CN107864932B - Drosophila culture and drug administration device for laboratory - Google Patents
Drosophila culture and drug administration device for laboratory Download PDFInfo
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- CN107864932B CN107864932B CN201711270574.0A CN201711270574A CN107864932B CN 107864932 B CN107864932 B CN 107864932B CN 201711270574 A CN201711270574 A CN 201711270574A CN 107864932 B CN107864932 B CN 107864932B
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention relates to a drosophila culturing and drug feeding device for a laboratory, belongs to the technical field of drosophila experimental devices for the laboratory, and solves the technical problems that different culture bottles are required to be replaced in the culturing and drug feeding processes of drosophila in the prior art, and the solution is as follows: the upper section and the middle section and the lower section are respectively connected through threaded connectors; the bottle stopper is arranged at the upper end face of the upper section, the liquid medicine adding pipe penetrates through the bottle stopper and is communicated with the upper section, and an anesthetic air inlet I is formed in the middle of the side wall of the upper section; the bottom of the lower section is provided with a culture medium, and the middle part of the side wall of the lower section is provided with a second anesthetic gas inlet; a sieve plate is arranged at one position of the threaded connection port, a baffle is arranged at the second position of the threaded connection port, and the handle drives the baffle or the sieve plate to do rotary motion from the 9 o 'clock position to the 12 o' clock position of the circular rotary track of the pointer through the rotating shaft. The device avoids the problem that a plurality of links and different culture bottles are needed in the process of doing drosophila drug administration experiments, and provides the experimental device with multiple links integrated.
Description
Technical Field
The invention belongs to the technical field of laboratory Drosophila experimental devices, and particularly relates to a laboratory Drosophila culturing and dosing device.
Background
Drosophila is a classical-mode organism, has the advantages of short period, easy breeding, low cost, rapid propagation, small individuals, more offspring, few chromosomes, obvious characters, gene homology and the like, and is widely applied to the research fields of genetics and developmental related research, drug development of nervous system diseases such as Parkinson disease, alzheimer disease and the like, drug addiction, aging, life span, sleep, biological rhythm, study and memory and the like.
Drosophila model organisms are often used as subjects in drug screening experiments to study treatment of disease. Generally, a method of drug administration by using a drug culture medium or a gun head is adopted according to experimental needs and drug characteristics. In the experimental process, a method of uniformly mixing the medicines in the culture medium is sometimes adopted for medicine intervention and treatment, the experimental operation is complex, and the medicines with proper proportion are required to be dissolved in the culture medium each time. The gun head administration method is adopted, so that the step of preparing a drug culture medium is avoided, but the method involves a plurality of steps, such as feeding, fasting, administration, feeding and the like, and each step needs to pour the drosophila into different culture bottles, for example: pouring the drosophila into an empty culture bottle from the culture bottle filled with the culture medium, and staying for 2 hours to enable the drosophila to be in a starvation state; pouring the drosophila into another culture bottle, injecting the medicine into the gun head, plugging the gun head into a cotton plug of the culture bottle, and feeding the drosophila; the drosophila is then poured into a flask containing the medium.
In summary, the current common gun head administration methods in laboratories have the following disadvantages:
1. the glass culture flask is adopted, the glass culture flask is fragile, the damage to experimental personnel caused by the breakage of the culture flask often occurs in the experimental process, and meanwhile, the experimental cost is increased.
2. In the process of administration, a plurality of links such as feeding, fasting, administration, feeding and the like are needed, and each link needs to pour the drosophila into different culture bottles, so that a great deal of time and effort are needed by experimenters.
3. Different culture bottles needed by the same batch of drosophila need to be marked in the same way, so that great workload is caused, errors such as pouring the drosophila into the wrong culture bottles and the like easily occur, and the accuracy of experimental results is affected.
4. For a large number of Drosophila drug screening experiments, a large number of culture bottles are needed, so that a large experiment space is occupied, and other experiments are affected.
5. The drug screening experiment needs a large number of fruit fly culture bottles, and in the process of cleaning the culture bottles, and the like, a large amount of precious experiment time and manpower are occupied.
6. During the administration period, the drosophila needs to be poured into different culture bottles, which often causes drosophila to fly out of the experimental device, and influences the number of experimental drosophila and the accuracy of the experiment.
7. The existing drug administration gun head is not marked with scales, which is not beneficial to recording the drug intake quantity of drosophila and influences the analysis of experimental results.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, solve the technical problem that the corresponding experimental instrument needs to be replaced in the process of culturing and experiment of drosophila in the prior art, and provide a drosophila culturing and drug administration device for a laboratory.
The invention is realized by the following technical scheme.
The utility model provides a device is cultivateed and administer medicine to fruit fly in laboratory, it includes blake bottle and threaded connection mouth, threaded connection mouth includes threaded connection mouth one and threaded connection mouth two, wherein: the culture bottle comprises an upper section, a middle section and a lower section, wherein the upper end faces and the lower end faces of the upper section and the lower section are both opened, the upper end face of the lower section is opened, the lower end face of the lower section is a sealed end, the upper section and the middle section are connected through a first threaded connector, and the middle section and the lower section are connected through a second threaded connector;
the bottle stopper is arranged at the upper end face of the upper section, the liquid medicine adding pipe penetrates through the bottle stopper and is communicated with the upper section, scales are arranged on the side wall of the liquid medicine adding pipe, cotton wool is plugged at the tip end part of the liquid medicine adding pipe, and an anesthetic air inlet I is arranged in the middle of the side wall of the upper section;
a culture medium can be added at the bottom of the lower section, and an anesthetic gas inlet II is formed in the middle of the side wall of the lower section;
the side wall of the threaded connection port is provided with a through hole, a rotating shaft penetrates through the through hole, a handle is arranged at the outer shaft end of the rotating shaft, a pointer is fixedly arranged at the outer end part of the rotating shaft, a limit stop is arranged on the outer side wall of the threaded connection port at the position of the pointer circular rotation track, limit stops are also arranged on the outer side walls of the upper section and the middle section at the position of the pointer circular rotation track, and the handle drives the baffle to perform rotary motion from the position of the pointer circular rotation track to the position of the pointer circular rotation track through the rotating shaft;
at the first thread connection port: the other end of the rotating shaft is provided with a sieve plate, and the outer side surface of the sieve plate is tightly attached to the inner wall of the first threaded connecting port;
at the second threaded connection port: the other end of the rotating shaft is provided with a baffle, the outer edge of the baffle is provided with a sealing ring, and the outer side surface of the sealing ring is tightly attached to the inner wall of the threaded connection port II.
Further, the sealing ring is made of silica gel.
Further, the anesthetic introduced into the first anesthetic gas inlet and the second anesthetic gas inlet is carbon dioxide gas.
Further, the upper section, the middle section and the lower section are all made of transparent materials, and the bottle stopper installed in the upper section is made of sponge or plastic.
Further, the material that the sieve was is hard plastics, is provided with the mesh on the sieve, and the mesh aperture is 1.5mm.
Compared with the prior art, the invention has the following beneficial effects.
1. The culture flask can adopt transparent organic glass material, is not fragile, avoids the injury to experimenters caused by the breakage of the culture flask in the experimental process, and simultaneously saves the experimental cost.
2. The number of times of pouring the drosophila into different culture bottles is reduced, the time cost is saved for the experimenters, and the experimental flow is reduced.
3. For a large number of fruit fly drug screening experiments, the number of required culture bottles can be reduced to a great extent, excessive experiment space waste is avoided, the number of culture bottles needing to be cleaned is reduced, and manpower and resources are saved.
4. In the experimental process, the drosophila can be ensured to exist in one device, and experimental errors caused by repeated drosophila pouring are avoided.
5. The device can effectively avoid drosophila to fly out of the experimental device during the administration period, and ensures the number of drosophila and the accuracy of experiments.
6. The device is convenient for observing the dosage and the residual dosage, is favorable for recording the dosage of the drug taken by the drosophila melanogaster, and can analyze the dosage and the action of the drug more accurately.
7. The device can simultaneously give different medicines to the drosophila, is convenient for observing the preference or aversion of the drosophila to the medicines, and is favorable for later experimental design and medicine adjustment.
8. The carbon dioxide anesthetic inlet is designed, so that the drosophila can be anesthetized after the end of the administration, and all drosophila are poured into other experimental devices for subsequent experiments. The fly-out device of the drosophila is avoided, the number of the drosophila required by the experiment can not be reached, and the experimental result is influenced.
In a word, this device provides a drosophila and cultivates and administer medicine device, has solved the problem that exists in the experimental process of drosophila administration at present.
Drawings
FIG. 1 is a schematic diagram showing the overall structure of a stage of culturing Drosophila in the lower stage.
FIG. 2 is a schematic view of the whole structure of the fruit fly from the lower section to the middle section.
Fig. 3 is a schematic view of the right-hand cross-sectional structure of fig. 2.
Fig. 4 is a schematic view of the overall structure of the drosophila in the mid-stage fasting resting stage.
FIG. 5 is a schematic diagram showing the overall structure of the drosophila administration part.
Fig. 6 is a schematic view of the right-hand cross-sectional structure of fig. 5.
Fig. 7 is a partially enlarged view of the portion a of fig. 6 when the pointer is engaged with the limit stop.
In the figure, 1 is a liquid medicine adding pipe, 2 is a bottle stopper, 3 is an upper section, 4 is an anesthetic air inlet I, 5 is a sieve plate, 6 is a threaded connector I, 7 is a middle section, 8 is a baffle, 9 is a sealing ring, 10 is a threaded connector II, 11 is a lower section, 12 is an anesthetic air inlet II, 13 is a through hole, 14 is a handle, 15 is a rotating shaft, 16 is a pointer, 17 is a limit stop block, and 18 is a culture medium.
Description of the embodiments
The invention is illustrated in detail below with reference to examples: the present embodiment is implemented on the premise of the technical scheme of the present invention, and a detailed implementation manner and a specific operation process are given, but the protection scope of the present invention is not limited to the following examples.
As shown in fig. 1 to 5, the drosophila culture and drug administration device for laboratory in this embodiment comprises a culture flask and a threaded connection port, wherein the threaded connection port comprises a first threaded connection port 6 and a second threaded connection port 10, and the first threaded connection port comprises: the culture bottle comprises an upper section 3, a middle section 7 and a lower section 11, wherein the upper end faces and the lower end faces of the upper section 3 and the lower section 11 are both opened, the upper end face of the lower section 11 is opened, the lower end face of the lower section 11 is a sealed end, the upper section 3 and the middle section 7 are connected through a first threaded connection port 6, and the middle section 7 and the lower section 11 are connected through a second threaded connection port 10;
the bottle stopper 2 is arranged at the upper end face of the upper section 3, the liquid medicine adding pipe 1 penetrates through the bottle stopper 2 and is communicated with the upper section 3, scales are arranged on the side wall of the liquid medicine adding pipe 1, cotton wool is plugged to the tip end part of the liquid medicine adding pipe 1 from the upper end of the liquid medicine adding pipe 1, and an anesthetic air inlet I4 is arranged in the middle of the side wall of the upper section 3;
a culture medium 18 can be added to the bottom of the lower section 11, and an anesthetic gas inlet II 12 is formed in the middle of the side wall of the lower section 11;
the side wall of the threaded connection port is provided with a through hole 13, a rotating shaft 15 penetrates through the through hole 13, a handle 14 is arranged at the outer shaft end of the rotating shaft 15, a pointer 16 is fixedly arranged at the outer end part of the rotating shaft 15, a limit stop 17 is arranged on the outer side wall of the threaded connection port at the 9 o 'clock position of the circular rotating track of the pointer 16, limit stops 17 are also arranged on the outer side walls of the upper section 3 and the middle section 7 at the 12 o' clock position of the circular rotating track of the pointer 16, and the handle 14 drives a baffle 8 to perform rotating motion at the 9 o 'clock position to the 12 o' clock position of the circular rotating track of the pointer 16 through the rotating shaft 15;
at threaded connection port one 6: the other end of the rotating shaft 15 is provided with a sieve plate 5, and the outer side surface of the sieve plate 5 is tightly attached to the inner wall of the first threaded connecting port 6;
at threaded connection port two 10: the other end of the rotating shaft 15 is provided with a baffle plate 8, the outer edge of the baffle plate 8 is provided with a sealing ring 9, and the outer side surface of the sealing ring 9 is tightly attached to the inner wall of the threaded connection port II 10.
Further, the sealing ring 9 is made of silica gel.
Further, the anesthetic gases introduced into the first anesthetic gas inlet 4 and the second anesthetic gas inlet 12 are carbon dioxide gas.
Further, the upper section 3, the middle section 7 and the lower section 11 are all made of transparent materials, and the bottle stopper 2 installed in the upper section 3 is made of sponge or plastic.
Further, the material that sieve 5 was is hard plastics, is provided with the mesh on the sieve 5, and the mesh aperture is 1.5mm.
The application process of the invention is as follows:
firstly, as shown in fig. 1, a second threaded connection port 10 is installed on the upper end surface of a lower section 11 through threaded connection, a baffle plate 8 is opened, a drosophila culture medium is put into the lower section 11, drosophila is put into the lower section 11, the baffle plate 8 is closed, the lower end surface of a middle section 7 is installed above the second threaded connection port 10 through threaded connection, an upper section 3 is installed above the upper end surface of the middle section 7 through a first threaded connection port 6, a bottle stopper 2 is plugged into an opening position of the upper end surface of the upper section 3, a screen plate 5 is closed, and an installed culture bottle is placed in a growth environment suitable for drosophila for cultivation for later experiments;
next, as shown in FIGS. 2 and 3, after the drosophila is sufficiently fed, CO is blown from the anesthetic gas inlet port II 12 into the lower section 11 2 Anesthetic gases. After the drosophila is anesthetized, the culture bottle is inverted, the baffle plate 8 is opened, the drosophila is poured into the middle section 7 from the lower section 11, and the baffle plate 8 is closed;
again, as shown in fig. 4, the culture bottle is rotated again to make the culture bottle put forward, the drosophila is fully laid down in the middle section 7, and at the same time, the liquid medicine adding pipe 1 is inserted into the upper section 3 through the bottle stopper 2 for later use;
finally, as shown in fig. 5 to 7, carbon dioxide anesthetic gas is blown into the culture flask through the anesthetic gas inlet I4 and the anesthetic gas inlet II 12 together, the sieve plate 5 is opened, and the experiment medicine is quantitatively dripped into the upper section 3 through the scale by the medicine liquid adding pipe 1 for observation; after the experiment is finished, all the parts are disassembled and cleaned, and the next use is reserved.
The foregoing is merely illustrative of the present invention, and the present invention is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the scope of the present invention should be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (3)
1. The utility model provides a device is cultivateed and doses with fruit fly in laboratory, it includes blake bottle and threaded connection mouth, threaded connection mouth includes threaded connection mouth one (6) and threaded connection mouth two (10), its characterized in that: the culture bottle comprises an upper section (3), a middle section (7) and a lower section (11), wherein the upper end faces and the lower end faces of the upper section (3) and the middle section (7) are both opened, the upper end face of the lower section (11) is opened, the lower end face of the lower section (11) is a closed end, the upper section (3) and the middle section (7) are connected through a first threaded connection port (6), and the middle section (7) and the lower section (11) are connected through a second threaded connection port (10); the upper section (3), the middle section (7) and the lower section (11) are made of transparent materials, and the bottle stopper (2) arranged in the upper section (3) is made of sponge or plastic;
the bottle stopper (2) is arranged at the upper end face of the upper section (3), the liquid medicine adding pipe (1) penetrates through the bottle stopper (2) and is communicated with the upper section (3), scales are arranged on the side wall of the liquid medicine adding pipe (1), cotton wool is plugged at the tip end of the liquid medicine adding pipe (1), and an anesthetic air inlet I (4) is arranged in the middle of the side wall of the upper section (3);
the bottom of the lower section (11) is adhered with a culture medium (18), and the middle part of the side wall of the lower section (11) is provided with an anesthetic gas inlet II (12); the anesthetic introduced into the first anesthetic gas inlet (4) and the second anesthetic gas inlet (12) is carbon dioxide gas;
the side wall of the threaded connection port is provided with a through hole (13), a rotating shaft (15) is arranged through the through hole (13), a handle (14) is arranged at the outer shaft end of the rotating shaft (15), a pointer (16) is fixedly arranged at the outer end part of the rotating shaft (15), a limit stop (17) is arranged at the 9 o 'clock position of the circular rotating track of the pointer (16) on the outer side wall of the threaded connection port, limit stops (17) are also arranged at the 12 o' clock position of the circular rotating track of the pointer (16) on the outer side walls of the upper section (3) and the middle section (7), and the handle (14) drives a baffle (8) to do rotary motion at the 9 o 'clock position to the 12 o' clock position of the circular rotating track of the pointer (16) through the rotating shaft (15);
at threaded connection port one (6): the other end of the rotating shaft (15) is provided with a sieve plate (5), and the outer side surface of the sieve plate (5) is tightly attached to the inner wall of the first threaded connecting port (6);
at the threaded connection port II (10): the other end of the rotating shaft (15) is provided with a baffle (8), the outer edge of the baffle (8) is provided with a sealing ring (9), and the outer side surface of the sealing ring (9) is tightly attached to the inner wall of the threaded connection port II (10).
2. The laboratory drosophila culture and drug delivery device of claim 1, wherein: the sealing ring (9) is made of silica gel.
3. The laboratory drosophila culture and drug delivery device of claim 1, wherein: the material of sieve (5) is hard plastics, is provided with the mesh on sieve (5), and the mesh aperture is 1.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711270574.0A CN107864932B (en) | 2017-12-05 | 2017-12-05 | Drosophila culture and drug administration device for laboratory |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711270574.0A CN107864932B (en) | 2017-12-05 | 2017-12-05 | Drosophila culture and drug administration device for laboratory |
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| Publication Number | Publication Date |
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| CN107864932A CN107864932A (en) | 2018-04-03 |
| CN107864932B true CN107864932B (en) | 2023-09-05 |
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| CN201711270574.0A Active CN107864932B (en) | 2017-12-05 | 2017-12-05 | Drosophila culture and drug administration device for laboratory |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111436400B (en) * | 2020-03-17 | 2021-09-24 | 南阳师范学院 | Laboratory fruit fly culture bottle interface device |
| CN114073241B (en) * | 2021-11-11 | 2023-02-07 | 青岛农业大学 | Observation device applied to parasitic wasps and manufacturing method thereof |
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| CN105404920A (en) * | 2015-10-30 | 2016-03-16 | 黄雅琴 | Drosophila fecundity statistical method and special statistical device |
| CN205266669U (en) * | 2016-01-11 | 2016-06-01 | 四川农业大学 | A erlenmeyer flask for raising fruit bat |
| CN205266668U (en) * | 2016-01-11 | 2016-06-01 | 四川农业大学 | A wide -necked bottle for fruit bat is cultivateed |
| CN205511729U (en) * | 2016-04-16 | 2016-08-31 | 菏泽学院 | Categorised identification device of laboratory fruit bat |
| CN205567525U (en) * | 2016-03-14 | 2016-09-14 | 四川农业大学 | Culture vessel and subassembly of a single fruit bat |
| CN206136939U (en) * | 2016-10-28 | 2017-05-03 | 台州学院 | Auxiliary device is cultivateed to fruit bat and subassembly is cultivateed to fruit bat |
| CN207544113U (en) * | 2017-12-05 | 2018-06-29 | 山西大医院 | A kind of use for laboratory drosophila culture and drug delivery device |
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2017
- 2017-12-05 CN CN201711270574.0A patent/CN107864932B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105404920A (en) * | 2015-10-30 | 2016-03-16 | 黄雅琴 | Drosophila fecundity statistical method and special statistical device |
| CN205266669U (en) * | 2016-01-11 | 2016-06-01 | 四川农业大学 | A erlenmeyer flask for raising fruit bat |
| CN205266668U (en) * | 2016-01-11 | 2016-06-01 | 四川农业大学 | A wide -necked bottle for fruit bat is cultivateed |
| CN205567525U (en) * | 2016-03-14 | 2016-09-14 | 四川农业大学 | Culture vessel and subassembly of a single fruit bat |
| CN205511729U (en) * | 2016-04-16 | 2016-08-31 | 菏泽学院 | Categorised identification device of laboratory fruit bat |
| CN206136939U (en) * | 2016-10-28 | 2017-05-03 | 台州学院 | Auxiliary device is cultivateed to fruit bat and subassembly is cultivateed to fruit bat |
| CN207544113U (en) * | 2017-12-05 | 2018-06-29 | 山西大医院 | A kind of use for laboratory drosophila culture and drug delivery device |
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