CN107753837A - 一种治疗慢性唇炎的新型中药组合物及制备方法 - Google Patents

一种治疗慢性唇炎的新型中药组合物及制备方法 Download PDF

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CN107753837A
CN107753837A CN201711015297.9A CN201711015297A CN107753837A CN 107753837 A CN107753837 A CN 107753837A CN 201711015297 A CN201711015297 A CN 201711015297A CN 107753837 A CN107753837 A CN 107753837A
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bark
radix
root
medicine composition
chinese
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罗倩茹
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Sichuan Juhao Biotechnology Co Ltd
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Sichuan Juhao Biotechnology Co Ltd
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗慢性唇炎的认识机理而提供一种治疗慢性唇炎的新型中药组合物，所述中药组合物的各个组分及其质量份比如下：生地黄100～180g、黄连25～70g、黄芩30～100g、生石膏150～700g、苦参50～100g、薄荷40～120g、金银花100～250g、蒲公英90～160g、当归80～160g、玄参90～160g、连翘150～300g、佩兰80～160g、生薏苡仁150～550g、蝉蜕30～70g、牡丹皮80～160g、防风50～120g、杏仁50～100g、白蔻仁25～60g、杯菊250～550g、厚朴30～120g、赤芍40～120g、蛇床子30～120g、淡竹叶60～100g、滑石100～350g、姜半夏30～100g、白术100～160g、白鲜皮50～120g、冰片3～6g、川槿皮30～100g等,本发明提供的药物是一个很好的中药组方。

Description

一种治疗慢性唇炎的新型中药组合物及制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种治疗慢性唇炎的新型中药组合物，特别是供慢性唇炎患者使用的新型中药组合物及制备方法的领域。
背景技术
祖国医学认为：慢性唇炎又称为慢性非特异性唇炎，是唇部的一种慢性、非特异性、炎症性病变。病程迁延，反复发作。
临床表现：
1．上、下唇均可发病，更好发于下唇。
2．反复发作，时轻时重，干燥季节加重，持续不愈。
慢性唇炎疾病分型：
A、慢性脱屑性唇炎：唇红部干燥、皲裂、表面有黄白色的脱屑，脱屑可以没有疼痛地撕下，下面是鲜红的“无皮”样组织。口周皮肤和口腔内的黏膜组织常常不会被累及。患者一般没有什么症状，如果继发感染会出现局部肿胀、疼痛等表现。
B、慢性糜烂性唇炎：唇红部反复糜烂，有炎性渗出物，形成黄色结痂，如果有出血可形成血痂。痂皮脱落可形成糜烂面，疼痛明显。患者可有发胀、发痒的症状。
那么，就如何找到一种可有效治疗慢性唇炎的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗慢性唇炎上，人们逐渐意识到了中医治疗慢性唇炎的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗慢性唇炎的现状，本发明的目的是在于提供一种治疗慢性唇炎的新型中药组合物，以解决慢性唇炎患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述慢性唇炎。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种治疗慢性唇炎的新型中药组合物及制备方法，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
生地黄100～180g、黄连25～70g、黄芩30～100g、生石膏150～700g、苦参50～100g、薄荷40～120g、金银花100～250g、蒲公英90～160g、当归80～160g、玄参90～160g、连翘150～300g、佩兰80～160g、生薏苡仁150～550g、蝉蜕30～70g、牡丹皮80～160g、防风50～120g、杏仁50～100g、白蔻仁25～60g、杯菊250～550g、厚朴30～120g、赤芍40～120g、蛇床子30～120g、淡竹叶60～100g、滑石100～350g、姜半夏30～100g、白术100～160g、白鲜皮50～120g、冰片3～6g、川槿皮30～100g、通草30～60g、白芍50～150g、地肤子90～160g、白草150～250g、遍地金90～160g、酒军30～350g、天花粉100～160g、明矾6～15g、紫草50～150g、陈皮30～120g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
一种治疗慢性唇炎的新型中药组合物及制备方法，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
生地黄115～150g、黄连30～60g、黄芩38～90g、生石膏180～600g、苦参58～90g、薄荷46～105g、金银花115～220g、蒲公英100～140g、当归90～140g、玄参100～140g、连翘180～260g、佩兰90～140g、生薏苡仁180～480g、蝉蜕38～60g、牡丹皮90～140g、防风58～105g、杏仁58～90g、白蔻仁30～52g、杯菊280～480g、厚朴38～105g、赤芍46～105g、蛇床子38～105g、淡竹叶70～90g、滑石115～310g、姜半夏38～90g、白术115～140g、白鲜皮58～105g、冰片4～5.5g、川槿皮38～90g、通草38～52g、白芍58～130g、地肤子100～140g、白草180～220g、遍地金100～140g、酒军38～310g、天花粉115～140g、明矾8～13g、紫草58～130g、陈皮38～105g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
一种治疗慢性唇炎的新型中药组合物及制备方法，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
生地黄130g、黄连52g、黄芩80g、生石膏520g、苦参80g、薄荷95g、金银花200g、蒲公英120g、当归120g、玄参120g、连翘230g、佩兰120g、生薏苡仁420g、蝉蜕52g、牡丹皮120g、防风95g、杏仁80g、白蔻仁45g、杯菊420g、厚朴95g、赤芍95g、蛇床子95g、淡竹叶80g、滑石280g、姜半夏80g、白术120g、白鲜皮95g、冰片5g、川槿皮80g、通草45g、白芍115g、地肤子120g、白草200g、遍地金120g、酒军280g、天花粉120g、明矾12g、紫草115g、陈皮95g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
一种治疗慢性唇炎的新型中药组合物及制备方法，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比共粉碎成（30～50目）颗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡45min，然后再将浸泡好的药物放入砂锅内，加入原料中药重量7～9 倍的冷开水进行第一次武火煎煮，待煎煮到18min时，转文火熬制125min，滤取药液；②药渣中再次加入原料中药重量6～8 倍的冷开水进行第二次武火煎煮，待煎煮到15min时，转文火熬制115min，滤取药液；③将两次药液混合浓缩成相对密度为1.08 的清膏，然后干燥、研末和消毒后备用；
C、①按照传统制备中药胶囊剂的方法，将“B”中研磨好的细末过筛后，加入适量的微粉硅胶、微晶纤维素和淀粉混合均匀，然后制备成胶囊剂（其胶囊锁合后总长度为23.3mm，药粉容量0.4～0.5g/粒），②继而抛光、消毒，分装密封即可。
一种治疗慢性唇炎的新型中药组合物及制备方法，其特征在于，所述服用方法为：将制备好的胶囊剂药物以每日三次服用，早中晚各服一次，给药量3.5g（7粒）/次，温开水送服，5天为一个疗程，服药2～3个疗程，症状消失，病获痊愈。
本发明组方中的各原料中药在中国药典、中国医学大辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
生地黄，性味：甘、寒，具有清热凉血、养阴、生津之功效，用于治疗热病舌绛烦渴、阴虚内热、骨蒸劳热、内热消渴、吐血、衄血、发斑发疹；
黄连，性味：苦、寒，具有泻火、燥湿、解毒、杀虫之功效，用于治疗时行热毒、伤寒、热盛心烦、痞满呕逆、菌痢、热泻腹痛、肺结按、吐、衄、下血、消渴、疳积、蛔虫病、百日咳、咽喉肿痛、火眼、口疮、痈疽疮毒、湿疹、汤火烫伤；
黄芩，性味：味苦、性寒，具有清热泻火、燥湿解毒、止血、安胎之功效，用于治疗肺热咳嗽、热病高热神昏、肝火头痛、目赤肿痛、湿热黄疸、泻痢、热淋、吐衄血、崩漏、胎热不安、痈肿疔疮；
生石膏，性味：辛甘，大寒，具有清热泻火之功效，能散肌表热、泻胃火，配伍其它药物治疗多种实热病症；
苦参，性味：味苦，性寒，具有清热燥湿、杀虫、利尿之功效，用于治疗热痢、便血、黄疸尿闭、赤白带下、阴肿阴痒、湿疹、湿疮、皮肤瘙痒、疥癣麻风，外治滴虫性阴道炎；
薄荷，性味：辛、凉，具有疏风、散热、辟秽、解毒之功效，用于治疗外感风热、头痛、目赤、咽喉肿痛、食滞气胀、口疮、牙痛、疮疥、瘾疹等症；
金银花，性味：性寒、味甘，具有清热解毒、抗炎、补虚疗风之功效，用于治疗胀满下疾、温病发热、热毒痈疡和肿瘤等症，其对于头昏头晕、口干作渴、多汗烦闷、肠炎、菌痢、麻疹、肺炎、乙脑、流脑、急性乳腺炎、败血症、阑尾炎、皮肤感染、痈疽疔疮、丹毒、腮腺炎、化脓性扁桃体炎等病症均有一定疗效；
蒲公英，性味：苦、甘、寒，具有清热解毒、消肿散结、利尿通淋之功效，用于治疗疔疮肿毒、乳痈、瘰疠、目赤、咽痛、肺痈、肠痈、湿热黄疸、热淋涩痛；
当归，性味：味甘、辛、微苦、性温，具有补血和血、调经止痛、润燥滑肠之功效，用于治疗月经不调、经闭腹痛、癥瘕结聚、崩漏;血虚头痛、眩晕、痿痹，肠燥便难、赤痢后重，痈疽疮窃、跌扑损伤等症；
玄参，性味：味甘、苦、咸、性微寒，具有清热凉血、滋阴降火、解毒散结之功效，用于治疗温热病热和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒；
连翘，性味：苦、凉，具有清热、解毒、散结、消肿之功效，用于治疗温热、丹毒、斑疹、痈疡肿毒、瘰疬、小便淋闭；
佩兰，性味：性平、味辛，具有化湿、醒脾开胃、发表解暑之功效，用于治疗湿浊中阻，脘痞呕恶，口中甜腻，口臭，多涎，暑湿表症，头胀胸闷；
生薏苡仁，性味：甘、淡、微寒，具有健脾、补肺、清热、利湿之功效，用于治疗泄泻、湿痹、筋脉拘挛、屈伸不利、水肿、脚气、肺痿、肺痈、肠痈、淋浊、白带等症；
蝉蜕，性味：性寒、味甘，具有散风除热、利咽透疹、解痉、退翳，属解表药下属分类的辛凉解表药，用于治疗风热感冒、咽痛、音哑、麻疹不透、风疹瘙痒、目赤翳障、惊风抽搐、破伤风等症；
牡丹皮，性味：辛苦、凉、微寒，具有清热、活血散瘀之功效，用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等；
防风，性味：味辛、甘、性微温，具有祛风解表、胜湿止痛、止痉定搐之功效，用于治疗外感表证、风疹瘙痒、风湿痹痛、破伤风等症；
杏仁，性味：苦、微温，有小毒，具有降气止咳平喘、润肠通便之功效，用于治疗咳嗽气喘、胸满痰多、血虚津枯、肠燥便秘；
白蔻仁，性味：辛、温，具有理气宽中、燥寒湿、解酒毒之功效，用于治疗胃痛腹胀、噫气反胃等症；
杯菊，性味：苦、凉，具有清热解毒、消炎止血、除湿利尿、杀虫之功效，用于治疗急性胃肠炎、中暑、膀胱炎、尿道炎、咽喉炎、口腔炎、吐血、衄血等症；
厚朴，性味：苦、辛、温，具有燥湿消痰、下气除满之功效，用于治疗湿阻中焦，脘腹胀满，食积气滞，腹胀便秘， 痰饮喘咳；此外，七情郁结，痰气互阻，咽中如有物阻，咽之不下、吐之不出的梅核气证，亦可取本品燥湿消痰，下气宽中之效；
赤芍，性味：苦、微寒，具有清热凉血、活血祛瘀之功效，用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤；
蛇床子，性味：味辛、苦、性温，具有燥湿祛风、杀虫止痒、温肾壮阳之功效，用于治疗阴痒带下、湿疹瘙痒、湿痹腰痛、肾虚阳痿、宫冷不孕；
淡竹叶，性味：味甘、淡、性寒，具有清热泻火、除烦、利尿之功效，用于治疗热病烦渴、口疮尿赤、热淋涩痛；
滑石，性味：甘、淡、寒，具有利尿通淋、清热解暑、祛湿敛疮之功效，用于治疗阳明病、少阴病、百合病、中风病、小便不利病等症；
姜半夏，性味：味辛，性温，具有温中、止咳、化痰、降逆止呕、抗菌之功效，用于治疗痰饮呕吐、胃脘痞满等症，并有显著的抑制胃液分泌作用，对胃溃疡有显著的预防和治疗作用；
白术，性味：甘、温，具有健脾益气、燥湿利水、止汗、安胎之
功效，用于脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安等疾病；
白鲜皮，性味：苦、寒，具有清热燥湿、祛风解毒之功效，用于治疗湿热疮毒、黄水淋漓、湿疹、风疹、疥癣疮癞、风湿热痹；
冰片，性味：辛苦、凉，具有通诸窍、散郁火、去翳明目、消肿止痛之功效，用于治疗中风口噤、热病神昏、惊痫痰迷、气闭耳聋、喉痹、口疮、中耳炎、痈肿、痔疮、目亦翳膜、蛲虫病；
川槿皮，性味：辛、苦、温，具有活血理气、祛风活络止痛之功效，用于治疗胃痛、腹痛、痛经、关节疼痛、跌扑损伤；
通草，性味：味甘、淡、性微寒，具有清热利尿、通气下乳之功效，用于治疗湿热淋证、水肿尿少、乳汁不下；
白芍，性味：苦、酸、微寒，具有养血和营、缓急止痛、敛阴平肝之功效，用于治疗月经不调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症；
地肤子，性味：味辛、苦、性寒，具有清热利湿、祛风止痒之功效，用于治疗小便涩痛、阴痒带下、风疹、湿疹、皮肤瘙痒；
白草，性味：甘、寒，具有清热利尿、凉血止血之功效，用于治疗热淋、尿血、肺热咳嗽、鼻衄、胃热烦渴；
遍地金，性味：苦、涩、寒，具有清热解毒、止泻之功效，用于治疗小儿白口疮、小儿肺炎、口腔炎、乳痛、黄水疮、毒蛇咬伤、腹泻、久痢等症；
酒军，性味：苦、寒，具有泻热通肠、凉血解毒、逐瘀通经之功效，用于治疗实热便秘、积滞腹痛、泻痢不爽、湿热黄疸、血热吐衄、目赤、咽肿、肠痈腹痛、痈肿疔疮、瘀血经闭、跌打损伤，外治水火烫伤，上消化道出血；酒大黄善清上焦血分热毒，用于目赤咽肿、齿龈肿痛；熟大黄泻下力缓、泻火解毒，用于火毒疮疡；大黄炭凉血化瘀止血，用于血热有瘀出血症；
天花粉，性味：性微寒、味甘、微苦，具有清热生津、消肿排脓。属清热药下属分类的清热泻火药，用于治疗热病烦渴、肺热燥咳、内热消渴、疮疡肿毒；
明矾，性味：味酸、涩、性寒，外用：具有解毒杀虫、燥湿止痒、内服止血止泻、祛除风痰之功效，外治用于湿疹、疥癣、脱肛、痔疮、聤耳流脓，内服用于久泻不止、便血、崩漏、癫痫发狂；桔矾收湿敛疮、止血化腐的功效，用于治疗湿疹湿疮、脱肛、痔疮、聤耳流脓、阴痒带下、鼻衄齿衄、鼻瘜肉；
紫草，性味：甘、咸，寒，具有凉血、活血、解毒透疹之功效，用于治疗血热毒盛、斑疹紫黑、麻疹不透、疮疡、湿疹、水火烫伤等症；
陈皮，性味：味辛、苦、性温，具有理气和中，燥湿化痰，利水通便之功效，用于治疗脾胃不和、脘腹胀痛、不思饮食、呕吐哕逆、痰湿阻肺、咳嗽痰多、胸膈满闷、头目眩晕、水肿、小便不利、大便秘结、乳痈疥癣、中鱼蟹毒、酒毒等症。
本发明药物是基于中医治疗慢性唇炎的原则，从依据慢性唇炎的病理机制及药理作用认为：就慢性唇炎，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的效果。
四、具体实施方式
本发明就是针对上述慢性唇炎的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个很好的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种治疗慢性唇炎的新型中药组合物，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
生地黄130g、黄连52g、黄芩80g、生石膏520g、苦参80g、薄荷95g、金银花200g、蒲公英120g、当归120g、玄参120g、连翘230g、佩兰120g、生薏苡仁420g、蝉蜕52g、牡丹皮120g、防风95g、杏仁80g、白蔻仁45g、杯菊420g、厚朴95g、赤芍95g、蛇床子95g、淡竹叶80g、滑石280g、姜半夏80g、白术120g、白鲜皮95g、冰片5g、川槿皮80g、通草45g、白芍115g、地肤子120g、白草200g、遍地金120g、酒军280g、天花粉120g、明矾12g、紫草115g、陈皮95g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
实施例2：
一种治疗慢性唇炎的新型中药组合物，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
生地黄150g、黄连60g、黄芩90g、生石膏600g、苦参90g、薄荷105g、金银花220g、蒲公英140g、当归140g、玄参140g、连翘260g、佩兰140g、生薏苡仁480g、蝉蜕60g、牡丹皮140g、防风105g、杏仁90g、白蔻仁52g、杯菊480g、厚朴105g、赤芍105g、蛇床子105g、淡竹叶90g、滑石310g、姜半夏90g、白术140g、白鲜皮105g、冰片5.5g、川槿皮90g、通草52g、白芍130g、地肤子140g、白草220g、遍地金140g、酒军310g、天花粉140g、明矾13g、紫草130g、陈皮105g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
实施例3：
一种治疗慢性唇炎的新型中药组合物，其特征在于，所述中药组合物的各个组分及质量份比如下所示：
生地黄180g、黄连70g、黄芩100g、生石膏700g、苦参100g、薄荷120g、金银花250g、蒲公英160g、当归160g、玄参160g、连翘300g、佩兰160g、生薏苡仁550g、蝉蜕70g、牡丹皮160g、防风120g、杏仁100g、白蔻仁60g、杯菊550g、厚朴120g、赤芍120g、蛇床子120g、淡竹叶100g、滑石350g、姜半夏100g、白术160g、白鲜皮120g、冰片6g、川槿皮100g、通草60g、白芍150g、地肤子160g、白草250g、遍地金160g、酒军350g、天花粉160g、明矾15g、紫草150g、陈皮120g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
典型病例
经临床诊断治疗慢性唇炎患者共1135例，年龄为12岁以上的755例，只有380例为12岁以下。1135例患者中痊愈的760例，有效的341例，无效的34例。总有效率达97%。

Claims (3)

1.一种治疗慢性唇炎的新型中药组合物，其特征在于，所述中药组合物的各个组分及其质量份比如下所示：
生地黄100～180g、黄连25～70g、黄芩30～100g、生石膏150～700g、苦参50～100g、薄荷40～120g、金银花100～250g、蒲公英90～160g、当归80～160g、玄参90～160g、连翘150～300g、佩兰80～160g、生薏苡仁150～550g、蝉蜕30～70g、牡丹皮80～160g、防风50～120g、杏仁50～100g、白蔻仁25～60g、杯菊250～550g、厚朴30～120g、赤芍40～120g、蛇床子30～120g、淡竹叶60～100g、滑石100～350g、姜半夏30～100g、白术100～160g、白鲜皮50～120g、冰片3～6g、川槿皮30～100g、通草30～60g、白芍50～150g、地肤子90～160g、白草150～250g、遍地金90～160g、酒军30～350g、天花粉100～160g、明矾6～15g、紫草50～150g、陈皮30～120g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的治疗慢性唇炎的新型中药组合物，其特征在于，所述中药组合物的各个组分及其质量份比如下所示：
生地黄115～150g、黄连30～60g、黄芩38～90g、生石膏180～600g、苦参58～90g、薄荷46～105g、金银花115～220g、蒲公英100～140g、当归90～140g、玄参100～140g、连翘180～260g、佩兰90～140g、生薏苡仁180～480g、蝉蜕38～60g、牡丹皮90～140g、防风58～105g、杏仁58～90g、白蔻仁30～52g、杯菊280～480g、厚朴38～105g、赤芍46～105g、蛇床子38～105g、淡竹叶70～90g、滑石115～310g、姜半夏38～90g、白术115～140g、白鲜皮58～105g、冰片4～5.5g、川槿皮38～90g、通草38～52g、白芍58～130g、地肤子100～140g、白草180～220g、遍地金100～140g、酒军38～310g、天花粉115～140g、明矾8～13g、紫草58～130g、陈皮38～105g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的治疗慢性唇炎的新型中药组合物，其特征在于，所述中药组合物的各个组分及其质量份比如下所示：
生地黄130g、黄连52g、黄芩80g、生石膏520g、苦参80g、薄荷95g、金银花200g、蒲公英120g、当归120g、玄参120g、连翘230g、佩兰120g、生薏苡仁420g、蝉蜕52g、牡丹皮120g、防风95g、杏仁80g、白蔻仁45g、杯菊420g、厚朴95g、赤芍95g、蛇床子95g、淡竹叶80g、滑石280g、姜半夏80g、白术120g、白鲜皮95g、冰片5g、川槿皮80g、通草45g、白芍115g、地肤子120g、白草200g、遍地金120g、酒军280g、天花粉120g、明矾12g、紫草115g、陈皮95g，辅料：微粉硅胶、微晶纤维素和淀粉适量。
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CN108434319A (zh) * 2018-03-30 2018-08-24 山西中医药大学 一种用于治疗唇风的中药组合物及其药剂制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108434319A (zh) * 2018-03-30 2018-08-24 山西中医药大学 一种用于治疗唇风的中药组合物及其药剂制备方法

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