CN107837356A - 一种治疗胃病的药物及其制备方法 - Google Patents
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Abstract
本发明涉及一种治疗胃病的药物及其制备方法。药物由下述重量配比的原料药组分经水煎制得：野菊花10‑20份，人参5‑15份，苦土1‑3份，蛇莲5‑15份，鸡内金5‑15份，麦芽5‑15份，山楂4‑7份，橘红15‑25份，仙人掌5‑15份，地榆5‑10份。其制备方法是，将鸡内金干燥，磨粉至20目，与苦土拌匀，装布袋备用；将布袋其它原料药组分混合，水煎。本发明对于治疗胃溃疡、胃糜烂、胃酸、胃胀及慢性胃炎，疗效尤其显著，对感染幽门螺杆菌的各类胃病具有起效快、疗效好、副作用小的治疗效果。
Description
技术领域
本发明涉及医药配制品技术领域，特别是一种治疗胃病的药物及其制备方法。
背景技术
在经济日益发展的当今社会，许多年轻人随着工作压力的增大和生活节奏的加快，传统的进餐时间被打乱，遗忘早餐、延迟午餐、晚餐丰盛，饮食没有规律，导致越来越多的人出现胃病病变；胃病，实际上是许多病的统称。它们有相似的症状，如上腹胃脘部不适、疼痛、饭后饱胀、嗳气、返酸，甚至恶心、呕吐等等。临床上常见的胃病有急性胃炎、慢性胃炎、胃溃疡、十二指肠溃疡、胃十二指肠复合溃疡、胃息肉、胃结石、胃的良恶性肿瘤，还有胃黏膜脱垂症、急性胃扩张、幽门梗阻等。
胃病的临床表现，最常见的有上腹部不适或疼痛、恶心、呕吐、腹泻、食欲不振。胃炎及十二指肠溃疡的症状则为上腹部烧灼痛，特别是在两顿饭之间，早餐前或在饮用橙汁、咖啡之后发生。严重者可有柏油便、黑便或血便。
目前，市场上虽然有大量治疗此类疾病的同类产品，但由于西药有副作用和刺激性不利于此类病症的治疗。近年来，不少中药新配方越来越多地被公开，专利及专利申请众多，配方各不相同，治疗效果也不尽相同。但医药行业的研究者们仍然坚持致力于开发和公开新的药物，以更好地为患者服务，减轻患者所受的病痛折磨。
2015年4月29日，中国发明专利申请公布号CN104547560A，公开了一种治疗胃病的药物及其制备方法；由下述重量配比的原料药制得：蛇莲8-15份，隔山消15-20份，橘皮5-8份，神曲7-9份，鸡内金3-5份，铁树芽7-15份，麦芽3-10份，山豆根7-15份，山楂5-8份，半夏7-12份，橘红5-10份，仙人掌15-25份，海螵蛸7-15份，地榆8-10份，茯苓12-20份，连翘8-20份，白芨15-25份，冰片1-10份。制备步骤：（1）筛选原料药，按重量配比取样，清洗、干燥、消毒；（2）粉碎，过800-1000目筛，混合均匀即可。该方法用来治疗胃病病症的平均有效率为95.5%。
发明内容
本发明目的是提供的一种治疗胃病的药物及其制备方法，对于治疗胃溃疡、胃糜烂、胃酸、胃胀及慢性胃炎，疗效尤其显著，对感染幽门螺杆菌的各类胃病具有起效快、疗效好、副作用小的治疗效果。
一种治疗胃病的药物及其制备方法，药物由下述重量配比的原料药组分经水煎制得：野菊花10-20份，人参5-15份，苦土1-3份，蛇莲5-15份，鸡内金5-15份，麦芽5-15份，山楂4-7份，橘红15-25份，仙人掌5-15份，地榆5-10份。
一种治疗胃病的药物的制备方法，包括以下步骤：
（1）筛选原料药，按重量配比取样；
（2）将鸡内金干燥，磨粉至20目，与苦土拌匀，装布袋备用；
（3）将布袋其它原料药组分混合，混合组分按1：2-4的重量比加水浸泡20分钟，先武火煮沸后文火水煎1-1.5小时，分离第一次水煎剂；再将药渣按1：1-2的重量加水，又先武火煮沸后文火水煎1-1.5小时，分离第二次水煎剂；两次的水煎剂混合，分早晚两次服用；
（4）七日为一个疗程，四个疗程可控，具体视病情定；
（5）孕妇在医生指导下服用。
本发明至少包括以下有益效果：本发明利用中医五行及辨证理论，据《寿世保元》记载：“夫胁痛者，厥阴肝经为病也。其症自两胁下痛引小腹，亦当视内外所感之邪而治之。若伤寒少阳，耳聋胁痛，风寒所袭而为协痛，此外因也。若因暴怒伤触，悲哀气结，饮食过渡，冷热失调，颠仆伤形，或痰积流注于胁，与血相搏，皆能为痛，此内因也。”认为胃病的病因为：风热之邪滞于肠胃，热结不散，灼伤津液，肠胃枯干，水谷出入之道不得通畅，消化阻滞，食入反出。治宜清气热、散结热、养津液、理肠胃。
本发明中：
野菊花贵在野生，美在天然；其性微寒、味苦而辛，可广泛用于治疗疔疮痈肿、咽喉肿痛、风火赤眼、头痛眩晕等病证；
人参，味甘、微苦，性温、平，能补中益气、补胃气；
苦土，用作抗酸剂和轻泻剂，用于胃酸过多、胃和十二指肠溃疡病；
蛇莲涩微苦，平，无毒；具有清热，解毒，收敛，生肌功效，在本发明中苦能清热泻火、生津止渴养津液；
鸡内金，健胃消食、固摄缩尿、消结石，在本发明中与苦土、山楂配伍，能健脾消食化滞、可以持久中和胃酸，利肠胃；
麦芽 味甘，平，行气消食，健脾开胃，回乳消胀；
山楂，消食化积、止痢疾、破气化瘀、降血压；本发明中与人参、麦芽配伍，可以产生理肠胃，补脾胃，散风的效果。
橘红 味辛、苦，性温，为利气要药，本发明中同野菊花配伍，辛能横行散结，苦能直行下降，泄热，起平胃、疏散风热、消炎作用；
仙人掌 味苦涩，性寒，本发明中行气活血，清热解毒，治心胃气痛。
地榆，凉血止血、消肿止痛，在本发明中起抗溃疡、抗菌作用；
本发明通过以上多种中药的合理配伍，清气热、散结热、养津液、和胃、调节肠胃运动、补脾胃、抗溃疡、抗菌、抗炎，使胃病得以治愈。
本发明临床主要用于急慢性胃炎、胃溃疡、慢性萎缩性胃炎、消化不良等的治疗。
本发明药物临床共100例使用，总有效率为96.5%，且用药方便快捷；治疗100例胃病临床观察情况报告如下:
1、病例选择：全部治疗组100例，均经病理诊断，确诊为胃病，其中急慢慢性胃炎53例，胃溃疡47例；
2、诊断依据：诊断主要依临床症状，胃镜所见及病理诊断；
3、辨证论治：依据1989年11月中国中西医结合学会消化系统疾病专业委员会诊断试行标准；
4、治疗方法：治疗组均停用其它药物和治疗，每人口服水煎剂，早晚两次服用；温开水漱口。一周为一个疗程，服四个疗程；
5、观察指标：治疗前、中、后，详细观察症状和体征变化，记在临床观察表中，治疗前后相关免疫学检测，做胃镜等病理检查；
6、结果：服药一周后记录结果，在服药满四周后统计疗效结果；
（1）疗效：急慢慢性胃炎53例，近期临床治愈26例，占49.1%；显效22例，占37.7%；有效4例，占7.6%；无效1例，占1.9%；总有效率为98.1%；
胃溃疡47例,近期临床治愈31例，占66%；显效10例，占21.2%；有效4例，占8.5%；无效2例，占4.3%；总有效率为95.7%；
疗效评价标准的定义是：
近期临床治愈：肠胃炎症状消失；
显效：肠胃炎症状明显减轻；
有效：肠胃炎症状较治疗前减轻；
无效：病情无任何改善的表现；
（2）经过本发明治疗的患者临床症状变化如下表，从下表可以看出，本发明对大部分患者在一周内症状开始改善，按照疗程服用的患者，都有很明显的效果；
| 病种 | 程度 | 疗程 | 症状改善对照说明 |
| 急性浅表性胃炎 | 轻度两年内 | 2—3周 | 胃酸，胃痛和胃胀1周内基本消失。 |
| 慢性浅表性胃炎 | 重度、病情五年内 | ≥3—4周 | 1周后：胃痛基本消失，胃胀、反酸、烧心、打嗝等症状偶有发作：1疗程后：幽门螺旋杆菌转阴症状消除80%，五年以下者连续服可痊愈。胃部机能恢复正常。 |
| 糜烂性胃炎 | 病情单一 | 2—3周 | 1周后：疼痛，消化不良，胃胀、烧心等症状明显改善。2—3周后：HP转阴、糜烂愈合、症状消除，食欲好。 |
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面对本发明做详细说明，以使本领域普通技术人员参阅本说明书后能够据以实施。
实施例1
1、处方：野菊花10份，人参15份，苦土1份，蛇莲15份，鸡内金5份，麦芽15份，山楂4份，橘红15份，仙人掌15份，地榆5份。
2、一种治疗胃病的药物的制备方法，包括以下步骤：
（1）筛选原料药，按重量配比取样；
（2）将鸡内金干燥，磨粉至20目，与苦土拌匀，装布袋备用；
（3）将布袋其它原料药组分混合，混合组分按1：2的重量比加水浸泡20分钟，先武火煮沸后文火水煎1小时，分离第一次水煎剂；再将药渣按1：1.5的重量加水，又先武火煮沸后文火水煎1小时，分离第二次水煎剂；两次的水煎剂混合，分早晚两次服用；
（4）七日为一个疗程，四个疗程可控，具体视病情定；
（5）孕妇在医生指导下服用。
实施例2
1、处方：野菊花20份，人参5份，苦土3份，蛇莲5份，鸡内金15份，麦芽5份，山楂7份，橘红25份，仙人掌5份，地榆10份。
2、一种治疗胃病的药物的制备方法，包括以下步骤：
（1）筛选原料药，按重量配比取样；
（2）将鸡内金干燥，磨粉至20目，与苦土拌匀，装布袋备用；
（3）将布袋其它原料药组分混合，混合组分按1：3的重量比加水浸泡20分钟，先武火煮沸后文火水煎1.2小时，分离第一次水煎剂；再将药渣按1：1的重量加水，又先武火煮沸后文火水煎1小时，分离第二次水煎剂；两次的水煎剂混合，分早晚两次服用；
（4）七日为一个疗程，四个疗程可控，具体视病情定；
（5）孕妇在医生指导下服用。
实施例3
1、处方：野菊花15份，人参10份，苦土2份，蛇莲10份，鸡内金10份，麦芽10份，山楂5份，橘红20份，仙人掌10份，地榆8份。
2、一种治疗胃病的药物的制备方法，包括以下步骤：
（1）筛选原料药，按重量配比取样；
（2）将鸡内金干燥，磨粉至20目，与苦土拌匀，装布袋备用；
（3）将布袋其它原料药组分混合，混合组分按1：4的重量比加水浸泡20分钟，先武火煮沸后文火水煎1.5小时，分离第一次水煎剂；再将药渣按1：2的重量加水，又先武火煮沸后文火水煎1.5小时，分离第二次水煎剂；两次的水煎剂混合，分早晚两次服用；
（4）七日为一个疗程，四个疗程可控，具体视病情定；
（5）孕妇在医生指导下服用。
以上所述仅为本发明的实施方案，并非因此限制本发明的专利范围，凡是利用本发明说明书内容所作的等效结构或等效流程变换，或间接或直接运用在其他相关技术领域，均包括在本发明的专利保护范围内。
Claims (2)
1.一种治疗胃病的药物，其特征在于：由下述重量配比的原料药组分经水煎制得：野菊花10-20份，人参5-15份，苦土1-3份，蛇莲5-15份，鸡内金5-15份，麦芽5-15份，山楂4-7份，橘红15-25份，仙人掌5-15份，地榆5-10份。
2.一种治疗胃病的药物的制备方法，其特征在于：包括以下步骤：
（1）筛选原料药，按重量配比取样；
（2）将鸡内金干燥，磨粉至20目，与苦土拌匀，装布袋备用；
（3）将布袋其它原料药组分混合，混合组分按1：2-4的重量比加水浸泡20分钟，先武火煮沸后文火水煎1-1.5小时，分离第一次水煎剂；再将药渣按1：1-2的重量加水，又先武火煮沸后文火水煎1-1.5小时，分离第二次水煎剂；两次的水煎剂混合，分早晚两次服用；
（4）七日为一个疗程，四个疗程可控，具体视病情定；
（5）孕妇在医生指导下服用。
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