CN107822642B - Device and method for in vivo sensing of nutrients and estimating tissue consumption or deposition thereof - Google Patents
Device and method for in vivo sensing of nutrients and estimating tissue consumption or deposition thereof Download PDFInfo
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- CN107822642B CN107822642B CN201711183711.7A CN201711183711A CN107822642B CN 107822642 B CN107822642 B CN 107822642B CN 201711183711 A CN201711183711 A CN 201711183711A CN 107822642 B CN107822642 B CN 107822642B
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- 235000015097 nutrients Nutrition 0.000 title claims abstract description 55
- 230000008021 deposition Effects 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 16
- 238000001727 in vivo Methods 0.000 title claims description 7
- 230000002792 vascular Effects 0.000 claims abstract description 35
- 239000000126 substance Substances 0.000 claims abstract description 32
- 239000000560 biocompatible material Substances 0.000 claims abstract description 31
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 24
- 238000001514 detection method Methods 0.000 claims abstract description 21
- 230000017531 blood circulation Effects 0.000 claims description 25
- 238000005070 sampling Methods 0.000 claims description 16
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- 230000008447 perception Effects 0.000 claims description 4
- 230000018514 detection of nutrient Effects 0.000 claims 4
- 241001465754 Metazoa Species 0.000 abstract description 7
- 238000011160 research Methods 0.000 abstract description 7
- 235000019728 animal nutrition Nutrition 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 238000003307 slaughter Methods 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 241000282887 Suidae Species 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
Abstract
The invention provides a device and a method for estimating the living body sensing and tissue consumption or deposition of nutrient substances. The blood vessel support comprises a blood vessel support with a net-shaped structure, wherein the outer wall of the blood vessel support is provided with a miniature nutrient substance detection sensor and a wireless transmitting unit for collecting signals; the inner wall of the vascular stent is annularly provided with a rigid thin-wall biocompatible material ring, and the rigid thin-wall biocompatible material ring is provided with a flowmeter; the outer wall of the vascular stent is also provided with a miniature battery for supplying power to the detection sensor, the wireless transmitting unit for collecting signals and the flowmeter; the acquisition signal wireless transmitting unit is in wireless connection with an external signal receiving device. The invention solves the problem of research hysteresis in animal nutrition and science, solves the living body online detection of various nutrient substances at one time, does not need animal slaughter, does not need subsequent test steps, saves a large amount of manpower and material resources, and maximally eliminates the problem of result difference caused by animal stress.
Description
Technical Field
The invention belongs to the technical field of animal nutrition, and particularly relates to a device and a method for estimating the living body sensing and tissue consumption or deposition of a nutrient substance based on an implantable sensing chip.
Background
In animal nutrition research, it is extremely important to accurately determine the nutrition requirement states of animals in different growth states at different times, but the nutrition requirement states can only be realized through the growth performance of feeding for a period of time and slaughter sampling research, and the research mode has many limitations and hysteresis, and can not timely reflect the transportation and metabolic processes of nutrients in the body, such as the influence caused by the stress of the animals in the sampling process, and complicated steps of sampling and later detection and waste of time economy. How to instantly know the nutritional requirements in the feeding process has great guiding significance, especially in scientific research.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a device and a method for estimating the nutrient substance living body sensing and the tissue consumption or deposition thereof based on an implantable sensing chip.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows:
the nutrient living body sensing and tissue consumption or deposition amount estimating device comprises a vascular stent (1) with a net structure, wherein a miniature nutrient detection sensor (3) and a wireless acquisition signal transmitting unit (4) are arranged on the outer wall of the vascular stent (1); the inner wall of the vascular stent (1) is annularly provided with a rigid thin-wall biocompatible material ring (5), and the rigid thin-wall biocompatible material ring (5) is provided with a flowmeter (6); the outer wall of the vascular stent (1) is also provided with a miniature battery (2) for supplying power to the detection sensor (3), the wireless signal acquisition transmitting unit (4) and the flowmeter (6); the acquisition signal wireless transmitting unit (4) is in wireless connection with an external signal receiving device (7).
Preferably, the vascular stent (1) is implanted in a blood vessel and the outer wall of the vascular stent (1) is in contact with the inner wall of the blood vessel.
Preferably, the miniature battery (2), the miniature nutrient substance detection sensor (3), the acquisition signal wireless transmitting unit (4) and the rigid thin-wall biocompatible material ring (5) are detachably connected with the vascular stent (1).
Wherein the inner diameter of the rigid thin-wall biocompatible material ring (5) is a fixed value.
The method for estimating the nutrient substance living body perception and the tissue consumption or deposition amount based on the estimation device comprises the following steps:
(1) Obtaining an outflow tissue blood flow rate i, an inflow tissue blood flow rate i for different sampling times by the estimation device according to any one of claims 1 to 4; i is different sampling times, i=1, 2, …, t;
(2) Substituting the outflow tissue blood flow rate i and the inflow tissue blood flow rate i obtained in the step (1) into the following formula to perform nutrient tissue consumption or deposition:
and (3) measuring the tissue deposition amount of the nutrient substance, wherein the tissue deposition amount of the nutrient substance is delta sigma (the blood flow rate of the outflow tissue, i is multiplied by the inner cavity cross-sectional area of the rigid thin-walled biocompatible material, i is multiplied by the nutrient substance concentration, i is different sampling time, and i=1, 2, … and t.
The invention is further described below:
the using method of the nutrient substance living body sensing and tissue consumption or deposition amount estimation device comprises the following steps: the blood vessel support is arranged in a blood vessel through implantation of a surgical operation means to the position of the blood vessel, the blood vessel support is supported by the rigid thin-wall biocompatible material ring, the miniature battery, the miniature nutrient monitoring sensor and the acquisition signal wireless transmitting unit are clamped between the blood vessel support and the blood vessel wall, the flowmeter and the miniature nutrient monitoring sensor acquire information and then transmit data to the acquisition signal wireless transmitting unit, the acquisition signal wireless transmitting unit transmits data signals to the external signal receiving device through the wireless sensing signal transmitter, and the external signal receiving device guides the data into the computer for processing and analysis.
The nutrient substance living body sensing can be directly used for obtaining the nutrient substance concentration of the device implanted in the blood vessel through the computer; the method is characterized by mainly monitoring the concentration change of nutrient substances in key blood vessels entering and exiting a specific tissue in real time, and combining blood flow according to a certain formula (measuring nutrient substance tissue deposition amount delta sigma (exiting tissue blood flow rate (outlet) i x rigid thin-wall biocompatible material ring inner cavity cross section area x selected nutrient substance concentration i-entering tissue blood flow rate (inlet) i x rigid thin-wall biocompatible material ring inner cavity cross section area x selected nutrient substance concentration i), wherein the method is used for estimating the tissue consumption (deposition) of the selected nutrient substances in a certain time according to different sampling times, i=1, 2, … and t.
In addition, the design concept of the invention can be applied to the fields of living body transportation and metabolism research of medicines and precursor compounds thereof, gases such as oxygen, toxins and other xenobiotics, ions, minerals, heavy metals and the like.
Compared with the prior art, the invention has the beneficial effects that:
1. monitoring the level of nutrient substances in animal blood vessels in real time, and solving the problem of research hysteresis in animal nutrition and science;
2. the detection of various nutrient substances can be detected by the sensor, so that the detection of the various nutrient substances can be solved at one time;
3. the animals are not required to be slaughtered, the subsequent test steps are not required, and a large amount of manpower and material resources are saved;
4. after the sensor is implanted for the second time, the problem of result difference caused by animal stress is solved to the greatest extent.
Drawings
FIG. 1 is a schematic diagram showing the structure of a device for estimating the in vivo sensing and tissue consumption or deposition amount of a nutrient substance according to the present invention;
FIG. 2 is a diagram of pig blood circulation.
In the figure: 1. a vascular stent; 2. a micro battery; 3. a miniature nutrient detection sensor; 4. a wireless signal acquisition transmitting unit; 5. a rigid thin-walled biocompatible material ring; 6. a flow meter; 7. an external signal receiving device.
Detailed Description
The invention is further described below with reference to the drawings and examples.
Example 1
Referring to fig. 1, the device for estimating the nutrient living body sensing and the tissue consumption or deposition comprises a vascular stent 1 with a net structure, wherein a miniature nutrient detection sensor 3 and a wireless transmitting unit 4 for collecting signals are arranged on the outer wall of the vascular stent 1; the inner wall of the vascular stent 1 is annularly provided with a rigid thin-wall biocompatible material ring 5, and the rigid thin-wall biocompatible material ring 5 is provided with a flowmeter 6; the outer wall of the vascular stent 1 is also provided with a miniature battery 2 for supplying power to the detection sensor 3, the acquisition signal wireless transmitting unit 4 and the flowmeter 6; the acquisition signal wireless transmitting unit 4 is in wireless electric connection with an external signal receiving device 7.
Wherein the vascular stent 1 is implanted into a blood vessel and the outer wall of the vascular stent 1 is contacted with the inner wall of the blood vessel.
The miniature battery 2, the miniature nutrient substance detection sensor 3, the acquisition signal wireless transmitting unit 4 and the rigid thin-wall biocompatible material ring 5 are detachably connected with the vascular stent 1.
The inner diameter of the rigid thin-wall biocompatible material ring 5 is a fixed value.
Example 2 the total amount of glucose absorbed by the intestinal tract was determined within 6 hours after feeding of the growing pig using the apparatus and method provided by the present invention.
According to the blood circulation characteristics of pigs, aortic blood vessels (figure 2A position) for supplying blood to intestinal tissues and portal blood vessels (figure 2B position) for collecting the intestinal tissues for liver after nutrient substances are absorbed by the intestinal tissues are selected, and the sensor devices for dynamically monitoring integrated glucose are respectively arranged at the A position and the B position. The total amount of glucose absorbed by the pig through the intestinal tract is = Σ (blood flow rate (out) i× (5) at B, blood flow rate (in) i× (5) at glucose concentration i-a at B, blood flow rate (in) i× (5) at i=1, 2, …, t.
The inner diameter of the biocompatible ring for placing blood vessels at the aortic site A is 5mm, and the inner diameter of the biocompatible ring for placing blood vessels at the site B is 13mm, and the blood volume through the intestinal tract can be calculated from the site B (no water is supplied to pigs in the test process) because the blood at the site A is supplied to other tissues besides the intestinal tract. The accuracy of the estimation increases with increasing data acquisition frequency.
The estimated total amount of glucose absorbed by the intestine within 6 hours after feeding the pig is:
＝3.14χ(1.3/2) 2 χ15.2χ(1800/1000)χ(8.60-5.76)+
3.14χ(1.3/2) 2 χ15.7χ(1800/1000)χ(10.97-6.28)+
3.14χ(1.3/2) 2 χ16.8χ(1800/1000)χ(11.72-6.36)+
3.14χ(1.3/2) 2 χ16.1χ(1800/1000)χ(11.50-6.80)+
3.14χ(1.3/2) 2 χ15.8χ(1800/1000)χ(10.20-6.30)+
3.14χ(1.3/2) 2 χ15.3χ(1800/1000)χ(8.62-5.79)+
3.14χ(1.3/2) 2 χ15.2χ(1800/1000)χ(8.05-6.02)+
3.14χ(1.3/2) 2 χ15.1χ(1800/1000)χ(7.56-6.11)+
3.14χ(1.3/2) 2 χ15.1χ(1800/1000)χ(7.95-6.45)+
3.14χ(1.3/2) 2 χ15.7χ(1800/1000)χ(8.35-6.63)+
3.14χ(1.3/2) 2 χ15.6χ(1800/1000)χ(8.11-6.01)+
3.14χ(1.3/2) 2 χ15.7χ(1800/1000)χ(6.08-5.14)
＝1283.2mmol＝231.18g。
Claims (7)
1. a device for estimating the perception of a living organism of a nutrient substance and the consumption or deposition of a tissue thereof, characterized in that the estimation device comprises a vascular stent (1) with a net structure, the vascular stent (1) is implanted into a blood vessel, and the outer wall of the vascular stent (1) is contacted with the inner wall of the blood vessel; the outer wall of the vascular stent (1) is provided with a miniature nutrient substance detection sensor (3) and a wireless transmitting unit (4) for collecting signals; the inner wall of the vascular stent (1) is annularly provided with a rigid thin-wall biocompatible material ring (5), and the rigid thin-wall biocompatible material ring (5) is provided with a flowmeter (6); the outer wall of the vascular stent (1) is also provided with a miniature battery (2) for supplying power to the detection sensor (3), the wireless signal acquisition transmitting unit (4) and the flowmeter (6); the wireless transmitting unit (4) for collecting signals is in radio connection with the external signal receiving device (7), and the miniature battery (2), the miniature nutrient substance detection sensor (3), the wireless transmitting unit (4) for collecting signals and the rigid thin-wall biocompatible material ring (5) are all detachably connected with the vascular stent (1).
2. The device for estimating the in vivo perception of nutrients and their consumption or deposition of tissues according to claim 1, characterized in that the internal diameter of the rigid thin-walled biocompatible ring (5) is a fixed value.
3. A device for estimating the perception of a living organism of a nutrient substance and the consumption or deposition of a tissue thereof, characterized in that the estimation device comprises a vascular stent (1) with a net structure, the vascular stent (1) is implanted into a blood vessel, and the outer wall of the vascular stent (1) is contacted with the inner wall of the blood vessel; the outer wall of the vascular stent (1) is provided with a miniature nutrient substance detection sensor (3) and a wireless transmitting unit (4) for collecting signals; the inner wall of the vascular stent (1) is annularly provided with a rigid thin-wall biocompatible material ring (5), and the inner diameter of the rigid thin-wall biocompatible material ring (5) is a fixed value; a flowmeter (6) is arranged on the rigid thin-wall biocompatible material ring (5); the outer wall of the vascular stent (1) is also provided with a miniature battery (2) for supplying power to the detection sensor (3), the wireless signal acquisition transmitting unit (4) and the flowmeter (6); the acquisition signal wireless transmitting unit (4) is in wireless connection with an external signal receiving device (7).
4. The device for estimating the nutrient substance living body perception and the tissue consumption or deposition thereof is characterized by comprising a vascular stent (1) with a net structure, wherein a miniature nutrient substance detection sensor (3) and a wireless acquisition signal transmitting unit (4) are arranged on the outer wall of the vascular stent (1); the inner wall of the vascular stent (1) is annularly provided with a rigid thin-wall biocompatible material ring (5), and the inner diameter of the rigid thin-wall biocompatible material ring (5) is a fixed value; a flowmeter (6) is arranged on the rigid thin-wall biocompatible material ring (5); the outer wall of the vascular stent (1) is also provided with a miniature battery (2) for supplying power to the detection sensor (3), the wireless signal acquisition transmitting unit (4) and the flowmeter (6); the acquisition signal wireless transmitting unit (4) is in wireless connection with an external signal receiving device (7); the miniature battery (2), the miniature nutrient substance detection sensor (3), the acquisition signal wireless transmitting unit (4) and the rigid thin-wall biocompatible material ring (5) are detachably connected with the vascular stent (1).
5. Method for estimating the in vivo perception of nutrients and their tissue consumption or deposition based on an estimation device according to any one of claims 1 to 2, characterized in that it comprises the following steps:
(1) Obtaining an outflow tissue blood flow rate i, an inflow tissue blood flow rate i at different sampling times by the estimation device according to any one of claims 1 to 2; i is different sampling times, i=1, 2, …, t;
(2) Substituting the outflow tissue blood flow rate i and the inflow tissue blood flow rate i obtained in the step (1) into the following formula to perform nutrient tissue consumption or deposition:
the nutrient tissue deposition amount = Σ (flow velocity of blood of the outflow tissue i x cross-sectional area of the inner cavity of the rigid thin-walled biocompatible material ring x nutrient concentration i-flow velocity of blood of the inflow tissue i x cross-sectional area of the inner cavity of the rigid thin-walled biocompatible material ring x nutrient concentration i), i is the different sampling time, i = 1,2, …, t.
6. A method of estimating the in vivo perception of nutrients and their tissue consumption or deposition based on the estimation device of claim 3, characterized in that it comprises the steps of:
(1) Obtaining an outflow tissue blood flow rate i, an inflow tissue blood flow rate i for different sampling times by the estimation device of claim 3; i is different sampling times, i=1, 2, …, t;
(2) Substituting the outflow tissue blood flow rate i and the inflow tissue blood flow rate i obtained in the step (1) into the following formula to perform nutrient tissue consumption or deposition:
the nutrient tissue deposition amount = Σ (flow velocity of blood of the outflow tissue i x cross-sectional area of the inner cavity of the rigid thin-walled biocompatible material ring x nutrient concentration i-flow velocity of blood of the inflow tissue i x cross-sectional area of the inner cavity of the rigid thin-walled biocompatible material ring x nutrient concentration i), i is the different sampling time, i = 1,2, …, t.
7. A method of estimating the in vivo perception of nutrients and their tissue consumption or deposition based on the estimation device of claim 4, characterized in that it comprises the steps of:
(1) Obtaining an outflow tissue blood flow rate i, an inflow tissue blood flow rate i for different sampling times by the estimation device of claim 4; i is different sampling times, i=1, 2, …, t;
(2) Substituting the outflow tissue blood flow rate i and the inflow tissue blood flow rate i obtained in the step (1) into the following formula to perform nutrient tissue consumption or deposition:
the nutrient tissue deposition amount = Σ (flow velocity of blood of the outflow tissue i x cross-sectional area of the inner cavity of the rigid thin-walled biocompatible material ring x nutrient concentration i-flow velocity of blood of the inflow tissue i x cross-sectional area of the inner cavity of the rigid thin-walled biocompatible material ring x nutrient concentration i), i is the different sampling time, i = 1,2, …, t.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008015634A1 (en) * | 2008-03-25 | 2009-10-01 | Nova Tissue Gmbh | Perfusion bioreactor for the production and/or cultivation of human or animal tissues/tissue equivalents, where the production is based on construct cultivated in the interior, comprises cover, inlet and outlet for fluid nutrient medium |
| CN104382676A (en) * | 2014-11-21 | 2015-03-04 | 清华大学深圳研究生院 | In-vivo wireless communication device based on vascular stent and wireless communication system |
| CN104684475A (en) * | 2012-07-09 | 2015-06-03 | 加州理工学院 | Implantable vascular system biosensor with grown capillary beds and uses thereof |
| CN106073749A (en) * | 2016-06-06 | 2016-11-09 | 任勇 | Velocity of blood flow monitoring device based on vein support and method thereof |
| CN209107360U (en) * | 2017-11-23 | 2019-07-16 | 中国科学院亚热带农业生态研究所 | The perception of nutriment living body and its tissue consumption or deposition amount estimation apparatus |
-
2017
- 2017-11-23 CN CN201711183711.7A patent/CN107822642B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008015634A1 (en) * | 2008-03-25 | 2009-10-01 | Nova Tissue Gmbh | Perfusion bioreactor for the production and/or cultivation of human or animal tissues/tissue equivalents, where the production is based on construct cultivated in the interior, comprises cover, inlet and outlet for fluid nutrient medium |
| CN104684475A (en) * | 2012-07-09 | 2015-06-03 | 加州理工学院 | Implantable vascular system biosensor with grown capillary beds and uses thereof |
| CN104382676A (en) * | 2014-11-21 | 2015-03-04 | 清华大学深圳研究生院 | In-vivo wireless communication device based on vascular stent and wireless communication system |
| CN106073749A (en) * | 2016-06-06 | 2016-11-09 | 任勇 | Velocity of blood flow monitoring device based on vein support and method thereof |
| CN209107360U (en) * | 2017-11-23 | 2019-07-16 | 中国科学院亚热带农业生态研究所 | The perception of nutriment living body and its tissue consumption or deposition amount estimation apparatus |
Non-Patent Citations (2)
| Title |
|---|
| 动静脉养分浓度差测定山羊营养物质净吸收方法的建立;张军民, 王艳玲;中国草食动物;第2卷(第05期);15-17 * |
| 用于营养物质代谢的猪动静脉插管技术的研究Ⅱ.门静脉营养物质净流量测定方法;李铁军, 印遇龙, 黄瑞林, 潘亚非, 谭翔文;中国畜牧杂志;第39卷(第02期);28-29 * |
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