CN107823251B

CN107823251B - A Chinese medicinal composition for nourishing bone and preventing osteoporosis

Info

Publication number: CN107823251B
Application number: CN201711168140.XA
Authority: CN
Inventors: 李新梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-11-21
Filing date: 2017-11-21
Publication date: 2020-02-11
Anticipated expiration: 2037-11-21
Also published as: CN107823251A

Abstract

The invention relates to a traditional Chinese medicine composition for nourishing bones and preventing osteoporosis, belonging to the field of traditional Chinese medicines. The invention relates to a traditional Chinese medicine composition for nourishing bones and preventing osteoporosis, which comprises the following components in parts by weight: 10-15 parts of rhizoma drynariae, 8-15 parts of angelica, 5-10 parts of pseudo-ginseng, 1-5 parts of pearl, 10-20 parts of cucumber seed, 2-8 parts of American ginseng and 2-8 parts of astragalus. The invention also provides a preparation method of the traditional Chinese medicine. The traditional Chinese medicine components have a synergistic interaction effect, and are helpful for treating osteoporosis and nourishing bone.

Description

A Chinese medicinal composition for nourishing bone and preventing osteoporosis

Technical Field

The invention relates to a traditional Chinese medicine composition for nourishing bones and preventing osteoporosis, belonging to the field of traditional Chinese medicines.

Background

Osteoporosis is a systemic bone disease in which bone density and bone quality are reduced due to various causes, bone microstructures are destroyed, bone brittleness is increased, and thus fracture is likely to occur.

Osteoporosis is divided into primary and secondary categories. Primary osteoporosis is classified into postmenopausal osteoporosis (type i), senile osteoporosis (type ii) and idiopathic osteoporosis (including juvenile type). Postmenopausal osteoporosis generally occurs in women within 5-10 years after menopause; senile osteoporosis generally refers to osteoporosis occurring in the elderly after age 70; however, idiopathic osteoporosis mainly occurs in adolescents, and the cause of the disease is unknown.

People with the following risk factors for osteoporosis are at risk groups for getting osteoporosis easily.

Risk factors for osteoporosis include:

(1) intrinsic factor

Ethnic group (caucasian and caucasian people have higher risk of osteoporosis than black people), old age, female menopause, maternal family history.

(2) Extrinsic factors

Low body weight, hypogonadism, smoking, excessive drinking, coffee and carbonated beverages, physical activity deficiency, braking, dietary nutritional imbalance, excessive or insufficient protein intake, high sodium diet, calcium and/or vitamin D deficiency (with little or no light), diseases affecting bone metabolism, or drugs applied to bone metabolism (glucocorticoids, immunosuppressants, heparin, anticonvulsants, anticancer drugs, aluminum-containing antacids, thyroid hormone, GnRH-a, dialysate, etc.).

2. Symptoms of disease

Osteoporosis itself comprises three main categories of symptoms:

(1) pain: patients may have soreness of the waist and back or soreness of the whole body, with pain aggravated or movement limited when the load is increased, and difficulty in turning over, sitting up and walking when the load is severe.

(2) Spinal deformity: people with severe osteoporosis may have shortened height and hunchback. Vertebral compression fracture can cause thoracic deformity, abdominal compression, affect cardiopulmonary function, etc.

(3) Fracture: fractures that occur as a result of non-traumatic or minor trauma are brittle fractures. Low energy or non-violent fractures, such as fractures that occur from falls from high or low standing heights or from other daily activities. Common sites of brittle fracture are thoracic, lumbar, hip, radial, distal ulna and proximal humerus.

The pain of osteoporosis can reduce the life quality of patients, the deformation of the spine and the fracture can cause disability, the patients have limited activities and can not take care of themselves, the incidence rate of pulmonary infection and bedsore is increased, the life quality and the death rate of the patients are increased, and the patients also bring heavy economic burden to individuals, families and society.

At present, the treatment schemes of osteoporosis are mainly divided into three main categories, one is that basic measures such as life style adjustment and calcium supplement taking can only prevent or slow down, and the treatment effect cannot be timely and effectively achieved aiming at patients who already suffer from osteoporosis; secondly, the medicine intervention is adopted, the treatment of osteoporosis is far from insufficient by only supplementing calcium, and medicines such as bone absorption resisting medicines, hormone medicines, bone formation promoting medicines and the like need to be added according to the condition of a patient; and thirdly, surgical treatment is adopted, so that the surgical treatment has large trauma and is particularly not suitable for the old with unsuitable physical conditions.

In conclusion, the search for a drug capable of effectively preventing and treating osteoporosis remains a very important problem in the field of orthopedics.

Disclosure of Invention

The invention aims to solve the technical problem of providing a traditional Chinese medicine composition for nourishing bone and preventing osteoporosis.

The invention relates to a traditional Chinese medicine for nourishing bones and preventing osteoporosis, which comprises the following components in parts by weight: 10-15 parts of rhizoma drynariae, 8-15 parts of angelica, 5-10 parts of pseudo-ginseng, 1-5 parts of pearl, 10-20 parts of cucumber seed, 2-8 parts of American ginseng and 2-8 parts of astragalus.

Wherein rhizoma Drynariae is named as Digittaria, rhizoma Coptidis, rhizoma Drynariae, herba Drynariae, radix seu caulis Derridis Hypoglauci, caulis et folium fici Pumilae, and herba Geranii. All the plants of the order Filiformes and the family Drynariae can be harvested all year round, removed of silt, dried, or burned to remove fuzz (scales). The product is in the shape of flat and long strip, is bent, has branches, has dense dark brown to dark brown small scales on the surface, is soft like hair, is brown or dark brown by a singer, has convex or concave round leaf marks on both sides and the upper surface, and has few petiole residues and fibrous root residues. Light weight, crisp texture, easy breaking, reddish brown section, yellow dot vascular bundle, and arranged into ring. No smell, light taste, slightly astringent. Tonify kidney, strengthen bone, heal wound and alleviate pain. Can be used for treating lumbago due to kidney deficiency, tinnitus, deafness, odontoseisis, traumatic injury, contusion, and fracture of bones and muscles; it is used externally to treat alopecia areata and vitiligo.

Angelica sinensis (with the scientific name: Angelica sinensis) is also called Angelica sinensis, Qibang, Xiangelicae sinensis, Minangelicae sinensis, Angelica sinensis Dahurica, and Aralia cordata, and is herbaceous for many years and 0.4-1 m higher. The flowering period is 6-7 months, and the fruit period is 7-9 months. Is dried root of Angelica sinensis (Angelica sinensis) Diels of Umbelliferae. Digging in late autumn, removing fibrous root and silt, bundling into small bundle after water is slightly evaporated, putting on shed, and slowly smoking with firework. The root of the whole angelica root is slightly cylindrical, the upper end of the root is called the "returning head", and the main root is called the "returning body" or "cunning body". The branch root is called the tail or leg, and the whole is called the whole return. Whole Chinese angelica can nourish blood and promote blood circulation, which is commonly called as blood-harmonizing; the angelica root has the functions of replenishing blood and blood, regulating menstruation, relieving pain, moistening dryness, lubricating intestines, resisting cancer, resisting aging and immunity.

Notoginseng, produced mainly in yunnan wenshan, is the dried root and rhizome of panax notoginseng (Burk.) f.h. chen, a plant of the family araliaceae. Digging before blossom in autumn, cleaning, separating main root, branch root and rhizome, and drying. It has effects in dispelling blood stasis, stopping bleeding, relieving swelling, and relieving pain, and can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.

The pearl is mainly produced in the bodies of pearl shellfish and nacre mollusks; the calcium carbonate-containing mineral (aragonite) beads produced by endocrine action are composed of a large number of fine aragonite crystals. Margarita has effects in tranquilizing mind, nourishing yin, calming endogenous wind, clearing away heat, eliminating phlegm, improving eyesight, removing toxic materials, and promoting granulation; can be used for treating palpitation, severe palpitation, epilepsy, convulsion, depression, dysphoria, thirst, throat numbness, aphtha, nebula, and unhealed skin and external diseases; also has unique functions in the aspects of improving the immunity of the human body, delaying senility, removing freckles, whitening, supplementing calcium and the like.

The cucumber seed has the effects of supplementing calcium, setting broken bone, strengthening bone and building body, and has good effects on lumbago and skelalgia, osteoporosis and femoral head necrosis of the old.

The name learning of American ginseng is as follows: panax quinquefolius is a perennial plant belonging to Panax of Araliaceae, and is called Panax quinquefolium, Panax quinquefolium and American ginseng.

Radix astragali is also called Mianqi, and is a perennial herb with a height of 50-100 cm. The main root is thick, woody, branched and grey-white. The stem is upright, the upper part is multi-branched, and the stem has fine edges and is white and soft. Produced in inner Mongolia, Shanxi, Gansu, Heilongjiang, etc. The astragalus root has been used for more than 2000 years, and has the functions of enhancing the immunologic function of organisms, protecting the liver, promoting urination, resisting aging, resisting stress, reducing blood pressure and having wider antibacterial action. But excessive superficial pathogenic factors, qi stagnation and dampness obstruction, food stagnation, initial carbuncle and deep-rooted carbuncle or excessive heat-toxicity after ulceration, and yin deficiency and yang hyperactivity are prohibited. Can be used for treating spontaneous perspiration due to exterior deficiency, night sweat due to yin deficiency, acute nephritic edema, chronic nephritic edema, spleen and kidney deficiency, yang qi deficiency, pyocutaneous disease, ulcer, lung qi deficiency, and qi deficiency.

In the invention, the drynaria rhizome, the angelica, the pseudo-ginseng, the American ginseng and the astragalus have synergistic interaction, and the pearl and the cucumber seed are added, so that the medicine effect can be greatly improved, the bone is nourished, and the osteoporosis is prevented.

Further, as a preferable scheme, the traditional Chinese medicine comprises the following components in parts by weight:

10-15g of rhizoma drynariae, 8-15g of angelica, 5-10g of pseudo-ginseng, 1-5g of pearl, 10-20g of cucumber seed, 2-8g of American ginseng and 2-8g of astragalus.

Furthermore, as a preferable scheme, the traditional Chinese medicine comprises the following components in parts by weight:

12 parts of drynaria rhizome, 10 parts of angelica, 7 parts of pseudo-ginseng, 3 parts of pearl, 15 parts of cucumber seed, 5 parts of American ginseng and 5 parts of astragalus.

Most preferably, the traditional Chinese medicine comprises the following components in parts by weight: 12g of rhizoma drynariae, 10g of angelica, 7g of pseudo-ginseng, 3g of pearl, 15g of cucumber seed, 5g of American ginseng and 5g of astragalus.

In another aspect, the invention also provides a preparation method of the traditional Chinese medicine for nourishing bones and preventing osteoporosis, which comprises the following steps:

a. parching semen Cucumidis sativi with strong fire for 8-15min, cooling to room temperature, and standing in dry place;

b. b, finely pulverizing the cucumber seeds obtained in the step a, sieving the powder by a 70-90-mesh medicine sieve to obtain cucumber seed powder, and placing the cucumber seed powder in a dry place;

c. pulverizing radix Angelicae sinensis, Notoginseng radix, radix Panacis Quinquefolii, radix astragali and Margarita into fine powder, sieving with 110-mesh sieve and 130-mesh sieve, and drying;

d. finely pulverizing rhizoma Drynariae, sieving with 90-110 mesh sieve, and drying;

e. mixing the obtained fine powders of the Chinese medicinal materials, and stirring in a stirrer for 15 min.

Further, the stir-frying time in the step a is preferably 10 min; in the step b, an 80-mesh medicine sieve is preferably used; in the step c, a 120-mesh medicine sieve is preferably used; preferably, a 100-mesh medicine sieve is used in the step f, and the stirring time in the step g is preferably 15 min.

In another aspect, the invention also provides traditional Chinese medicine powder prepared by the preparation method and application of the traditional Chinese medicine powder in preventing osteoporosis.

Has the advantages that:

1. the invention adopts common traditional Chinese medicinal materials, and has no side effect;

2. the components of the invention have synergistic interaction, which is helpful for treating osteoporosis;

3. the components of the invention have synergistic interaction, and are helpful for nourishing bone.

Drawings

FIG. 1 example 3 patient is administered X tablets prior to administration;

FIG. 2 example 3 the patient is administered the drug and then the X-ray is taken at the affected part.

Detailed Description

The following examples are provided to further illustrate the embodiments of the present invention and are not intended to limit the scope of the present invention.

Example 1

The traditional Chinese medicine is prepared according to the following steps and components:

a. parching 10g cucumber seeds with strong fire for 10min, cooling to room temperature, and standing in dry place;

b. b, finely pulverizing the cucumber seeds obtained in the operation a to obtain cucumber seed powder, and placing the cucumber seed powder in a dry place;

c. respectively pulverizing 10g rhizoma Drynariae, 8g radix Angelicae sinensis, 5g Notoginseng radix, 2g radix Panacis Quinquefolii, 2g radix astragali, and 1g Margarita, and drying;

d. b, finely screening the cucumber seed powder obtained in the step b by using a 70-mesh medicine sieve, and placing fine powder in a dry place;

e. fine screening the bone crushing and supplementing powder obtained in the step c by using a 90-mesh medicine sieve, and placing the fine powder in a dry place;

f. fine screening the angelica powder, the pseudo-ginseng powder, the American ginseng powder, the astragalus powder and the pearl powder obtained in the step c by using a 110-mesh medicine sieve, and placing the fine powder in a dry place;

g. mixing the obtained fine powders of the Chinese medicinal materials, and stirring in a stirrer for 15 min.

The taking method comprises the following steps: the obtained Chinese medicinal powder is administered at different times, one dose in 15 days and three times a day.

The patients: zhangqi for women, 61 years old

The disease symptoms are as follows: in the previous year, the steel nail can be used for fixing at the affected part due to femoral fracture, and the steel nail can be removed after the fracture part is healed, but the steel nail cannot be removed due to severe osteoporosis. After the medicament is taken for 9 months, the osteoporosis symptom is relieved, and the steel nail is smoothly removed.

Example 2

a. parching 20g cucumber seeds with strong fire for 10min, cooling to room temperature, and standing in dry place;

c. respectively pulverizing 15g rhizoma Drynariae, 15g radix Angelicae sinensis, 10g Notoginseng radix, 8g radix Panacis Quinquefolii, 8g radix astragali, and 5g Margarita, and drying;

d. b, finely screening the cucumber seed powder obtained in the step b by using a 90-mesh medicine sieve, and placing fine powder in a dry place;

e. fine screening the bone meal powder obtained in the step c by using a 110-mesh medicine sieve, and placing the fine powder in a dry place;

f. fine screening the angelica powder, the pseudo-ginseng powder, the American ginseng powder, the astragalus powder and the pearl powder obtained in the step c by using a 130-mesh medicine sieve, and placing the fine powder in a dry place;

The taking method comprises the following steps: the obtained Chinese patent medicine (powder) is taken in time-sharing mode, 15 days is one dose, and three times a day.

The patients: 30 years old, Han-Zeng, female

The disease symptoms are as follows: the right femoral head necrosis is characterized by infantile paralysis and congenital acetabular dysplasia through misdiagnosis 20 years ago, and is actually ischemic femoral head necrosis caused by a trauma history, the right femoral head and femoral shaft serious low-density compact bone is displayed by X-ray tablets in the coming period, and the bone density of an affected part is obviously increased after the medicine is taken for 7 months in the treatment process.

Example 3

a. parching semen Cucumidis sativi 15g with strong fire for 10min, cooling to room temperature, and standing in dry place;

c. respectively pulverizing 12g rhizoma Drynariae, 10g radix Angelicae sinensis, 7g Notoginseng radix, 5g radix Panacis Quinquefolii, 5g radix astragali, and 3g Margarita, and drying;

d. b, finely screening the cucumber seed powder obtained in the step b by using a 80-mesh medicine sieve, and placing fine powder in a dry place;

e. fine screening the bone crushing and supplementing powder obtained in the step c by using a 100-mesh medicine sieve, and placing the fine powder in a dry place;

f. sieving radix Angelicae sinensis powder, Notoginseng radix powder, radix Panacis Quinquefolii powder, radix astragali powder, and Margarita powder with 120 mesh sieve, and drying the fine powder;

The patients: wangzhi, 52 years old, male

The disease symptoms are as follows: the history of femoral head necrosis for more than 10 years, the femoral head necrosis is treated in 2016 and 5 months, and the patient is shown by X-ray film, which is shown in the attached figure 1: the left femoral head and femoral neck compression fracture, the low-density image of bone of the left femoral head and femoral shaft, the left hip joint socket narrowing and the femoral head nutritional hole diminishing. The preparation is taken three times a day in two cycles of treatment with medicines, the total period is 5 months (the first cycle is 3 months, the second cycle is 2 months, and the two cycles are discontinuous), and the bone density of hip joints and femoral backbones on two sides is increased by 5 months in 2016 years through X-ray (shown in figure 2) compared with that of the bone density of bone on the hip joints and the femoral backbones on two sides in 2017, the bone density is clear and visible, and the generation of trabecular bone at the position of the left femoral head under-continuous line is clear and good.

Comparative example 1

d. screening the Chinese medicinal powder obtained in b and c with 80-mesh sieve, and drying the fine powder;

The patients: senior, male, age 68

The disease symptoms are as follows: the knee joint pain, slight deformation, weakness of legs during walking and difficult load bearing are detected by X-ray examination to remove the degenerative change of the knee joint, and osteoporosis is diagnosed at the same time, and the pain is relieved obviously after 7 months of taking the medicament, and the osteoporosis symptom is improved obviously.

The unified and rough screening method is adopted, namely all the components are screened by using a 80-mesh medicine screen, the obtained traditional Chinese medicine effect is not exerted to the maximum, and the inventor continuously tries to find that the effect of the formula disclosed by the invention is exerted to the maximum by adopting a grading screening process, so that a more ideal treatment effect is achieved.

In addition, the inventor also tries to change the stir-frying time of the cucumber seeds and the storage environment of other traditional Chinese medicines, and the method disclosed in the specification of the invention is not ideal.

Comparative example 2

c. respectively pulverizing 12g rhizoma Drynariae, 7g Notoginseng radix, 5g radix Panacis Quinquefolii, 5g radix astragali, and 3g Margarita, and drying;

f. fine screening the pseudo-ginseng powder, the American ginseng powder, the astragalus powder and the pearl powder obtained in the step c by using a 120-mesh medicine sieve, and placing the fine powder in a dry place;

The patients: yi in some, women, 37 years old

The disease symptoms are as follows: two fetuses are born before one year, symptoms such as limb weakness, tooth occlusion capacity reduction and the like often appear after the production, osteoporosis is diagnosed after physical examination, after 8 months of taking the medicament, the symptoms are obviously relieved, limb weakness almost disappears, the tooth occlusion capacity is basically recovered, and the osteoporosis symptoms are obviously improved.

The formula in the comparative example 2 is the formula adopted by the inventor before, the effect is not particularly ideal after the medicine is taken without adding the Chinese angelica, and the inventor continuously adjusts the formula to find that the medicine effect of the whole formula is greatly improved after the Chinese angelica is added.

Further, applicants have attempted to replace the components of the formulations of the present invention with other components, or to reduce the number of components by 1-2, with much reduced effectiveness.

Claims

1. The traditional Chinese medicine composition for nourishing the bone and preventing the osteoporosis is characterized by comprising the following components in parts by weight:

2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight:

12g of rhizoma drynariae, 10g of angelica, 7g of pseudo-ginseng, 3g of pearl, 15g of cucumber seed, 5g of American ginseng and 5g of astragalus.

3. The preparation method of the traditional Chinese medicine composition according to any one of claims 1 to 2, which is characterized by comprising the following steps:

e. mixing the obtained fine powders of the Chinese medicinal materials, and stirring in a stirrer for 10-20 min.

4. The preparation method of the traditional Chinese medicine composition according to claim 3, which is characterized by comprising the following steps:

a. parching semen Cucumidis sativi with strong fire for 10min, cooling to room temperature, and standing in dry place;

b. b, finely pulverizing the cucumber seeds obtained in the step a, sieving the powder by a 80-mesh medicine sieve to obtain cucumber seed powder, and placing the cucumber seed powder in a dry place;

c. pulverizing radix Angelicae sinensis, Notoginseng radix, radix Panacis Quinquefolii, radix astragali, and Margarita into fine powder, sieving with 120 mesh sieve, and drying;

d. finely pulverizing rhizoma Drynariae, sieving with 100 mesh sieve, and drying;

5. A Chinese medicinal powder prepared according to any one of claims 3-4.

6. The use of the Chinese medicinal powder of claim 5 for the preparation of a medicament for preventing osteoporosis.