CN107714999A - 一种用于治疗痛风的汤剂药物及其制备方法 - Google Patents

一种用于治疗痛风的汤剂药物及其制备方法 Download PDF

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CN107714999A
CN107714999A CN201711130626.4A CN201711130626A CN107714999A CN 107714999 A CN107714999 A CN 107714999A CN 201711130626 A CN201711130626 A CN 201711130626A CN 107714999 A CN107714999 A CN 107714999A
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗痛风的认识机理而提供一种用于治疗痛风的汤剂药物，所述药物的各个组分及其质量份比如下：葛根10～16g、黄柏3～15g、金钱草15～65g、丹参5～16g、黑五味子2～7g、茯苓9～16g、甘草3～15g、白头翁10～16g、川朴3～12g、薏苡仁15～55g、龟板15～45g、泽泻6～15g、车前子9～16g、石斛6～16g、细辛1～5g、鸡血藤15～30g；本发明提供的药物是一个很好的中药组方。

Description

一种用于治疗痛风的汤剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种用于治疗痛风的汤剂药物，特别是供痛风患者使用的汤剂药物及其制备方法的领域。
背景技术
医者认为：痛风是由单钠尿酸盐（MSU）沉积所致的晶体相关性关节病，与嘌呤代谢紊乱和（或）尿酸排泄减少所致的高尿酸血症直接相关，特指急性特征性关节炎和慢性痛风石疾病，主要包括急性发作性关节炎、痛风石形成、痛风石性慢性关节炎、尿酸盐肾病和尿酸性尿路结石，重者可出现关节残疾和肾功能不全。痛风常伴腹型肥胖、高脂血症、高血压、2型糖尿病及心血管病等表现。
那么，就如何找到一种可有效治疗痛风的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗痛风上，人们逐渐意识到了中医治疗痛风的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗痛风的现状，本发明的目的是在于提供一种用于治疗痛风的汤剂药物，以解决痛风患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述痛风。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种用于治疗痛风的汤剂药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
葛根10～16g、黄柏3～15g、金钱草15～65g、丹参5～16g、黑五味子2～7g、茯苓9～16g、甘草3～15g、白头翁10～16g、川朴3～12g、薏苡仁15～55g、龟板15～45g、泽泻6～15g、车前子9～16g、石斛6～16g、细辛1～5g、鸡血藤15～30g。
一种用于治疗痛风的汤剂药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
葛根11～14g、黄柏5～13g、金钱草18～56g、丹参6～14g、黑五味子3～6g、茯苓10～14g、甘草5～13g、白头翁11～14g、川朴5～11g、薏苡仁16～48g、龟板16～40g、泽泻7～13g、车前子10～14g、石斛7～14g、细辛2～4g、鸡血藤18～26g。
一种用于治疗痛风的汤剂药物及其制备方法，其特征在于，所述药物的各个组分及质量份比如下所示：
葛根13g、黄柏12g、金钱草48g、丹参13g、黑五味子5g、茯苓13g、甘草12g、白头翁13g、川朴10g、薏苡仁42g、龟板35g、泽泻12g、车前子13g、石斛13g、细辛3g、鸡血藤23g。
一种用于治疗痛风的汤剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比分别粉碎成粗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡45min，然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内，注入过药68mm的冷开水进行第一次武火煎煮，待煎煮到15min时，转文火熬制35 min，滤取药液；②药渣中再次注入过药65mm的微温开水进行第二次武火煎煮，待煎煮到10min时，转文火熬制30 min，滤取药液；③将两次药液混合浓缩成50%的中药液540ml（毫升）即可。
一种用于治疗痛风的汤剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的中药液以一天服用，每日一剂，早中晚各服一次，给药量180ml（毫升）/次，趁温服。15天为一个疗程，服药3～7个疗程后，经检查：血尿酸降至正常范围，症状消失，随访5月余，未见复发。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
葛根，性味：味甘、辛、性凉，具有解肌退热、透疹、生津止渴升阳止泻之功效，用于治疗表证发热、项背强痛、麻疹不透、热病口渴、阴虚消渴、热泻热痢、脾虚泄泻；
黄柏，性味：味苦、寒，具有清热燥湿、泻火除蒸、解毒疗疮之功效，用于治疗湿热泻痢、黄疸、带下、热淋、脚气、痿{辟、骨蒸劳热、盗汗、遗精、疮疡肿毒、湿疹瘙痒，盐黄柏滋阴降火，用于阴虚火旺、盗汗骨蒸；
金钱草，性味：味甘、咸、性微寒，具有利湿退黄、利尿通淋、解毒消肿之功效，用于治疗湿热黄疸、胆胀胁痛、石淋、热淋、小便涩痛、痈肿疔疮、蛇虫咬伤；
丹参，性味：味苦、性微寒，具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效，用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒等症；
黑五味子，性味：酸、甘、温，具有收敛固涩、益气生津、补肾宁心之功效，用于治疗久嗽虚喘、梦遗滑精、遗尿尿频、久泻不止、自汗、盗汗、津伤口渴、短气脉虚、内热消渴、心悸失眠；
茯苓，性味：性平、味甘、淡，具有利水渗湿、健脾宁心之功效，属利水渗湿药下属分类的利水消肿药，用于治疗水肿尿少、痰饮眩悸、脾虚食少、便溏泄泻、心神不安、惊悸失眠；
甘草，性味：甘、平，具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效，用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒等症；
白头翁，性味：苦、寒，具有清热解毒、凉血止痢之功效，用于治疗热毒血痢、阴痒带下；
川朴，性味：苦、辛、性温，具有行气消积、燥湿除满、降逆平喘之功效，用于治疗食积气滞、腹胀便秘、湿阻中焦、脘痞吐泻、痰壅气逆、胸满喘咳等症；
薏苡仁，性味：甘、淡、微寒，具有利湿健脾、舒筋除痹、清热排脓之功效，用于治疗水肿、脚气、小便淋沥、湿温病、泄泻带下、风湿痹痛、筋脉拘挛、肺痈、肠痈、扁平疣等症；
龟板，性味：咸甘、平，具有滋阴、潜阳、补肾、健骨之功效，用于治疗肾阴不足、骨蒸劳热、吐血、衄血、久咳、遗精、崩漏、带下、腰痛、骨痿、 阴虚风动、久痢、久疟、痔疮、小儿囟门不合；
泽泻，性味：味甘、淡、性寒，具有利水渗湿、泄热、化浊降脂之功效，用于治疗小便不利、水肿胀满、泄泻尿少、痰饮眩晕、热淋涩痛、高脂血症；
车前子，性味：味甘、性寒，具有清热利尿通淋、渗湿止泻、明目、祛痰之功效，用于治疗热淋涩痛、水肿胀满、暑湿泄泻、目赤肿痛、痰热咳嗽等症；
石斛，性味：甘、微寒, 具有生津益胃、滋阴清热、润肺益肾、明目强腰之功效，用于治疗热病伤津、口干烦渴、胃阴不足、胃痛干呕、肺燥干咳、虚热不退、阴伤目暗、腰膝软弱；
细辛，性味：辛温，具有散风祛寒、通窍止痛、下气祛痰之功效，用于治疗风寒感冒、鼻塞头痛、风寒湿痹、气逆痰多喘咳、牙痛等症；
鸡血藤，性味：味苦、微甘、性温，具有活血舒筋、养血调经之功效，用于治疗手足麻木、肢体瘫痪、风湿痹痛、妇女有经不调、痛经、闭经等症。
本发明药物是基于中医治疗痛风的原则，从依据痛风的病理机制及药理作用认为：就痛风一证，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述痛风的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种用于治疗痛风的汤剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
葛根13g、黄柏12g、金钱草48g、丹参13g、黑五味子5g、茯苓13g、甘草12g、白头翁13g、川朴10g、薏苡仁42g、龟板35g、泽泻12g、车前子13g、石斛13g、细辛3g、鸡血藤23g。
实施例2：
一种用于治疗痛风的汤剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
葛根14g、黄柏13g、金钱草56g、丹参14g、黑五味子6g、茯苓14g、甘草13g、白头翁14g、川朴11g、薏苡仁48g、龟板40g、泽泻13g、车前子14g、石斛14g、细辛4g、鸡血藤26g。
实施例3：
一种用于治疗痛风的汤剂药物，其特征在于，所述药物的各个组分及质量份比如下所示：
葛根16g、黄柏15g、金钱草65g、丹参16g、黑五味子7g、茯苓16g、甘草15g、白头翁16g、川朴12g、薏苡仁55g、龟板45g、泽泻15g、车前子16g、石斛16g、细辛5g、鸡血藤30g。
典型病例：
经临床诊断治疗痛风患者共1380例，年龄为57岁以上的853例，只有527例为57岁以下。1380例患者中血尿酸降至正常范围的有935例，有效的321例，无效的124例。总有效率达91%。

Claims (3)

1.一种用于治疗痛风的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
葛根10～16g、黄柏3～15g、金钱草15～65g、丹参5～16g、黑五味子2～7g、茯苓9～16g、甘草3～15g、白头翁10～16g、川朴3～12g、薏苡仁15～55g、龟板15～45g、泽泻6～15g、车前子9～16g、石斛6～16g、细辛1～5g、鸡血藤15～30g。
2.根据权利要求1所述的用于治疗痛风的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
葛根11～14g、黄柏5～13g、金钱草18～56g、丹参6～14g、黑五味子3～6g、茯苓10～14g、甘草5～13g、白头翁11～14g、川朴5～11g、薏苡仁16～48g、龟板16～40g、泽泻7～13g、车前子10～14g、石斛7～14g、细辛2～4g、鸡血藤18～26g。
3.根据权利要求1至2所述的用于治疗痛风的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
葛根13g、黄柏12g、金钱草48g、丹参13g、黑五味子5g、茯苓13g、甘草12g、白头翁13g、川朴10g、薏苡仁42g、龟板35g、泽泻12g、车前子13g、石斛13g、细辛3g、鸡血藤23g。
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