CN107822642A - Nutriment live body perceives and its tissue consumption or deposition estimation apparatus and method - Google Patents
Nutriment live body perceives and its tissue consumption or deposition estimation apparatus and method Download PDFInfo
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- CN107822642A CN107822642A CN201711183711.7A CN201711183711A CN107822642A CN 107822642 A CN107822642 A CN 107822642A CN 201711183711 A CN201711183711 A CN 201711183711A CN 107822642 A CN107822642 A CN 107822642A
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- 230000008021 deposition Effects 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 30
- 238000001514 detection method Methods 0.000 claims abstract description 15
- 230000017531 blood circulation Effects 0.000 claims description 18
- 210000004204 blood vessel Anatomy 0.000 claims description 8
- 235000015097 nutrients Nutrition 0.000 claims description 8
- 238000005070 sampling Methods 0.000 claims description 8
- 235000016709 nutrition Nutrition 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 2
- 230000035764 nutrition Effects 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 abstract description 7
- 238000011160 research Methods 0.000 abstract description 7
- 235000019728 animal nutrition Nutrition 0.000 abstract description 4
- 238000003307 slaughter Methods 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 abstract description 2
- 206010068052 Mosaicism Diseases 0.000 abstract 1
- 210000003765 sex chromosome Anatomy 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 238000012544 monitoring process Methods 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000031891 intestinal absorption Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 206010060766 Heteroplasia Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Consumption or deposition estimation apparatus and method are perceived and organized the invention provides a kind of nutriment live body.It includes the intravascular stent of network structure, and the intravascular stent outer wall is provided with miniature nutriment detection sensor and collection signal wireless transmitting unit；The intravascular stent inwall is equipped with rigid thin wall's biocompatibility material ring, and rigid thin wall's biocompatibility material ring is provided with flowmeter；The intravascular stent outer wall is additionally provided with the minicell for being powered to detection sensor, collection signal wireless transmitting unit, flowmeter；The collection signal wireless transmitting unit and external signal reception device dedicated radio link.The present invention solves Animal nutrition and the research hysteresis sex chromosome mosaicism in science, disposably solves the live body on-line checking of a variety of nutriments, without animal slaughtering, without follow-up test step, largely use manpower and material resources sparingly, eliminate the result difference problem that Animal stress is brought to the full extent.
Description
Technical field
The invention belongs to technical field of animal nutrition, and in particular to a kind of nutriment based on implantable sensing chip is lived
Body-sensing know and organize consumption or deposition estimation apparatus and method.
Background technology
In Animal nutrition research, precisely determine that the nutritional need state of different time difference growth conditions animal is extremely heavy
Will, but can only often be taken a sample to research by the growth performance and butchering of a period of time raising to realize, such research
Mode has many limitations, has hysteresis quality, it is impossible to reflects nutriment transhipment in vivo and metabolic process in time, such as takes
The influence that stress be brought of animal during sample, the waste of sampling and the cumbersome step and time of late detection economically.Such as
Immediately its nutritional need is understood during where feeding has great directive significance, especially in scientific research.
The content of the invention
A kind of it is contemplated that overcome the deficiencies in the prior art, there is provided nutriment live body based on implantable sensing chip
Perceive and its organize consumption or deposition estimation apparatus and method.
In order to achieve the above object, technical scheme provided by the invention is：
The nutriment live body perceives and its organized consumption or deposition amount estimation apparatus to include the blood vessel of network structure
Support (1), intravascular stent (1) outer wall are provided with miniature nutriment detection sensor (3) and collection signal wireless transmission list
First (4)；Intravascular stent (1) inwall is equipped with rigid thin wall's biocompatibility material ring (5), rigid thin wall's biofacies
Capacitive material ring (5) is provided with flowmeter (6)；Intravascular stent (1) outer wall, which is additionally provided with, to be used for detection sensor (3), adopts
Collect signal wireless transmitting unit (4), the minicell (2) of flowmeter (6) power supply；The collection signal wireless transmitting unit (4)
With external signal reception device (7) dedicated radio link.
Preferably, intravascular stent (1) implantable intravascular and intravascular stent (1) outer wall contacts with blood vessel.
Preferably, the minicell (2), miniature nutriment detection sensor (3), collection signal wireless transmitting unit
(4), rigid thin wall's biocompatibility material ring (5) is detachably connected with intravascular stent (1).
Wherein, the internal diameter of rigid thin wall's biocompatibility material ring (5) is fixed value.
Nutriment live body based on above-mentioned estimation device perceives and its evaluation method bag of tissue consumption or deposition
Include following steps：
(1) the outflow Tissue Blood liquid stream of different sampling stages is obtained by any one of Claims 1-4 estimation device
Fast i, flow into tissue blood flow velocity i；I is different sampling stages, i=1,2 ..., t；
(2) outflow tissue blood flow velocity i, the inflow tissue blood flow velocity i obtained step (1) substitutes into equation below and carried out
Nutriment tissue consumption or deposition：
Determine nutriment tissue deposition amount=∑ (outflow tissue blood flow velocity i × rigid thin wall's biocompatibility material
Ring intracavity section product × nutrient concentrations i- flows into tissue blood flow velocity i × rigid thin wall's biocompatibility material ring inner chamber and cut
Area × nutrient concentrations i), i is different sampling stages, i=1,2 ..., t.
The invention will be further described below：
Nutriment live body of the present invention perceives and the application method of tissue consumption or deposition amount estimation apparatus is：It is logical
Cross surgical operation means and be implanted into purpose vessel position, by intravascular stent installation in the blood vessel, rigid thin wall's biocompatibility
Material ring props up intravascular stent, minicell, miniature nutriment monitoring sensor and collection signal wireless transmitting unit card
Between intravascular stent and vascular wall, collection is sent data to after flowmeter and miniature nutriment monitoring sensor collection information
Signal wireless transmitting unit, collection signal wireless transmitting unit is by wireless sensing signal projector by data signal transmission to outside
Portion's signal receiving device, external signal reception device import data to computer and carry out Treatment Analysis.
Nutriment live body, which perceives, can directly pass through the nutrient concentrations in computer acquisition device implantable intravascular；Nutrition
Material tissue deposition amount is estimated, mainly by monitoring the concentration into the crucial intravascular nutriment of into and out particular organization in real time
Change, with reference to blood flow according to certain formula (measure nutriment tissue deposition amount=∑ (outflow tissue blood flow velocity
(going out) i × rigid thin wall's biocompatibility material ring intracavity section accumulates × selectes nutrient concentrations i- and flows into tissue blood flow velocity
(entering) i × rigid thin wall's biocompatibility material ring intracavity section accumulates × selectes nutrient concentrations i), is different sampling stages,
I=1,2 ..., t, you can tissue consumption (deposition) amount of nutriment is selected in estimation certain time.
In addition, the nutriment includes but is not limited to nutriment and its metabolin, mentality of designing of the invention may be used also
Work for the gas such as medicine and its precursor compound, oxygen, toxin and other heteroplasia matter, ion, mineral matter and heavy metals etc.
Body is transported and metabolism research field.
Compared with prior art, beneficial effects of the present invention are：
1. nutrient level in monitoring animal blood vessels in real time, solves Animal nutrition and is asked with the research hysteresis quality in science
Topic；
2. can detect the detection of a variety of nutriments by sensor, disposably solves the detection of a variety of nutriments；
3. without animal slaughtering, without follow-up test step, largely use manpower and material resources sparingly；
4. after time implanted sensor, the result difference problem that Animal stress is brought is eliminated to the full extent.
Brief description of the drawings
Fig. 1 is that nutriment live body of the present invention perceives and organizes consumption or deposit the structural representation of amount estimation apparatus；
Fig. 2 is pig blood circulation figure.
In figure：1st, intravascular stent；2nd, minicell；3rd, miniature nutriment detection sensor；4th, collection signal is wirelessly sent out
Penetrate unit；5th, rigid thin wall's biocompatibility material ring；6th, flowmeter；7th, external signal reception device.
Embodiment
The present invention is further illustrated with reference to the accompanying drawings and examples.
Embodiment 1
Referring to Fig. 1, the nutriment live body perceives and organized consumption or deposition amount estimation apparatus to include network structure
Intravascular stent 1, the outer wall of intravascular stent 1 be provided with miniature nutriment detection sensor 3 and collection signal wireless transmission list
Member 4；The inwall of intravascular stent 1 is equipped with rigid thin wall's biocompatibility material ring 5, rigid thin wall's biocompatibility material
Matter ring 5 is provided with flowmeter 6；The outer wall of intravascular stent 1 is additionally provided with for detection sensor 3, collection signal wireless transmission
The minicell 2 that unit 4, flowmeter 6 are powered；The collection signal wireless transmitting unit 4 is wireless with external signal reception device 7
Electrical connection.
Wherein, the implantable intravascular of the intravascular stent 1 and outer wall of intravascular stent 1 contacts with blood vessel.
The minicell 2, miniature nutriment detection sensor 3, collection signal wireless transmitting unit 4, rigid thin wall
Biocompatibility material ring 5 is detachably connected with intravascular stent 1.
The internal diameter of rigid thin wall's biocompatibility material ring 5 is fixed value.
Through intestinal absorption in 6 hours after the utilization of embodiment 2 device and method provided by the invention measure grower pigs feed
The total amount of glucose.
According to pig blood cycle specificity, the aorta vessel (Fig. 2A positions) of intestinal tissue blood supply is chosen to be and via enteron aisle
After tissue resorption nutriment, collect the portal vein blood vessel (Fig. 2 B locations) that intestinal tissue carries out liver, respectively in A and B positions
Put the sensor device for installing integrated glucose dynamic monitoring provided by the invention.The total amount of glucose of the pig through intestinal absorption=
(velocity of blood flow (goes out) concentration of glucose i-A at i × (5) rigid thin wall biocompatibility material ring intracavity section product × B to ∑ at B
Place's velocity of blood flow (enters) concentration of glucose i), i=1 at i × (5) rigid thin wall biocompatibility material ring intracavity section product × A,
2,…,t。
After measured, the biocompatibility material ring internal diameter that blood vessel is laid at sustainer A be 5mm, the biology of blood vessel placement at B
Compatibility material ring internal diameter is 13mm, because at A blood except supply parenterally also supply its hetero-organization, can via the blood flow volume of enteron aisle
Calculated at from B and (do not provide drinking-water to pig during experiment).The degree of accuracy of estimation improves with the increase of data acquiring frequency.
The estimation total amount of the glucose through intestinal absorption is in 6 hours after pig feed：
=3.14 χ (1.3/2)2χ15.2χ(1800/1000)χ(8.60-5.76)+
3.14χ(1.3/2)2χ15.7χ(1800/1000)χ(10.97-6.28)+
3.14χ(1.3/2)2χ16.8χ(1800/1000)χ(11.72-6.36)+
3.14χ(1.3/2)2χ16.1χ(1800/1000)χ(11.50-6.80)+
3.14χ(1.3/2)2χ15.8χ(1800/1000)χ(10.20-6.30)+
3.14χ(1.3/2)2χ15.3χ(1800/1000)χ(8.62-5.79)+
3.14χ(1.3/2)2χ15.2χ(1800/1000)χ(8.05-6.02)+
3.14χ(1.3/2)2χ15.1χ(1800/1000)χ(7.56-6.11)+
3.14χ(1.3/2)2χ15.1χ(1800/1000)χ(7.95-6.45)+
3.14χ(1.3/2)2χ15.7χ(1800/1000)χ(8.35-6.63)+
3.14χ(1.3/2)2χ15.6χ(1800/1000)χ(8.11-6.01)+
3.14χ(1.3/2)2χ15.7χ(1800/1000)χ(6.08-5.14)
=1283.2mmol=231.18g.
Claims (5)
1. a kind of nutriment live body perceives and its tissue consumption or deposition amount estimation apparatus, it is characterised in that the estimation
Device includes the intravascular stent (1) of network structure, and intravascular stent (1) outer wall is provided with miniature nutriment detection sensor
(3) and collection signal wireless transmitting unit (4)；Intravascular stent (1) inwall is equipped with rigid thin wall's biocompatibility material
Ring (5), rigid thin wall's biocompatibility material ring (5) are provided with flowmeter (6)；Intravascular stent (1) outer wall is also set
There is the minicell (2) for being powered to detection sensor (3), collection signal wireless transmitting unit (4), flowmeter (6)；It is described
Gather signal wireless transmitting unit (4) and external signal reception device (7) dedicated radio link.
2. nutriment live body as claimed in claim 1 perceives and organized consumption or deposition amount estimation apparatus, its feature to exist
In, intravascular stent (1) implantable intravascular and intravascular stent (1) outer wall contacts with blood vessel.
3. nutriment live body as claimed in claim 1 perceives and its tissue consumption or deposition amount estimation apparatus, its feature
It is, the minicell (2), miniature nutriment detection sensor (3), collection signal wireless transmitting unit (4), rigidity are thin
Wall biocompatibility material ring (5) is detachably connected with intravascular stent (1).
4. nutriment live body as claimed in claim 1 perceives and organized consumption or deposition amount estimation apparatus, its feature to exist
In the internal diameter of rigid thin wall's biocompatibility material ring (5) is fixed value.
5. the nutriment live body based on any one of Claims 1-4 estimation device perceives and its tissue consumption or heavy
The evaluation method of accumulated amount, it is characterised in that methods described comprises the following steps：
(1) by any one of Claims 1-4 it is described estimation device obtain different sampling stages outflow tissue blood flow velocity i,
Flow into tissue blood flow velocity i；I is different sampling stages, i=1,2 ..., t；
(2) outflow tissue blood flow velocity i, the inflow tissue blood flow velocity i obtained step (1) substitutes into equation below and carries out nutrition
Material tissue consumption or deposition：
Nutriment tissue deposition amount=∑ is determined (in outflow tissue blood flow velocity i × rigid thin wall's biocompatibility material ring
Chamber sectional area × nutrient concentrations i- flows into tissue blood flow velocity i × rigid thin wall's biocompatibility material ring intracavity section product
× nutrient concentrations i), i are different sampling stages, i=1,2 ..., t.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711183711.7A CN107822642B (en) | 2017-11-23 | 2017-11-23 | Device and method for in vivo sensing of nutrients and estimating tissue consumption or deposition thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711183711.7A CN107822642B (en) | 2017-11-23 | 2017-11-23 | Device and method for in vivo sensing of nutrients and estimating tissue consumption or deposition thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN107822642A true CN107822642A (en) | 2018-03-23 |
| CN107822642B CN107822642B (en) | 2024-04-02 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008015634A1 (en) * | 2008-03-25 | 2009-10-01 | Nova Tissue Gmbh | Perfusion bioreactor for the production and/or cultivation of human or animal tissues/tissue equivalents, where the production is based on construct cultivated in the interior, comprises cover, inlet and outlet for fluid nutrient medium |
| CN104382676A (en) * | 2014-11-21 | 2015-03-04 | 清华大学深圳研究生院 | In-vivo wireless communication device based on vascular stent and wireless communication system |
| CN104684475A (en) * | 2012-07-09 | 2015-06-03 | 加州理工学院 | Implantable vascular system biosensor with grown capillary beds and uses thereof |
| CN106073749A (en) * | 2016-06-06 | 2016-11-09 | 任勇 | Velocity of blood flow monitoring device based on vein support and method thereof |
| CN209107360U (en) * | 2017-11-23 | 2019-07-16 | 中国科学院亚热带农业生态研究所 | The perception of nutriment living body and its tissue consumption or deposition amount estimation apparatus |
-
2017
- 2017-11-23 CN CN201711183711.7A patent/CN107822642B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008015634A1 (en) * | 2008-03-25 | 2009-10-01 | Nova Tissue Gmbh | Perfusion bioreactor for the production and/or cultivation of human or animal tissues/tissue equivalents, where the production is based on construct cultivated in the interior, comprises cover, inlet and outlet for fluid nutrient medium |
| CN104684475A (en) * | 2012-07-09 | 2015-06-03 | 加州理工学院 | Implantable vascular system biosensor with grown capillary beds and uses thereof |
| CN104382676A (en) * | 2014-11-21 | 2015-03-04 | 清华大学深圳研究生院 | In-vivo wireless communication device based on vascular stent and wireless communication system |
| CN106073749A (en) * | 2016-06-06 | 2016-11-09 | 任勇 | Velocity of blood flow monitoring device based on vein support and method thereof |
| CN209107360U (en) * | 2017-11-23 | 2019-07-16 | 中国科学院亚热带农业生态研究所 | The perception of nutriment living body and its tissue consumption or deposition amount estimation apparatus |
Non-Patent Citations (2)
| Title |
|---|
| 张军民, 王艳玲: "动静脉养分浓度差测定山羊营养物质净吸收方法的建立", 中国草食动物, vol. 2, no. 05, pages 15 - 17 * |
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