CN107789568A - A kind of new brain-tonifying and kidney-nourishing Chinese medicine composition and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of new brain-tonifying and kidney-nourishing Chinese medicine composition and preparation method thereof, said composition is less than 10 μm of red ginseng by average grain diameter, pilose antler and cicada slough medicinal powder, it is less than l00 μm of great burdock achene with average grain diameter, spina date seed, the fruit of Cherokee rose, fructus amomi, cardamom and dog testes and penis and 100 μm of Chinese cassia tree is less than by average grain diameter, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE, radix cyathulae, honeysuckle, the capsule of weeping forsythia, Chinese yam, polygala, Radix Angelicae Sinensis, Poria cocos, rhizoma atractylodis macrocephalae, cassia twig, radix glycyrrhizae, the taste medicinal powder of stir-baked RADIX PAEONIAE ALBA etc. 23 forms, its preparation method is that above-mentioned medicinal powder is added into coating pan or mixer, pill-rolling or be mixed into by medicinal powder with adhesive sticks together after adding adhesive, pass through machine pusher, cutting, the naked ball of round as a ball pelletization mode, finally use keel, oyster Ultramicro-powder is coated.Beneficial effects of the present invention are：Improved by ultramicro grinding, low temperature technology, and with Chinese medicine microparticle coating, reduce additional auxiliary material heavy metal risk, improved the dissolution release of active principle, improve curative effect, reduce ball weight, economize on resources.

Description

A kind of new brain-tonifying and kidney-nourishing Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to a kind of new Chinese medicine composition and preparation method, and in particular to a kind of new brain-invigorating and kidney-tonifying pill Chinese traditional medicine composition Thing and preparation method thereof.

Background technology

It is forgetful as caused by speen-kidney dificiency, have a sleepless night, have a dizzy spell, tinnitus, palpitaition, soreness and weakness of waist and knees, the neurasthenia such as seminal emission Symptom, it is the more typical subhealth symptom of society, though being unable to threat to life, has a strong impact on the quality of life and body of people Heart health.

Brain-invigorating and kidney-tonifying pill is that Chinese Pharmacopoeia 2015 edition one records kind, cures mainly forgetful, insomnia caused by speen-kidney dificiency, head Swoon the diseases such as dizzy, tinnitus, palpitaition, Yao Xi Acid soft, seminal emission, neurasthenia.The applicant Linqing pharmaceutical factory of traditional Chinese medicine applied for a patent in 1994 A kind of preparation method of numbers 94110752.3 brain-invigorating and kidney-tonifying pill, is disclosed using 25 kinds of Chinese herbal medicines as raw material, and take with three oxygen Change two iron or ochre to be coated for raw material, pass through Chinese medicine dispensing, cleaning, crushing, sieving, mixing, general ball, drying, enrobing processes system The preparation method for obtaining brain-invigorating and kidney-tonifying pill, but the patent was deactivated in 2007.

2005, the present inventor applied for a kind of " brain-tonifying and kidney-nourishing of film coating of Patent No. 200510012764.3 Method for producing pills ", disclose a kind of process of film coating.

Due to being influenceed by conventional art, medicine pill is all directly to crush medicinal material medicinal powder is made to be used as medicine；Pill medicinal powder grain Degree is thicker, and many active components can not fully be released absorption in expensive thin medicine, mineral drug, animal drugs therein；It is existing traditional Disintegrating process major defect is：

1）Eucaryotic cell structure can not be destroyed, influences the release and dissolution of active ingredient in medicinal material；

2）Crushing process is because mechanical heat energy influences, and temperature is up to more than 80 DEG C, to rich in grease type, protein-based active ingredient Stability adversely affect；

3）Mineral substance, the crushing complexity of animal medicinal material different parts are different, granular size is differed and cause mixing not Uniformly, the inconsistent phenomenon of active principle release dissolution, the homogeneity of product quality is influenceed;

4）It is coated with talcum powder, iron oxide, increases heavy metal risk.

These problems also directly influence the stability of medicine effective component and the absorption of human body, cause the wave of herb resource Take and pharmaceutical effectiveness declines, potential safety hazard be present.Therefore, inventor is studied by largely testing, to these mineral drugs, The disintegrating process of animal kind medicine is improved using micronizing, low temperature technology, and is coated with Chinese medicine, reduces additional mineral The heavy metal risk that class accessory strips come, ball weight is reduced, improve curative effect, it is safe.

The content of the invention

The technical problem to be solved in the present invention is to provide a kind of new brain-tonifying and kidney-nourishing Chinese medicine composition, is to Patent No. 200510012764.3 further improvement improve；By, classification grinding preferred to composition process, improve insoluble drug release and Bioavilability, medicinal material cost is reduced, save herb resource；And it is coated with mineral drug Ultramicro-powder, it is auxiliary reduces additional coating Expect the high security risk of heavy metal, reduce dosage, therapeutic equivalence.In addition, present invention also offers the preparation method of the medicine.

To reach above-mentioned purpose, this invention takes following technical scheme：A kind of new brain-tonifying and kidney-nourishing Chinese medicine composition is by putting down Equal particle diameter is less than 10 μm of red ginseng, pilose antler and cicada slough medicinal powder, with average grain diameter be less than l00 μm of great burdock achene, spina date seed, the fruit of Cherokee rose, Fructus amomi, cardamom and dog testes and penis and by average grain diameter less than 100 μm Chinese cassia tree, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE, radix cyathulae, honeysuckle, company Stick up, Chinese yam, polygala, Radix Angelicae Sinensis, Poria cocos, rhizoma atractylodis macrocephalae, cassia twig, radix glycyrrhizae, the 23 taste medicinal powder such as stir-baked RADIX PAEONIAE ALBA composition capsule core, coated with average grain diameter Keel, the coating of oyster ultramicro medicine powder less than 10 μm.

The new brain-tonifying and kidney-nourishing Chinese medicine composition is made up of the raw material of following part by weight：Ginseng 22-26g, pilose antler 4-7g, Dog testes and penis 10-15g, Chinese cassia tree 26-33g, smallflower milkwort herb with root 10-13g, stir-baked FRUCTUS ARCTII 12-19g, fruit of Cherokee rose 8-12, charred CORTEX EUCOMMIAE 30-38g, river Root of bidentate achyranthes 30-38g, honeysuckle 22-29g, capsule of weeping forsythia 20-25g, cicada slough 18-22g, Chinese yam 40-50g, RADIX POLYGALAE PREPARATA 38-45g, spina date seed 38-45g, fructus amomi 38-45g, Radix Angelicae Sinensis 33-38g, Poria cocos 75-87g, rhizoma atractylodis macrocephalae 38-45g, cassia twig 30-38g, radix glycyrrhizae 25-30g, stir-fry Root of herbaceous peony 30-38g, cardamom 30-38g.

Preferably, the new brain-tonifying and kidney-nourishing Chinese medicine composition is made up of the raw material of following part by weight：

Ginseng 24g, pilose antler 5.6g, dog testes and penis 13.9g, Chinese cassia tree 30g, smallflower milkwort herb with root 12g, stir-baked FRUCTUS ARCTII 17.8g, the fruit of Cherokee rose 11.9, Du Secondary charcoal 35.5g, radix cyathulae 35.5g, honeysuckle 25.8g, capsule of weeping forsythia 23.8g, cicada slough 19.2g, Chinese yam 47.6g, RADIX POLYGALAE PREPARATA 41.6g, Spina date seed 41.6g, fructus amomi 41.6g, Radix Angelicae Sinensis 35.7g, Poria cocos 83.2g, rhizoma atractylodis macrocephalae 41.6g, cassia twig 34.7g, radix glycyrrhizae 27.8g, stir-fry Root of herbaceous peony 34.7g, cardamom 34.7g.

The preparation method of new brain-tonifying and kidney-nourishing Chinese medicine composition, its preparation mainly comprise the following steps：

a）Medicinal material ultramicro grinding technique：By red ginseng, pilose antler, keel, oyster and cicada slough by processing requirement through cleaning, washing, drying Dispensing is distinguished after processing, is first crushed by common grinder, medicinal powder fineness is reached 150-200 μm；Again by the medicine after coarse powder Powder carries out ultramicro grinding with superfine communication technique, medicinal powder average grain diameter fineness is less than l0 μm；

b）Medicinal material cryogenic crushing process：By kind subclass medicinal material and animal drug great burdock achene, spina date seed, Jin Ying containing grease-like composition Son, fructus amomi, cardamom and dog testes and penis are according to processing requirement through cleaning, wash, after drying and processing by recipe quantity dispensing；Using various skills Art carries out low-temperature grinding；

C) conventional disintegrating process：By the taste medicinal material of Chinese cassia tree, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE etc. 14 by processing requirement through cleaning, washing, at drying Recipe quantity dispensing, the fine powder being ground into below 100 μm of average grain diameter are pressed after reason；

D) hybrid technique：Ginseng in ultramicro grinding, pilose antler, cicada slough powder, low-temperature grinding powder and the medicinal powder that routinely crushes are being mixed It is well mixed in container；

E) pill making craft：Pill mode has two kinds, when by medicinal powder add coating pan or hand it is flat in, add adhesive pill-rolling side Formula, sticked together second, medicinal powder is put to be mixed into mixer with adhesive, by machine through extruding, cutting, round as a ball pelletization mode；

F) art for coating：Obtained naked ball is put in coating pan, 10% keel, oyster is weighed with total ball（1:1.2）Ultramicro-powder is coated, Finally bag color clothing.

Superfine communication technique refers to make material, by high-speed impact and friction, reach a μm level granularity in mill tube using medium Micronization technology.The present invention is preferably crushed with micronizer, and the micronizer is made up of some groups of stainless steel tank bodies, Continuous production is realized using vacuum selection by winnowing facility, using medium under the higher-order of oscillation of oscillator, shearing is produced, hits and grind A variety of mechanical forces such as mill realize the crushing to material, and advantage is that medicinal powder average grain diameter through miniaturization processing is less than 100 μm, single Potential energy consumption can complete powder surface modification cladding operation much smaller than conventional airslide disintegrating mill, reduce granule surface activity material Oxidational losses；Crushing process closed operation, loss late are low.

Study on Supermicro-pulverization of Traditional Chinese Drugs refers to that superfine communication technique is combined with traditional Chinese medicine theory, by Chinese medicine, Chinese medical extract, Chinese medicine preparation, Chinese medicine preparation etc. are micronized, and the technology can improve the quality of Chinese medicine, the utilization rate of Chinese medicine be improved, in having promoted The standardization of medicine, it is one of important channel of the modernization of Chinese medicine.

In the case of identical similar inventory, Study on Supermicro-pulverization of Traditional Chinese Drugs technology can improve the dissolution rate of active ingredient, be This, the present inventor by contrast object of red ginseng in this composition by having carried out following checking test：

By table 1, in the case of identical similar inventory, ultramicro grinding red ginseng content is higher by 23% left side compared with Ordinary pulverization The right side, prompt, the dissolution rate of active ingredient in medicinal material can be significantly improved by ultramicro grinding, conclusion is coincide with relevant report.

Reach the usage amount with former technique identical dissolution efficiency for the medicinal material after checking ultramicro grinding, according to above-mentioned experiment Data, intend being reduced to the medicinal material of ultramicro grinding the 80% of original prescription amount, according to novel composing prescription dispensing, determine in mixture effectively into The content divided, the experimental result such as table 2 of investigation：

Indicate：Former handicraft product is brain tonic（1）；Product is brain tonic after process modification（2）

Found out by data above, the red ginseng medicinal material after ultramicro grinding, though only the 80% of original prescription inventory, mixture Middle every Testing index content is suitable with original formulation, and tentatively show increases drug-eluting by ultramicro grinding reduces medicinal material usage amount Method it is feasible.

The present invention compared with prior art, has the advantages that：

1st, mineral substance medicinal material Ultramicro-powder is done into coating powder, reduces the use of talcum powder, iron oxide coating auxiliary material, reduce stomach and intestine Road stimulates, and security improves.

2nd, expensive thin medicinal material ultramicro grinding, medicinal material usage amount reduce 20-30%.The fineness ratio of medicinal powder is more uniform after ultramicro grinding, For average grain diameter under 10 μm, its degree of refinement is not related to atom or intervention and operation in molecular structure aspect still, does not occur Obvious molecule structure change, the attribute of Chinese medicine is not influenceed, the change of pharmacodynamic profile and major function, ensure that the steady of Chinese medicine It is qualitative.

3rd, the crushing technology such as ultra micro, low temperature avoids the component damages caused by heated, makes membranolysis, accelerates effective The pharmacological activity of the dissolution rate of composition, bioavailability and medicine, clinical efficacy is improved, save herb resource.

The obtained new brain-invigorating and kidney-tonifying pill after ultramicro grinding, modified technique, indication, instructions of taking are without changing Become；Technique is more advanced, pharmacological activity, clinical efficacy improve；Remove additional talcum powder, iron oxide coating, subtract GI irritation Less, security improves, and pill volume diminishes, it is more convenient to take.

Embodiment

Below in conjunction with embodiments of the invention, the technical scheme in the embodiment of the present invention is described further.

Embodiment 1

a）Medicinal material ultramicro grinding technique：By red ginseng, pilose antler, keel, oyster and cicada slough by processing requirement through cleaning, washing, drying Dispensing is distinguished after processing, is first crushed by common grinder, medicinal powder fineness is reached 150-200 μm；Again by the medicine after coarse powder Powder carries out ultramicro grinding with superfine communication technique, medicinal powder average grain diameter fineness is less than 10 μm；

b）Medicinal material cryogenic crushing process：By kind subclass medicinal material and animal drug great burdock achene, spina date seed, Jin Ying containing grease-like composition Son, fructus amomi, cardamom and dog testes and penis are according to processing requirement through cleaning, wash, after drying and processing by recipe quantity dispensing；Using various skills Art carries out low-temperature grinding；

C) conventional disintegrating process：By the taste medicinal material of Chinese cassia tree, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE etc. 14 by processing requirement through cleaning, washing, at drying Recipe quantity dispensing, the fine powder being ground into below 100 μm of average grain diameter are pressed after reason；

D) hybrid technique：Ginseng in ultramicro grinding, pilose antler, cicada slough powder, low-temperature grinding powder and the medicinal powder that routinely crushes are being mixed It is well mixed in container；

E) pill making craft：First medicinal powder is added in coating pan, adds adhesive pill-rolling mode pill；

F) art for coating：Obtained naked ball is put in coating pan, is coated with keel, oyster Ultramicro-powder, finally bag color clothing.

Embodiment 2

a）Medicinal material ultramicro grinding technique：By red ginseng, pilose antler, keel, oyster and cicada slough by processing requirement through cleaning, washing, drying Dispensing is distinguished after processing, is first crushed by common grinder, medicinal powder fineness is reached 150-200 μm；Again by the medicine after coarse powder Powder carries out ultramicro grinding with superfine communication technique, makes medicinal powder average grain diameter fineness at 10 μm；

b）Medicinal material cryogenic crushing process：By kind subclass medicinal material and animal drug great burdock achene, spina date seed, Jin Ying containing grease-like composition Son, fructus amomi, cardamom and dog testes and penis are according to processing requirement through cleaning, wash, after drying and processing by recipe quantity dispensing；Using various skills Art carries out low-temperature grinding；

C) conventional disintegrating process：By the taste medicinal material of Chinese cassia tree, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE etc. 14 by processing requirement through cleaning, washing, at drying Recipe quantity dispensing, the fine powder being ground into below 100 μm of average grain diameter are pressed after reason；

D) hybrid technique：Ginseng in ultramicro grinding, pilose antler, cicada slough powder, low-temperature grinding powder and the medicinal powder that routinely crushes are being mixed It is well mixed in container；

E) pill making craft：Medicinal powder is put to be mixed into mixer with adhesive and sticked together, by machine through extruding, cutting, round as a ball pelletization Mode pill；

Remaining is the same as embodiment 1.

Above example illustrates, using in the parameter area of the present invention program, qualified sample can be made, below with reality Apply sample made from example 1 and carry out toxicity and clinical trial respectively.

（One）Toxicity test

Test method：Healthy rat 60, body weight 130g or so, hero female half and half.Animal adaptability is used to test after raising 1 week. Animal is divided into 3 groups by body weight sex Stochastic Equilibrium（Former technique brain-invigorating and kidney-tonifying pill is used（1）Represent, used after modified technique（2）Table Show）.2d takes blood from animal afterbody before experiment, determines red blood cell (RBC), the hemoglobin of animal（Hb）, leucocyte（WBC）, day AST (AST), ALT (ALT), urea nitrogen (B Μ N), creatinine (Grea).3 during experiment Group animal distinguishes daily IG ordinary waters and the brain-tonifying and kidney-nourishing liquid of various dose, is administered daily 1 time, continuous 70d.During experiment, weekly Weigh record the weight of animals 1 time.

During experiment, have no that animal has obvious abnormal response.At the end of experiment, every measure, and to administration above is repeated The front and rear and rat body weight of Different Preparation, rat serum cell detection, rat blood serum Liver function grade carry out contrast test, real Test and the results are shown in Table 3,4,5,6.

The rat body weight measurement result of table 3

Rat serum cell detection results before table 4 is administered

Rat blood serum hepatic and renal function detection X ± SD before table 5 is administered

Compare unknown significance difference between group

Rat serum cell detection X-+SD after table 6 is administered 10 weeks

Compare unknown significance difference between group

（Two）Clinical trial

According to the brain-tonifying and kidney-nourishing of product, replenish qi to invigorate the spleen, the effect of tranquilizing the mind, with reference to Pharmacological test results, choose Shandong Province Vertical hospital, Zibo central hospital, the affiliated hospital's internal medicine disease neurasthenia of Shandong College of Traditional Chinese Medicine the 4th and sex dysfunction are to grind Study carefully object, carried out 400 Clinical Comparison Studies, wherein 200 are brain tonic with former handicraft product（1）Group, remaining 200 use change It is brain tonic to enter rear new technology product（2）Group, specific clinical data statistics such as table 7.

Table 7 control it is previous as statistics table

Test method：

1st, it is all meet above-mentioned diagnosis and MethodsThe cases enrolled, take brain-invigorating and kidney-tonifying pill, every time 15 balls, twice a day, 4 weeks are a course for the treatment of.

2nd, toxic side effect：Observation patient whether there is fash, gastrointestinal discomfort during medication and after medication, before and after medication often Rule check.

3rd, during observing, other associated treatment medicines must not be taken.

Criterion of therapeutical effect：

1st, clinical cure：Symptom and sign disappears, and physico-chemical examination is normal.

2nd, it is effective：Cardinal symptom sign disappears, and physico-chemical examination is normal.

3rd, effectively：Cardinal symptom sign disappears substantially, and physico-chemical examination makes moderate progress.

4th, it is invalid：The each side that compared with before treatment is without progress.

Experimental result such as table 8, table 9：

The brain tonic of table 8（1）Two disease curative effect statistical forms of group

The brain tonic of table 9（2）Two disease curative effect statistical forms of group

Learnt by above-mentioned two tables result：The effective percentage of above two technique does not have notable difference, illustrates therapeutic equivalence.

Adverse reaction：

All experimental observation patients, the obvious anomalous variation of symptom, sign and physico-chemical examination is found no, illustrates this product to people Body is without any side effects.

Model case：

Example 1：Patient Li Yuming, man, 48 years old, cadre, forgetful insomnia and dreamful sleep, spiritlessness and weakness, when to feel palpitation uneasy, while companion There is soreness of waist and knee joint, aversion to cold and cold limbs 5 years, aggravate 1 month, it is to our hospital before 11 days Mays in 2000, survey T：37 DEG C, P：78 times/ Point, R：17 beats/min, BP：110/70mmHg, the light tongue of tongue nature is white, and deep thready pulse, physical examination is without exception, and doctor trained in Western medicine is diagnosed as neurasthenia, in Doctor is diagnosed as kidney deficiency, kidney yang deficiency syndrome, advises its oral brain-invigorating and kidney-tonifying pill（2）, 15 tablets each time, twice a day, 3 weeks all diseases disappear after medication Lose, then look into electrocardiogram, Liver and kidney function, blood urine is conventional normal, and during medication, any adverse reaction does not occur.(the Shandong traditional Chinese medical science The 4th attached institute of medicine university provides)

Example 2：Old XX, man, 32 years old, driver, there is something lost because premature ejaculation 3 months is to our hospital on May 15th, 2000, during readme premature ejaculation Essence, body have the soreness of waist, and dizzy palpitaition, lassitude, white sweat limb is cold, and pink tongue tongue is white, deeptensepulse, and no positive sign of having a medical check-up, doctor trained in Western medicine is examined It is kidney-yang deficiency to break as hypogona dism, tcm diagnosis, gives brain-invigorating and kidney-tonifying pill（2）, 15 tablets each time, 2 times a day, guard against and be intended to first quarter moon, Medication 2 weeks, that is, feel symptom mitigation, take medicine 4 weeks, all diseases disappear, and sexual life is adhered to more than 8 minutes, during medication, does not find any Adverse reaction, efficacy evaluation are cured for disease.(Shandong Prov. Hospital offer)

Presently preferred embodiments of the present invention is these are only, is not intended to limit the invention, it is all in the spirit and principles in the present invention Within all any modification, equivalent and improvement made etc., should be included in the scope of the protection.

Claims (4)

1. a kind of new brain-tonifying and kidney-nourishing Chinese medicine composition, its feature is less than 10 μm of red ginseng, pilose antler and cicada slough medicinal powder by average grain diameter, It is less than l00 μm of great burdock achene, spina date seed, the fruit of Cherokee rose, fructus amomi, cardamom and dog testes and penis with average grain diameter and 100 μ is less than by average grain diameter It is m Chinese cassia tree, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE, radix cyathulae, honeysuckle, the capsule of weeping forsythia, Chinese yam, polygala, Radix Angelicae Sinensis, Poria cocos, rhizoma atractylodis macrocephalae, cassia twig, sweet The taste medicinal powder of grass, stir-baked RADIX PAEONIAE ALBA etc. 23 forms, and is coated by keel of the average grain diameter less than 10 μm, Concha Ostreae micropowder.

A kind of 2. new brain-tonifying and kidney-nourishing Chinese medicine composition according to claim 1, it is characterized in that the original by following part by weight Material is made：

Ginseng 22-26g, pilose antler 4-7g, dog testes and penis 10-15g, Chinese cassia tree 26-33g, smallflower milkwort herb with root 10-13g, stir-baked FRUCTUS ARCTII 12-19g, gold Cherry 8-12, charred CORTEX EUCOMMIAE 30-38g, radix cyathulae 30-38g, honeysuckle 22-29g, capsule of weeping forsythia 20-25g, cicada slough 18-22g, Chinese yam 40- 50g, RADIX POLYGALAE PREPARATA 38-45g, spina date seed 38-45g, fructus amomi 38-45g, Radix Angelicae Sinensis 33-38g, Poria cocos 75-87g, rhizoma atractylodis macrocephalae 38-45g, Cassia twig 30-38g, radix glycyrrhizae 25-30g, stir-baked RADIX PAEONIAE ALBA 30-38g, cardamom 30-38g.

A kind of 3. new brain-tonifying and kidney-nourishing Chinese medicine composition according to claim 2, it is characterized in that the original by following part by weight Material is made：

Ginseng 24g, pilose antler 5.6g, dog testes and penis 13.9g, Chinese cassia tree 30g, smallflower milkwort herb with root 12g, stir-baked FRUCTUS ARCTII 17.8g, the fruit of Cherokee rose 11.9, Du Secondary charcoal 35.5g, radix cyathulae 35.5g, honeysuckle 25.8g, capsule of weeping forsythia 23.8g, cicada slough 19.2g, Chinese yam 47.6g, RADIX POLYGALAE PREPARATA 41.6g, Spina date seed 41.6g, fructus amomi 41.6g, Radix Angelicae Sinensis 35.7g, Poria cocos 83.2g, rhizoma atractylodis macrocephalae 41.6g, cassia twig 34.7g, radix glycyrrhizae 27.8g, stir-fry Root of herbaceous peony 34.7g, cardamom 34.7g.

4. a kind of preparation method of new brain-tonifying and kidney-nourishing Chinese medicine composition, it is characterised in that comprise the following steps：

a）Medicinal material ultramicro grinding technique：By red ginseng, pilose antler, keel, oyster and cicada slough by processing requirement through cleaning, washing, drying Dispensing is distinguished after processing, is first crushed by common grinder, medicinal powder fineness is reached 150-200 μm, then by the medicine after coarse powder Powder carries out ultramicro grinding with superfine communication technique, medicinal powder average grain diameter fineness is less than l0 μm；

b）Medicinal material cryogenic crushing process：By kind subclass medicinal material and animal drug great burdock achene, spina date seed, Jin Ying containing grease-like composition Son, fructus amomi, cardamom and dog testes and penis are according to processing requirement through cleaning, wash, after drying and processing by recipe quantity dispensing；Using various technologies Carry out low-temperature grinding；

C) conventional disintegrating process：By the taste medicinal material of Chinese cassia tree, smallflower milkwort herb with root, charred CORTEX EUCOMMIAE etc. 14 by processing requirement through cleaning, washing, at drying Recipe quantity dispensing, the fine powder being ground into below 100 μm of average grain diameter are pressed after reason；

D) hybrid technique：Ginseng in ultramicro grinding, pilose antler, cicada slough powder, low-temperature grinding powder and the medicinal powder that routinely crushes are being mixed It is well mixed in container；

E) pill making craft：Pill mode has two kinds, when by medicinal powder add coating pan or hand it is flat in, add adhesive pill-rolling side Formula, sticked together second, medicinal powder is put to be mixed into mixer with adhesive, by machine through extruding, cutting, round as a ball pelletization mode；

F) art for coating：Obtained naked ball is put in coating pan, 10% keel, oyster is weighed with total ball（1:1.2）Ultramicro-powder is coated, Finally bag color clothing.