CN107864671A - 星形细胞创伤节和神经创伤生物标志物 - Google Patents

星形细胞创伤节和神经创伤生物标志物 Download PDF

Info

Publication number
CN107864671A
CN107864671A CN201680032940.6A CN201680032940A CN107864671A CN 107864671 A CN107864671 A CN 107864671A CN 201680032940 A CN201680032940 A CN 201680032940A CN 107864671 A CN107864671 A CN 107864671A
Authority
CN
China
Prior art keywords
tbi
injury
aldoc
blbp
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680032940.6A
Other languages
English (en)
Chinese (zh)
Inventor
伊那-彼特·沃纳
J·A·鲁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN107864671A publication Critical patent/CN107864671A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01259—[Fructose-bisphosphate aldolase]-lysine N-methyltransferase (2.1.1.259)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/40—Disorders due to exposure to physical agents, e.g. heat disorders, motion sickness, radiation injuries, altitude sickness, decompression illness
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201680032940.6A 2015-05-05 2016-05-05 星形细胞创伤节和神经创伤生物标志物 Pending CN107864671A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562157389P 2015-05-05 2015-05-05
US62/157,389 2015-05-05
PCT/US2016/031043 WO2016179426A1 (en) 2015-05-05 2016-05-05 Astrocyte traumatome and neurotrauma biomarkers

Publications (1)

Publication Number Publication Date
CN107864671A true CN107864671A (zh) 2018-03-30

Family

ID=57218432

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680032940.6A Pending CN107864671A (zh) 2015-05-05 2016-05-05 星形细胞创伤节和神经创伤生物标志物

Country Status (7)

Country Link
US (3) US10557859B2 (enExample)
EP (1) EP3292414B1 (enExample)
JP (1) JP6839854B2 (enExample)
CN (1) CN107864671A (enExample)
ES (1) ES2873509T3 (enExample)
IL (1) IL255351A0 (enExample)
WO (1) WO2016179426A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6839854B2 (ja) * 2015-05-05 2021-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 星状細胞トラウマトーム（ｔｒａｕｍａｔｏｍｅ）および神経外傷のバイオマーカー
US11709168B2 (en) * 2017-05-23 2023-07-25 Brainbox Solutions, Inc. Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma
WO2019099732A1 (en) * 2017-11-16 2019-05-23 Brainbox Solutions, Inc. Protein biomarker indicators of neurological injury and/or disease and methods of use thereof
AU2018395255B2 (en) 2017-12-29 2025-02-20 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
EP4053559A1 (en) * 2021-03-01 2022-09-07 Consorcio Centro de Investigación Biomédica en Red, M.P. (CIBER) Methods for the measurement of protein c and activated protein c

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040186A (zh) * 2004-07-01 2007-09-19 帕拉迪姆医疗有限公司 受体gpr86的用途
CN101983337A (zh) * 2008-02-04 2011-03-02 班扬生物标记公司 用于诊断或治疗脑损伤的方法
CN103118698A (zh) * 2010-05-28 2013-05-22 意识-Nrg公司 神经调节素同种型，神经调节素多肽和其使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8492107B2 (en) * 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2007136617A2 (en) * 2006-05-18 2007-11-29 Walter Reed Army Institute Of Research (Wrair) Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis of brain injury
CA2766057A1 (en) 2009-06-19 2010-12-23 Banyan Biomarkers, Inc. Biomarker assay of neurological condition
KR101211280B1 (ko) * 2010-03-26 2012-12-11 가톨릭대학교 산학협력단 신규한 뇌손상 질환 진단용 마커 및 이의 용도
WO2012051519A2 (en) 2010-10-14 2012-04-19 The Johns Hopkins University Biomarkers of brain injury
WO2015157300A1 (en) 2014-04-07 2015-10-15 Iron Horse Diagnostics, Inc Traumatic brain injury and neurodegenerative biomarkers, methods, and systems
CA2962400A1 (en) 2014-09-25 2016-03-31 Oxeia Biopharmaceuticals, Inc. Methods of treating traumatic brain injury
JP6839854B2 (ja) * 2015-05-05 2021-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 星状細胞トラウマトーム（ｔｒａｕｍａｔｏｍｅ）および神経外傷のバイオマーカー

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040186A (zh) * 2004-07-01 2007-09-19 帕拉迪姆医疗有限公司 受体gpr86的用途
CN101983337A (zh) * 2008-02-04 2011-03-02 班扬生物标记公司 用于诊断或治疗脑损伤的方法
CN103118698A (zh) * 2010-05-28 2013-05-22 意识-Nrg公司 神经调节素同种型，神经调节素多肽和其使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MAURICE M.A.L. PELSERS ET AL.: "Brain- and Heart-Type Fatty Acid-Binding Proteins in the Brain: Tissue Distribution and Clinical Utility", 《CLINICAL CHEMISTRY》 *
XINYU YANG ET AL.: "Expressive proteomics profile changes of injured human brain cortex due to acute brain trauma", 《BRAIN INJURY》 *
毛伟峰 等: "大鼠创伤性脑损伤后海马齿状回中脑脂结合蛋白的表达变化", 《解剖学报》 *

Also Published As

Publication number Publication date
US20180364259A1 (en) 2018-12-20
US20220299531A1 (en) 2022-09-22
EP3292414A4 (en) 2018-09-26
US11249094B2 (en) 2022-02-15
JP2018523092A (ja) 2018-08-16
US10557859B2 (en) 2020-02-11
US12339289B2 (en) 2025-06-24
US20200278359A1 (en) 2020-09-03
EP3292414A1 (en) 2018-03-14
EP3292414B1 (en) 2021-04-07
JP6839854B2 (ja) 2021-03-17
WO2016179426A1 (en) 2016-11-10
ES2873509T3 (es) 2021-11-03
IL255351A0 (en) 2017-12-31

Similar Documents

Publication Publication Date Title
US12461112B2 (en) Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma
US12339289B2 (en) Astrocyte traumatome and neurotrauma biomarkers
US20170299615A1 (en) Biomarker for cognitive dysfunction diseases, and method for detection of cognitive dysfunction diseases using the biomarker
US11726100B2 (en) Method of treating large vessel occlusion stroke
CN107533048A (zh) 用于诊断脑损伤或神经退行性变的方法和组合物
US9977036B2 (en) Diagnostic markers for multiple sclerosis
BR112020005445A2 (pt) método para a detecção de proteínas do inflamassoma como biomarcadores de transtornos neurológicos
ES2598248B1 (es) Método in vitro y kit para el pronóstico o predicción de la respuesta al tratamiento con agentes antipsicóticos por parte de pacientes que han sufrido un primer episodio psicótico
EP3002588B1 (en) Use of a biomarker for diagnosing schizophrenia
KR102108176B1 (ko) 알츠하이머성 치매 진단용 펩타이드 바이오마커
WO2010005077A1 (ja) パーキンソン病の疾患関連たんぱく質およびその使用
US12584925B2 (en) Method of treating large vessel occlusion stroke
KR102544219B1 (ko) 코펩틴의 농도를 이용한 외상성 뇌 손상의 진단 방법
KR20200024004A (ko) 알츠하이머성 치매 진단용 펩타이드 바이오마커
US9182413B2 (en) Methods and devices for diagnosing cardiac disorders
WO2012038574A1 (es) Método de diagnóstico de alergia ocular infantil
EP4142705A2 (en) Compositions and methods for treating inflammasome related diseases or conditions

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180330