CN108186978A - 一种用于治疗痛风的汤剂药物及其制备方法 - Google Patents
一种用于治疗痛风的汤剂药物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗痛风的认识机理而提供一种用于治疗痛风的汤剂药物,所述药物的各个组分及其质量份比如下:土茯苓25~56g、黄茋10~36g、附子3~16g、羌活10~26g、制半夏3~10g、川牛膝6~12g、白芍5~15g、仙灵脾3~10g、莪术3~12g、萆薢5~15g、当归6~15g、山慈姑3~10g、枣仁10~16g、细辛1~4g、茯苓10~16g、防风5~12g、牛蒡子5~10g、独活3~12g、炙甘草2~12g、肉桂2~6g、三梭5~12g、川芎5~12g、威灵仙6~12g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种用于治疗痛风的汤剂药物,特别是供痛风患者使用的汤剂药物及其制备方法的领域。
背景技术
据文献资料显示:痛风是嘌呤代谢异常致使尿酸合成增加而导致的代谢性疾病。肾功能异常时,由于肾脏的尿酸清除率下降也会引起尿酸水平上升。血浆中的尿酸达到饱和,导致尿酸单钠结晶沉积在远端关节周围相对缺乏血管的组织中。这种结晶的出现可导致单关节或者多关节的急性炎性滑膜炎,痛风在男性中较为多见,拇趾是最常见的受累区域,50%~70%的初次发病就在于此。90%的痛风患者在其一生中的某个时期会发生第一跖趾关节受累。其他可能受累的足部区域有足背部、足跟以及踝部。除了累及关节之外,尿酸结晶还可以沉积在皮下,被称作痛风结节。
目前,痛风尚无根治的方法,临床上多用甾体类抗炎药、糖皮质激素、别嘌呤醇、秋水仙碱等,这类药品能迅速缓解疼痛。但也存在一定的缺陷,治标不治本,副作用大,长期服用,还对人体的胃肠道、肝肾功能有较大的损害。
那么,就如何找到一种可有效治疗痛风的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗痛风上,人们逐渐意识到了中医治疗痛风的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗痛风的现状,本发明的目的是在于提供一种用于治疗痛风的汤剂药物,以解决痛风患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述痛风。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种用于治疗痛风的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓25~56g、黄茋10~36g、附子3~16g、羌活10~26g、制半夏3~10g、川牛膝6~12g、白芍5~15g、仙灵脾3~10g、莪术3~12g、萆薢5~15g、当归6~15g、山慈姑3~10g、枣仁10~16g、细辛1~4g、茯苓10~16g、防风5~12g、牛蒡子5~10g、独活3~12g、炙甘草2~12g、肉桂2~6g、三梭5~12g、川芎5~12g、威灵仙6~12g。
一种用于治疗痛风的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓28~50g、黄茋11~32g、附子5~14g、羌活11~23g、制半夏4~9g、川牛膝7~11g、白芍6~13g、仙灵脾5~9g、莪术4~11g、萆薢6~14g、当归7~13g、山慈姑4~9g、枣仁11~15g、细辛2~3.5g、茯苓11~14g、防风6~11g、牛蒡子6~9g、独活5~11g、炙甘草3~11g、肉桂3~5g、三梭6~11g、川芎6~11g、威灵仙7~11g。
一种用于治疗痛风的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓43g、黄茋28g、附子13g、羌活20g、制半夏8g、川牛膝10g、白芍12g、仙灵脾8g、莪术10g、萆薢13g、当归12g、山慈姑8g、枣仁13g、细辛3g、茯苓13g、防风10g、牛蒡子8g、独活10g、炙甘草10g、肉桂4g、三梭10g、川芎10g、威灵仙10g。
一种用于治疗痛风的汤剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡40min,然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内,注入过药65mm的冷开水进行第一次武火煎煮,待煎煮到15min时,转文火熬制35 min,滤取药液;②药渣中再次注入过药60mm的微温开水进行第二次武火煎煮,待煎煮到10min时,转文火熬制30 min,滤取药液;③将二次药液混合浓缩成50%的中药液600ml(毫升)即可。
一种用于治疗痛风的汤剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的中药液以一天服用,早中晚各服一次,给药量200ml(毫升)/次,饭后半小时温服。(忌烟、酒、生葱、生蒜、辛辣刺激性食物)。30天为一个疗程,治疗2~5个疗程后,检查:血尿酸降至正常范围,临床症状及体征全部消失。
本发明组方中的各原料中药在中国药典、中国辞典以及其中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
土茯苓,性味:甘淡、平,具有解毒、除湿、利关节之功效,用于治疗梅毒、淋浊、筋骨挛痛、脚气、疔疮、痈肿、瘰疬等症;
黄茋,性味:甘、微温,具有补气固表、利尿托毒、排脓、敛疮生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症;
附子,性味:味辛、甘、性大热,具有回阳救逆、补火助阳、散寒止痛之功效,用于治疗亡阳虚脱、肢冷脉微、心阳不足、胸痹心痛、虚寒吐泻、脘腹冷痛、肾阳虚衰、阳痿宫冷、阴寒水肿、阳虚外感、寒湿痹痛;
羌活,性味:辛苦、温,具有散表寒、祛风湿、利关节之功效,用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒;
制半夏,性味:辛、温,有毒,具有燥湿化痰、降逆止呕、消痞散结之功效,用于治疗痰多咳喘、痰饮眩悸、风痰眩晕、痰厥头痛、呕吐反胃、胸脘痞闷、梅核气,生用外治痈肿痰核,姜半夏多用于降逆止呕;
川牛膝,性味:甘、微苦、性平,具有活血祛瘀、祛风利湿之功效,用于治疗血瘀经闭、难产、胞衣不下、产后瘀血腹痛、热淋、石淋、痛经、风湿腰膝疼痛;
白芍,性味:苦、酸、微寒,具有养血和营、缓急止痛、敛阴平肝之功效,用于治疗月经不调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症;
仙灵脾,性味:味辛、甘、性温,具有补肾壮阳、祛风除湿、强筋键骨之功效,用于治疗阳痿遗精、虚冷不育、尿频失楚、肾虚喘咳、腰膝酸软、风湿痹痛、半身不遂、四肢不仁;
莪术,性味:味辛、苦、性温,具有行气破血、消积止痛之功效,用于治疗血气心痛、饮食积滞、脘腹胀痛、血滞经闭、痛经、症瘕瘤痞块、跌打损伤;
萆薢,性味:苦甘、平,具有利湿去浊、祛风除痹之功效,用于治疗淋浊白带、腰膝痹痛、湿热疮毒;
当归,性味:味甘、辛、苦、性温,具有补血、活血、调经止痛、润燥滑肠之功效,用于治疗血虚诸证、月经不调、经闭、痛经、癥瘕结聚、崩漏、虚寒腹痛、痿痹、肌肤麻木、肠燥便难、赤痢后重、痈疽疮疡、跌扑损伤;
山慈姑,性味:甘、微辛、凉,具有清热解毒、化痰散结之功效,用于治疗痈肿疔毒、瘰疬痰核、蛇虫咬伤、瘸瘕痞块;
枣仁,性味:甘、酸、平,具有补肝、宁心、敛汗、生津之功效,用于治疗虚烦不眠、惊悸多梦、体虚多汗、津伤口渴;
细辛,性味:辛、温,具有解表散寒、祛风止痛、通窍、温肺化饮之功效,用于治疗风寒感冒、头痛、牙痛、风湿痹痛、鼻渊、肺寒咳嗽等症;
茯苓,性味:味甘、淡、性平,具有利水渗湿、健脾、宁心之功效,用于治疗水肿尿少、痰饮眩悸、脾虚食少、便溏泄泻、心神不安、惊悸失眠;
防风,性味:味辛、甘、性微温,具有祛风解表、胜湿止痛、止痉定搐之功效,用于治疗外感表证、风疹瘙痒、风湿痹痛、破伤风等病症;
牛蒡子,性味:味辛、苦、性寒,具有疏散风热、宣肺透疹、解毒利咽之功效,用于治疗风热感冒、咳嗽痰多、麻疹、风疹、荨麻疹、疹出不畅、咽喉肿痛、痄腮、流行性腮腺炎、丹毒、痈肿疮毒;
独活,性味:味辛、苦、性微温,具有祛风除湿、痛痹止痛之功效,用于治疗风寒湿痹、要洗疼痛、少阴伏风头痛、风寒挟湿头痛;
炙甘草,性味:性温、味甘,具有补脾和胃、益气复脉之功效,用于治疗脾胃虚弱、倦怠乏力、心悸动、脉结代等症;
肉桂,性味:辛、甘、热,具有补火助阳、引火归源、散寒止痛、温经通脉之功效,用于治疗肾阳不足、命门火畏寒肢冷、腰膝酸软、阳痿遗精、小便不利或频数、短气喘促、浮肿尿少诸证、命门 火衰、火不归源、戴阳、格阳、及上热下寒、面赤足冷、头晕耳鸣、口舌糜破、脾肾虚寒、脘腹冷痛、食减便溏、肾虚腰痛、寒湿痹痛、寒疝疼痛、宫冷不孕、痛经经闭、产后瘀滞腹痛、阴疽流注、或虚寒痈疡脓成不溃、或溃后不敛;
三梭,性味:辛、苦、平,具有破血行气、消积止痛之功效,用于治疗症瘕痞块、痛经、瘀血经闭、胸痹心痛、食积胀痛;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛;
威灵仙,性味:味辛、咸、性温,具有祛风湿、通经络的之功效,用于治疗风湿痹痛、肢体麻木、筋脉拘挛、屈伸不利等症。
本发明药物是基于中医治疗痛风的原则,从依据痛风的病理机制及药理作用认为:就痛风,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述痛风的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种用于治疗痛风的汤剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓43g、黄茋28g、附子13g、羌活20g、制半夏8g、川牛膝10g、白芍12g、仙灵脾8g、莪术10g、萆薢13g、当归12g、山慈姑8g、枣仁13g、细辛3g、茯苓13g、防风10g、牛蒡子8g、独活10g、炙甘草10g、肉桂4g、三梭10g、川芎10g、威灵仙10g。
实施例2:
一种用于治疗痛风的汤剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓50g、黄茋32g、附子14g、羌活23g、制半夏9g、川牛膝11g、白芍13g、仙灵脾9g、莪术11g、萆薢14g、当归13g、山慈姑9g、枣仁15g、细辛3.5g、茯苓14g、防风11g、牛蒡子9g、独活11g、炙甘草11g、肉桂5g、三梭11g、川芎11g、威灵仙11g。
实施例3:
一种用于治疗痛风的汤剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓56g、黄茋36g、附子16g、羌活26g、制半夏10g、川牛膝12g、白芍15g、仙灵脾10g、莪术12g、萆薢15g、当归15g、山慈姑10g、枣仁16g、细辛4g、茯苓16g、防风12g、牛蒡子10g、独活12g、炙甘草12g、肉桂6g、三梭12g、川芎12g、威灵仙12g。
典型病例:
经临床诊断治疗痛风患者共1630例,年龄为54岁以上的995例,只有635例为54岁以下。1630例患者中症状及体征全部消失的有1004例,有效的544例,无效的82例。总有效率达95%。
Claims (3)
1.一种用于治疗痛风的汤剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓25~56g、黄茋10~36g、附子3~16g、羌活10~26g、制半夏3~10g、川牛膝6~12g、白芍5~15g、仙灵脾3~10g、莪术3~12g、萆薢5~15g、当归6~15g、山慈姑3~10g、枣仁10~16g、细辛1~4g、茯苓10~16g、防风5~12g、牛蒡子5~10g、独活3~12g、炙甘草2~12g、肉桂2~6g、三梭5~12g、川芎5~12g、威灵仙6~12g。
2.根据权利要求1所述的用于治疗痛风的汤剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓28~50g、黄茋11~32g、附子5~14g、羌活11~23g、制半夏4~9g、川牛膝7~11g、白芍6~13g、仙灵脾5~9g、莪术4~11g、萆薢6~14g、当归7~13g、山慈姑4~9g、枣仁11~15g、细辛2~3.5g、茯苓11~14g、防风6~11g、牛蒡子6~9g、独活5~11g、炙甘草3~11g、肉桂3~5g、三梭6~11g、川芎6~11g、威灵仙7~11g。
3.根据权利要求1至2所述的用于治疗痛风的汤剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
土茯苓43g、黄茋28g、附子13g、羌活20g、制半夏8g、川牛膝10g、白芍12g、仙灵脾8g、莪术10g、萆薢13g、当归12g、山慈姑8g、枣仁13g、细辛3g、茯苓13g、防风10g、牛蒡子8g、独活10g、炙甘草10g、肉桂4g、三梭10g、川芎10g、威灵仙10g。
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