CN211122547U - Sample collection and detection device - Google Patents

Abstract

The utility model relates to a sample collecting and detecting device, which is used for collecting and analyzing and detecting the analyzed object in a liquid sample, and comprises a collecting cavity and a detecting cavity communicated with the collecting cavity; the detection cavity comprises a detection plate and a sealing piece, the detection plate is located on the side wall of the collection cavity, and the sealing piece is used for sealing the detection plate. The utility model discloses a device is when realizing the function of collecting and detecting, and the device structure is also simplified, has both simplified production technology, has still improved the yields of manufacturing again when practicing thrift the cost.

Description

Sample collection and detection device

Technical Field

The utility model relates to a detection device is collected to the sample, in particular to is used for collecting the collection detection device that fluid sample retests.

Background

The following background is provided to aid the reader in understanding the present invention and is not admitted to be prior art.

The technology of detecting whether an analyte exists in a sample by using the principle of an immunological binding reaction is widely used in various fields. It can be used to detect analytes in various biological samples (saliva, blood, urine, serum, sweat, etc.) to monitor diseases and human health (early pregnancy, tumors, infectious diseases, drugs, etc.). The underlying principle of such detection techniques is to establish the ability to specifically bind between immune molecules, such as antibodies and antigens, haptens/antibodies, biotin and avidin, and the like.

In the field of medical diagnosis, it is a common method to collect a test liquid sample by using a testing device or a testing cup and determine whether the liquid sample contains an analyte. Such test devices or test cups typically require the sample to be collected in a sample container and the associated technician inserts a test strip and immerses a portion of the test strip in the sample, removes the test strip after a number of hours, and reads the test results.

US2004/0184954 and US2004/0237674 disclose devices for collecting saliva and detecting the presence of illegal drug components in the saliva. In both patents, devices and methods are provided for collecting and testing saliva, wherein after a sample is collected on a collector, the sample is squeezed by an external force applied to an absorbent member on the collector into a collection chamber, and then tested. In addition, chinese patent CN202693584U also discloses a device for collecting and testing samples, in which liquid is collected from a saliva collecting cotton into a saliva cylinder by squeezing the saliva cylinder and the saliva collecting cotton on a connecting rod, and then flows into a testing cavity communicated with the saliva cylinder, and then testing is performed.

In actual conditions, the existing saliva collecting and detecting device is usually manufactured and collected separately and then combined with the detection cavity for use, the manufacturing process is complex, the manufacturing reject ratio is high, and meanwhile, the manufacturing cost is high.

SUMMERY OF THE UTILITY MODEL

The utility model provides a detection device is collected to new sample, it will detect the chamber integration on collecting the chamber to the device has simplified production technology when realizing the function of collecting and detecting, has still improved the yields of manufacturing when practicing thrift the cost.

Particularly, the utility model provides a sample collection and detection device for collecting and analyzing the analyte in the detection liquid sample, the sample collection and detection device includes a collection cavity and a detection cavity in fluid communication with the collection cavity; the detection cavity comprises a detection plate and a sealing piece, the detection plate is located on the side wall of the collection cavity, and the sealing piece is used for sealing the detection plate.

The detection plate is positioned on the side wall of the collection cavity, namely the detection plate is a part of the side wall of the collection cavity, so that the material and the process for independently manufacturing the detection cavity are saved, and the material cost and the process cost are greatly saved.

In some preferred embodiments, the device further comprises a cover body covering the collecting cavity; the cover body is provided with a vent hole. The air vent is arranged to enable the covered collection cavity to be communicated with the atmosphere, so that the air pressure in the collection cavity is reduced, and the sealing piece and the detection plate are prevented from being pressed by the air pressure to be not firm in sealing.

In some preferred embodiments, the sealing sheet is a transparent adhesive sticker.

In some preferred embodiments, the detection plate is recessed from 1 to 2mm above the outer surface of the side wall of the collection chamber. The detection plate is provided with a depression formed on the outer surface of the side wall of the collection cavity for placing the sealing sheet, so that the sealing sheet and the whole collection cavity are positioned on the same plane.

In some preferred embodiments, the test plate is provided with one or more recesses for receiving test elements.

In some preferred embodiments, a hollow-out area is arranged at the bottom of the detection plate, a liquid storage tank is arranged at the bottom of the collection cavity corresponding to the hollow-out area, and the liquid storage tank is communicated with the detection plate through the hollow-out area.

In some preferred embodiments, the bottom of the collection chamber has a bottom recess communicating with the reservoir. After the liquid sample is extruded to the bottom groove, the liquid sample flows to the liquid storage tank connected with the bottom groove along the groove, so that the sample collected by the collecting rod can be fully collected in the liquid storage tank and is in contact with the testing element of the detection area, and the completion of detection is ensured.

In some preferred embodiments, the collection chamber is connected with the cover body in a reversible manner. The collecting cavity is connected with the cover body in a turnover mode, and the cover body can cover the collecting cavity or be opened from the collecting cavity conveniently.

In some preferred embodiments, the kit further comprises a sample collection wand comprising an absorbent member and a hollow collection wand, the absorbent member attached to one end of the collection wand and the absorbent member in fluid communication with the collection wand; an indication strip is arranged in the collecting rod. In a more specific embodiment, the collection member is in fluid communication with the indicator strip.

In some preferred embodiments, the collecting cavity is of a rectangular parallelepiped structure, and the detection plates are respectively located on two or four opposite sides of the side wall of the rectangular parallelepiped collecting cavity.

Advantageous effects

The utility model discloses a device is when realizing the function of collecting and detecting, and the device structure is also simplified, has both simplified production technology, has still improved the yields of manufacturing again when practicing thrift the cost.

Drawings

Fig. 1 is a schematic view of the sample collection and detection device of the present invention.

Fig. 2 is an exploded view of the sample collection and detection device of the present invention.

Fig. 3 is a schematic diagram of the detection area of the present invention.

Fig. 4 is another schematic view of the sample collection and detection device of the present invention.

Fig. 5 is a schematic cross-sectional view of the sample collection and detection device of the present invention.

Fig. 6 is another schematic cross-sectional view of the sample collection and detection device of the present invention.

Fig. 7 is an operation diagram of the sample collection and detection device of the present invention.

Fig. 8 is another schematic cross-sectional view of the sample collection and testing device of the present invention.

Reference numerals

The sample collecting and detecting device 100, the collecting cavity 10, the liquid storage tank 11, the bottom groove 12, the boss 13, the fence 14, the cover body 20, the vent hole 21, the detecting cavity 30, the detecting plate 31, the sealing plate 32, the groove 33, the hollowed-out area 34, the recess 35, the sample collecting rod 40, the absorbing part 41, the collecting rod 42, the indicating strip 43 and the testing element 50

Detailed Description

The structures referred to in the present invention or these terms of art used are further described below.

Detection of

Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, a chemical, organic compound, inorganic compound, metabolic product, drug or drug metabolite, organic tissue or a metabolite of organic tissue, nucleic acid, protein, or polymer. In addition, detection indicates the amount of the test substance or material. Further, the assay means immunodetection, chemical detection, enzyme detection, and the like.

Sample(s)

The term sample as used herein refers to a substance that can be used to detect, assay or diagnose the presence of an analyte of interest. The sample may be, for example, a liquid sample, which may include blood, plasma, serum, urine, saliva, and various exudates, and may also include a liquid solution formed by pre-treating a solid sample and a semi-solid sample. The collected sample may be used for immunoassay, chemical assay, enzymatic assay, etc. to detect the presence of the analyte. In a preferred embodiment, the sample of the present invention is a saliva sample.

Analyte substance

Any analyte can be analyzed using the device and method of the present invention. The analyte can be detected in any liquid or liquefied sample, such as urine, saliva, blood, plasma, or serum. The analyte may also be a hapten, which includes a drug of abuse (e.g., a drug of abuse). By "drug of abuse" (DOA) is meant the use of a drug (usually acting to paralyze nerves) at a non-medical destination. The device can also be used for detecting the detection which belongs to the medical application and is easy to take overdose, such as tricyclic antidepressant (imipramine or the like) and acetaminophen, etc. After being absorbed by human body, the medicines are decomposed into different small molecular substances, and the small molecular substances exist in body fluids such as blood, urine, saliva, sweat and the like or exist in partial body fluids.

Test element 50

The test element 50 may be selected from a lateral flow test strip that detects a variety of analytes. Of course, other suitable test elements may be used with the present invention. Various test elements may be combined and used in the present invention. One form is a test strip. Test strips for the analysis of analytes, such as drugs or metabolites indicative of a physical condition, in a sample may be in various forms, such as immunoassay or chemical assay forms. The test strip may be used in a non-competitive or competitive assay format. The test strip includes a bibulous material having a sample receiving area, a reagent area, and a test area. The sample is applied to the sample receiving area and flows by capillary action to the reagent area. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized at the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte to the zone, or to one of the reagents of the reagent zone. The label for indicating the detection signal is present in the reagent zone or in a separate label zone.

Typical non-competitive assay formats are: if the sample contains the analyte, a signal is generated, and if the analyte is not contained, no signal is generated. In a competition method, a signal is generated if the analyte is not present in the sample and no signal is generated if the analyte is present.

The test element 50 may be a test strip, and may be selected from a material that absorbs or does not absorb water. The test strip may include a variety of materials for liquid sample delivery. One of the test strips may be coated with another material, such as a nitrocellulose membrane coated with filter paper. One region of the test strip may be selected from one or more materials and another region may be selected from a different one or more materials. The test strip may be adhered to some support or hard surface for improved strength when the test strip is held in place. The analyte is detected by a signal producing system, such as one or more enzymes that specifically react with the analyte, and one or more compositions of the signal producing system are immobilized on the analyte detection zone of the test strip by a method such as that described above for the immobilization of a specific binding substance on the test strip. The signal-producing substance may be on the sample-receiving, reagent, or detection zone, or the entire test strip, and the substance may be impregnated on one or more materials of the test strip. A solution containing the signal is applied to the surface of the strip or one or more materials of the strip are immersed in the solution containing the signal. The strip to which the solution containing the signal substance was added was dried.

The various regions of the test strip may be arranged as follows: a sample receiving area, a reagent area, a detection area, a control area, a sample adulteration area and a liquid sample absorption area. The control zone is located behind the detection zone. All zones may be arranged on a strip of test paper using only one material. It is also possible to use different materials for the different zones. The zones may be in direct contact with the liquid sample, or different zones may be arranged according to the direction of flow of the liquid sample, with the ends of each zone being contiguous with and overlapping the ends of the other zone. The material used can be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms. In some preferred embodiments, the test element may be one or more. The plurality of test elements may each detect a different analyte in the sample.

Sample collection wand 40

Generally, the sample collection wand 40 includes an absorbent member 41 and a collection wand 42, with the absorbent member 41 being located at one end of the collection wand 42 as shown in FIG. 2. The absorbent member 41 is typically made of a medical grade sponge or foam material commonly used in the art. However, many other materials may be used to form the absorbent member, such as cotton or paper, or any other material having water-absorbing properties. The collection rod is generally rigid to facilitate manipulation of the absorbent member. The collection rod may be made of materials commonly used in the art, such as plastic, wood, metal, or cardboard. In some embodiments, the collection rod 42 is a hollow structure, and an indicator strip 43 is disposed in the hollow cavity, wherein the indicator strip 43 changes color after contacting the liquid sample, so as to facilitate observation of whether the absorbent member 41 absorbs the full sample. In one embodiment, the top of the absorbent member 41 is attached to the bottom of the collection rod 42. More specifically, the top of the absorbent member 41 contacts the bottom of the indicator strip 43 located within the collection rod 42. In some preferred embodiments, in order to allow the liquid in the absorbent member 41 to be squeezed more thoroughly and also to prevent the sample collection wand 10 from being placed randomly, the sample collector is provided with threads for mating with the collection well to secure the collection wand 40 to the collection well. In some embodiments, a handle 44 is also provided at the top of the collection rod to facilitate the operation of the collection rod 40 by the operator.

Detection chamber 30

The detection chamber 30 is generally a cavity for accommodating the test element 50 and allowing the liquid sample to enter the cavity 30 to contact the test element 50 for detection. The shape of the test element 50 may be varied and may be designed according to the shape and number of test elements to be accommodated. The utility model discloses in, test element is test paper strip 50.

In the following detailed description, reference is made to the accompanying drawings, which form a part hereof, and in which is shown by way of illustration specific embodiments in which the invention may be practiced. We do not exclude that the invention can also be implemented with other embodiments and that the structure of the invention can be changed without violating the scope of the invention.

As shown in FIGS. 1-8, the device 100 of the present invention has a collection chamber 10 and a detection chamber 30, wherein the collection chamber 10 is in fluid communication with the detection chamber 30. Wherein, the detection cavity 30 is positioned on the collection cavity 10, and the two parts share part of the structure. Specifically, the detection chamber 30 includes a detection plate 31 and a sealing plate 32, and the sealing plate 32 is used for covering and sealing the detection plate 31. Sensing plate 31 is part of collection chamber 10, and more specifically sensing plate 31 is part of the side wall of collection chamber 20. Therefore, in the production process, the detection plate 31 and the collection cavity 10 are integrally formed, and the process flow is saved. Also, material is saved because separate collection chamber side walls and detection chambers are not required.

The detection plate 31 is recessed 1-2mm from the side wall of the collection chamber 20. I.e. the test plate located on the side wall of the collection chamber has a depression 35 in relation to the same side wall of the collection chamber, which depression 35 is 1-2mm deep. The recess 35 is used for placing the sealing disc 32.

In some embodiments, seal 32 is used to seal test plate 31 such that a sealed cavity 30 formed by seal 32 and test plate 31 seals test element 50 therein. The sealing plate 32 is usually made of transparent material for easy observation of the detection result of the test element 50. In one embodiment, the sealing piece 32 is a transparent adhesive. A transparent adhesive sticker is adhered to the detection plate 31 to form a sealed detection cavity 30.

In some embodiments, where the test element 50 is a test strip, the test plate 32 may have one or more recesses 33 formed therein for receiving the test strip.

In order to communicate the detection chamber 30 with the collection chamber 10, a hollow-out area 34 is provided at the bottom of the detection plate 31, and the hollow-out area 34 is also located on the side wall of the collection chamber 10, so that the collection chamber 10 communicates with the detection chamber 30. When the strip is mounted on the detection plate 31, the sample-receiving area of the strip is located in the hollow area 34, so that the sample-receiving area can contact the liquid sample in the collection chamber 10. In a more specific embodiment, a liquid storage tank 11 is arranged at the bottom of the collection cavity 10 at a position corresponding to the hollow area 34, a sample collected in the collection cavity 10 flows into the liquid storage tank 11, and meanwhile, a sample receiving area of the test strip is also located in the liquid storage tank 11, so that the sample receiving area of the test strip is in contact with a liquid sample in the liquid storage tank 11, and detection is realized.

The sample collection and detection device 100 of the present invention further comprises a sample collection rod 40, which comprises an absorption member 41 and a hollow collection rod 42, wherein the absorption member 41 is connected to one end of the collection rod 42, and the absorption member 41 is in fluid communication with the collection rod 42; an indicator strip 43 is provided in the collection rod 42. The sample collection wand 40 is used to collect a sample of a subject, such as saliva, while transferring the sample into the collection chamber 10. The indicator bar 43 is used to indicate whether the absorbent member 42 absorbs the full sample, and when the indicator bar 43 changes color, it indicates that the absorbent member 42 absorbs the full sample.

The utility model discloses an among the sample collection detection device 100, collect chamber 10 bottom and be equipped with boss 13, this boss 13 is located bottom intermediate position, and has the clearance between the 10 lateral walls of collection chamber, and this clearance is reservoir 11 promptly. When the sample collection wand 40 is inserted into the collection chamber 10, the absorbent member 41 is contacted and pressed by the boss 13, causing liquid to flow into the reservoir 11.

In a more preferred embodiment, a fence 14 is provided around the boss 13, the absorbent member 41 is located in the space formed by the boss 13 and the fence 14, and the liquid sample squeezed out of the absorbent member 41 is also in the space. Meanwhile, a bottom groove 12 is provided on the boss 13, and the bottom groove 12 is connected to the reservoir 11. When the liquid sample is squeezed out, it flows into the bottom recess 12 and then into the reservoir 11. This facilitates adequate collection of the liquid sample. In other preferred embodiments, the opening of the bottom recess 12 extends to the rail 14, thereby ensuring that the bottom recess 12 is in sufficient fluid communication with the liquid in the reservoir 11.

The collecting cavity 10 further comprises a cover body 20 covering the collecting cavity 10, in one embodiment, the collecting cavity 10 and the cover body 20 are connected in a turnover mode, and the cover body 20 is convenient to cover the collecting cavity 10. Because of the utility model provides a detection chamber 30 is closed by pick-up plate 31 and gasket 32 lid and is sealed to form, for preventing that pressure is too big to lead to gasket 32 and pick-up plate 31 split, is equipped with air vent 21 on lid 20, closes when lid 20 lid and seals after collecting chamber 10, collects the atmospheric pressure in the chamber 10 because of air vent 21's intercommunication, the same with atmospheric pressure, never, can not produce and collect chamber 10 and detect the too big phenomenon of intracavity 30 internal gas pressure. In a specific embodiment, the collection chamber 10 is a rectangular parallelepiped structure, and how many test strips are placed can be considered according to the type of analyte to be detected, that is, the detection plate 31 can be disposed on one, two, three, or four sides of the side wall of the collection chamber 10. Correspondingly, the number of the bottom grooves 12 of the boss 13 at the bottom of the collection cavity 10 can be two, and the two bottom grooves 12 are arranged in a crossed manner and respectively correspond to the four liquid storage tanks 11 at the bottoms of the four side walls of the collection cavity.

The method of the present invention for collecting and testing a liquid sample by the sample collection and testing device 100 will be described in detail below.

1. Allowing the sample collection wand 40 to collect the liquid sample and the absorbent member 41 to fill with the liquid sample; specifically, the plastic envelope on the absorbent member 41 is torn and removed, a sample is collected through the absorbent member 41 (for example, the sample is put into the mouth of a subject to absorb saliva, or put into a container in which a liquid sample is collected to absorb the sample), the indicator strip 43 is observed, and when the indicator strip 43 changes color, the absorbent member 41 is filled with the liquid sample;

2. aligning the absorbent member 41 of the collector bar directly above the collection chamber 10 and vertically inserting the collector bar 40 into the collection chamber 10; when the absorbing component 41 contacts the boss 13, the collecting rod 40 is continuously pressed downwards until the collecting rod 40 stops moving downwards; at this time, the liquid on the absorbing member 41 is pressed and flows into the boss 13 and the bottom groove 12 of the boss;

3. standing the sample collection and detection device for 1001-5 minutes; the liquid flowing into the boss 13 directly flows into the reservoir 11 through the bottom groove 13 and contacts the test element 50, completing the detection.

Claims (10)

1. The sample collecting and detecting device is used for collecting and analyzing and detecting the analyte in the liquid sample and is characterized by comprising a collecting cavity and a detecting cavity communicated with the collecting cavity; the detection cavity comprises a detection plate positioned on the side wall of the collection cavity and a sealing sheet for sealing the detection area.

2. The specimen collection and testing device of claim 1, further comprising a cover covering the collection chamber; the cover body is provided with a vent hole.

3. The specimen collection and testing device of claim 1, wherein said sealing patch is a transparent adhesive.

4. The specimen collection and testing device of claim 1, wherein the test plate is recessed from about 1 mm to about 2mm of the outer surface of the side wall of the collection well.

5. The specimen collection testing device of claim 1, wherein the test plate has one or more recesses for receiving the test elements.

6. The sample collection and detection device according to claim 1, wherein a hollow-out area is formed at the bottom of the detection plate, a liquid storage tank is formed at the bottom of the collection cavity corresponding to the hollow-out area, and the liquid storage tank is communicated with the detection plate through the hollow-out area.

7. The device of claim 6, wherein the bottom of the collection chamber has a bottom recess that communicates with the reservoir.

8. The device of claim 2, wherein the collection chamber is pivotably coupled to the cover.

9. The sample collection and testing device of claim 1, further comprising a sample collection wand including an absorbent member and a hollow collection wand, the absorbent member attached to one end of the collection wand and the absorbent member in fluid communication with the collection wand; an indication strip is arranged in the collecting rod.

10. The apparatus for collecting and testing specimen according to claim 1, wherein the collecting chamber is a rectangular parallelepiped, and the testing board is located on one, two, three or four sides of the sidewall of the rectangular parallelepiped collecting chamber.

Images