CN107782883A - A kind of collection and detection device of fluid sample - Google Patents
A kind of collection and detection device of fluid sample Download PDFInfo
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- CN107782883A CN107782883A CN201610730524.5A CN201610730524A CN107782883A CN 107782883 A CN107782883 A CN 107782883A CN 201610730524 A CN201610730524 A CN 201610730524A CN 107782883 A CN107782883 A CN 107782883A
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
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- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention relates to a kind of collection and detection device of fluid sample, including housing the test chamber of testing element and collecting the collecting chamber of storage fluid sample, liquid communication between test chamber and collecting chamber, collecting chamber includes collection port, bottom wall and side wall, includes at least three contact points being generally aligned in the same plane in collecting chamber side wall；The collection and detection device, which has, collects position and test position, when collection and detection device is in collection position, by collecting chamber bottom wall supports collection and detection device；When collection and detection device is in test position, collection and detection device is supported by the contact point of collecting chamber side wall.Collection and detection device of the present invention is simple in construction, low using blowing manufacturing process, manufacturing cost；Test can be opened as needed, it is convenient to determine the detection time started；Using transversely arranged test strips, in test chamber of the same area, can arrange more strips, can test more projects simultaneously.
Description
Technical field
The invention belongs to medical diagnosis class article technical field, can quickly be collected more particularly to one kind and detect sample
In whether the collection and detection device containing one or more target analytes.
Background technology
Following background technology is used to help reader and understands the present invention, and is not construed as prior art.
The abuse problem of medicine or drugs has become the social concern of getting worse.U.S. Department of Health and Human Services's door
The investigation of 2003 finds that the ratio of drug abuse is up to 8.2% in the American of more than 12 years old.With the hair of economic society
Exhibition, the ratio of drug abuse gradually increase, and the medicament categories abused are also more and more.
Liquid sample typically is collected using detection means to the quick detection of the Drug Abuses such as drugs, then by correlation
Technical staff inserts detection strip and the part submergence of detection strip is taken out strip in the sample, after certain time and is read
Testing result.However, in order to drugs operation and monitoring drug-taking problem, this test has become a mark many when
Quasi-ordering, for example, employ, go to school, physical culture, law enforcement etc., operated by amateur testing staff.It is therefore desirable to provide a kind of detection
Device, avoid operating personnel from touching the sample in open liquid collection and detection device, jeopardize the health of operating personnel.Together
When, it is also desirable to the collection and detection device can stored samples, with facilitate sampled in the case where there is objection to testing result it is multiple
Inspection.Be additionally, since the test of drug abuse turns into a standardization program, it is also desirable to which the price of detection means is sufficiently minimized, energy
Enough meets the needs of large-scale use.
Further, since smoker has the motivation for concealing drug abuse or Drug Abuse, there is sample adulteration；
Meanwhile the substantially species of medicine used in person to be detected can not be accurately estimated before detection, accordingly, it would be desirable to utilize an inspection
Survey the medicine that device detects sample adulteration situation simultaneously in one-time detection and the possibility of multiple types is sucked as far as possible.
In some existing detection means, there is the lid that the test strips of multiple detection different pharmaceuticals are placed on to detection means
On, inverted device detects to realize after being closed the lid after collecting fluid sample.But the space of lid is limited, the examination that can be accommodated
Paper slip quantity is also few, and therefore, the medicine that can be detected simultaneously in same sample is relatively fewer.Also, this detection means needs
Will integration testing element and sealer sealing in lid, complex in manufacturing process, cost is high.Meanwhile these devices
It is operationally also complex, the initial time of the inconvenient accurate interpretation detection of lay operators.
The content of the invention
The invention provides a kind of collection and detection device of new fluid sample, asking for existing detection means is overcome
Topic, the device after sample is collected only need overturn (toppling over) i.e. can be achieved detect, it is both easy to operate and can quickly interpretation detection
Initial time, meanwhile, the device of the structure can accommodate more testing elements, realize that detection is more after primary sample simultaneously
Medicine, also, the device is simple and convenient in manufacturing process, greatlys save manufacturing cost.
First, a kind of collection and detection device of the fluid sample provided in the present invention, including house the detection of testing element
Chamber and the collecting chamber for collecting storage fluid sample, liquid communication between test chamber and collecting chamber, wherein, collecting chamber includes collecting
Mouthful, bottom wall and side wall, include at least three contact points being generally aligned in the same plane in collecting chamber side wall；The collection and detection device tool
Have and collect position and test position, when collection and detection device is in collection position, by collecting chamber bottom wall supports collection and detection device；
When collection and detection device is in test position, collection and detection device is supported by the contact point of collecting chamber side wall.At least three contacts
Point can form stable support, for supporting collection and detection device, in some specific embodiments, and at least three contact point positions
In on a face, collection and detection device is supported by this face.
In some preferred embodiments, after collection and detection device collects sample, it is turned to by collecting position up to detecting position
Put, carry out the detection of sample.Wherein, it can topple over or overturn 45 °~135 ° to overturn or topple over, 60 °~120 °, 75 °~
105 °, 80 °~100 °, or 85 °, 90 °, 95 °.Further, can also any suitable angle, the angle only needs full
For foot when collecting position, liquid sample will not overflow or flow to test chamber；In the state of detection, fluid specimen collection detection means
It can keep stable under the support of contact point, fluid sample can flow into test chamber from collecting chamber.
In some preferred embodiments, the side in face where the test chamber is connected at least three contact points.
In some embodiments, the testing element in the test chamber is perpendicular to the face where contact point.It is more highly preferred to
In embodiment, the testing element in test chamber is also both perpendicular to collecting chamber through bottom wall and the axis of collection port.That is, survey
Element is tried when being detected after the collection and detection device is toppled over, the perpendicular state in fluid level of testing element, so as to protect
Demonstrate,prove liquid sample and the other end is reached by one end of testing element, realize lateral flow to complete to detect.
That is, in a preferred embodiment, when collection and detection device, which is in, collects position, the test member in test chamber
Part horizontal parallel is arranged in test chamber.Likewise, testing element for collecting chamber, is horizontally arranged in collecting chamber side wall
On, so as to arrange more testing elements, the realization of detection means is disposably detected multiple different drug tests.
In other embodiments, the sample application zone of testing element is adjacent to the face where contact point.
In some specific embodiments, test chamber includes allowing liquid to be flowed into inspection from collecting chamber adjacent to one end of collection port
Survey the injection port of chamber and allow gas to be flowed into the gas channel of collecting chamber from test chamber.Injection port and the neighbouring collection of gas channel
Mouthful, collection and detection device can be made when collecting position, injection port and gas channel (referring mainly to air admission hole) detect positioned at collection
At device higher position, the sample in collecting chamber will not touch injection port, so as to liquid not phase between collecting chamber and test chamber
Connection.
In some preferred embodiments, steam vent that gas channel includes being connected with test chamber, it is connected with collecting chamber
Logical steam vent, and the air-flow of connection air admission hole and steam vent overflow and rise passage.
In preferred embodiment, when collection and detection device is located at inspection positions, injection port position is not higher than test
The position of the sample application zone of element.
In the embodiment being more highly preferred to, when collection and detection device is located at inspection positions, air inlet hole site be higher than into
Sample mouth position, and air inlet hole site is less than the position of testing element marked region.It that is to say, when collection and detection device is positioned at detection
During opening position, the horizontal level of air admission hole is higher than the horizontal level of injection port, meanwhile, the horizontal level of air admission hole is less than test member
The horizontal level of the testing element marked region of part.More specifically in embodiment, when collection and detection device is located at detecting position
When putting place, the position of steam vent is higher than the position of air admission hole.The gas in test chamber is discharged to outside test chamber by steam vent.
More specifically in embodiment, gas is discharged in collecting chamber for some.
In some embodiments, the collection and detection device also includes covering and sealing the lid of collecting chamber.Lid covers
And after sealing collecting chamber, the collecting chamber of collection and detection device and test chamber is in the state of a sealing, so as to be collection
Fluid exchange between chamber and test chamber provides condition.
In some specific embodiments, test chamber includes the detection plate for accommodating testing element, and gas channel is positioned at detection
Plate.
In more specifical embodiment, neck is provided with the detection plate, described gas channel is located in neck.
Now, test chamber is not connected directly with collecting chamber, and test chamber is connected by gas channel with collecting chamber, test chamber
The interior air-flow entered by the gas that liquid enters and discharges by the air admission hole on neck in neck, which overflows, rises passage, reaches on neck
Steam vent, by steam vent by gas discharge test chamber outside, reach collecting chamber in.
In some specific embodiments, the size of air admission hole is between 0.5-1mm, after liquid reaches air inlet position, by
In surface tension of liquid phenomenon air admission hole by hydraulic seal so that the gas and liquid in test chamber reach balance so that
Liquid is maintained at the height of air admission hole, and detection is sufficiently used for so as to which the testing element that ensure that in test chamber can be absorbed to
Sample, testing result will not be influenceed because amount of liquid is excessive again.
In some preferred embodiments, collecting chamber side wall include at least one section be in cambered surface indent side wall, it is described at least
Three contact points are located at this in the side wall of cambered surface indent；When collection and detection device is in test position, described cambered surface indent
Side wall support collection and detection device.
In the sidewall sections of the sidewall design cambered surface indent of collecting chamber, on the one hand, the holding of the cambered surface indent and operator
Radian connects, and is advantageous to operator and holds collection and detection device；On the other hand, the design of the larger depression of interior recess, can be reduced
The volume of urine cup, under conditions of same volume samples collecting amount, there is higher liquid level, when upset urine cup starts test,
It can ensure to have the sample of abundant volume to enter test chamber, reduce because subject detects the feelings of failure caused by mismatching
Condition.
In some preferred embodiments, collecting chamber side wall includes at least one section side wall in plane, described test chamber position
At flat sidewall.Test chamber is not limited at flat sidewall, as long as disclosure satisfy that installation testing element.Herein, will examine
Survey chamber is arranged on the side-walls in plane, is advantageous to dispose test-strips as much as possible, is also convenient for liquid sample at test chamber bottom
Portion is flowed, and facilitates each test-strips to be reacted under conditions of roughly the same with sample contact, is advantageous to testing conditions control.Separately
On the one hand, test chamber is being set in the side-walls of plane, compared to curved surface, can more easily observing testing result, be advantageous to standard
True interpretation testing result.
In specific embodiment, collecting chamber side wall includes at least one section in the side wall of cambered surface indent and at least one section in flat
The side wall in face, described flat sidewall are connected with the side wall of cambered surface indent.
Be connected with test chamber or detection plate planar outer walls be connected to cambered surface indent side wall side, when detection means is turned over
After turning, the side wall of cambered surface indent turns into the bottom of detection means, supports detection means, and is located at the side of the side wall of cambered surface indent
The flat sidewall on side is still in side wall state, and the side wall of the cambered surface indent perpendicular to bottom, so that the liquid in collecting chamber
It is able to enter the test chamber being connected at flat sidewall by injection port, realizes detection.
In some specific embodiments, collecting chamber side wall include one section in plane side wall, one section in cambered surface indent
Side wall and one section of side wall in cambered surface evagination, three sections of side walls are sequentially connected and connect, enclose to form whole collecting chamber side wall；Test chamber or
Detection plate is connected at plane, and cambered surface and the hand of sunken inside and outer protrusion take the shape for state of holding to fit, and conveniently take.
More specifically in embodiment, at least one depression is included in collecting chamber side wall, described at least one depression is located at
In another connected side wall different from the described side wall in cambered surface indent being connected with flat sidewall.
The depression is engaged with inner concave arc surface, and when user collects liquid sample, thumb is placed in the cambered surface of indent, and eats
Refer to or middle finger is placed in the depression, can conveniently take and hold collection and detection device, avoid sliding.
In further embodiments, collecting includes at least two depressions in test chamber, and it is in arc that at least one depression, which is located at,
In the side wall of the indent in face, at least one depression is positioned at the side different from the described indent in cambered surface being connected with flat sidewall
In another connected side wall of wall.
Two depressions can more facilitate the positioning of hand thumb and forefinger, operator is held steadily collection and detection device.
On the other hand, two depressions form the bayonet socket of indent in collecting chamber side wall, can be fixed on test chamber in the bayonet socket.
On the other hand, invention also provides a kind of method using collection and detection device, and collection and detection device, which includes housing, to be surveyed
Try the test chamber of element and collect the collecting chamber of storage fluid sample, liquid communication between test chamber and collecting chamber, collecting chamber
Including collection port, bottom wall and side wall, at least three contact points being generally aligned in the same plane are included in collecting chamber side wall；It is described to collect inspection
Surveying device has collection position and test position, when collection and detection device is in collection position, is collected by collecting chamber bottom wall supports
Detection means；When collection and detection device is in test position, collection and detection device is supported by the contact point of the collecting chamber side wall；
Wherein,
It is in collection and detection device and collects position, collects liquid sample；
Collection and detection device is overturn to test position by collecting position；
Detect sample.
Beneficial effect
The collection and detection device of the present invention is simple in construction, can use and be blow molded manufacturing process, manufacturing cost is low；Being capable of basis
Need to open and test, it is convenient to determine the detection time started, it is determined that the optimal result viewing time；Compared to traditional vertical array
Test strips, the application uses transversely arranged test strips, and in test chamber of the same area, can arrange more strips, energy
It is enough to test more projects simultaneously.
Brief description of the drawings
Fig. 1 is a kind of collection and detection device schematic diagram (signal when collection and detection device is positioned at collection position of the present invention
Figure)；
Fig. 2 is that (collection and detection device is located at test position to test chamber diagrammatic cross-section in collection and detection device of the invention
When schematic diagram)；
Fig. 3 is the decomposing schematic representation of the collection and detection device of the present invention；
Fig. 4 is the front schematic view of the detection plate lower plate of the present invention；
Fig. 5 is the back side (reverse side) schematic diagram of the detection plate lower plate of the present invention.
Reference：
Collection and detection device 800, collecting chamber, urine cup 100, test chamber, detection plate 200, testing element, test strips 300, receive
Collect bottom of chamber wall 110, collecting chamber side wall 120, the collection port 130 of collecting chamber, face (cambered surface indent side wall, contact where contact point
Face) 121, the face (flat sidewall) 122 where test chamber, the side wall 123 of cambered surface evagination, test chamber one end 204, test chamber is another
End 203, injection port 210, gas channel air admission hole 220, neck (gas channel) 230, steam vent 240, testing element groove
260, detection plate upper plate 201, detection plate lower plate 202, detection plate lower plate front 2021, back 2022 under detection plate, after neck
Plate 231, depression 124, the sample application zone 301 of testing element, the marked region 302 of testing element, lid 400
Embodiment
Structure of the present invention or these used technical terms are described further below.
Detection
" detection " represents to chemically examine or test a kind of material or material whether there is, such as, but this is not limited to, chemicals
Matter, organic compound, inorganic compound, metabolism product, medicine or drug metabolite, organic organization or organic organization
Metabolin, nucleic acid, protein or polymer.In addition, detection represents test substances or the quantity of material.Furtherly, chemical examination is gone back
Represent immune detection, chemical detection, enzyme detection etc..
Antibody
" antibody " refers to immunoglobulin, either natural or some or all of synthesis.This term also wraps
Include wherein keep binding ability antibody derivative, also including it is any containing with the binding domain homologue of immunoglobulin or
The largely protein of homologous binding domain.These protein are derived from natural materials, it is also possible to part or
All synthesize.A kind of antibody is probably the either polyclonal of monoclonal.A kind of antibody is probably any immunoglobulin
A member in type, include the immunoglobulin class of any mankind：IgG, IgM, IgA, IgD, IgG and IgE." antibody fragment "
It is derivative or a part less than total length for antibody for antibody.Antibody fragment can retain at least one full length antibody
The notable site of binding ability.The example of antibody fragment includes Fab, Fab', F (ab')2, scFv, Fv, dsFv dimers, and Fd
Fragment, but not only include the above.
Test strips
Apply to the horizontal effluent reagent strip that the test strips of the present invention can be known as, the specific knot of these reagent strips
Structure and Cleaning Principle are technology known to persons skilled in the art in the prior art.Common reagent strip, including sample
Region of acceptance, marked region, detection zone and suction zone, include in detection zone to detect whether containing analyte
Necessary chemical substance, after detection terminates, can occur the detection line 241 and control line 242 that represent result in detection zone.
Typically conventional detection reagent bar is nitrocellulose assay strip, i.e., detection zone includes nitrocellulose filter (NC films),
Specific binding molecule is fixed on nitrocellulose filter to show the end of detection, can also be cellulose acetate film or nylon membrane etc.
Deng.The width of usual test strips is between 3mm-6mm.
The type of analyte
The example that can be used in the analyte of stable detection of the present invention promotees including (but not only including) human chorionic
Gonadal hormone (hCG), lutropin (LH), ovarioestrogen (FSH), hepatitis C virus (HCV), hepatitis B (HBV), hepatitis B
The medicine of surface antigen, AIDS virus and any abuse.Analyte can detect in any liquid or liquefied sample
Arrive, such as urine, saliva, blood, blood plasma or serum.The example of other analytes also has flesh ammonia acid anhydride acid, bilirubin, nitrous
Hydrochlorate, protein (nonspecific), blood, leucocyte, blood glucose, heavy metal and toxin, bacterial component is (for example, particular type
Bacterium special protein and sugar, such as colon bacillus 0157:H7, staphylococcus aureus, salmonella, aerogenesis pod
Film clostridium, campylobacter, listeria monocytogenes, V. parahaemolyticus, or wax bacillus).Any other suitable side
The analyte of stream test form can be detected with the present apparatus.
The type of sample
Any kind of sample can be tested with the device of the present invention, including body fluid is (for example, urine and other bodies
Liquid, and clinical sample).Fluid sample may originate from solid or semisolid sample, including excrement, biological tissue and food
Sample.These solids and semisolid sample can be transformed into fluid sample by any suitable method, such as in one kind
Mixed in appropriate liquid, stamp broken, macerated, be incubated, dissolving or enzymolysis solid sample (for example, water, phosphate buffer or
Other buffer solutions)." biological sample " includes the sample from animal living, plant and food, also including urine, saliva, blood
With blood constituent, cerebrospinal fluid, vaginal swab, seminal fluid, excrement, sweat, secretion, tissue, organ, tumour, tissue and organ
It is the conditioned media of culture, cell culture and there, either people or animal.Foodstuff samples include finished food
Thing composition and last product, meat, cheese, wine, milk and drinking water.Plant sample include from any plant, plant tissue,
The sample of the conditioned media of plant cell cultures and there." environmental sample " is that those are derived from the sample of environment (for example, lake water
The sample of sample or other water bodys, sewage sample, pedotheque, groundwater sample, seawater sample, the sample of runoff water).
Sewage and related waste can also be included in environmental sample.
In the following detailed description, the subsidiary reference word of legend is a part here, and it is to illustrate this
Invention can the mode of actable specific concrete scheme illustrate.We, which are not precluded from the present invention, can also carry out others specifically
Scheme and the structure for changing the present invention in the case of the use range without prejudice to the present invention.
As depicted in figs. 1 and 2, the collection and detection device 800 for the present invention mainly includes collecting chamber 100 and test chamber
200, and the lid 400 of sealing collecting chamber.Collecting chamber 100 is used to collecting and storing fluid sample, and test chamber 200 is an envelope
The cavity closed, being capable of liquid communication between the test chamber 200 and collecting chamber 100 for housing testing element 300.Work as liquid
After being collected in collecting chamber 100, lid 400 covers and seals the collection port 130 of collecting chamber, makes the liquid in collecting chamber 100
Sealed and polluted without being leaked to outside collection and detection device 800, while make the collecting chamber 100 and test chamber 200 of connection
The space of a sealing is formed, facilitates follow-up detection to operate.
On the collection and detection device 800, have and collect position (Fig. 1) and test position (Fig. 2).Collection and detection device
800 in when collecting position, and the bottom wall 110 of collecting chamber contacts with supporting surface (plane for placing collection and detection device 800), that is, receives
The bottom wall 110 of collection chamber is used to support the collection and detection device 800；When collection and detection device 800 is located at the collection position, inspection is collected
Simultaneously stored samples can be collected by surveying device 800.When collection and detection device 800 is located at test position, collection and detection device 800 passes through
At least three contact points support in collecting chamber side wall 120, specifically, having one in collecting chamber side wall 120 includes at least three
The face 121 that individual contact point is formed, the face 121 are used to support the collection and detection device 800 during test position；Collection and detection device
800 when being located at test position, and collection and detection device 800 starts to detect sample.In one specific embodiment, as shown in figure 1, receiving
Collect detection means 800 positioned at position is collected, the bottom of collection and detection device 800 is used as with putting by the bottom wall 110 of collecting chamber
The supporting surface contact of collection and detection device 800 is put, supports whole collection and detection device 800；And in Fig. 2, collection and detection device
800 are in test position, the bottom of the part of collecting chamber side wall 120 as collection and detection device 800, support whole collection
Detection means 800, now, the face 121 where at least three contact points are located in collecting chamber side wall 120, and are detected as collecting
The bottom of device 800 supports whole collection and detection device 800.
Collection and detection device 800 can reach test position by collecting position by overturning, and that is to say collection detection dress
The support bottom for putting 800 is changed into a face 121 of collecting chamber side wall from collecting chamber bottom wall 110, specifically, can be by that will receive
Collection detection means 800 overturns certain angle to realize.In the present embodiment, according to collecting chamber and the structure of test chamber, Ke Yitong
Cross to turn over collection and detection device 800 and turn 90 degrees, the support bottom surface of collection and detection device 800 is transformed to by collecting chamber bottom wall 110
A part for the side wall 120 of collecting chamber, reverses direction can be according to this faces 121 of the collecting chamber side wall for support positioned at receipts
The which side for collecting chamber 100 adjusts, that is, needs to overturn the supporting surface with three contact points to the bottom of collection and detection device 800
Portion.
In use, collection and detection device 800 is collected into liquid sample first positioned at position is collected, collects detection dress
After the completion of putting 800 collection samples, collection and detection device 800 is turned to up to test position by collecting position, carries out the inspection of sample
Survey.In collection and detection device 800 of the present invention, collection and detection device 800 is turned over and turn 90 degrees.Overturn in collection and detection device 800
During, the liquid in collecting chamber 100 flows because of the conversion of the position of collection and detection device 800, and passes through collecting chamber 100 and inspection
Survey the part that chamber 200 connects and enter test chamber 200, and engaged test element 300, testing element 300 detect to sample.
In some preferred embodiments, test chamber 200 is connected to the side wall 120 of collecting chamber, more specifically, test chamber 200
The side in face 121 where being connected to contact point.So, when collection and detection device 800 is located at test position, i.e. collecting chamber side wall
At least three contact points where face 121 as 800 bottom of collection and detection device when, test chamber 200 and in test chamber 200
Testing element 300 perpendicular to bottom (namely perpendicular at least three contact points where face 121), meanwhile, in test chamber 200
Testing element 300 is also perpendicularly to the fluid level of the liquid sample in collecting chamber 100, so as to ensure that sample can smoothly enter inspection
Chamber 200 is surveyed, is contacted with the testing element 300 of intracavitary and completes to detect.More excellent, testing element 300 is also both perpendicular to collection
Chamber 100 is through bottom wall 110 and the axis of collection port 130.More specifically, collection and detection device 800 is surveyed positioned at when collecting position
Examination element 300 is horizontally arranged in test chamber 200, and is horizontally arranged in the side wall of collecting chamber 100 (shown in Fig. 3)；Work as collection
When detection means 800 is turned to test position, testing element 300 is vertical row relative to the bottom 121 of collection and detection device 800
Row, as shown in Figure 2.
More specifically in embodiment, in order to ensure that sample sequentially flows through testing element 300, detection, testing element are realized
Sample application zone 301 adjacent to the face 121 where at least three contact points.Namely collection and detection device 800 is in detecting position
When putting, the sample application zone 301 of testing element is located at the bottom of testing element 300, to ensure sample application zone 301 at first
Touch liquid sample.
In the collection and detection device 800 of the present invention, test chamber 200 is located in collecting chamber side wall 120, test chamber one end 203
The bottom wall 110 of neighbouring collecting chamber, collection port 130 of the test chamber other end 204 adjacent to collecting chamber.Wherein, test chamber is neighbouring collects
Mouthful one end 204 include allowing liquid from collecting chamber 100 to be flowed into the injection port 210 of test chamber 200 and allow gas from test chamber stream
Enter to collecting chamber gas channel 230.Injection port 210 makes liquid communication between collecting chamber 100 and test chamber 200, is examined collecting
During survey device 800 is overturn to test position by collection position, the liquid sample in collecting chamber 100 passes through injection port 210
Into in test chamber 200.And gas channel 230 is then used to discharge what is be extruded by the entrance of liquid sample in test chamber 200
Gas.Therefore, when collection and detection device 800 is located at test position, in order to ensure that sample smoothly enters test chamber 200, air-flow
The position of passage 230 needs the position higher than injection port 210.
In some embodiments, gas channel 230 is overflow to rise passage and be connected to the excessive passage that rises of the air-flow by an air-flow (schemes
In fail to show) air admission hole 220 at both ends and exhaust outlet 240 form.In order to ensure that the gas channel 230 can realize discharge inspection
The gas of chamber 200 is surveyed, when collection and detection device 800 is located at test position, the position of steam vent 240 is higher than air admission hole 220
Position.In one specific embodiment, air admission hole 220 is located at the bottom of gas channel 230, and steam vent 240 is located at gas channel
230 top.
In practical operation, the sample into test chamber 200 needs the sample application zone of engaged test element 300 first
301, and only contacted with sample application zone 301, it just can guarantee that the realization of the collection and detection device 800 detection.In the present invention,
The height that sample enters test chamber 200 is adjusted by the position of injection port 210 and the position of gas channel 230, makes liquid
The level control of body sample is in the sample application zone 301 of testing element.Specifically, when collection and detection device 800 is positioned at inspection
When surveying opening position, position of the position of injection port 210 not higher than the sample application zone 301 of testing element；The air inlet of gas channel
The position of hole 220 is higher than the position of injection port 210, and the position of air admission hole 220 of gas channel is less than testing element marked region 302
Position.Liquid sample is during collection and detection device 800 is turned to up to test position by collection position, collecting chamber 100
Put and change, change in location occurs therewith for the liquid sample in collecting chamber 100, and liquid flows to the contact in the direction of collection port 130
Face 121 where point, so as to flow into while adjacent to the injection port 210 in face 121 where collection port 130 and contact point, pass through sample introduction
Mouth 210 enters test chamber 200, reaches at the sample application zone 301 for the testing element 300 being located in test chamber 200 (because of sample introduction
210 positions of mouth are not higher than the position of sample application zone 301), meanwhile, the gas of test chamber 200 is extruded because liquid enters, edge
The gas channel 230 being in communication with the outside is discharged outside test chamber 200.Specifically, the gas of test chamber 200 passes through air inlet after being extruded
Hole 220, which enters air-flow, overflows and rises passage, and overflowing to rise in passage in air-flow flow to up to steam vent 240, then is discharged by steam vent 240 whole
Individual gas channel 230, namely be discharged to outside test chamber 200.When collection and detection device 800 is totally turned over to test position,
Liquid sample goes successively to test chamber 200, until liquid level of the liquid sample in test chamber 200 reaches entering for gas channel
During 220 opening position of stomata, the hydraulic seal air admission hole 220, make not connect between gas channel 230 and test chamber 200, test chamber
200 are sealed, and the gas and liquid in test chamber 200 reach poised state, and the liquid in collecting chamber 100 does not enter back into test chamber
200, so as to which the liquid level in test chamber 200 is identical with the position height of air admission hole 220, positioned at the marked region of testing element
302 lower section, i.e., only the sample application zone 301 of testing element 300 being capable of contact liq sample.
The collecting chamber side wall 120 of the collection and detection device 800 of the present invention includes at least one section side wall in cambered surface indent
121, at least three contact points for support are located at the side wall 121 that this is in cambered surface indent, therefore, collection and detection device 800
During in test position, the side wall 121 of the cambered surface indent supports collection and detection device 800.Or collecting chamber side wall 120 is also
Including the side wall 122 at least one section in plane, the side wall 122 of the plane is used to accommodate or connecting detection chamber 200.And more
In preferred embodiment, collecting chamber side wall 120 includes at least one section in the side wall 121 of cambered surface indent and at least one section in plane
Side wall 122, described flat sidewall 122 are connected with the side wall 121 of cambered surface indent.Wherein, test chamber 200 is located at the side wall of plane
At 122, at least three contact points are located at this in the side wall 121 of cambered surface indent；When collection and detection device 800 is in test position
When, the side wall 121 of cambered surface indent is as bottom support collection and detection device 800.
In a specific embodiment in the present invention, detection means 800 is by the urine cup 100 of one end open as collection
Chamber, and test chamber is made up of detection plate 200, detection plate 200 is inserted in urine cup 100 and is fixed on the madial wall of urine cup 100.Such as
Shown in Fig. 3, detection plate 200 is divided to detect upper plate 201 and detection lower plate 202, and detecting in lower plate 202 has multiple receiving test members
The groove 260 of part 300, testing element 300 are placed in groove 260, are then detected upper plate 201 and are covered simultaneously sealing detection lower plate
202 form the cavity 200 of sealing, and after the detection plate 200 inserts urine cup 100, testing element 300 is laterally positioned in urine cup side wall 120
On, namely testing element 300 is perpendicular to the axial direction of urine cup 100, also, testing element 300 is used for what is supported perpendicular to urine cup 100
Contact surface 121.
In some embodiments, testing element 300 is the test paper that analyte detection in sample is realized using lateral flow
Bar.The test strips include sample application zone 301, marked region 302, detection zone and suction zones successively by bottom to top
Domain.
Make that urine cup 100 is connected with detection plate 200 is close to the sample introduction at urine cup opening 130 positioned at detection lower plate 102
Mouth 210, as shown in Fig. 2 the injection port 210 is also located at the bottom of detection plate 200 simultaneously, the contact surface of support to be used for close to urine cup
121, its position is not higher than the sample application zone 301 of test strips.Also there is neck 230, the neck in the top of injection port 210
230 are used to discharge the gas in detection plate 200.
In one specific embodiment, as shown in figure 4, the neck 230 is by being arranged on detection plate lower plate front 2021
Bossing forms with the fixing seal of neck back plate 231.Neck 230 is located at detection plate lower plate with test strips 300 in same direction
202 adjacent to one end of urine cup opening 130 (collection port of collecting chamber).The bottom of neck 230 (one end of neighbouring injection port 210) has
Air admission hole 220, air admission hole 220 make the hollow space (air-flow, which overflows, rises passage, not shown in figure) of neck be connected with detection plate 200
Logical, in a specific embodiment, air admission hole is located at the front of neck, namely the front 2021 of detection plate, as shown in Figure 4.Card
The top of groove 230 has steam vent 240, and therefore, the position of steam vent 240 is higher than the position of air admission hole 220；The steam vent 240 is preferred
Positioned at the back side of neck 230, as shown in figure 5, namely positioned at detection lower plate 202 the back side 2022；Certainly, other embodiments
In, steam vent 240 can also be located at the side wall of neck 230, and be communicated to the side wall of detection plate 200 etc..Steam vent 240 and inspection
Connected outside drafting board 200, more specifically, the steam vent 240 is connected with urine cup 100 (collecting chamber), the hollow bulb in neck 230
The gas divided is discharged in urine cup 100 by steam vent 240.After liquid enters detection plate 200, the air in detection plate 200
Entered by air admission hole 220 in the hollow space of neck 230, steam vent 240 is reached after the hollow space of neck 230 is flowed through, led to
Steam vent 240 is crossed to be discharged in urine cup 100.
More specifically, the side wall that one section of 122, one sections of side wall in plane is in cambered surface indent is included in urine cup side wall 120
121 and one section be in cambered surface evagination side wall 123, this three sections of side walls, which are sequentially connected, to be connect, and encloses whole urine cup side wall 120.Inspection
Drafting board 200 is inserted into inner chamber at the side wall 122 of plane, and the cambered surface of the side wall 121 of indent and the side wall 123 of evagination is taken with hand holds
The shape of state fits, and conveniently takes.
In collection and detection device 800 of the present invention, include at least one depression in collecting chamber side wall 100, described at least one
Individual depression is in another connected side wall different from the described side wall in cambered surface indent being connected with flat sidewall 122.Or
Person, collecting includes at least two depressions in test chamber 100, and at least one depression is located in the side wall in cambered surface indent, at least
There is a depression to be located in another connected side wall different from the described side wall in cambered surface indent being connected with flat sidewall.Specifically
Include two depressions 124 onto the embodiment of urine cup, in urine cup side wall 120；Two depressions 124 are located at the institute of detection plate 200 respectively
In the both sides of flat sidewall 122, more specifically, a depression 124 in the indent side wall 121, neighbouring indent side wall 121 with
The junction of flat sidewall 122, another depression 124 is in evagination side wall 123, adjacent plane side wall 122 and evagination side wall 123
Junction.The depression 124 for being respectively in the plane both sides of detection plate 200 is used for the thumb and forefinger of placement operation person, also, recessed
Fall into 124 and also form bayonet socket in urine cup madial wall, be just fixed the detection plate 200 of position in the inner, detection plate 200 is installed more
It is stable.
In some preferable modes, at side depression 124 wherein, multiple depressions can be again set thereunder, used
In other fingers of placement operation person.
In some improved embodiments, in order to realize that more analytes of same sample disposably detect, Ke Yi
Two-sided (front and reverse side, installation test strips in the front of detection plate 200 being shown as in Fig. 3) engaging test strips are set in detection plate 200,
One dividing plate is set in detection plate, test strips are placed in the positive and negative of dividing plate, on the positive and negative of dividing plate covers respectively
Plate 201 and lower plate 202, the fluid connection of injection port 210 is to upper plate 201 and the sample of the test strips of lower plate 201 in detection plate 200
Region of acceptance 301, or it is respectively provided with injection port 210 in the upper and lower corresponding position of plate 201,202 of detection plate.Now, neck 230
(gas channel) can be opened on upper plate 210 and lower plate 202 respectively, and neck 230 can also be provided separately within dividing plate；With
Upper type is not intended to limit, and is set in a manner of neck 230 can be realized the function of the air discharge of detection plate；And it is vented
Hole 240 can be opened in the side wall of neck 230 or the front of neck, reverse side etc..
In other improved specific embodiments, in order to place more test strips 300, the side wall 120 of urine cup is provided with
The side wall 122 of two planes, it is specifically as follows plane 122, concave surface 121, plane 122 and convex surface 123 and is sequentially connected, enclose urine
The side wall 120 of cup.The equal grafting detection plate 200 in the position of side wall 122 of two planes, more possible medicines can be examined simultaneously
Survey.
In other embodiments, plane 122, concave surface 121 and the position relationship on convex surface 123 of urine cup side wall 120 can roots
According to needing to set, for example along counterclockwise, side wall 120 be sequentially plane 122, concave surface 121 and convex surface 123, is relatively adapted to right
Hand is taken and held.And clockwise, side wall 120 is sequentially plane 122, convex surface 123 and concave surface 121, is adapted to left hand to take and holds.
In some embodiments, urine cup 100 and detection plate 200 are made by transparent material, to facilitate the collection of observation sample
Reading of situation and testing result etc..
The specifically used method of the present embodiment urine cup 100 is described below.
Detection plate 200 with multiple test strips for contacting different analytes respectively is inserted in the plane of urine cup 100
At side wall 122, detection plate 200 is connected with urine cup 100 by injection port 210 with neck 230.
First, whole urine cup device 800 is placed on supporting surface, now, the bottom 110 of urine cup is located on supporting surface, i.e.,
Urine cup device 800 opens the lid 400 in urine cup opening 130 positioned at position (Fig. 1) is collected, and collects liquid sample and (passes through urine cup
Opening 130 adds sample), such as urine.
Secondly, (liquid level of general sample is no more than 2/3 height of urine cup, and sample after the completion of sample is collected
Liquid level be not less than to urine cup height 1/3), covering lid 400 seals urine cup 100.
3rd, urine cup device 800 is overturn, the indent side wall 121 of urine cup side wall is turned at supporting surface, as urine cup
The bottom of device 800, i.e. urine cup device 800 are overturn to test position (Fig. 2).
4th, liquid sample enters detection plate 200, the sample of sample contact test strips in inspection positions, urine cup 100
Region of acceptance 301, test strips 300 detect sample.
5th, the testing result in test strips 300 is read, completes detection.
Claims (19)
1. a kind of collection and detection device of fluid sample, including house the test chamber of testing element and collect storage fluid sample
Collecting chamber, liquid communication between test chamber and collecting chamber, it is characterised in that collecting chamber includes collection port, bottom wall and side wall, receives
Include at least three contact points being generally aligned in the same plane in collection chamber side wall；The collection and detection device, which has, collects position and detection
Position, when collection and detection device is in collection position, by collecting chamber bottom wall supports collection and detection device；Collection and detection device is in
During test position, collection and detection device is supported by the contact point of collecting chamber side wall.
2. collection and detection device according to claim 1, it is characterised in that after collection and detection device collects sample, by receiving
Collection position is turned to up to test position, carries out the detection of sample.
3. collection and detection device according to claim 1, it is characterised in that the test chamber is connected at least three contacts
The side in face where point.
4. collection and detection device according to claim 1, it is characterised in that testing element in the test chamber perpendicular to
Face where contact point.
5. collection and detection device according to claim 4, it is characterised in that the sample application zone of testing element is neighbouring to be connect
Face where contact.
6. collection and detection device according to claim 1, it is characterised in that test chamber includes allowing adjacent to one end of collection port
Liquid from collecting chamber is flowed into the injection port of test chamber and allows gas to be flowed into the gas channel of collecting chamber from test chamber.
7. collection and detection device according to claim 6, it is characterised in that gas channel includes what is be connected with test chamber
Air admission hole, the steam vent being connected with collecting chamber, and the air-flow of connection air admission hole and steam vent overflow and rise passage.
8. collection and detection device according to claim 7, it is characterised in that when collection and detection device is located at inspection positions
When, position of the injection port position not higher than the sample application zone of testing element.
9. collection and detection device according to claim 7, it is characterised in that when collection and detection device is located at inspection positions
When, air inlet hole site is higher than injection port position, and air inlet hole site is less than the position of testing element marked region.
10. detection means according to claim 7, it is characterised in that when collection and detection device is located at test position, row
The position of stomata is higher than the position of air admission hole.
11. collection and detection device according to claim 1, it is characterised in that the collection and detection device also includes covering
And seal the lid of collecting chamber.
12. collection and detection device according to claim 6, it is characterised in that the test chamber includes accommodating testing element
Detection plate, gas channel is located at detection plate.
13. collection and detection device according to claim 12, it is characterised in that be provided with neck, described gas in detection plate
Circulation road is located in neck.
14. collection and detection device according to claim 1, it is characterised in that, collecting chamber side wall is in arc including at least one section
The side wall of face indent, at least three described contact points are located at this in the side wall of cambered surface indent；Collection and detection device is in inspection
When location is put, the side wall support collection and detection device of the cambered surface indent.
15. collection and detection device according to claim 1, it is characterised in that, collecting chamber side wall includes at least one section in flat
The side wall in face, the test chamber are located at the side-walls of plane.
16. the collection and detection device according to claims 14 or 15, it is characterised in that, collecting chamber side wall includes at least one section
It is in the side wall of plane in the side wall of cambered surface indent and at least one section, described flat sidewall is connected with the side wall of cambered surface indent.
17. collection and detection device according to claim 16, it is characterised in that, include in collecting chamber side wall at least one recessed
Fall into, described at least one depression is located at another phase for the side wall different from the described indent in cambered surface being connected with flat sidewall
In side wall even.
18. collection and detection device according to claim 16, it is characterised in that, collect recessed including at least two in test chamber
Fall into, at least one depression is located in the side wall in the indent of cambered surface, and at least one depression is different positioned at being connected with flat sidewall
In in another connected side wall of the side wall of the described indent in cambered surface.
19. a kind of method using collection and detection device, collection and detection device includes housing test chamber and the collection of testing element
Store the collecting chamber of fluid sample, liquid communication between test chamber and collecting chamber, it is characterised in that collecting chamber includes collecting
Mouthful, bottom wall and side wall, include at least three contact points being generally aligned in the same plane in collecting chamber side wall；The collection and detection device tool
Have and collect position and test position, when collection and detection device is in collection position, by collecting chamber bottom wall supports collection and detection device；
When collection and detection device is in test position, collection and detection device is supported by the contact point of the collecting chamber side wall；
Wherein,
It is in collection and detection device and collects position, collects liquid sample；
Collection and detection device is overturn to test position by collecting position；
Detect sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610730524.5A CN107782883A (en) | 2016-08-26 | 2016-08-26 | A kind of collection and detection device of fluid sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610730524.5A CN107782883A (en) | 2016-08-26 | 2016-08-26 | A kind of collection and detection device of fluid sample |
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| Publication Number | Publication Date |
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| CN107782883A true CN107782883A (en) | 2018-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610730524.5A Pending CN107782883A (en) | 2016-08-26 | 2016-08-26 | A kind of collection and detection device of fluid sample |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101556277A (en) * | 2009-01-05 | 2009-10-14 | 艾博生物医药(杭州)有限公司 | Detecting device |
| CN102589928A (en) * | 2011-01-15 | 2012-07-18 | 艾博生物医药(杭州)有限公司 | Fluid sample detecting device |
| CN102680276A (en) * | 2011-03-15 | 2012-09-19 | 艾博生物医药(杭州)有限公司 | Detection device |
| CN205235988U (en) * | 2015-11-21 | 2016-05-18 | 艾博生物医药(杭州)有限公司 | Collection and detection device of fluid sample |
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2016
- 2016-08-26 CN CN201610730524.5A patent/CN107782883A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101556277A (en) * | 2009-01-05 | 2009-10-14 | 艾博生物医药(杭州)有限公司 | Detecting device |
| CN102589928A (en) * | 2011-01-15 | 2012-07-18 | 艾博生物医药(杭州)有限公司 | Fluid sample detecting device |
| CN102680276A (en) * | 2011-03-15 | 2012-09-19 | 艾博生物医药(杭州)有限公司 | Detection device |
| CN205235988U (en) * | 2015-11-21 | 2016-05-18 | 艾博生物医药(杭州)有限公司 | Collection and detection device of fluid sample |
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