CN107875286A - A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof - Google Patents

A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof Download PDF

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CN107875286A
CN107875286A CN201711146072.7A CN201711146072A CN107875286A CN 107875286 A CN107875286 A CN 107875286A CN 201711146072 A CN201711146072 A CN 201711146072A CN 107875286 A CN107875286 A CN 107875286A
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nti
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/28—Measuring arrangements characterised by the use of optical techniques for measuring areas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82—Preparation or application process involves sonication or ultrasonication

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Abstract

The invention discloses a kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, the nti-freckle water includes following component by weight：Zang Xi is not in the mood for 200 230 parts of dish leaf piece, 70 90 parts of lid flower Hymenocallis americana petal, 140 170 parts of Guizhou Province combined-ear chrysanthemum blade, 600 parts of water.The nti-freckle water of the present invention combines multiple element, effectively desalinates chloasma faciei, and significantly improves color spot reproduction condition, so as to make up deficiency of the prior art for light spot.

Description

A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof
Technical field
The present invention relates to a kind of nti-freckle water and preparation method thereof, especially a kind of nti-freckle water of significantly desalination chloasma faciei And preparation method thereof.
Background technology
Face's color spot, also referred to as facial colour spot, refer to face's spot different with ambient color.The Crack cause of face's color spot A lot, species is more complicated, and mainly having the factors such as hereditary factors, ultraviolet irradiation, endocrine reason, habits and customs to stimulate makes The increased activity of free radical.Free radical is being attacked and destroyed in cell processes, cell mortality and metabolic disorder, intracellular miscellaneous Matter can not be metabolized, and cause pigment deposition, and neonatal cell quantity is largely reduced (neonatal cell makes an important factor for whitening of skin) Form face's color spot.
Chloasma is also referred to as chloasma hepaticum, for the yellowish-brown pigmentation of face.More symmetrical butterflies are distributed in cheek.It is more common in female Property, estrogen level height is main cause in blood, and its morbidity is relevant with gestation, Long-term Oral contraceptive, paramenia.Damage and be Yellowish-brown or dark brown patch, is often symmetrically distributed in cheekbone cheek, can also involve periorbit, forehead, upper lip and nose, and edge is typically brighter It is aobvious.Without subjective symptom and general malaise.The color spot depth and season, Exposure to Sunlight, endocrine factors are relevant.Stress is stayed up late, tired Skin lesion can be aggravated.
Prior art does not have significant effect to desalination chloasma faciei, because Zang Xi is not in the mood for dish leaf piece, lid flower spider Orchid valve, Guizhou Province combined-ear chrysanthemum blade contains many chemical compositions, accordingly, it is determined that the mixed proportion of three kinds of plant tissues, so as to reach To both desalinating chloasma, while and can reaches the effect for preventing that it from regenerating, significant.
The content of the invention
It is an object of the invention to overcome prior art insufficient, there is provided a kind of liquid medicine, especially can effectively desalinate facial Huang Foxiness, and color spot reproduction condition is significantly improved, the purpose of the present invention is realized by following technical proposals：Medicine is added in the present invention The composition and weight proportion of agent be：
Zang Xi is not in the mood for dish leaf piece 200-230 parts, and preferred weight part is 210 parts.Zang Xi is not in the mood for dish (Classification system： Arenaria stracheyi Edgew) it is the short and small draft of Caryophyllaceae Arenaria, blade meat, wire Long Circle, long 5-6 is in the least Rice, wide 2-3 millimeters are flat, and the Zang Xi used in the present invention is not in the mood for dish leaf piece and picks up from western Tibet drawing Ga Chi.
Lid spends Hymenocallis americana petal 70-90 parts, and preferred weight part is 75 parts.Lid spends Hymenocallis americana (Classification system： Esmeralda bella Rchb.f.) it is orchid family flower spider epidendrum, Hua great is extended into spider shape, the long and narrow circle of petal, November at florescence, the lid flower Hymenocallis americana petal used in of the invention pick up from south of Yunnan Jinghong.
Guizhou Province combined-ear chrysanthemum blade 140-170 parts, preferred weight part are 140 parts.Guizhou Province combined-ear chrysanthemum (Classification system：Synotis Guizhouensis) it is composite family combined-ear chrysanthemum category perennial herb, leaf tool short handle, drapes over one's shoulders needle-like Long Circle, used in the present invention Guizhou Province combined-ear chrysanthemum blade picks up from Pingba County, Guizhou.
The parts by weight of water 600.
Preparation method of the present invention is as follows：
(1) take Zang Xi not to be in the mood for dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to dry at room temperature 10-15 days, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind It is broken, it is well mixed with 300 parts by weight absolute ethyl alcohols, obtains three kinds of plant tissue mixed liquors；
(3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
The water-based energy evaluation test of nti-freckle of the present invention is as follows：
First, skin irritation test：
2.5~3kg healthy rabbits 60 are selected, every rabbit back is symmetrical to select shaving 2.5cm at 202, it is right with itself Carried out according to test method(s), apply 0.5g products of the present invention every time, twice daily, left side or right side are smeared at random, observe and record 24h, The reacting phenomenon of skin after 72h.
As a result show：Have no that the local excitations such as rubefaction, dermexanthesis, water lump are reacted after applying product 24h, 72h of the present invention, say Bright nti-freckle water of the present invention is to be perfectly safe, without any adverse reaction.
2nd, efficacy validation
Select 25-45 year female volunteers similar in 180 chloasma faciei colors and distribution, this 180 female volunteers Chloasma faciei distribution situation be：Two cheeks and nose are intensive, and forehead and other positions are a small amount of.Test site is Jiangxi Province Nanchang City, above volunteer checks by the ten hospital dermatology department experts in Nanchang City, Jiangxi Province to be met standard and selects, and is divided into 12 groups, and 11 Group is test group, and one group is control group, every group of 15 people, product of the control group without nti-freckle component, test group product of the present invention, Every human face was taken pictures before on-test, and marks a maximum chloasma of every human face, its area is measured and remembers Record, while be compared using colour atla with this maximum chloasma, if chloasma color and luster is uneven, take most deep color Contrasted, record the maximum chloasma color numbering of each human face, it is yellowish-brown that product is acted on into face during on-test At spot, once in the morning and once at night, it is used continuously three months.The length and width of each human face's maximum chloasma are measured after three months, record is every Human face is newly-increased or the size of reduction is more than or equal to 10mm2Chloasma number, all measurement area of chloasma in experiment Instrument be a kind of microspur measuring instrument.Each human face's maximum chloasma color numbering is recorded, is numbered to everyone, with testing forefront Table contrasts, and the colour atla name of an article is the color logical colours of skin of PANTONETMGuide, brand PANTONE, model STG201, manufacturer position In the U.S..The logical colour of skin guide [PANTONE SkinTone Guide] of coloured silk is according in the various human skin types of scientific measurement Thousand kinds of actual colours of skin and work out.Aim at reproduction to formulate closest to the entity colour of skin, the color storehouse is the complete visual ginseng of human skin Examine, be the accurate unique international color standard for matching the colour of skin suitable for the related any market of the colour of skin.Each color logical colour of skin Guide numbering is made up of four alphanumerics, and front two refers to skin colourity or background color, and latter two refer to skin color or brightness.
A kind of microspur measuring instrument, including microspur measurement plate and macro camera.
A kind of microspur measurement plate, washer enter row matrix with a width of 1 millimeter square lattice for 1 lattice unit of length and arranged Row.
Further, the square lattice matrix of flat board has 10 row * 10 to arrange, and has 50 row * 50 to arrange, and has 60 row * 60 to arrange, there is 70 Row * 70 is arranged, and has 80 row * 80 to arrange, and has 90 row * 90 to arrange, and has 100 row * 100 to arrange, and has 150 row * 150 to arrange, and has 200 row * 200 to arrange.
Further, the surrounding of the square lattice matrix is frame.
Further, four sides of the frame set handle respectively.
Further, flat board is made up of clear flexible material.
Further, flat board is made up of transparent silica gel.
Further, flat board is made up of transparent flexible plastic.
Brief description of the drawings
Fig. 1 is a kind of overall structure diagram of the embodiment one of microspur measurement plate of the present invention.
Fig. 2 is a kind of overall structure diagram of the embodiment two of microspur measurement plate of the present invention.
In figure, 1- square lattices；2- square lattice matrixes；3- flat boards；4- handles.
Embodiment
Embodiment one
A kind of microspur measuring instrument, including microspur measurement plate and macro camera,
A kind of microspur measurement plate, flat board 3 enter row matrix row with a width of 1 millimeter square lattice 1 for 1 lattice unit of length above Row.The surrounding of the square lattice matrix 2 is frame.Flat board is made up of clear flexible material.
In use, microspur measurement plate is attached to the position for having chloasma of the face of volunteer, due to microspur measurement plate Material is transparent, can appear the shape of chloasma.Taken pictures again with macro camera, in electronic photo to be copied to computer Amplification, calculates how many square lattice 1 in yellowish-brown spot region, if only some is yellowish-brown for the grid of yellowish-brown spot edge Spot, it is calculated as 0.5 square lattice 1, that is, 0.5mm2.The area of chloasma=grid number * 1mm2.Thus can be substantially Measure the area of irregular chloasma.
Slab design is that can pass through the shape that microspur measurement plate sees chloasma for the effect of transparent material, will be flat The effect that plate is designed as flexible material is, the general face of people is not plane, there is certain arc, and flexible material can be with The face contour of fitting arc completely, reduces error.
The square lattice 1 of 2 kinds of the square lattice matrix of flat board has 10 row * 10 to arrange, and has 50 row * 50 to arrange, and has 60 row * 60 Row, have 70 row * 70 to arrange, have 80 row * 80 to arrange, have 90 row * 90 to arrange, have 100 row * 100 to arrange, have 150 row * 150 to arrange, there is 200 row * 200 row.It can so be used for measuring different size of chloasma, naturally it is also possible to measure the plane of other irregular shapes.
Embodiment two
A kind of microspur measurement plate, four sides of the frame set handle 4 respectively.Flat board is made up of transparent silica gel.It is or flat Plate is made up of transparent flexible plastic.
Handle 4 can facilitate operator to hold microspur measurement plate, and when can prevent from being taken a picture with macro camera, behaviour The hand of author shelters from square lattice 1.
Embodiments of the invention and its result are further elaborated below.
Embodiment 1-11 is test group, and embodiment 12 is control group, and per embodiment, the experiment people of number 15, right before on-test Taken pictures per human face, and mark a maximum chloasma of every human face, measured its length and width and calculate its area, simultaneously It is compared using colour atla with this maximum chloasma, if chloasma color and luster is uneven, takes most deep color to carry out pair Than, record the maximum chloasma color numbering of each human face, act on product at chloasma faciei during on-test, it is early Evening is each once, is used continuously three months.The area of each human face's maximum chloasma is measured after three months, is recorded new per human face Increase or the size of reduction is more than or equal to 10mm2Chloasma number, in experiment it is all measurement area of chloasma instrument be A kind of microspur measuring instrument.Each human face's maximum chloasma color numbering is recorded, gives everyone to number, is done pair with list before experiment Than the colour atla name of an article is the color logical colours of skin of PANTONETMGuide, brand PANTONE, model STG201, manufacturer is positioned at U.S. State.The logical colour of skin guide [PANTONE SkinTone Guide] of coloured silk is according to thousands of kinds in the various human skin types of scientific measurement The actual colour of skin and work out.Aim at reproduction to formulate closest to the entity colour of skin, the color storehouse is the complete visual reference of human skin, is fitted Any market related for the colour of skin, it is unique international color standard of the accurate matching colour of skin.Each color logical colour of skin guide Numbering is made up of four alphanumerics, and front two refers to skin colourity or background color, and latter two refer to skin color or brightness.
Embodiment 1
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 210, the parts by weight of lid gaily-colored butterfly orchid valve 75, Guizhou Province combined-ear chrysanthemum blade 140 Parts by weight are dried 10-15 days at room temperature, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind It is broken, it is well mixed with 300 parts by weight absolute ethyl alcohols, obtains three kinds of plant tissue mixed liquors；
(3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is and average every People reduces 4.00 chloasma；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Embodiment 2
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 230, the parts by weight of lid gaily-colored butterfly orchid valve 80, Guizhou Province combined-ear chrysanthemum blade 160 Parts by weight are dried 10-15 days at room temperature, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind It is broken, it is well mixed with 300 parts by weight absolute ethyl alcohols, obtains three kinds of plant tissue mixed liquors；
(3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is and average every People reduces 3.80 chloasma；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Subject number Test front face chloasma numbering Test rear face chloasma numbering
1 2R13 1R04
2 3R13 1R09
3 2R14 1R04
4 2R14 1R04
5 2R13 2R05
6 3R13 2R04
7 2R13 1R04
8 2R14 1R05
9 2R14 1R04
10 2R13 1R05
11 3R14 2R09
12 2R13 1R05
13 3R13 1R04
14 2R13 1R04
15 2R13 1R04
Embodiment 3
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 220, the parts by weight of lid gaily-colored butterfly orchid valve 70, Guizhou Province combined-ear chrysanthemum blade 170 Parts by weight are dried 10-15 days at room temperature, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind It is broken, it is well mixed with 300 parts by weight absolute ethyl alcohols, obtains three kinds of plant tissue mixed liquors；
(3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is and average every People reduces 3.60 chloasma；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Embodiment 4
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 205, the parts by weight of lid gaily-colored butterfly orchid valve 90, Guizhou Province combined-ear chrysanthemum blade 150 Parts by weight are dried 10-15 days at room temperature, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind It is broken, it is well mixed with 300 parts by weight absolute ethyl alcohols, obtains three kinds of plant tissue mixed liquors；
(3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is and average every People reduces 3.93 chloasma；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Subject number Test front face chloasma numbering Test rear face chloasma numbering
1 3R14 1R11
2 3R13 2R09
3 3R13 1R10
4 2R14 1R04
5 2R13 1R09
6 3R13 2R04
7 2R14 1R11
8 2R13 1R05
9 3R14 1R08
10 2R13 1R05
11 3R13 2R04
12 3R14 1R05
13 2R13 1R04
14 2R14 1R09
15 2R13 1R04
Embodiment 5
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 200, the parts by weight of lid gaily-colored butterfly orchid valve 85, Guizhou Province combined-ear chrysanthemum blade 165 Parts by weight are dried 10-15 days at room temperature, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind It is broken, it is well mixed with 300 parts by weight absolute ethyl alcohols, obtains three kinds of plant tissue mixed liquors；
(3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is and average every People reduces 3.73 chloasma；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Embodiment 6
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) take Zang Xi not to be in the mood for the parts by weight of dish leaf piece 210 to dry at room temperature 10-15 days, i.e., 25 DEG C, indoor relative humidity is 45%-55%；
(2) Zang Xi dried be not in the mood for into dish leaf piece be put into mortar to grind, be well mixed with 300 parts by weight absolute ethyl alcohols, Obtain plant tissue mixed liquor；
(3) the plant tissue mixed liquor normal temperature ultrasonic extraction obtained (2) is filtered to remove absolute ethyl alcohol after 40 minutes, remains Remaining mixture pours into beaker, adds 600 parts by weight water, is sealed with preservative film, and the nti-freckle water is produced after placing 24 hours.
Result of the test：1st, 15 human faces are 10mm more than or equal to size after testing2New spot have 2.73, without old spot Reduce；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Subject number Test front face chloasma numbering Test rear face chloasma numbering
1 3R13 2R12
2 2R13 2R10
3 2R14 2R09
4 2R13 2R08
5 2R14 2R11
6 3R14 2R12
7 3R14 2R14
8 2R14 2R11
9 2R13 2R10
10 3R13 3R10
11 3R13 2R12
12 2R13 2R10
13 3R13 2R10
14 2R14 2R09
15 3R13 2R13
Embodiment 7
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) parts by weight of lid gaily-colored butterfly orchid valve 75 are taken to dry at room temperature 10-15 days, i.e., 25 DEG C, indoor relative humidity is 45%-55%；
(2) the lid gaily-colored butterfly orchid valve dried is put into mortar and ground, mixed with 300 parts by weight absolute ethyl alcohols It is even, obtain plant tissue mixed liquor；
(3) the plant tissue mixed liquor normal temperature ultrasonic extraction obtained (2) is filtered to remove absolute ethyl alcohol after 40 minutes, remains Remaining mixture pours into beaker, adds 600 parts by weight water, is sealed with preservative film, and the nti-freckle water is produced after placing 24 hours.
Result of the test：1st, 15 human faces are 10mm more than or equal to size after testing2New spot have 2.60, without old spot Reduce；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Embodiment 8
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) parts by weight of Guizhou Province combined-ear chrysanthemum blade 140 are taken to dry at room temperature 10-15 days, i.e., 25 DEG C, indoor relative humidity is 45%-55%；
(2) the Guizhou Province combined-ear chrysanthemum blade dried is put into mortar and ground, be well mixed, obtain with 300 parts by weight absolute ethyl alcohols To plant tissue mixed liquor；
(3) the plant tissue mixed liquor normal temperature ultrasonic extraction obtained (2) is filtered to remove absolute ethyl alcohol after 40 minutes, remains Remaining mixture pours into beaker, adds 600 parts by weight water, is sealed with preservative film, and the nti-freckle water is produced after placing 24 hours.
Result of the test：1st, 15 human faces are 10mm more than or equal to size after testing2New spot have 2.33, without old spot Reduce；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Subject number Test front face chloasma numbering Test rear face chloasma numbering
1 2R14 2R11
2 3R13 2R09
3 2R13 2R09
4 2R14 2R09
5 2R13 2R11
6 3R13 3R10
7 2R14 2R09
8 2R13 2R12
9 3R13 3R10
10 2R14 2R10
11 3R13 2R10
12 2R13 2R09
13 2R13 2R11
14 2R13 2R10
15 3R13 3R11
Embodiment 9
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) take that Zang Xi is not in the mood for the parts by weight of dish leaf piece 210, the parts by weight of lid gaily-colored butterfly orchid valve 75 dry 10-15 at room temperature My god, i.e., 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried is not in the mood for dish leaf piece, lid gaily-colored butterfly orchid valve is put into mortar and ground, with 300 parts by weight Absolute ethyl alcohol is well mixed, and obtains two kinds of plant tissue mixed liquors；
(3) the two kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is average that everyone is yellow Foxiness reduces 1.13；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Embodiment 10
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) take that Zang Xi is not in the mood for the parts by weight of dish leaf piece 210, the parts by weight of Guizhou Province combined-ear chrysanthemum blade 140 are dried 10-15 days at room temperature, I.e. 25 DEG C, indoor relative humidity 45%-55%；
(2) Zang Xi dried dish leaf piece is not in the mood for, Guizhou Province combined-ear chrysanthemum blade is put into mortar and ground, anhydrous with 300 parts by weight Ethanol is well mixed, and obtains two kinds of plant tissue mixed liquors；
(3) the two kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is average that everyone subtracts Few chloasma 1.07；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Subject number Test front face chloasma numbering Test rear face chloasma numbering
1 2R13 1R13
2 3R13 2R10
3 3R13 2R09
4 3R14 2R10
5 2R14 1R13
6 3R14 2R12
7 2R14 1R14
8 3R13 2R13
9 2R14 1R13
10 3R13 2R09
11 3R13 2R10
12 2R13 1R10
13 3R13 2R11
14 2R13 1R12
15 3R13 2R12
Embodiment 11
A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof, comprises the following steps：
(1) parts by weight of lid gaily-colored butterfly orchid valve 75, the parts by weight of Guizhou Province combined-ear chrysanthemum blade 140 are taken to dry at room temperature 10-15 days, I.e. 25 DEG C, indoor relative humidity 45%-55%；
(2) the lid gaily-colored butterfly orchid valve, the Guizhou Province combined-ear chrysanthemum blade that dry are put into mortar and ground, with 300 parts by weight without Water-ethanol is well mixed, and obtains two kinds of plant tissue mixed liquors；
(3) the two kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove anhydrous second after 40 minutes Alcohol, remaining mixture pour into beaker, add 600 parts by weight water, are sealed with preservative film, and the nti-freckle is produced after placing 24 hours Water.
Result of the test：1st, 15 human faces nothing is 10mm more than or equal to size after testing2New spot, it is average that everyone subtracts Few chloasma 1.67；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, the change of 15 people, three months rear face maximum chloasma colors is as shown in the table：
Embodiment 12
The present embodiment is check experiment, without any processing.
Result of the test：1st, 15 human faces are 10mm more than or equal to size after testing2New spot have 7.53, without old spot Reduce；Take the exact value of two behind decimal point.
2nd, the change of 15 people, three months rear face maximum area of chloasma is as shown in the table：
3rd, 15 people, three months rear face maximum chloasma colors have intensification sign, as shown in the table：

Claims (3)

  1. A kind of 1. nti-freckle water of significantly desalination chloasma faciei, it is characterised in that：
    (1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 210, the parts by weight of lid gaily-colored butterfly orchid valve 75, the Guizhou Province combined-ear chrysanthemum leaf The parts by weight of piece 140 dry about 10-15 days, i.e., 25 DEG C, indoor relative humidity 45%-55% at room temperature；
    (2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind, with 300 parts by weight absolute ethyl alcohols are well mixed, and obtain three kinds of plant tissue mixed liquors；
    (3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove absolute ethyl alcohol after 40 minutes, remain Remaining mixture pours into beaker, and remaining mixture pours into beaker, adds 600 parts by weight water, is sealed with preservative film, places 24 The nti-freckle water is produced after hour.
  2. 2. a kind of preparation method of the nti-freckle water of significantly desalination chloasma faciei, it is characterised in that step is as follows：
    (1) Zang Xi is taken not to be in the mood for the parts by weight of dish leaf piece 210, the parts by weight of lid gaily-colored butterfly orchid valve 75, the Guizhou Province combined-ear chrysanthemum leaf The parts by weight of piece 140 dry about 10-15 days, i.e., 25 DEG C, indoor relative humidity 45%-55% at room temperature；
    (2) Zang Xi dried is not in the mood for into dish leaf piece, lid gaily-colored butterfly orchid valve, Guizhou Province combined-ear chrysanthemum blade to be put into mortar and grind, with 300 parts by weight absolute ethyl alcohols are well mixed, and obtain three kinds of plant tissue mixed liquors；
    (3) the three kinds of plant tissue mixed liquor normal temperature ultrasonic extractions obtained (2) are filtered to remove absolute ethyl alcohol after 40 minutes, remain Remaining mixture pours into beaker, and remaining mixture pours into beaker, adds 600 parts by weight water, is sealed with preservative film, places 24 The nti-freckle water is produced after hour.
  3. 3. a kind of microspur measurement plate, washer carries out matrix arrangement with a width of 1 millimeter square lattice for 1 lattice unit of length, The surrounding of the square lattice matrix is frame, and flat board is made up of clear flexible material.
CN201711146072.7A 2017-11-17 2017-11-17 A kind of nti-freckle water of significantly desalination chloasma faciei and preparation method thereof Withdrawn CN107875286A (en)

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CN106038678A (en) * 2016-06-30 2016-10-26 济南星懿医药技术有限公司 Pharmaceutical composition for treating chloasma and preparation method thereof

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CN104306651A (en) * 2014-11-05 2015-01-28 西藏金哈达药业有限公司 Tibetan medicine composition with whitening and freckle removing function and application and preparation method of Tibetan medicine composition
CN104814904A (en) * 2015-05-18 2015-08-05 樊文花 Phalaenopsis brightening mask and preparation method thereof
CN106038678A (en) * 2016-06-30 2016-10-26 济南星懿医药技术有限公司 Pharmaceutical composition for treating chloasma and preparation method thereof

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