CN107864671A - 星形细胞创伤节和神经创伤生物标志物 - Google Patents

星形细胞创伤节和神经创伤生物标志物 Download PDF

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Publication number
CN107864671A
CN107864671A CN201680032940.6A CN201680032940A CN107864671A CN 107864671 A CN107864671 A CN 107864671A CN 201680032940 A CN201680032940 A CN 201680032940A CN 107864671 A CN107864671 A CN 107864671A
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China
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tbi
aldoc
injury
sample
blbp
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Pending
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CN201680032940.6A
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English (en)
Chinese (zh)
Inventor
伊那-彼特·沃纳
J·A·鲁
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University of California San Diego UCSD
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University of California San Diego UCSD
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Publication of CN107864671A publication Critical patent/CN107864671A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01259—[Fructose-bisphosphate aldolase]-lysine N-methyltransferase (2.1.1.259)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/40—Disorders due to exposure to physical agents, e.g. heat disorders, motion sickness, radiation injuries, altitude sickness, decompression illness
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201680032940.6A 2015-05-05 2016-05-05 星形细胞创伤节和神经创伤生物标志物 Pending CN107864671A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562157389P 2015-05-05 2015-05-05
US62/157,389 2015-05-05
PCT/US2016/031043 WO2016179426A1 (en) 2015-05-05 2016-05-05 Astrocyte traumatome and neurotrauma biomarkers

Publications (1)

Publication Number Publication Date
CN107864671A true CN107864671A (zh) 2018-03-30

Family

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Family Applications (1)

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CN201680032940.6A Pending CN107864671A (zh) 2015-05-05 2016-05-05 星形细胞创伤节和神经创伤生物标志物

Country Status (7)

Country Link
US (3) US10557859B2 (enExample)
EP (1) EP3292414B1 (enExample)
JP (1) JP6839854B2 (enExample)
CN (1) CN107864671A (enExample)
ES (1) ES2873509T3 (enExample)
IL (1) IL255351A0 (enExample)
WO (1) WO2016179426A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3292414B1 (en) * 2015-05-05 2021-04-07 The Regents of the University of California Astrocyte traumatome and neurotrauma biomarkers
WO2018217792A1 (en) * 2017-05-23 2018-11-29 Immunarray USA, Inc. Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma
EP3710836A4 (en) * 2017-11-16 2021-10-27 Brainbox Solutions, Inc. PROTEIN BIOMARKER INDICATORS OF NEUROLOGICAL INJURY AND / OR DISEASE AND METHOD OF USE THEREOF
CN111699391A (zh) 2017-12-29 2020-09-22 雅培实验室 用于诊断和评估创伤性脑损伤的新型生物标志物和方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040186A (zh) * 2004-07-01 2007-09-19 帕拉迪姆医疗有限公司 受体gpr86的用途
CN101983337A (zh) * 2008-02-04 2011-03-02 班扬生物标记公司 用于诊断或治疗脑损伤的方法
CN103118698A (zh) * 2010-05-28 2013-05-22 意识-Nrg公司 神经调节素同种型，神经调节素多肽和其使用

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US8492107B2 (en) * 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2007136617A2 (en) * 2006-05-18 2007-11-29 Walter Reed Army Institute Of Research (Wrair) Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury
EP3355059A3 (en) 2009-06-19 2018-09-26 Banyan Biomarkers, Inc. Biomarker assay of neurological condition
KR101211280B1 (ko) * 2010-03-26 2012-12-11 가톨릭대학교 산학협력단 신규한 뇌손상 질환 진단용 마커 및 이의 용도
EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
EP3129780A4 (en) 2014-04-07 2017-12-13 Iron Horse Diagnostics Inc. Traumatic brain injury and neurodegenerative biomarkers, methods, and systems
CA2962400A1 (en) 2014-09-25 2016-03-31 Oxeia Biopharmaceuticals, Inc. Methods of treating traumatic brain injury
EP3292414B1 (en) * 2015-05-05 2021-04-07 The Regents of the University of California Astrocyte traumatome and neurotrauma biomarkers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040186A (zh) * 2004-07-01 2007-09-19 帕拉迪姆医疗有限公司 受体gpr86的用途
CN101983337A (zh) * 2008-02-04 2011-03-02 班扬生物标记公司 用于诊断或治疗脑损伤的方法
CN103118698A (zh) * 2010-05-28 2013-05-22 意识-Nrg公司 神经调节素同种型，神经调节素多肽和其使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MAURICE M.A.L. PELSERS ET AL.: "Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility", 《CLINICAL CHEMISTRY》 *
XINYU YANG ET AL.: "Expressive proteomics profile changes of injured human brain cortex due to acute brain trauma", 《BRAIN INJURY》 *
毛伟峰 等: "大鼠创伤性脑损伤后海马齿状回中脑脂结合蛋白的表达变化", 《解剖学报》 *

Also Published As

Publication number Publication date
EP3292414A1 (en) 2018-03-14
US20200278359A1 (en) 2020-09-03
US20220299531A1 (en) 2022-09-22
EP3292414A4 (en) 2018-09-26
US20180364259A1 (en) 2018-12-20
US11249094B2 (en) 2022-02-15
JP2018523092A (ja) 2018-08-16
JP6839854B2 (ja) 2021-03-17
ES2873509T3 (es) 2021-11-03
US12339289B2 (en) 2025-06-24
WO2016179426A1 (en) 2016-11-10
EP3292414B1 (en) 2021-04-07
US10557859B2 (en) 2020-02-11
IL255351A0 (en) 2017-12-31

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