CN107823559A - 一种治疗痛风的内服药物及其制备方法 - Google Patents

一种治疗痛风的内服药物及其制备方法 Download PDF

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CN107823559A
CN107823559A CN201711129791.8A CN201711129791A CN107823559A CN 107823559 A CN107823559 A CN 107823559A CN 201711129791 A CN201711129791 A CN 201711129791A CN 107823559 A CN107823559 A CN 107823559A
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罗娟
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Chengdu Feilong Water Treatment Technology Institute
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗痛风的认识机理而提供一种治疗痛风的内服药物，所述药物的各个组分及其质量份比如下：海金沙6～16g、独活3～15g、金钱草15～65g、萆薢5～15g、黑豆10～36g、五味子3～7g、甘草3～13g、川朴3～12g、莪术3～12g、龟板15～45g、陈皮3～16g、鸡内金3～12g、连翘6～16g、砂仁3～8g、没药3～7g、海风藤6～15g；本发明提供的药物是一个很好的中药组方。

Description

一种治疗痛风的内服药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗痛风的内服药物，特别是供痛风患者使用的内服药物及其制备方法的领域。
背景技术
医者认为：痛风是由单钠尿酸盐（MSU）沉积所致的晶体相关性关节病，与嘌呤代谢紊乱和（或）尿酸排泄减少所致的高尿酸血症直接相关，特指急性特征性关节炎和慢性痛风石疾病，主要包括急性发作性关节炎、痛风石形成、痛风石性慢性关节炎、尿酸盐肾病和尿酸性尿路结石，重者可出现关节残疾和肾功能不全。痛风常伴腹型肥胖、高脂血症、高血压、2型糖尿病及心血管病等表现。
那么，就如何找到一种可有效治疗痛风的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗痛风上，人们逐渐意识到了中医治疗痛风的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗痛风的现状，本发明的目的是在于提供一种治疗痛风的内服药物，以解决痛风患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量
份比，可有效治疗上述痛风一证。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗痛风的内服药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
海金沙6～16g、独活3～15g、金钱草15～65g、萆薢5～15g、黑豆10～36g、五味子3～7g、甘草3～13g、川朴3～12g、莪术3～12g、龟板15～45g、陈皮3～16g、鸡内金3～12g、连翘6～16g、砂仁3～8g、没药3～7g、海风藤6～15g。
一种治疗痛风的内服药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
海金沙7～14g、独活5～13g、金钱草18～56g、萆薢6～13g、黑豆11～32g、五味子4～6g、甘草5～12g、川朴5～11g、莪术5～11g、龟板16～40g、陈皮5～14g、鸡内金5～11g、连翘7～14g、砂仁5～7g、没药4～6g、海风藤7～13g。
一种治疗痛风的内服药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
海金沙13g、独活12g、金钱草50g、萆薢12g、黑豆26g、五味子5g、甘草11g、川朴10g、莪术10g、龟板36g、陈皮13g、鸡内金10g、连翘13g、砂仁6g、没药5g、海风藤12g。
一种治疗痛风的内服药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比分别粉碎成粗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡40min，然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内，注入过药66mm的冷开水进行第一次武火煎煮，待煎煮到15min时，转文火熬制35 min，滤取药液；②药渣中再次注入过药62mm的微温开水进行第二次武火煎煮，待煎煮到10min时，转文火熬制30 min，滤取药液；③将两次药液混合浓缩成50%的中药液480ml（毫升）即可。
一种治疗痛风的内服药物及其制备方法，其特征在于，所述服用方法为：将制备好的中药液以一天服用，每日一剂，早中晚各服一次，给药量160ml（毫升）/次，趁温服。18天为一个疗程，服药3～7个疗程后，经检查：血尿酸降至正常范围，症状消失，随访一年余，未见复发。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
海金沙，性味：味甘、咸、性寒，具有清利湿热、通淋止痛之功效，用于治疗热淋、石淋、血淋、膏淋、尿道涩痛；
独活，性味：辛、苦、微温，具有祛风除湿、通痹止痛之功效，用于治疗风寒湿痹、腰膝疼痛、少阴伏风头痛；
金钱草，性味：味甘、咸、性微寒，具有利湿退黄、利尿通淋、解毒消肿之功效，用于治疗湿热黄疸、胆胀胁痛、石淋、热淋、小便涩痛、痈肿疔疮、蛇虫咬伤等症；
萆薢，性味：苦甘、平，具有利湿去浊、祛风除痹之功效，用于治疗淋浊白带、腰膝痹痛、湿热疮毒；
黑豆，性味：甘、平，具有益精明目、养血祛风、利水、解毒之功效，用于治疗阴虚烦渴、头晕目昏、体虚多汗、肾虚腰痛、水肿尿少、痹痛拘挛、手足麻木、药食中毒；
五味子，性味：酸、甘、温，具有收敛固涩、益气生津、补肾宁心之功效，用于治疗久嗽虚喘、梦遗滑精、遗尿尿频、久泻不止、自汗、盗汗、津伤口渴、短气脉虚、内热消渴、心悸失眠；
甘草，性味：甘、平，具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效，用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒；
川朴，性味：苦、辛、性温，具有行气消积、燥湿除满、降逆平喘之功效，用于治疗食积气滞、腹胀便秘、湿阻中焦、脘痞吐泻、痰壅气逆、胸满喘咳；
莪术，性味：苦辛、温，具有破血行气，消积止痛之功效，用于治疗血气心痛、饮食积滞、脘腹胀痛、血滞经闭、痛经、症瘕瘤痞块、跌打损伤，还用于血瘀腹痛、肝脾肿大、心腹胀痛、积聚、症瘕肿块、妇女血瘀经闭、跌打损伤作痛饮食积滞；
龟板，性味：咸甘、平，具有滋阴、潜阳、补肾、健骨之功效，用于治疗肾阴不足、骨蒸劳热、吐血、衄血、久咳、遗精、崩漏、带下、腰痛、骨痿、 阴虚风动、久痢、久疟、痔疮、小儿囟门不合；
陈皮，性味：味辛、苦、性温，具有理气和中，燥湿化痰，利水通便之功效，用于治疗脾胃不和、脘腹胀痛、不思饮食、呕吐哕逆、痰湿阻肺、咳嗽痰多、胸膈满闷、头目眩晕、水肿、小便不利、大便秘结、乳痈疥癣、中鱼蟹毒、酒毒等症；
鸡内金，性味：甘、平，具有健胃消食、涩精止遗、通淋化石之功效，用于治疗食积不消、呕吐泻痢、小儿疳积、遗尿、遗精、石淋涩痛、胆胀胁痛；
连翘，性味：味苦，性微寒。 具有清热解毒、散结消肿、疏散风热之功效，用于治疗热病初起、风热感冒、发热、心烦、咽喉肿痛、斑疹、丹毒、瘰疬、痈疮肿毒、急性肾炎、热淋等症；
砂仁，性味：味辛、性温，具有化湿开胃、温脾止泻、理气安胎之功效，用于治疗湿浊中阻、脘痞不饥、脾胃虚寒、呕吐泄泻、妊娠恶阻、胎动不安；
没药，性味：味辛、苦、性平，具有散瘀定痛、消肿生肌之功效，用于治疗胸痹心痛、胃脘疼痛、痛经经闭、产后瘀阻、癥瘕腹痛、风湿痹痛、跌打损伤、痈肿疮疡；
海风藤，性味：味辛、苦、性微温，具有祛风湿、通经络、止痹痛之功效，用于治疗风寒湿痹、肢节疼痛、筋脉拘挛、屈伸不利。
本发明药物是基于中医治疗痛风的原则，从依据痛风的病理机制及药理作用认为：就痛风一证，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述痛风的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗痛风的内服药物，其特征在于，所述药物的各个组分及质量份比如下所示：
海金沙13g、独活12g、金钱草50g、萆薢12g、黑豆26g、五味子5g、甘草11g、川朴10g、莪术10g、龟板36g、陈皮13g、鸡内金10g、连翘13g、砂仁6g、没药5g、海风藤12g。
实施例2：
一种治疗痛风的内服药物，其特征在于，所述药物的各个组分及质量份比如下所示：
海金沙14g、独活13g、金钱草56g、萆薢13g、黑豆32g、五味子6g、甘草12g、川朴11g、莪术11g、龟板40g、陈皮14g、鸡内金11g、连翘14g、砂仁7g、没药6g、海风藤13g。
实施例3：
一种治疗痛风的内服药物，其特征在于，所述药物的各个组分及质量份比如下所示：
海金沙16g、独活15g、金钱草65g、萆薢15g、黑豆36g、五味子7g、甘草13g、川朴12g、莪术12g、龟板45g、陈皮16g、鸡内金12g、连翘16g、砂仁8g、没药7g、海风藤15g。
典型病例：
经临床诊断治疗痛风患者共1375例，年龄为56岁以上的850例，只有525例为56岁以下。1375例患者中血尿酸降至正常范围的有930例，有效的321例，无效的124例。总有效率达91%。

Claims (3)

1.一种治疗痛风的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
海金沙6～16g、独活3～15g、金钱草15～65g、萆薢5～15g、黑豆10～36g、五味子3～7g、甘草3～13g、川朴3～12g、莪术3～12g、龟板15～45g、陈皮3～16g、鸡内金3～12g、连翘6～16g、砂仁3～8g、没药3～7g、海风藤6～15g。
2.根据权利要求1所述的治疗痛风的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
海金沙7～14g、独活5～13g、金钱草18～56g、萆薢6～13g、黑豆11～32g、五味子4～6g、甘草5～12g、川朴5～11g、莪术5～11g、龟板16～40g、陈皮5～14g、鸡内金5～11g、连翘7～14g、砂仁5～7g、没药4～6g、海风藤7～13g。
3.根据权利要求1至2所述的治疗痛风的内服药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
海金沙13g、独活12g、金钱草50g、萆薢12g、黑豆26g、五味子5g、甘草11g、川朴10g、莪术10g、龟板36g、陈皮13g、鸡内金10g、连翘13g、砂仁6g、没药5g、海风藤12g。
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