CN107847590B - 针对白细胞介素36受体(il-36r)的抗体 - Google Patents

针对白细胞介素36受体(il-36r)的抗体 Download PDF

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CN107847590B
CN107847590B CN201680034793.6A CN201680034793A CN107847590B CN 107847590 B CN107847590 B CN 107847590B CN 201680034793 A CN201680034793 A CN 201680034793A CN 107847590 B CN107847590 B CN 107847590B
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CN107847590A (zh
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P·鲍尔斯
A·J·麦克奈特
D·J·金
M·隆代伊
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Anaptysbio Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201680034793.6A 2015-04-15 2016-04-15 针对白细胞介素36受体(il-36r)的抗体 Active CN107847590B (zh)

Priority Applications (1)

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CN202210803364.8A CN115925932A (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体（il-36r）的抗体

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Application Number Priority Date Filing Date Title
US201562147824P 2015-04-15 2015-04-15
US62/147,824 2015-04-15
PCT/US2016/027676 WO2016168542A1 (en) 2015-04-15 2016-04-15 Antibodies directed against interleukin 36 receptor (il-36r)

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CN202210803364.8A Division CN115925932A (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体（il-36r）的抗体

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CN107847590A CN107847590A (zh) 2018-03-27
CN107847590B true CN107847590B (zh) 2022-07-26

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CN201680034793.6A Active CN107847590B (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体(il-36r)的抗体
CN202210803364.8A Pending CN115925932A (zh) 2015-04-15 2016-04-15 针对白细胞介素36受体（il-36r）的抗体

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US (3) US10526410B2 (enExample)
EP (2) EP4176900A1 (enExample)
JP (4) JP6913026B2 (enExample)
KR (1) KR102666920B1 (enExample)
CN (2) CN107847590B (enExample)
AU (1) AU2016248208B2 (enExample)
CA (1) CA2982555A1 (enExample)
DK (1) DK3283110T3 (enExample)
ES (1) ES2914243T3 (enExample)
MX (2) MX2017013080A (enExample)
PL (1) PL3283110T3 (enExample)
RU (1) RU2745898C2 (enExample)
SG (1) SG11201708061TA (enExample)
WO (1) WO2016168542A1 (enExample)

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ES2914243T3 (es) * 2015-04-15 2022-06-08 Anaptysbio Inc Anticuerpos dirigidos contra el receptor de la interleuquina 36 (IL-36R)
EP3601350A1 (en) * 2017-03-27 2020-02-05 Boehringer Ingelheim International GmbH Anti il-36r antibodies combination therapy
EP3400962A1 (en) 2017-05-09 2018-11-14 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Inhibitors of il-38 for use in treating and/or preventing cancer in a subject
US12227567B2 (en) 2017-07-25 2025-02-18 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
CA3090421A1 (en) * 2018-03-14 2019-09-19 Boehringer Ingelheim International Gmbh Use of anti-il-36r antibodies for treatment of inflammatory bowel disease
CA3093692A1 (en) * 2018-03-14 2019-09-19 Boehringer Ingelheim International Gmbh Use of anti-il-36r antibodies for treatment of generalized pustular psoriasis
EP3823989A2 (en) * 2018-07-16 2021-05-26 Regeneron Pharmaceuticals, Inc. Anti-il36r antibodies
SMT202400300T1 (it) * 2018-07-16 2024-09-16 Regeneron Pharma Modelli di roditori della sindrome ditra e loro utilizzo
CN110818796B (zh) * 2018-08-09 2022-11-08 东莞市朋志生物科技有限公司 一种抗人ca153蛋白的重组抗体
AU2019405782A1 (en) 2018-12-21 2021-06-17 23Andme, Inc. Anti-IL-36 antibodies and methods of use thereof
EP3902604A1 (en) * 2018-12-27 2021-11-03 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for treatment of palmoplantar pustulosis
CN116063520A (zh) 2019-01-30 2023-05-05 真和制药有限公司 抗gal3抗体及其用途
EP3934617A1 (en) * 2019-03-08 2022-01-12 Boehringer Ingelheim International GmbH Anti-il-36r antibody formulations
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AR120913A1 (es) * 2019-12-27 2022-03-30 Teijin Pharma Ltd Anticuerpo que inhibe específicamente la señalización de il-36r
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法
EP4182022A1 (en) 2020-07-17 2023-05-24 Boehringer Ingelheim International GmbH Anti-il-36r antibodies for the treatment of neutrophilic dermatoses
IL299648A (en) * 2020-07-30 2023-03-01 Anaptysbio Inc Anti-interleukin 36 receptor therapy for psoriasis
WO2022026829A1 (en) 2020-07-30 2022-02-03 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for skin toxicity
CN112094349B (zh) * 2020-11-04 2021-02-09 上海华奥泰生物药业股份有限公司 靶向于白介素36r的抗体及其制备方法和应用
US20240084021A1 (en) 2021-01-08 2024-03-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa
WO2022150644A1 (en) 2021-01-08 2022-07-14 Anaptysbio, Inc. Anti-interleukin 36 receptor (il-36r) therapy for acne
TW202302644A (zh) * 2021-03-04 2023-01-16 德商百靈佳殷格翰國際股份有限公司 治療gpp之方法
JP2024512384A (ja) 2021-03-12 2024-03-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 汎発型膿疱性乾癬における抗ｉｌ－３６ｒ抗体による処置に関連したバイオマーカー
KR20240021800A (ko) * 2021-05-12 2024-02-19 아납티스바이오, 아이엔씨. 항체 조성물
US20250282859A1 (en) 2021-07-12 2025-09-11 Institut National de la Santé et de la Recherche Médicale Use of il-36 inhibitors for the treatment of netherton syndrome
TW202323293A (zh) * 2021-10-29 2023-06-16 新加坡商創響私人有限公司 新型抗ｉｌ－３６ｒ抗體
CN115724975A (zh) * 2022-10-20 2023-03-03 江苏荃信生物医药股份有限公司 抗人白介素36受体单克隆抗体及其应用

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HK1252009A1 (zh) 2019-05-10
US20180094065A1 (en) 2018-04-05
JP7212098B2 (ja) 2023-01-24
US10526410B2 (en) 2020-01-07
CN107847590A (zh) 2018-03-27
US20200087408A1 (en) 2020-03-19
RU2745898C2 (ru) 2021-04-02
EP3283110A4 (en) 2019-02-27
JP2018512157A (ja) 2018-05-17
WO2016168542A1 (en) 2016-10-20
CN115925932A (zh) 2023-04-07
SG11201708061TA (en) 2017-10-30
RU2017139481A3 (enExample) 2019-09-19
KR102666920B1 (ko) 2024-05-20
CA2982555A1 (en) 2016-10-20
EP3283110A1 (en) 2018-02-21
EP3283110B1 (en) 2022-04-20
ES2914243T3 (es) 2022-06-08
KR20180002687A (ko) 2018-01-08
AU2016248208A1 (en) 2017-11-09
RU2017139481A (ru) 2019-05-15
JP7721585B2 (ja) 2025-08-12
US12391761B2 (en) 2025-08-19
JP6913026B2 (ja) 2021-08-04
JP2023040236A (ja) 2023-03-22
AU2016248208B2 (en) 2022-03-24
US11130814B2 (en) 2021-09-28
MX2023001791A (es) 2023-03-10
DK3283110T3 (da) 2022-05-23
EP4176900A1 (en) 2023-05-10
PL3283110T3 (pl) 2022-06-27
JP2021118710A (ja) 2021-08-12
JP2025163120A (ja) 2025-10-28
US20210388095A1 (en) 2021-12-16
MX2017013080A (es) 2018-02-09
HK1250941A1 (en) 2019-01-18
NZ736535A (en) 2024-08-30
BR112017022086A2 (pt) 2018-07-03

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