CN107802680A - A kind of Chinese medicine external composition for treating paronychia and preparation method thereof - Google Patents
A kind of Chinese medicine external composition for treating paronychia and preparation method thereof Download PDFInfo
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- CN107802680A CN107802680A CN201711188914.5A CN201711188914A CN107802680A CN 107802680 A CN107802680 A CN 107802680A CN 201711188914 A CN201711188914 A CN 201711188914A CN 107802680 A CN107802680 A CN 107802680A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
It is an object of the invention to disclose a kind of Chinese medicine external composition for treating paronychia and preparation method thereof, the weight proportion of its composition includes：13 parts of purified water, 13 parts of catechu, 26 parts of cloves, 26 parts of rheum officinale, 4 12 parts of camphor, 26 parts of menthol, 20 90 parts of 95% ethanol, 39 parts of radix cynanchi bungei.And raw material, stirring and dissolving is taken to discharge afterwards completely successively.It has hygroscopic myogenic sore, and heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, the effect of turbid drops in dampness elimination, so as to reach the effect for the treatment of paronychia.
Description
Technical field
The invention belongs to technical field of Chinese medicine, is related to a kind of Chinese medicine external composition for treating paronychia and its preparation side
Method.
Background technology
Biotechnology extract solution, refer to people based on modern life science, the science with reference to other basic science is former
Reason, using advanced scientific and technological means, according to advance design improvement organism or processing biological raw material, produced for the mankind
Required product reaches certain purpose.
Paronychia be nail in addition to free edge, its excess-three side connects with skinfold, connecting portion formed trench, paronychia
The infection occurred at nail groove position, subungual abscess is the infection between nail and nail matrix, and both can mutually convert or exist simultaneously,
Paronychia is more because nail groove and its tissue around stab, abrades, ingrowing nail or caused by pulling out after " fall prickle ", and subungual abscess is often by paronychia
Stabbed under sprawling generation or first and cause infection or finger tip crush injury and cause subungual hematoma scabies secondary infection, pathogenic bacteria are mainly golden yellow
Staphylococcus, so finding specific specific material medicine is made Chinese medicine composition, effective clinical effectiveness is produced, is that research is opened
The primary control problem of hair.
Current most medicine, is formulated, the unsatisfactory curative effect in Clinical practice using antibiotic or chemical reagent, should
With certain limitation is received, moreover, people can bring more side effect simultaneously when using the medicine.
Therefore, according to the defects of set forth above, be badly in need of on the market a kind of Chinese medicine external composition for treating paronychia and its
Preparation method.
The content of the invention
Based on this, for it is set forth above the shortcomings that and shortcoming technical problem, it is an object of the invention to open one kind to control
Chinese medicine external composition of paronychia and preparation method thereof is treated, the Chinese medicine external composition has hygroscopic myogenic sore, under rushing down
Attack product, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, the effect of dampness elimination drop is turbid.
A kind of Chinese medicine external composition for treating paronychia, the weight proportion of its composition include：
Purified water 1-3 parts, catechu 1-3 parts, cloves 2-6 parts, rheum officinale 2-6 parts, camphor 4-12 parts, menthol 2-6 parts, 95% ethanol
20-90 parts, radix cynanchi bungei 3-9 parts.
A kind of Chinese medicine external composition for treating paronychia, its composition are made up of the component of following portions by weight：Purified water 2
Part, 2 parts of catechu, 4 parts of cloves, 4 parts of rheum officinale, 8 parts of camphor, 4 parts of menthol, 70 parts of 95% ethanol, 6 parts of radix cynanchi bungei.
A kind of preparation method for the Chinese medicine external composition for treating paronychia, its process include：
A, catechu, cloves, rheum officinale, the radix cynanchi bungei bulk drug of the deal are taken, the removal of impurity and non-medicinal effects is gone, adds water to cook 1-
3 times, decoct every time 1-3 hours, collecting decoction, filtration, decocting liquid is concentrated into 40-60 DEG C, and it is the clear of 1.05-1.15 to survey relative density
Cream, room temperature to be cooled to, add ethanol to make alcohol content be 50-70%, stir evenly, refrigerate 24-72 hours, take supernatant, filter, filtrate is returned
Ethanol is received, is concentrated into 45-60 DEG C, relative density 1.20-1.40 medicinal extract is surveyed, takes medicinal extract；
B, take the ethanol of the deal to pour into aqueous phase pot, add camphor, menthol carries out dispersing and dissolving, at the uniform velocity 30 points of stirring
Clock, 30 revs/min of speed；
C, by the medicinal extract of above-mentioned gained, add in above-mentioned aqueous phase pot, stir 30 minutes to uniform, 25 revs/min of mixing speed, then
Plus the purified water for stating deal, continue stirring 20 minutes to uniform, 25 revs/min of mixing speed, take semi-finished product censorship, censorship is closed
Discharged after lattice, dosing filling machine is filling again after discharging；
D, pack, storage.
The present invention, it is preferred according to the viewpoint of differentiation of tcm, it is scientific formulation, reasonable, it is easy to use, safe, can
Lean on, mainly by the direct effect of the raw materials such as radix cynanchi bungei, rheum officinale, catechu, by above-mentioned setting, it can reach treatment paronychia
Effect.
The present invention, its application method are：After cleaning skin, take this product appropriate, gently drop on affected part, 3-5 times on the one.
Embodiment
A kind of Chinese medicine external composition for treating paronychia that one embodiment of the invention provides and preparation method thereof.
In a kind of embodiment, a kind of Chinese medicine external composition for treating paronychia, its composition by following portions by weight group
Divide and be made：2 parts of purified water, 2 parts of catechu, 4 parts of cloves, 4 parts of rheum officinale, 8 parts of camphor, 4 parts of menthol, 70 parts of 95% ethanol, radix cynanchi bungei
6 parts.
It is in the prescription of the present invention, the effect of various raw materials：
Catechu：Catechu（Scientific name：Acacia catechu）It is the plant of pulse family Acacia.It is distributed in India, the island of Taiwan, Burma
The ground such as pasture, the Guangdong in Africa and China's Mainland, Yunnan, Zhejiang, Guangxi, the area of 500 meters to 600 meters of height above sea level is grown on, it is more
It is grown in wild.Meridian distribution of property and flavor：It is bitter, puckery, it is slightly cold.Return lung passes through, and has hygroscopic myogenic sore.For unhealing ulcer, eczema, aphtha,
The pain of injury caused by falling and tumbling, the effect of traumatism and bleeding.
Cloves：Go out Tang Zhenquan《Haigoushen》.Alias flos caryophylli.For plant clove of myrtaceae
Eugeniacaryophyllata Thunb. dry flower.Produce Indonesia, Vietnam and the ground such as East Africa is coastal；China is wide
There is cultivation in east.It is pungent, temperature.Eugenol is in vitro to bars such as the plague, typhoid fever, paratyphoid, diphtheria, dysentery, large intestine, deformation and anthraxs
Bacterium, staphylococcus aureus, comma bacillus etc. have bacteriostasis, and epidermis fungi can also be suppressed.
Rheum officinale：States Pharmacopoeia specifications human drugs rheum officinale should come from sorrel（Rheum palmatumL.）, Rheum officinale
（Rheum offcinale Baill.）, Rheum tanguticum Maxim（Rheum tanguticum Maxim.ex Balf.）Dry root
And rhizome.Autumn end cauline leaf is withered or secondary spring germination before excavate, remove radicula, scrape off crust, valve cutting or section, rope wear bunchiness it is dry or
Convection drying, heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.
Camphor：For the branch of canella camphor tree, dry, leaf and root, through crystalline particulate made from refinement.Thick camphor generally exists
Winter processing is raw material with 50 years raw above camphor tree trunks and root, and water proof distills in wooden rice steamer after chipping, camphor and camphor
Oil distillates with vapor, and condensation gained white crystal is thick camphor, and oily liquids is camphorated oil.Total yield 2.0~2.5%.Thick camphor tree
Brain is refined two methods of blowing sublimed method and continuous rectification sublimed method.China is based on sublimed method of drying.Thick camphor first pass through from
Scheming is put into the melting of distillation pot, distillation except deoiling and water, and the air that camphor steam enters with pot top blast is concomitantly introduced into the 1st sublimation chamber,
Control chilling temperature obtains powdered crystalline finished product.The 2nd, cut of the 3rd sublimation chamber is subsequently entered, because control temperature is relatively low, low boiling point
In camphor moisture and oil in company with a small amount of camphor steam in this condensation-crystallization, be camphor crude product（Oil-containing water more than 8%）, need weight
New sublimation purifying.Chinese natural Gum Camphor has two kinds of powdery and bulk.Quality meets pharmacopoeia of each country specification：Fusing point 174~179
DEG C ,+41 °~+43 ° of specific rotation village, often used in village names（20% in ethanol）, for nonvolatile matter below 0.05%, moisture meets 1 gram plus the milli of petroleum ether 10
Rise clarification dissolving.
Menthol：A kind of chemical agent, menthol in the leaf and stem of peppermint by being extracted, white crystal, molecular formula
C10H20O, it is the main component in peppermint and lavender essential oil.Menthol described in the present embodiment, using overcritical titanium dioxide
The menthol that carbon extracts from peppermint（Menthol）.
Ethanol：It is a kind of organic matter, is commonly called as alcohol, chemical formula is CH3CH2OH (C2H6O or C2H5OH) or EtOH, is band
There is the saturated monohydroxy alcohol of a hydroxyl, be a kind of inflammable, volatile colourless transparent liquid under normal temperature, normal pressure, it water-soluble
Liquid has the smell of aroma, and slightly stimulates.There are smells of wine and the pungent flavour stimulated, micro-sweet.
Radix cynanchi bungei：For climber fruticuli, there are cylinder or spheroidal meat root tuber, stem is very thin and tough, by microtriche;Blade
For halberd shape to life, two sides is closeer with blade face by thick and stiff hair;Umbellate cyme is born in axil, and summer opens white flowers;Follicle radish fruit drapes over one's shoulders pin
Shape, it is single raw or twin.It is distributed in Henan in the Korea peninsula and China's Mainland, Hebei, Shanxi, the Inner Mongol, Shandong, Liaoning, sweet
The ground such as respectful, be grown on the area of 1500 meters of height above sea level, it is more raw in the bushes in roadside, hillside, mountain valley, sill may or rock slot
In.Jiangsu Coastal plants radix cynanchi bungei since the Qing Dynasty, more than 100 years so far, the plantation of local farmers large area, and forms
Complete radix cynanchi bungei industrial chain.
In a kind of embodiment, a kind of Chinese medicine external composition for treating paronychia and preparation method thereof, its process includes：
A, catechu, cloves, rheum officinale, the radix cynanchi bungei bulk drug of the deal are taken, the removal of impurity and non-medicinal effects is gone, adds water to cook 1-
3 times, decoct every time 1-3 hours, collecting decoction, filtration, decocting liquid is concentrated into 40-60 DEG C, and it is the clear of 1.05-1.15 to survey relative density
Cream, room temperature to be cooled to, add ethanol to make alcohol content be 50-70%, stir evenly, refrigerate 24-72 hours, take supernatant, filter, filtrate is returned
Ethanol is received, is concentrated into 45-60 DEG C, relative density 1.20-1.40 medicinal extract is surveyed, takes medicinal extract；
B, take the ethanol of the deal to pour into aqueous phase pot, add camphor, menthol carries out dispersing and dissolving, at the uniform velocity 30 points of stirring
Clock, 30 revs/min of speed；
C, by the medicinal extract of above-mentioned gained, add in above-mentioned aqueous phase pot, stir 30 minutes to uniform, 25 revs/min of mixing speed, then
Plus the purified water for stating deal, continue stirring 20 minutes to uniform, 25 revs/min of mixing speed, take semi-finished product censorship, censorship is closed
Discharged after lattice, dosing filling machine is filling again after discharging；
D, pack, storage.
By a kind of Chinese medicine external composition for treating paronychia manufactured in the present embodiment, through multidigit, patient tries out, obtain compared with
Satisfied effect, now arrange as an example.
Mr. Chen, 28 years old, because above too narrow when wearing pointed shoes, the soft tissue of toes is expressed to, is gone out when foot is squeezed
Sweat, and pointed shoes poor air permeability, in-shoe environment become moist through with it is sultry, foot's skin is therefore heated to swell, breed bacteria, toenail
The tissue of side is red, swollen, pain, the symptom of paronychia occurs.With multi-medicament, it can not effect a radical cure, voluntarily medication of being in
Cream external application（Specific medication is unknown）, taken effect with a Zhou Yuwu, gone to a doctor then, with Chinese medicine external composition affected part of exterior coating of the present invention,
Further consultation after day 3-5 times, 7 days, paronychia symptom disappear substantially.
The general principle and principal character and advantages of the present invention of the present invention has been shown and described above, for this area skill
For art personnel, it is clear that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing substantially from the present invention spirit or
In the case of essential characteristic, the present invention can be realized in other specific forms.Which point therefore, no matter from the point of view of, all should incite somebody to action
Embodiment regards exemplary as, and be it is nonrestrictive, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that all changes fallen in the implication and scope of the equivalency of claim are included in the present invention
It is interior.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (3)
- A kind of 1. Chinese medicine external composition for treating paronychia and preparation method thereof, it is characterised in that the weight proportion bag of composition Include：Purified water 1-3 parts, catechu 1-3 parts, cloves 2-6 parts, rheum officinale 2-6 parts, camphor 4-12 parts, menthol 2-6 parts, 95% ethanol 20-90 parts, radix cynanchi bungei 3-9 parts.
- 2. a kind of Chinese medicine external composition for treating paronychia according to claim 1 and preparation method thereof, its feature exists In composition is made up of the component of following portions by weight：It is 2 parts of purified water, 2 parts of catechu, 4 parts of cloves, 4 parts of rheum officinale, 8 parts of camphor, thin 4 parts of lotus brain, 70 parts of 95% ethanol, 6 parts of radix cynanchi bungei.
- 3. a kind of Chinese medicine external composition for treating paronychia according to claim 1 or 2 and preparation method thereof, its feature It is the preparation method, its process includes：A, catechu, cloves, rheum officinale, the radix cynanchi bungei bulk drug of the deal are taken, the removal of impurity and non-medicinal effects is gone, adds water to cook 1- 3 times, decoct every time 1-3 hours, collecting decoction, filtration, decocting liquid is concentrated into 40-60 DEG C, and it is the clear of 1.05-1.15 to survey relative density Cream, room temperature to be cooled to, add ethanol to make alcohol content be 50-70%, stir evenly, refrigerate 24-72 hours, take supernatant, filter, filtrate is returned Ethanol is received, is concentrated into 45-60 DEG C, relative density 1.20-1.40 medicinal extract is surveyed, takes medicinal extract；B, take the ethanol of the deal to pour into aqueous phase pot, add camphor, menthol carries out dispersing and dissolving, at the uniform velocity 30 points of stirring Clock, 30 revs/min of speed；C, by the medicinal extract of above-mentioned gained, add in above-mentioned aqueous phase pot, stir 30 minutes to uniform, 25 revs/min of mixing speed, then Plus the purified water for stating deal, continue stirring 20 minutes to uniform, 25 revs/min of mixing speed, take semi-finished product censorship, censorship is closed Discharged after lattice, dosing filling machine is filling again after discharging；D, pack, storage.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186737A (en) * | 2018-03-21 | 2018-06-22 | 湖南文理学院 | A kind of external application drops for treating paronychia and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797334A (en) * | 2010-04-26 | 2010-08-11 | 严德华 | External ointment for treating onychomycosis and paronychia |
| CN102526246A (en) * | 2012-01-22 | 2012-07-04 | 李志勇 | Externally-used ointment for relieving paronychia pain |
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2017
- 2017-11-24 CN CN201711188914.5A patent/CN107802680A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797334A (en) * | 2010-04-26 | 2010-08-11 | 严德华 | External ointment for treating onychomycosis and paronychia |
| CN102526246A (en) * | 2012-01-22 | 2012-07-04 | 李志勇 | Externally-used ointment for relieving paronychia pain |
Non-Patent Citations (2)
| Title |
|---|
| 张景: "《偏方治大病大全》", 31 July 2016 * |
| 杨坤等: "中药黄柏酊治疗甲沟炎115例临床疗效观察", 《云南中医中药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186737A (en) * | 2018-03-21 | 2018-06-22 | 湖南文理学院 | A kind of external application drops for treating paronychia and its preparation method and application |
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