CN107802882A - 一种医用新材料 - Google Patents

一种医用新材料 Download PDF

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CN107802882A
CN107802882A CN201711082730.0A CN201711082730A CN107802882A CN 107802882 A CN107802882 A CN 107802882A CN 201711082730 A CN201711082730 A CN 201711082730A CN 107802882 A CN107802882 A CN 107802882A
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黄建文
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
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Abstract

本发明涉及一种医用新材料，由以下质量份的原料制备：α‑氰基丙烯酸甲酯16‑28份、对苯二酚0.03‑0.09份、芦荟纳米微粉10‑20份、大豆蛋白粉25‑45份、壳聚糖20‑30份、醋酸1‑5份、抗菌剂0.5‑1.5份、粘合剂1‑4份。本发明将几种组分按比例组合成一种新材料，极大的提高了其抗冲击能力，该新材料固化速度适中，粘合强度高，对皮肤刺激性小，固化后无疤痕。

Description

一种医用新材料
技术领域
本发明涉及新材料技术领域，尤其涉及一种医用新材料。
背景技术
医用胶水是代替缝针用的新兴医用产品，医用胶水的主要成分是a-氰基丙稀酸酯，其在生物体组织的聚合速度最快。医用胶水在创面血液和组织液中阴离子的作用下，能快速聚合固化成膜并与创面镶嵌紧密，可牢固地保持伤口的对合状态，且胶膜可阻止血球、血小板通过，在凝血酶和纤维蛋白原的共同作用下，封闭创面断裂的小血管可以有效止血，同时胶膜将组织和细菌隔离，还具有抗感染和保护创面的作用。聚合物中的醚链还具有止痛作用，因此医用胶水具有粘和、止血、止痛、消炎、护创、促进愈合等综合功效。
与传统的技术相比，医用胶水具有减少疼痛、缝合的伤口小以及降低术后复发率等优点，但是，现有的医用胶水还存在缺陷：抗冲击能力差、降解速度慢、黏结力强度不够的缺点。
发明内容
本发明所要解决的技术问题是提供一种医用新材料，旨在解决现用医用胶水的抗冲击能力差、降解速度慢、黏结力强度的问题。
本发明解决上述技术问题的技术方案如下：
一种医用新材料，由以下质量份的原料制备：α-氰基丙烯酸甲酯16-28 份、对苯二酚0.03-0.09份、芦荟纳米微粉10-20份、大豆蛋白粉25-45份、壳聚糖20-30份、醋酸1-5份、抗菌剂0.5-1.5份、粘合剂1-4份。
在上述技术方案的基础上，本发明还可以做如下改进。
进一步，所述的一种医用新材料，由以下质量份的原料制备：α-氰基丙烯酸甲酯20份、对苯二酚0.07份、芦荟纳米微粉15份、大豆蛋白粉37 份、壳聚糖25份、醋酸3份、抗菌剂1.0份、粘合剂2份。
进一步，所述芦荟纳米微粉的制备方法是：取新鲜芦荟，干燥至水分含量11～15％，粉碎至粒径350-450nm。
进一步，所述粘合剂为聚乙烯醇聚甲基纤维中的一种或两种。
进一步，所述医用新材料的制备方法，包括以下步骤：去离子水配置浓度25-35％的壳聚糖溶液，再加入壳聚糖溶液体积5-6倍的去离子水，加热至 45-55℃，依次加入α-氰基丙烯酸甲酯、对苯二酚、芦荟纳米微粉、大豆蛋白粉、醋酸、抗菌剂和粘合剂混合搅拌均匀，调整固含至生产要求，即可。
本发明的有益效果是：本发明配方简单，制作工艺简单，省时省力，降低了生产成本；本发明加入芦荟纳米微粉提高了其抗冲击能力，壳聚糖组分增加产品的抑制细菌活性，本发明产品固化速度适中，粘合强度高，对皮肤刺激性小，固化后无疤痕。
具体实施方式
以下结合具体实施例对本发明的原理和特征进行描述，所举实例只用于解释本发明，并非用于限定本发明的范围。
实施例1
本实施例提供一种医用新材料，由以下质量份的原料制备：α-氰基丙烯酸甲酯20份、对苯二酚0.07份、芦荟纳米微粉15份、大豆蛋白粉37份、壳聚糖25份、醋酸3份、抗菌剂1.0份、粘合剂2份。
上述新材料的制备方法包括以下步骤：去离子水配置浓度25-35％的壳聚糖溶液，再加入壳聚糖溶液体积5-6倍的去离子水，加热至45-55℃，依次加入α-氰基丙烯酸甲酯、对苯二酚、芦荟纳米微粉、大豆蛋白粉、醋酸、抗菌剂和粘合剂混合搅拌均匀，调整固含至生产要求，即可。
实施例2
本实施例提供一种医用新材料，由以下质量份的原料制备：α-氰基丙烯酸甲酯17份、对苯二酚0.04份、芦荟纳米微粉11份、大豆蛋白粉26份、壳聚糖20份、醋酸2份、抗菌剂0.6份、粘合剂1份。
上述新材料的制备方法包括以下步骤：去离子水配置浓度25-35％的壳聚糖溶液，再加入壳聚糖溶液体积5-6倍的去离子水，加热至45-55℃，依次加入α-氰基丙烯酸甲酯、对苯二酚、芦荟纳米微粉、大豆蛋白粉、醋酸、抗菌剂和粘合剂混合搅拌均匀，调整固含至生产要求，即可。
实施例3
本实施例提供一种医用新材料，由以下质量份的原料制备：α-氰基丙烯酸甲酯25份、对苯二酚0.09份、芦荟纳米微粉19份、大豆蛋白粉44份、壳聚糖30份、醋酸4份、抗菌剂1.4份、粘合剂4份。
上述新材料的制备方法包括以下步骤：去离子水配置浓度25-35％的壳聚糖溶液，再加入壳聚糖溶液体积5-6倍的去离子水，加热至45-55℃，依次加入α-氰基丙烯酸甲酯、对苯二酚、芦荟纳米微粉、大豆蛋白粉、醋酸、抗菌剂和粘合剂混合搅拌均匀，调整固含至生产要求，即可。
专利号为CN 105770980 A的专利公开了一种医用胶水及其制备方法，依照该专利制备的新材料，分别对该专利提供的五组实施例制备的新材料的性能进行测试，测试结果如下表：
实施例1 实施例2 实施例3 实施例4 实施例5
粘结强度/MPa 695 703 710 706 699
降解时间/d 9 8 7 7 8
固化时间/s 6 5 5 5 6
对本发明提供的三组实施例制备的新材料的性能进行测试，测试结果如下表：
实施例1 实施例2 实施例3
粘结强度/MPa 736 740 745
降解时间/d 6 5 5
固化时间/s 4 3 4
上述测量数据表明，本发明制备的材料具有良好的粘结强度，固化时间短，生产效率高，降解速度快，减少了环境污染，经济效益好。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。

Claims (5)

1.一种医用新材料，其特征在于，由以下质量份的原料制备：α-氰基丙烯酸甲酯16-28份、对苯二酚0.03-0.09份、芦荟纳米微粉10-20份、大豆蛋白粉25-45份、壳聚糖20-30份、醋酸1-5份、抗菌剂0.5-1.5份、粘合剂1-4份。
2.根据权利要求1所述的一种医用新材料，其特征在于，由以下质量份的原料制备：α-氰基丙烯酸甲酯20份、对苯二酚0.07份、芦荟纳米微粉15份、大豆蛋白粉37份、壳聚糖25份、醋酸3份、抗菌剂1.0份、粘合剂2份。
3.根据权利要求1所述的一种医用新材料，其特征在于：所述芦荟纳米微粉的制备方法是：取新鲜芦荟，干燥至水分含量11～15％，粉碎至粒径350-450nm。
4.根据权利要求1所述的一种医用新材料，其特征在于：所述粘合剂为聚乙烯醇聚甲基纤维中的一种或两种。
5.根据权利要求1或2所述的一种医用新材料的制备方法，其特征在于，包括以下步骤：去离子水配置浓度25-35％的壳聚糖溶液，再加入壳聚糖溶液体积5-6倍的去离子水，加热至45-55℃，依次加入α-氰基丙烯酸甲酯、对苯二酚、芦荟纳米微粉、大豆蛋白粉、醋酸、抗菌剂和粘合剂混合搅拌均匀，调整固含至生产要求，即可。
CN201711082730.0A 2017-11-07 2017-11-07 一种医用新材料 Withdrawn CN107802882A (zh)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105536036A (zh) * 2015-12-31 2016-05-04 佛山铭乾科技有限公司 一种医用新材料
CN105617452A (zh) * 2015-12-31 2016-06-01 佛山铭乾科技有限公司 一种医用生物新材料

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105536036A (zh) * 2015-12-31 2016-05-04 佛山铭乾科技有限公司 一种医用新材料
CN105617452A (zh) * 2015-12-31 2016-06-01 佛山铭乾科技有限公司 一种医用生物新材料

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Application publication date: 20180316