing of the present invention), full cortex resection operation model, 3d is free before miniature pig is tested
Feed.8% sodium sulfide solution removal back wool of 1d before testing.After for 24 hours, in 70% ethanol disinfection of preserved skin area, 10% is hydrated chlorine
Sour intraperitoneal injection of anesthesia (1-1.5mL/kg).With surgical scissors and tweezers, 6 diameters are cut off in each pig back linea vertebralis two sides
For the full thick-layer skin of 1.5 × 1.5cm.Combine dressing product of the present invention and absorbability gelfoam (positive control) are used respectively
It in two sides wound, is covered, then bandaged with paraffin degreasing gauze.15d after operation, 10% hydration chloric acid intraperitoneal injection fiber crops
Liquor-saturated, the clip holostrome surface of a wound is observed for histology.Histoorgan is fixed through 10% formalin, routine paraffin wax embedding, slice thick 4~5
μm, HE and Masson trichrome stain.The healing state of the digital camera shooting record surface of a wound,
See that Fig. 3 photo records: 1: cellulose combine dressing product group of the present invention；2: absorbability gelatin foam group；3: sterile yarn
Cloth group.As shown in Figure 1, more 1st day in oozing of blood and sepage, from figure 3, it can be seen that cellulose combine dressing of the invention
Product group 1 compares absorbability gelatin foam group 2, and imbibition is preferable, applicating property is preferable, and product bounces back after imbibition, Bu Huifa
Raw infiltrate to surrounding health tissue is infected, and does not have the case where blood exudation.The skin of miniature pig heals substantially in 15 days, more
Phenomena such as during conjunction without obvious hemotoncus, necrosis, infection, compare gauze group 3, it can be seen that the wound of healing is also more smooth.
As shown in figure 4, the dyeing of the full cortex healing skin of miniature pig, cellulose combine dressing product group of the present invention is (see Fig. 4
(a)) many less than sterile gauze group (see Fig. 4 (c)) inflammatory cell, the case where healing of tissue no hyper-proliferative, occurs.
Since cellulose material has the presence of sodium ion, so participating in playing the work of a degree of control infection in agglutination
With so product group is compared with the control group, inflammatory cell will lack.
Claims (10)
1. a kind of cellulose combine dressing of high wet strength, which is characterized in that the dressing is from top to bottom respectively cellulose
Spongy layer, sterile gauze layer, cellulose sponge layer；The cellulose sponge layer uses cellulose and its derivates aqueous solution, acid
Property aqueous solution or alkaline aqueous solution, crosslinking agent mixing crosslinking be made；The dressing is in spongy.
2. dressing as described in claim 1, which is characterized in that the dressing is from top to bottom respectively the fiber of 1-4cm thickness
Plain spongy layer, the sterile gauze layer of 0.01mm thickness, 1-4cm thickness cellulose sponge layer.
3. dressing as claimed in claim 1 or 2, which is characterized in that the porosity of the cellulose sponge layer reach 80% with
On, micropore size is 10-50 μm.
4. a kind of preparation method of the cellulose combine dressing of high wet strength as described in any one of claims 1-3, feature
It is, includes the following steps:
(1) certain density cellulose and its derivates aqueous solution is prepared, is stirred evenly；
(2) solution of step (1) is sequentially added into a certain amount of acidic aqueous solution or alkaline aqueous solution and crosslinking agent in order, is stirred
It mixes uniformly；
(3) mixed liquor of step (2) is subjected to water-bath cross-linking reaction at a certain temperature；
(4) by sterile gauze single berth on mold, the reaction solution of step (3) is poured into, carries out pre-freeze, freeze-drying obtains sponge
Shape combination product；
(5) the spongy combination product that step (4) obtains cut, dispensed, sterilized, obtain a kind of fiber of high wet strength
Plain combine dressing.
5. a kind of preparation method of the cellulose combine dressing of high wet strength according to claim 4, it is characterised in that:
In step (1), the cellulose and its derivates aqueous solution is selected from carboxyl methyl cellulose, hydroxyethyl cellulose HEC, hydroxypropyl
One or more of base cellulose HPMC mixture, the mass percent concentration of solution are 1-5%.
6. a kind of preparation method of the cellulose combine dressing of high wet strength according to claim 5, it is characterised in that: institute
The brookfield viscosity for stating cellulose and its derivates is 150-6500mPa.s.
7. a kind of preparation method of the cellulose combine dressing of high wet strength according to claim 4, it is characterised in that:
In step (2), the alkaline aqueous solution is sodium hydroxide, sodium bicarbonate, any one in calcium bicarbonate, the alkaline water
The concentration of solution is 0.2-0.8mol/L, and the volume ratio of the alkaline aqueous solution and reaction solution is 2:100-6:100；The acid
Property aqueous solution be acetic acid, malic acid, citric acid, any one in hydrochloric acid, the concentration of the acidic aqueous solution is 0.1-
The volume ratio of 1.0mol/L, the acidic aqueous solution and reaction solution is 2:100-8:100.
8. a kind of preparation method of the cellulose combine dressing of high wet strength according to claim 4, it is characterised in that:
In step (2), the crosslinking agent, including 1,4-butanediol diglycidyl ether or 1, the bis-epoxy of 2,7,8- diepoxyoctanes
Compound or 1- (3- dimethylamino-propyl) -3- ethyl carbodiimide；The mass ratio of the crosslinking agent and material is 1:0.1-1:
0.8。
9. a kind of preparation method of the cellulose combine dressing of high wet strength according to claim 4, it is characterised in that:
In step (3), the bath temperature of the water-bath cross-linking reaction is 30-90 DEG C, reaction time 2-12h.
10. a kind of preparation method of the cellulose combine dressing of high wet strength according to claim 1, it is characterised in that:
In step (4), the temperature of the pre-freeze is -20 DEG C, and the freeze-drying temperature is -50 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811495331.1A CN109276745A (en) | 2018-12-07 | 2018-12-07 | A kind of cellulose combine dressing of high wet strength and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811495331.1A CN109276745A (en) | 2018-12-07 | 2018-12-07 | A kind of cellulose combine dressing of high wet strength and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109276745A true CN109276745A (en) | 2019-01-29 |
Family
ID=65173978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811495331.1A Pending CN109276745A (en) | 2018-12-07 | 2018-12-07 | A kind of cellulose combine dressing of high wet strength and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109276745A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332039A (en) * | 2021-05-31 | 2021-09-03 | 西南大学 | Continuous drainage sugarcane sponge dressing |
| CN115160637A (en) * | 2021-04-01 | 2022-10-11 | 诺一迈尔(山东)医学科技有限公司 | Degradable hemostatic sponge and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552965A (en) * | 2012-01-17 | 2012-07-11 | 东华大学 | Method for preparing nano-cellulose antibacterial composite material through on-line culture |
| CN103877606A (en) * | 2014-01-23 | 2014-06-25 | 华侨大学 | Absorbable bleeding-stopping compound sponge and preparation method thereof |
| CN107189111A (en) * | 2016-11-23 | 2017-09-22 | 浙江美华鼎昌医药科技有限公司 | A kind of preparation method of cellulose composite sponge |
-
2018
- 2018-12-07 CN CN201811495331.1A patent/CN109276745A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552965A (en) * | 2012-01-17 | 2012-07-11 | 东华大学 | Method for preparing nano-cellulose antibacterial composite material through on-line culture |
| CN103877606A (en) * | 2014-01-23 | 2014-06-25 | 华侨大学 | Absorbable bleeding-stopping compound sponge and preparation method thereof |
| CN107189111A (en) * | 2016-11-23 | 2017-09-22 | 浙江美华鼎昌医药科技有限公司 | A kind of preparation method of cellulose composite sponge |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115160637A (en) * | 2021-04-01 | 2022-10-11 | 诺一迈尔(山东)医学科技有限公司 | Degradable hemostatic sponge and preparation method thereof |
| CN115160637B (en) * | 2021-04-01 | 2023-12-01 | 诺一迈尔(山东)医学科技有限公司 | Degradable hemostatic sponge and preparation method thereof |
| CN113332039A (en) * | 2021-05-31 | 2021-09-03 | 西南大学 | Continuous drainage sugarcane sponge dressing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2338464T3 (en) | COMPOSITE MATERIAL, ESPECIALLY FOR MEDICAL USE, AND PROCEDURE TO PRODUCE THE MATERIAL. | |
| RU2646728C1 (en) | Hemostatic biologically absorbable device with polyethylene glycol as a binding substance | |
| JPH09122227A (en) | Medical material and manufacture thereof | |
| CN113769156B (en) | Hybrid fiber sponge with functions of hemostasis and wound repair and preparation method thereof | |
| CN105521520B (en) | A kind of preparation method of bombyx mori silk fibroin hemostatic material | |
| CN105031740A (en) | Waterproof and breathable bionic artificial skin and preparation method thereof | |
| JP2007518457A (en) | Cellulose derived from heat-denatured microorganisms for in vivo transplantation | |
| CN107261195B (en) | Preparation method and application of antibacterial biomass gel net for sports wound rehabilitation dressing | |
| JP2011523425A (en) | Hydrocolloid-containing material that quickly wets, its production method and its use | |
| JP2005046601A (en) | Biodegradable hemostatic wound dressing | |
| JP2010213984A (en) | In-vivo implanting medical material containing softener and/or moisturizer, method of adjusting content of softener and/or moisturizer in in-vivo implanting medical material, and method for producing in-vivo implanting medical material | |
| CN109481737A (en) | Bionical double-deck dressing of one kind and preparation method thereof | |
| JP2009516038A (en) | Molded body based on crosslinked gelatinous material, method for producing the molded body, and use of the molded body | |
| CN108042838B (en) | Preparation method of antioxidant nanofiber electrospun membrane medical dressing | |
| CN109276745A (en) | A kind of cellulose combine dressing of high wet strength and preparation method thereof | |
| TWI263501B (en) | Sponge wound dressing made from chitin and alginate and method for forming the same | |
| JP2022531489A (en) | Tissue-derived porous matrix and its preparation and usage | |
| US9370604B2 (en) | Planar implant | |
| CN106215219B (en) | Wound treatment material | |
| CN108434508A (en) | A kind of rush wound healing gel dressing and preparation method thereof | |
| CN115671365B (en) | Crosslinked recombinant collagen sponge and preparation method and application thereof | |
| CN106267305B (en) | Hemostatic material | |
| CN104744723B (en) | Chitosan medical material and its preparation method and application | |
| JP2012512705A (en) | Minimal tissue adherent implantable material | |
| TWI334878B (en) | Degradable dressing for wound healing appilcation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190129 |