CN107814795B - 作为urat1抑制剂的化合物 - Google Patents
作为urat1抑制剂的化合物 Download PDFInfo
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- CN107814795B CN107814795B CN201610815191.6A CN201610815191A CN107814795B CN 107814795 B CN107814795 B CN 107814795B CN 201610815191 A CN201610815191 A CN 201610815191A CN 107814795 B CN107814795 B CN 107814795B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
化合物 | IC<sub>50</sub>(nM) |
I-1 | 11.0 |
I-2 | 14.3 |
I-3 | 18.9 |
I-4 | 17.5 |
II-1 | 12.1 |
II-2 | 15.4 |
II-4 | 14.9 |
III-1 | 17.5 |
III-2 | 13.1 |
III-3 | 15.2 |
III-4 | 10.8 |
III-5 | 12.9 |
III-6 | 11.6 |
IV-1 | 10.2 |
IV-2 | 25.5 |
IV-3 | 13.0 |
IV-4 | 14.3 |
IV-5 | 14.8 |
IV-6 | 17.6 |
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610815191.6A CN107814795B (zh) | 2016-09-12 | 2016-09-12 | 作为urat1抑制剂的化合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610815191.6A CN107814795B (zh) | 2016-09-12 | 2016-09-12 | 作为urat1抑制剂的化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107814795A CN107814795A (zh) | 2018-03-20 |
CN107814795B true CN107814795B (zh) | 2020-12-18 |
Family
ID=61601027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610815191.6A Active CN107814795B (zh) | 2016-09-12 | 2016-09-12 | 作为urat1抑制剂的化合物 |
Country Status (1)
Country | Link |
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CN (1) | CN107814795B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109608432B (zh) * | 2018-12-17 | 2022-10-11 | 江苏艾立康医药科技有限公司 | 作为urat1抑制剂的噻吩类衍生物 |
CN111943957B (zh) * | 2019-05-17 | 2023-01-06 | 中国医学科学院药物研究所 | 喹啉甲酰胺类化合物及其制备方法和用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186824A (zh) * | 2008-10-15 | 2011-09-14 | 橘生药品工业株式会社 | 稠环衍生物及其医药用途 |
CN102186832A (zh) * | 2008-09-04 | 2011-09-14 | 亚德生化公司 | 调节尿酸含量的化合物、组合物及其使用方法 |
-
2016
- 2016-09-12 CN CN201610815191.6A patent/CN107814795B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186832A (zh) * | 2008-09-04 | 2011-09-14 | 亚德生化公司 | 调节尿酸含量的化合物、组合物及其使用方法 |
CN102186824A (zh) * | 2008-10-15 | 2011-09-14 | 橘生药品工业株式会社 | 稠环衍生物及其医药用途 |
Non-Patent Citations (2)
Title |
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Nasipuri, Dhanonjoy,等.Polycyclic systems. Part XVIII. Synthesis of methyl 2-(1-naphthyl)-5-oxocyclopent-1-enylacetate, methyl β-5-(1-naphthyl)-2-furylpropionate, and a few related compounds.《Journal of the Indian Chemical Society》.1978,第55卷(第6期),第580-583页. * |
Polycyclic systems. Part XVIII. Synthesis of methyl 2-(1-naphthyl)-5-oxocyclopent-1-enylacetate, methyl β-5-(1-naphthyl)-2-furylpropionate, and a few related compounds;Nasipuri, Dhanonjoy,等;《Journal of the Indian Chemical Society》;19780630;第55卷(第6期);第580-583页 * |
Also Published As
Publication number | Publication date |
---|---|
CN107814795A (zh) | 2018-03-20 |
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Legal Events
Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 211100 Building 5, 568 longmian Avenue, Jiangning District, Nanjing City, Jiangsu Province Patentee after: Jiangsu ailikang Pharmaceutical Technology Co.,Ltd. Address before: 211100 Building 5, 568 longmian Avenue, Jiangning District, Nanjing City, Jiangsu Province Patentee before: JIANGSU ALICORN PHARMACEUTICAL Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220311 Address after: 314499 building 4, cuckoo Lake Science and Technology Innovation Park, No. 500, shuiyueting East Road, Xiashi street, Haining City, Jiaxing City, Zhejiang Province Patentee after: Ailikang Pharmaceutical Co.,Ltd. Address before: 211100 Building 5, 568 longmian Avenue, Jiangning District, Nanjing City, Jiangsu Province Patentee before: Jiangsu ailikang Pharmaceutical Technology Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Compounds as URAT1 inhibitors Effective date of registration: 20230313 Granted publication date: 20201218 Pledgee: Zhejiang Haining Rural Commercial Bank Co.,Ltd. Chengnan sub branch Pledgor: Ailikang Pharmaceutical Co.,Ltd. Registration number: Y2023330000512 |