CN107744578A - A kind of anaesthetic for treating Amenorrhea and its preparation technology and application - Google Patents
A kind of anaesthetic for treating Amenorrhea and its preparation technology and application Download PDFInfo
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Abstract
A kind of a kind of application the present invention relates to anaesthetic for treating Amenorrhea and its preparation technology and as anthelmintic, there is provided anaesthetic for treating Amenorrhea, it is characterised in that：The anaesthetic is made up of the bulk drug of following parts by weight：45 55 parts of elecampane, 20 30 parts of bush, 1,8 0.03 0.07 parts of Cineole, 30 40 parts of betel nut, its preparation technology are：The bulk drug is mixed, is ground into fine powder, in addition, anaesthetic is applied to clinic as anthelmintic for oral administration.Beneficial effect is：The anaesthetic of the present invention can treat the amenorrhoea caused by a variety of causes, significant effect, raw material is easy to get, without any side effects, and preparation technology is simple, breach the crushing of anaesthetic conventional preparation techniques crude drug, a kind of modern illiteracy thing preparation technology suitable for medicine of the present invention is formd, raw material has been saved, has improved drug effect, it is easy to promote and uses, new approach is opened for the Mongolian medicine treatment of amenorrhoea.
Description
Technical field
The present invention relates to a kind of anaesthetic and its preparation technology and application, a kind of anaesthetic for treating Amenorrhea and its preparation technology and
Application as anthelmintic.
Background technology
Amenorrhea, refer to healthy women over 18 years old and menarche not to or rise on time and interrupt more than 3 months persons,
Also name is not closed the moon, the moon, Yue Shui, moon water do not come, menstruation is obstructed, blood closes, amenorrhea, menses is obstructed, the moon is obstructed, the moon makes not
Come, the moon water it is obstructed, menstruation is not all right, amenia, Amenorrhea is unfavorable, passages through which vital energy circulates is not all right, passages through which vital energy circulates is obstructed, through wait it is not all right, have a rest, have a rest through etc..
Mongolian medicine thinks, its pathogenesis, or because deficiency of qi and blood, long-term lose are supported, and it is biochemical to influence seven elements, causes the right ascension through mansion exhausted eventually and closes
Through, or through mansion directly by disease, it is impossible to pass through, or for a long time outside by cold-dampness, the wet turbid interior victory of priming is lower to rent arteries and veins key and cause menses obstructed,
Or because living environment change and the direct stimulation such as sudden frightened, violent rage, melancholy cause three it is unbalance, so as to cause Amenorrhea.Cover
The conventional four taste bush soup of doctor, motherwort luckiness ball, seven taste matrimony vines the prescription such as dissipate and take the circumstances into consideration one take repeatedly or several doses coordinate alternating
Using Amenorrhea is treated, experienced Mongolian medicine is needed to be suited the remedy to the case after diagnosis before treatment, for causing due to different pathogeny
Illness, also want each prescription to be used cooperatively, with the experience of doctor and feel for foundation, therefore to doctor level and mastery require
It is too high, it is difficult to which that popularization and application, improper use can also aggravate the state of an illness, patient is lost trust and accreditation to anaesthetic.In addition, also have
Prescription contained dragon's blood is import medicine such as in four taste bush soup, expensive, raw material is difficult to obtain.
The content of the invention
It is an object of the invention to provide a kind of evident in efficacy, raw material is easy to get, prepare it is simple, it is without any side effects, and can
With a kind of anaesthetic and its preparation technology for treating Amenorrhea of a wide range of popularization and application.
Above-mentioned purpose is realized by following technical scheme：A kind of anaesthetic for treating Amenorrhea, it is characterised in that：The anaesthetic
It is made up of the bulk drug of following parts by weight：Elecampane 45-55 parts, bush 20-30 parts, 1,8- Cineole 0.03-0.07 parts, Bin
Bulky 30-40 parts.
The 1,8- Cineoles are substituted by the bulk drug of following parts by weight：Amomum cardamomum 20-30 parts.
Safflower 3-8 parts are added in the bulk drug.
Tsaoko 20-30 parts, galangal 20-30 parts are added in the bulk drug.
Vitamin C 0.03-0.07 parts are added in the bulk drug.
The anaesthetic is made up of the bulk drug of following parts by weight：Elecampane 50kg, bush 25kg, Amomum cardamomum 25kg, betel nut
35kg, safflower 5kg, tsaoko 25kg, galangal 25kg.
The anaesthetic is made up of the bulk drug of following parts by weight：50 parts of elecampane, 25 parts of bush, 25 parts of Amomum cardamomum, betel nut
35 parts, 5 parts of safflower, 25 parts of tsaoko, 25 parts of galangal, 0.05 part of vitamin C.
A kind of preparation technology of described anaesthetic, is characterized in：The bulk drug is mixed, is ground into fine powder, crosses 100 mesh
Sieve, it is well mixed, dispenses and produce；Or first mix the bulk drug in addition to 1.8- Cineoles, fine powder is ground into, then will
1.8- Cineoles are mixed, sieve, and are well mixed, dispense and produce.
The preparation technology of described anaesthetic, is characterized in：By the bulk drug under -100 DEG C~-120 DEG C temperature conditionss
Mix, crush, when medical surfaces temperature is identical with indoor temperature, dispenses and produce.
The preparation technology of described anaesthetic, is characterized in：Bulk drug will be stated to be put into liquid nitrogen frozen pulverizer, crush temperature
For -110 DEG C, constant temperature is ground into the superfine powder of 200 mesh, is well mixed, dispenses and produce.
A kind of preparation technology of described anaesthetic, is characterized in：Bilayer tablet is made in the bulk drug, 1.8- will be contained
The inner layer piece master of Cineole or betel nut or tsaoko or galangal or Amomum cardamomum or ascorbic bulk drug as double-layer tablets
Material, remaining component are the major ingredient of the outer-skin sheet of double-layer tablets.
The anaesthetic is applied to clinic as anthelmintic for oral administration.
The beneficial effects of the invention are as follows：The anaesthetic of the present invention can treat amenorrhoea caused by a variety of causes, significant effect,
Raw material is easy to get, without any side effects, and preparation technology is simple, breaches anaesthetic conventional preparation techniques-crude drug and crushes, forms
A kind of modern illiteracy thing preparation technology suitable for medicine of the present invention, raw material is saved, has improved drug effect, has been easy to promote and uses,
New approach is opened for the Mongolian medicine treatment of amenorrhoea.
Embodiment
Inventor has done substantial amounts of research work to this side, including the selecting of each medicine, the ratio of medicine in prescription, prepares work
Skill etc., high effect nontoxic, green optimum formula and optimal preparation technology are finally given, several typical cases are described below
Embodiment：
The first embodiment：
The anaesthetic is made up of the bulk drug of following parts by weight：Elecampane 45-55 parts, bush 20-30 parts, 1,8- Cineole
0.03-0.07 parts, betel nut 30-40 parts.It is preferred that 50 parts of elecampane, 25 parts of bush, 1,8- 0.05 part of Cineole, 35 parts of betel nut.
Bulk drug is analyzed：
Elecampane：Mongolian name agate slave《Errorless anaesthetic mirror》, different name：Its its lattice of agate slave Ba Dala, Gao You-haler De Situ-are high
Excellent-my Tan-Dao Sile-its its lattice《Anaesthetic will》.
Chemical composition：Radia heleii is containing synanthrin up to 44% or so, 1%-2% containing volatile oil, and main component is in elecampane in oil
Ester, isoalantolactone, dihydroisoalantolactone, alantic acid, alantol and triterpene composition dammaradienol acetic acid
Ester etc..The property of medicine：It is sweet, bitter, pungent, it is mild-natured.Imitate greasy, sharp, dry, again.Major function：Clear bar up to xeothermic, Xie He is according to blood phase intermal comflict, middle benefit gas
Help digestion, whet the appetite, only shouting pain.Cure mainly cold headache, pernicious shiver with cold, warm disease initial stage, conspicuous to cause asthma uncomfortable in chest according to blood, thoracic dorsal is migrans
Pain, do not feel like eating, vomiting with acid regurgitation, stomach, liver, the treasured such as disease of intestine and small intestine, He Yixi headaches and blood-head headache.
Bush：Mongolian name Cao Men-hair all, Buddhist nun's Gu phlogiston.For legume bush（Caesalpinia sappan L.）'s
Dry duramen.This product is sweet, salty, cool in nature, light；There is removing heat from blood, blood stasis of dispelling, the effect of menstruation regulating.（1）Blood ruffian, mass formed by blood stasis.（2）Amenorrhea,
Irregular menstruation, dysmenorrhoea, the soreness of waist and ache in legs of women and headache.Chemical composition：Heartwood alkyl compound containing chromogen, including 3- deoxidations Soviet Union
The Multiple components such as wooden ketone B, hematoxylone B, bush phenol.
Betel nut：Mongolian name Gao You《Errorless anaesthetic mirror》, different name Ba Ta《Errorless anaesthetic mirror》.Source：For babassu Bin
Bulky seed.
Chemical composition：Seed 0.3%-0.6% containing alkaloid, master is arecaline, guvacolines, arecaidine etc., contains
Condensed tannin 15%, mainly there are dextrorotation cachou extract, betel nut tannin A, B etc., in addition fatty oily 14%, mannose, galactolipin, sucrose
Amino acid etc..It is bitter, pungent, it is warm-natured.Major function：Dispelling cold kidney tonifying, diuresis, permanent tooth, expelling parasite.Cure mainly testis pendant pain, waist and knee joint
Ache, kidney is trembled with fear, and kidney is conspicuous according to, chronic kidney disease, roundworm disease, taeniasis.
1,8- Cineoles：English name：1,8-Cineole Chinese nicknames：Eucalyptol；Folium eucalypti (oil) element;1.8 eucalyptus oil
Alcohol；The alcohol English alias of terpinene 4：Cajeputol；25% Terpinen-4-OI CAS No.：470-82-6 molecular formula：
C10H18O molecular weight：154.25 oil soluble flavors, colorless oil transparency liquid.There are camphor breath and refrigerant herbal medicine taste
Road.176~177 DEG C of boiling point, 1~1.5 DEG C of fusing point, 1 DEG C of freezing point, 47~48 DEG C of flash-point.Being dissolved in ethanol, (1mL is dissolved in 5mL 60%
Ethanol), ether, chloroform, glacial acetic acid, propane diols, glycerine and most of nonvolatile oils, be slightly soluble in water.Fragrance detection threshold value 1~
64μg/kg.Because 1, 8-Cineole has fresh, refrigerant special aroma, except in food flavor, being also used in oral hygiene
In agent material.For medicinal herbs type essence, the essence such as essential oil and toothpaste, tooth powder, oral cavity freshener, medicated soap is prepared, is also relatively used for
Medicine.With antipyretic, anti-inflammatory, antibacterial, anti-corrosion, relieving asthma and analgesic activity.From commercially available pharmaceutical grade 1,8- Cineoles.
Mongolian medicine thinks, amenorrhoea pathogenesis, or because deficiency of qi and blood, long-term lose are supported, and it is biochemical to influence seven elements, causes eventually through the red of mansion
The amenorrhoea through exhausted, or through mansion directly by disease, it is impossible to pass through, or it is long-term outer lower to rent arteries and veins key and cause by cold-dampness, the wet turbid interior victory of priming
Menses are obstructed, or because living environment change and the direct stimulation such as sudden frightened, violent rage, melancholy cause three it is unbalance, so as to lead
Cause Amenorrhea.Bush removing heat from blood, blood stasis of dispelling, it is monarch drug in a prescription in above-mentioned prescription, betel nut goes kidney to tremble with fear, and is ministerial drug, Zhi Qiben, and elecampane is clear
Ba Da is xeothermic, and Xie He helps digestion according to blood phase intermal comflict, middle benefit gas, and appetizing, only shouting pain, the regulation of qi and blood is adjutant, 1,8- Cineole, for volatilization
Oil, there is volatility, while assisting said medicine removing internal damp evil, its fresh, refrigerant special aroma can open strongly fragrant only anger,
The spiritual mood of people is adjusted, is adjuvant, said medicine complements each other, the spirit such as treatment kidney is cold, the anemia deficiency of blood, violent rage, melancholy
Stimulation is led and causes Amenorrhea.
Liquid nitrogen, liquid nitrogen, character：Colourless, odorless, tasteless, almost complete inert gas, non-combustible.Physical property：Fusing point -210
℃；- 195.8 DEG C of boiling point;- 147 DEG C of critical-temperature；Critical pressure 3.39Mpa.
Preparation technology one：First the bulk drug in addition to 1.8- Cineoles is mixed, is ground into fine powder, then by 1.8-
Cineole is mixed, crosses 100 mesh sieves, is well mixed, dispenses and produce.Specification：Per packed 2 grams.
Usage and dosage：One time 1-2 grams, warm water takes, 1-2 times on the one.
Clinical test
Any toxic side effect is not being found by toxicological test, animal pharmacology effect experiment is achieved according on the basis of, from
Since 2000, on the premise of patient is voluntary, most patients are accepted for medical treatment, have chosen 90.Wherein：Deficiency of qi and blood causes amenorrhea patients
30 people, experience cold-evil or cold constitution causes the people of amenorrhea patients 30, nervous, pressure is big etc., and mental element causes amenorrhea patients
30 people, age, between 18-45 one full year of life.With 7 days for a course for the treatment of, three courses for the treatment of are limited.Diagnostic criteria and treatment standard
Reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, People's Medical Officer Press, edit Sun Chuanxing）.With reference to this hair
Bright particularity, formulate clinical treatment standard of the present invention.Cure：Menstruation recovery is normal.Take a turn for the better：Menstruation is irregularly risen.It is invalid
：Amenorrhoea symptom is without any improvement.It the results are shown in Table 1.
Table 1
Cure rate（%）=cure number/sum;Total effective rate（%）=(sum-invalid number)/sum.
From table 1, the cure rate of amenorrhoea caused by this Effect of Mongolian Medicine Treating a variety of causes is more than 60%, total effective rate
More than 80%.
Preparation technology two：Further, the bulk drug is mixed under -100 DEG C~-120 DEG C temperature conditionss, powder
It is broken, when medical surfaces temperature is identical with indoor temperature, dispenses and produce.
Selection process：Bulk drug will be stated and be put into liquid nitrogen frozen pulverizer（Zhen Fengyaohua Machinery Co., Ltd.s of Jiangyin City model
YM-40 types）In, it is -110 DEG C to crush temperature, and constant temperature is ground into 200 targeted fine powders, is well mixed, dispenses and produce.
Specification：Per packed 2 grams.
Usage and dosage：One time 1-2 grams, warm water takes, 1-2 times on the one.
The preparation technology crushed using cryogenic freezing, its object is to：Reduce the volatile substances such as volatile oil among medicine
Volatilization, preserve the property of medicine, and crush granularity it is smaller, be easy to take, be easy to absorption of human body.Put into practice and demonstrate,prove through substantial amounts of preparation technology
It is real：- 100 DEG C~-120 DEG C of its temperature range, when being particularly -110 DEG C, obtained medicine, the stability of medicine is best, largely
Clinical efficacy contrast test show that its drug effect is best, cure rate highest.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate averagely improves 3%, have received good therapeutic effect.
Preparation technology three：After crushed, direct packaging further, the bulk drug is not made medicine double into bag
Synusia agent, 1.8- Cineoles, betel nut bulk drug will be contained as the inner layer piece major ingredient of double-layer tablets, remaining component, i.e. elecampane, Soviet Union
Wood, the major ingredient as the outer-skin sheet of double-layer tablets.Its inner layer piece, the auxiliary material of outer-skin sheet are the customary adjuvant of tablet, in double-layer tablets
Tabletting produces in tablet press machine, and due to being prior art, reason, is not described in detail herein as space is limited.Specification：Every contains major ingredient
0.4g。
Usage and dosage：2-4 piece, warm water take, 1-2 times on the one.
Purpose using this technique is：（1）Composition reason：1.8- Cineoles are that volatile oil is volatile, sudden and violent for a long time
It is volatile in airbreak gas, drug effect is influenceed, also contains a large amount of volatile ingredients in betel nut, therefore be placed in inner layer piece；（2）The property of medicine
Reason：Bush, building fragrance monarch-minister drug, as outer-skin sheet, the cold effect of its removing heat from blood, Eradicates blood stasis, kidney of dispelling first is played in human body,
After outer layer disintegration of tablet, 1.8- Cineoles, betel nut in internal layer tablet play assistant jointly therewith makes effect, complements each other, has
The effect of having played medicine of effect.
Clinical test：
Since two thousand, on the premise of patient is voluntary, most patients are accepted for medical treatment, choose 90.Wherein：Deficiency of qi and blood causes to close
Through the people of patient 30, experience cold-evil or cold constitution causes the people of amenorrhea patients 30, it is nervous, pressure is big etc., and mental element causes to close
Through the people of patient 30, age, between 18-45 one full year of life.With 7 days for a course for the treatment of, three courses for the treatment of are limited.Diagnostic criteria and control
Treatment standard reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, People's Medical Officer Press, edit Sun Chuanxing）.Knot
The particularity of the present invention is closed, formulates clinical treatment standard of the present invention.Cure：Menstruation recovery is normal.Take a turn for the better：Menstruation irregularly comes
Tide.It is invalid：Amenorrhoea symptom is without any improvement.It the results are shown in Table 2.
Table 2
| Sum | Cure number | Improvement number | Invalid number | Cure rate（%） | Total effective rate（%） | |
| Deficiency of qi and blood patient | 30 | 20 | 6 | 4 | 66.7 | 86.7 |
| Experience cold-evil or cold constitution patient | 30 | 21 | 4 | 5 | 70 | 83.3 |
| Mental element patient | 30 | 21 | 5 | 4 | 70 | 86.7 |
| Amount to | 90 | 62 | 15 | 13 | 68.9 | 85.6 |
Cure rate（%）=cure number/sum;Total effective rate（%）=(sum-invalid number)/sum.
From table 2, using anaesthetic made from this preparation technology, total cure rate of amenorrhoea caused by treating a variety of causes
For 68.9%, total total effective rate is 85.6%.With " anaesthetic made from the preparation technology of preparation technology one " compares, and total controls
More rate is significantly improved, and total total effective rate is significantly improved.
In addition, find in the crowd for the side of taking this medicine, there is 30 in the therapeutic process of 270 cases of above-mentioned three groups of data
Example patient, take this medicine while cured amenorrhoea disease, also cured intestinal parasitical diseases（Roundworm, tapeworm, hookworm, pinworm
Deng）.
In addition 30 Enterozoa patients are selected again, taken according to the method described above, its deworming rates has reached 85%, drives
Worm positive effect have received unexpected treatment effect higher than the anthelminthic effect that toosendanin or arecaline progress expelling parasite is used alone
Fruit.
Second of embodiment：
Elecampane 45-55 parts, bush 20-30 parts, Amomum cardamomum 20-30 parts, preferably betel nut 30-40 parts, 50 parts of elecampane, bush 25
Part, 25 parts of Amomum cardamomum, 35 parts of betel nut.
Amomum cardamomum：Mongolian name looks into dry-SUGEMULE《Myrobalan's beading》, different name E La-para is wooden, vigorous benevolence is match sound《It is errorless
Anaesthetic reflects》.For zingiberaceous plant Amomum cardamomum and the fruit of amomum compactum Soland ex Maton.Chemical composition：Contain volatile oil in Amomum cardamomum seed, its into
It is 1,8 Cineoles to divide content highest（1,8-cineole）Up to 66.87%, of a relatively high has nopinene 10.93%, australene
3.17%, cloves alkene 3.01%, borneol acetic acid esters 2.02%, alpha-terpineol 2.03%, linalool 1.39% etc..Amomum compactum Soland ex Maton seed
Containing volatile oil, its component content highest is 1,8- cineoles（68.56%）, of a relatively high has Eucarvone（14.67%）, α-
Terpinol（10.82%）, γ-firpene（10.39%）, fanesol, linalool, cymol.The property of medicine：Acrid flavour, hardship, it is warm-natured.
Imitate light, dry, greasy, sharp.Major function：Kidney of dispelling is trembled with fear, and town is conspicuous according to middle benefit gas, helping digestion, open desire, preventing or arresting vomiting.It is conspicuous according to disease, chronic renal to cure mainly kidney
Disease, conspicuous stagnant according to the stasis of blood, insomnia, indigestion, renal shutdown, lumbago caused by deficiency of kidney.
In above-mentioned prescription, the bulk drug compared with the first embodiment is distinguished：1.8- Cineoles, this illiteracy are instead of with Amomum cardamomum
Medicine, main component are 1.8- Cineoles, this displacement for substituting not simple active ingredient, further compared with 1.8- Cineoles
, Amomum cardamomum, kidney of dispelling is trembled with fear, and town is conspicuous according to middle benefit gas, helping digestion, while playing the effect of 1.8- Cineoles, eliminate the bad anti-of medicine
Should, i.e., apocleisis, weakness of the spleen and the stomach disease, and taste are the foundation of acquired constitution of people, source of generating QI and blood, strengthening the spleen and stomach, qi and blood punching is full of, auxiliary
Help bush, elecampane treatment amenorrhoea.
Preparation technology one：The preparation technology of the anaesthetic of described treatment Amenorrhea, it is characterised in that：The bulk drug is mixed
Close, be ground into fine powder, cross 100 mesh sieves, be well mixed, dispense and produce.Specification：Per packed 3 grams.
Usage and dosage：One time 1.5-3 grams, warm water takes, 1-2 times on the one.
Clinical test
Any toxic side effect is not being found by toxicological test, animal pharmacology effect experiment is achieved according on the basis of, from
Since 2000, on the premise of patient is voluntary, most patients are accepted for medical treatment, have chosen 90.Wherein：Deficiency of qi and blood causes amenorrhea patients
30 people, experience cold-evil or cold constitution causes the people of amenorrhea patients 30, nervous, pressure is big etc., and mental element causes amenorrhea patients
30 people, age, between 18-45 one full year of life.With 7 days for a course for the treatment of, three courses for the treatment of are limited.Diagnostic criteria and treatment standard
Reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, People's Medical Officer Press, edit Sun Chuanxing）.With reference to this hair
Bright particularity, formulate clinical treatment standard of the present invention.Cure：Menstruation recovery is normal.Take a turn for the better：Menstruation is irregularly risen.It is invalid
：Amenorrhoea symptom is without any improvement.It the results are shown in Table 3.
Table 3
| Sum | Cure number | Improvement number | Invalid number | Cure rate（%） | Total effective rate（%） | |
| Deficiency of qi and blood patient | 30 | 22 | 5 | 3 | 73.3 | 90 |
| Experience cold-evil or cold constitution patient | 30 | 22 | 4 | 4 | 73.3 | 86.7 |
| Mental element patient | 30 | 23 | 3 | 4 | 76.7 | 86.7 |
| Amount to | 90 | 67 | 12 | 11 | 74.4 | 87.8 |
Cure rate（%）=cure number/sum;Total effective rate（%）=(sum-invalid number)/sum.
From table 3, using anaesthetic made from this side this technique, amenorrhoea caused by a variety of causes, total cure rate are treated
For 74.4%, total total effective rate is 87.8%.With must having substantially compared with cure rate, total total effective rate for the first embodiment
Raising, have received good therapeutic effect.
Preparation technology two：Further, the bulk drug is mixed under -100 DEG C~-120 DEG C temperature conditionss, powder
It is broken, when medical surfaces temperature is identical with indoor temperature, dispenses and produce.
Selection process：Bulk drug will be stated to be put into liquid nitrogen frozen pulverizer, it is -110 DEG C to crush temperature, and constant temperature is ground into
The superfine powder of 200 mesh, it is well mixed, dispenses and produce.
Specification：Per packed 3 grams.
Usage and dosage：One time 1.5-3 grams, warm water takes, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 2%, have received good therapeutic effect.
Preparation technology three：Further, bilayer tablet is made in the bulk drug, by Amomum cardamomum, the bulk drug of betel nut
As the inner layer piece major ingredient of double-layer tablets, the major ingredient of remaining composition, i.e. elecampane, bush as the outer-skin sheet of double-layer tablets.Its internal layer
Piece, the auxiliary material of outer-skin sheet are the customary adjuvant of tablet, in double-layer tablets tablet press machine tabletting produce, due to being prior art, limit
In length reason, it is not described in detail herein.Specification：Every 0.5g containing major ingredient.
Usage and dosage：2-4 piece, warm water take, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 4%, have received good therapeutic effect.
In addition 30 Enterozoa patients to be selected again, taken according to the method described above, its deworming rates has reached 85.5%,
Anthelminthic effect have received unexpected treatment apparently higher than the anthelminthic effect that toosendanin or arecaline progress expelling parasite is used alone
Effect.
The third embodiment：
Safflower 3-8 parts, preferably 5 parts of safflower are added in the bulk drug of second of embodiment.
It is preferred that elecampane 50kg, bush 25kg, Amomum cardamomum 25kg, betel nut 35kg, safflower 5kg,
Bulk drug is analyzed：
Safflower：Mongolian name Gu Gu wood《Recognize medicine Bai Jingjian》, different name E Busen-Gu Gu wood, E Ligen are match sound, Hang Gage
Its-Ulan《Errorless anaesthetic mirror》.Source：The flower of feverfew safflower.
Chemical composition：Containing carthamic acid, carthamone, neocarthamin, carthamus tinctorius yellow colour A and B, separately containing chlorogenic acid, caffeic acid
Volatile ingredient is planted etc. a variety of phenols components and more than ten.Separately contain 16 kinds of amino acid, safflower polysaccharide.The property of medicine：Sweet, slight bitter, it is cool in nature.
Imitate soft, soft, solid, blunt, again.Major function：Cool blood, arteries and veins is locked, menstruation regulating, is cleared liver, salubrity, is relieved pain, detumescence.Liver heat is cured mainly, menstruation is not
Adjust, spitting blood, nosebleed epistaxis, traumatism and bleeding, blood-head headache, heart heat, blood-head.
In above-mentioned prescription, compared with the bulk drug difference of second of embodiment：Cool property medicine safflower is added, one can adjust it
The warm nature of remaining medicine, human body is set to be easy to receive, absorb the drug, moreover it is possible to antagonism of the constitution to warm nature medicine of trembling with fear was avoided, its
Two, safflower cool blood, arteries and veins is locked, menstruation regulating, has to bush, elecampane and assists a ruler in governing a country menstruation regulating, the effect of so as to treat amenorrhoea, with remaining medicine
Complement each other and treat amenorrhoea caused by a variety of causes.
In substantial amounts of choosing side's experiment, safflower was also once selected to substitute safflower, though safflower has the change of one wordThe difference lies in a single word with safflower,
But two kinds of medicines that source is entirely different, chemical composition differs widely, and has regulating menoxenia from its effect, therefore
Used safflower in the experiment of choosing side.Result of the test is unsatisfactory, compared with the prescription containing safflower, at the place containing safflower
Side, has the following disadvantages：First, cure rate reduces by 5%；Secondly：In 10% patient, there is allergic urticaria and fash
Deng adverse reaction.
Preparation technology one：The bulk drug is mixed, is ground into fine powder, crosses 100 mesh sieves, is well mixed, is dispensed and produce.Rule
Lattice：Per packed 3 grams.
Usage and dosage：One time 1.5-3 grams, warm water takes, 1-2 times on the one.
Clinical test
Any toxic side effect is not being found by toxicological test, animal pharmacology effect experiment is achieved according on the basis of, from
Since 2000, on the premise of patient is voluntary, most patients are accepted for medical treatment, have chosen 90.Wherein：Deficiency of qi and blood causes amenorrhea patients
30 people, experience cold-evil or cold constitution causes the people of amenorrhea patients 30, nervous, pressure is big etc., and mental element causes amenorrhea patients
30 people, age, between 18-45 one full year of life.With 7 days for a course for the treatment of, three courses for the treatment of are limited.Diagnostic criteria and treatment standard
Reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, People's Medical Officer Press, edit Sun Chuanxing）.With reference to this hair
Bright particularity, formulate clinical treatment standard of the present invention.Cure：Menstruation recovery is normal.Take a turn for the better：Menstruation is irregularly risen.It is invalid
：Amenorrhoea symptom is without any improvement.It the results are shown in Table 4.
Table 4
| Sum | Cure number | Improvement number | Invalid number | Cure rate（%） | Total effective rate（%） | |
| Deficiency of qi and blood patient | 30 | 25 | 3 | 2 | 83.3 | 93.3 |
| Experience cold-evil or cold constitution patient | 30 | 26 | 2 | 2 | 86.7 | 93.3 |
| Mental element patient | 30 | 26 | 2 | 2 | 86.7 | 93.3 |
| Amount to | 90 | 77 | 7 | 6 | 85.6 | 93.3 |
Cure rate（%）=cure number/sum;Total effective rate（%）=(sum-invalid number)/sum.
From table 4, using anaesthetic made from this side this technique, amenorrhoea caused by a variety of causes, total cure rate are treated
For 85.6%, total total effective rate is 93.3%.With first and second kind of embodiment must be compared with cure rate, total total effective rate
It is significantly improved, have received good therapeutic effect.
Preparation technology two：Further, the bulk drug is mixed under -100 DEG C~-120 DEG C temperature conditionss, powder
It is broken, when medical surfaces temperature is identical with indoor temperature, dispenses and produce.
Selection process：Bulk drug will be stated to be put into liquid nitrogen frozen pulverizer, it is -110 DEG C to crush temperature, and constant temperature is ground into
The superfine powder of 200 mesh, it is well mixed, dispenses and produce.
Specification：Per packed 3 grams.
Usage and dosage：One time 1.5-3 grams, warm water takes, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 2%, have received good therapeutic effect.
Preparation technology three：Bilayer tablet is made in the bulk drug, using Amomum cardamomum, betel nut bulk drug as double-layer tablets
Inner layer piece major ingredient, the major ingredient of remaining composition, i.e. elecampane, bush, safflower as the outer-skin sheet of double-layer tablets.Its inner layer piece, outer layer
The auxiliary material of piece is the customary adjuvant of tablet, starch, dextrin etc., in double-layer tablets tablet press machine tabletting produce, due to being existing skill
Art, reason, is not described in detail herein as space is limited.Specification：Every 0.5g containing major ingredient.
Usage and dosage：2-4 piece, warm water take, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 3%, have received good therapeutic effect.
In addition 30 Enterozoa patients are selected again, taken according to the method described above, its deworming rates has reached 86%, drives
Worm positive effect have received unexpected treatment effect higher than the anthelminthic effect that toosendanin or arecaline progress expelling parasite is used alone
Fruit.
4th kind of embodiment：
On the basis of the third embodiment bulk drug, tsaoko 20-30 parts, galangal 20-30 parts are added.
It is preferred that elecampane 50kg, bush 25kg, Amomum cardamomum 25kg, betel nut 35kg, safflower 5kg, tsaoko 25kg, galangal
25kg。
Tsaoko：Mongolian name loud, high-pitched sound is ancient draws, and different name moral human relations are that match sound, vigorous cloth account for, grasp Ge Selide《Errorless anaesthetic mirror》, it is ginger
The ripening fruits of section's plant tsaoko.Property of medicine acrid flavour, it is warm-natured.Imitate dry, light, rough.Major function：Stomach, the malaria of dispelling are conspicuous according to middle benefit gas disappears
Food.It is conspicuous according to abdominal distension, vomiting is dropped, conspicuous to be had a headache according to property up to dry, indigestion, stomach to cure mainly malaria bar.Chemical composition：In fruit
Containing volatile oil, master contains 1, 8-Cineole in oil（1,8-cineole）, trans-Z- undecylene aldehydes etc..Volatile Oil from Seed mainly has
1, 8-Cineole, neral etc..
Galangal：Mongolian name Ulan-loud, high-pitched sound《Errorless anaesthetic mirror》, different name east drawing, Bao-loud, high-pitched sound, Ga Maer《Errorless anaesthetic mirror》.
For the rhizome of zingiberaceous plant galangal.Chemical composition：Rhizome contains curcumin, dihydro curcumin, hexahydrocurcumin, 5- diketone etc. two
Phenylheptan class compound；The flavone compounds such as Galangin, Quercetin, Kaempferol, Kaempferol；Also Cineole（1,8-
cineole）, firpene（pinene）, cadinene（cadinene）Deng volatile oil.The property of medicine：Acrid flavour, sweet, row temperature.Imitate it is rough, it is dry,
It is floating, sharp.Major function：Middle benefit gas, appetizing, help digestion, except bar up to dry conspicuous according to salubrity, apocenosis is talked.Control stomach fire to decay, indigestion, eat
It is intended to depressed etc..
Compared with the third embodiment, tsaoko, the galangal of addition, tsaoko, stomach of dispelling, malaria are conspicuous according to middle benefit gas helps digestion, high
Galingal middle benefit gas, appetizing, help digestion, it is intended that the taste such as indigestion are bad anti-caused by further elimination medicine effect on human body
Should.
Preparation technology one：The bulk drug is mixed, is ground into fine powder, crosses 100 mesh sieves, is well mixed, is dispensed and produce.Rule
Lattice：Per packed 3 grams.
Usage and dosage：One time 1.5-3 grams, warm water takes, 1-2 times on the one.
Clinical test
Any toxic side effect is not being found by toxicological test, animal pharmacology effect experiment is achieved according on the basis of, from
Since 2000, on the premise of patient is voluntary, most patients are accepted for medical treatment, have chosen 90.Wherein：Deficiency of qi and blood causes amenorrhea patients
30 people, experience cold-evil or cold constitution causes the people of amenorrhea patients 30, nervous, pressure is big etc., and mental element causes amenorrhea patients
30 people, age, between 18-45 one full year of life.With 7 days for a course for the treatment of, three courses for the treatment of are limited.Diagnostic criteria and treatment standard
Reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, People's Medical Officer Press, edit Sun Chuanxing）.With reference to this hair
Bright particularity, formulate clinical treatment standard of the present invention.Cure：Menstruation recovery is normal.Take a turn for the better：Menstruation is irregularly risen.It is invalid
：Amenorrhoea symptom is without any improvement.It the results are shown in Table 5.
Table 5
| Sum | Cure number | Improvement number | Invalid number | Cure rate（%） | Total effective rate（%） | |
| Deficiency of qi and blood patient | 30 | 25 | 3 | 2 | 83.3 | 93.3 |
| Experience cold-evil or cold constitution patient | 30 | 25 | 3 | 2 | 83.3 | 93.3 |
| Mental element patient | 30 | 26 | 2 | 2 | 86.7 | 93.3 |
| Amount to | 90 | 76 | 7 | 6 | 84.4 | 93.3 |
Cure rate（%）=cure number/sum;Total effective rate（%）=(sum-invalid number)/sum.
From table 5, using anaesthetic made from this side this technique, amenorrhoea caused by a variety of causes, total cure rate are treated
For 84.4%, total total effective rate is 93.3%.It is total cure rate 85.6% with the third embodiment preparation technology one, total total
Effective percentage 93.3% is compared without significant change.
Preparation technology two：Further, the bulk drug is mixed under -100 DEG C~-120 DEG C temperature conditionss, powder
It is broken, when medical surfaces temperature is identical with indoor temperature, dispenses and produce.
Selection process：Bulk drug will be stated to be put into liquid nitrogen frozen pulverizer, it is -110 DEG C to crush temperature, and constant temperature is ground into
The superfine powder of 200 mesh, it is well mixed, dispenses and produce.
Specification：Per packed 3 grams.
Usage and dosage：One time 1.5-3 grams, warm water takes, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 2%, have received good therapeutic effect.
Preparation technology three：Bilayer tablet is made in the bulk drug, by Amomum cardamomum, betel nut, tsaoko, galangal bulk drug
As the inner layer piece major ingredient of double-layer tablets, the major ingredient of remaining composition, i.e. elecampane, bush, safflower as the outer-skin sheet of double-layer tablets.Its
Inner layer piece, the auxiliary material of outer-skin sheet are the customary adjuvant of tablet, in double-layer tablets tablet press machine tabletting produce, due to being existing skill
Art, reason, is not described in detail herein as space is limited.Specification：Every 0.5g containing major ingredient.
Usage and dosage：2-4 piece, warm water take, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 3%, have received good therapeutic effect.
In addition 30 Enterozoa patients are selected again, taken according to the method described above, its deworming rates has reached 86%, drives
Worm positive effect have received unexpected treatment effect higher than the anthelminthic effect that toosendanin or arecaline progress expelling parasite is used alone
Fruit.
5th kind of embodiment：
Vitamin C 0.03-0.07 parts, preferred vitamin C0.05 parts are added in the bulk drug of the 4th kind of embodiment.
It is preferred that elecampane 50kg, bush 25kg, Amomum cardamomum 25kg, betel nut 35kg, safflower 5kg, tsaoko 25kg, galangal
25kg, vitamin C 0.05kg.
Vitamin C（English：Vitamin C, also known as L-AA）, in the flat crystal of no color or smell, it is soluble in
Water, insoluble in organic solvent.Formed for antibody and collagen, tissue repairing（Including some redoxes）, phenylalanine, junket
The metabolism of propylhomoserin, folic acid, the utilization of iron, carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxyl color
Amine, the complete of blood vessel is kept, promote the institute such as nonheme iron absorption required, while vitamin C has been also equipped with anti-oxidant, anti-freedom
Base, suppress the formation of tyrosinase, so as to reach whitening, the effect of light spot.
In human body, vitamin C is high-efficiency antioxidant agent, for mitigating ascorbate peroxidase enzyme（ascorbate
peroxidase）The oxidation stress of substrate（oxidative stress）.Also needed in also many important biosynthetic processes
Vitamin C participation is wanted to act on.
Compared with the 4th kind of embodiment, vitamin C is added, its object is to strengthen body immunity, improves curative effect,
But unexpected effect is have received, significantly improving occurs in cure rate.
Preparation technology one：The bulk drug is mixed, is ground into fine powder, crosses 100 mesh sieves, is well mixed, is dispensed and produce.Rule
Lattice：Per packed 2 grams.
Usage and dosage：One time 1-2 grams, warm water takes, 1-2 times on the one.
Clinical test
Any toxic side effect is not being found by toxicological test, animal pharmacology effect experiment is achieved according on the basis of, from
Since 2000, on the premise of patient is voluntary, most patients are accepted for medical treatment, have chosen 90.Wherein：Deficiency of qi and blood causes amenorrhea patients
30 people, experience cold-evil or cold constitution causes the people of amenorrhea patients 30, nervous, pressure is big etc., and mental element causes amenorrhea patients
30 people, age, between 18-45 one full year of life.With 7 days for a course for the treatment of, three courses for the treatment of are limited.Diagnostic criteria and treatment standard
Reference《Clinical disease diagnosis is according to healing improvement standard》（The second edition, People's Medical Officer Press, edit Sun Chuanxing）.With reference to this hair
Bright particularity, formulate clinical treatment standard of the present invention.Cure：Menstruation recovery is normal.Take a turn for the better：Menstruation is irregularly risen.It is invalid
：Amenorrhoea symptom is without any improvement.It the results are shown in Table 6.
Table 6
| Sum | Cure number | Improvement number | Invalid number | Cure rate（%） | Total effective rate（%） | |
| Deficiency of qi and blood patient | 30 | 27 | 2 | 1 | 90 | 96.7 |
| Experience cold-evil or cold constitution patient | 30 | 28 | 0 | 2 | 93.3 | 93.3 |
| Mental element patient | 30 | 29 | 1 | 0 | 96.7 | 100 |
| Amount to | 90 | 84 | 3 | 3 | 93.3 | 96.7 |
From table 6, using anaesthetic made from this side this technique, amenorrhoea caused by a variety of causes is treated, total cure rate is
93.3%, total total effective rate is 96.7%.Compared with previous embodiment, must cure rate, total total effective rate have significantly
Improve, have received good therapeutic effect.
Preparation technology two：Further, the bulk drug is mixed under -100 DEG C~-120 DEG C temperature conditionss, powder
It is broken, when medical surfaces temperature is identical with indoor temperature, dispenses and produce.
Selection process：Bulk drug will be stated to be put into liquid nitrogen frozen pulverizer, it is -110 DEG C to crush temperature, and constant temperature is ground into
The superfine powder of 200 mesh, it is well mixed, dispenses and produce.
Specification：Per packed 2 grams.
Usage and dosage：One time 1-2 grams, warm water takes, 1-2 times on the one.
Clinical test：
Using the present embodiment, " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment, and result of the test is shown：
Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " total cure rate of anaesthetic prepared by preparation technology one " improves
2%, it have received good therapeutic effect.
Preparation technology three：Bilayer tablet is made in the bulk drug, by tsaoko, galangal, Amomum cardamomum, betel nut, vitamin C
Inner layer piece major ingredient of the bulk drug as double-layer tablets, the outer-skin sheet of remaining composition, i.e. elecampane, bush, safflower as double-layer tablets
Major ingredient.Its inner layer piece, the auxiliary material of outer-skin sheet are the customary adjuvant of tablet, in double-layer tablets tablet press machine tabletting produce, due to
It is prior art, reason, is not described in detail herein as space is limited.Specification：Every 0.5g containing major ingredient.
Usage and dosage：2-4 piece, warm water take, 1-2 times on the one.
Clinical test：Using the present embodiment " clinical testing procedure described in preparation technology one " carries out clinical comparison experiment,
Result of the test is shown：Using Effect of Mongolian Medicine Treating amenorrhoea made from this preparation technology, relatively using " anaesthetic prepared by preparation technology one "
Total cure rate improves 2%, have received good therapeutic effect.
In addition 30 Enterozoa patients to be selected again, taken according to the method described above, its deworming rates has reached 85.9%,
Anthelminthic effect have received unexpected treatment apparently higher than the anthelminthic effect that toosendanin or arecaline progress expelling parasite is used alone
Effect.
Claims (12)
- A kind of 1. anaesthetic for treating Amenorrhea, it is characterised in that：The anaesthetic is made up of the bulk drug of following parts by weight：Elecampane 45-55 parts, bush 20-30 parts, 1,8- Cineole 0.03-0.07 parts, betel nut 30-40 parts.
- 2. the anaesthetic for the treatment of Amenorrhea according to claim 1, it is characterised in that：The 1,8- Cineoles are by following weight The bulk drug of part substitutes：Amomum cardamomum 20-30 parts.
- 3. the anaesthetic for the treatment of Amenorrhea according to claim 2, it is characterised in that：Safflower 3-8 parts are added in the bulk drug.
- 4. the anaesthetic for the treatment of Amenorrhea according to claim 3, it is characterised in that：Tsaoko 20-30 is added in the bulk drug Part, galangal 20-30 parts.
- 5. the anaesthetic for the treatment of Amenorrhea according to claim 4, it is characterised in that：Vitamin is added in the bulk drug C0.03-0.07 parts.
- 6. the anaesthetic for the treatment of Amenorrhea according to claim 4, it is characterised in that：The anaesthetic by following parts by weight raw material Medicine is made：Elecampane 50kg, bush 25kg, Amomum cardamomum 25kg, betel nut 35kg, safflower 5kg, tsaoko 25kg, galangal 25kg.
- 7. the anaesthetic for the treatment of Amenorrhea according to claim 5, it is characterised in that：The anaesthetic by following parts by weight raw material Medicine is made：50 parts of elecampane, 25 parts of bush, 25 parts of Amomum cardamomum, 35 parts of betel nut, 5 parts of safflower, 25 parts of tsaoko, 25 parts of galangal, dimension Raw plain C0.05 parts.
- 8. the preparation technology of the anaesthetic of the treatment Amenorrhea as described in claim 1,2,3,4,5,6 or 7, it is characterised in that：By institute Bulk drug mixing is stated, is ground into fine powder, crosses 100 mesh sieves, is well mixed, is dispensed and produce；Or first mix the bulk drug in addition to 1.8- Cineoles, fine powder is ground into, then 1.8- Cineoles are mixed with it Close, sieve, be well mixed, dispense and produce.
- 9. the preparation technology of the anaesthetic of the treatment Amenorrhea as described in claim 1,2,3,4,5,6 or 7, it is characterised in that：By institute State bulk drug to mix under -100 DEG C~-120 DEG C temperature conditionss, crush, when medical surfaces temperature is identical with indoor temperature, Dispense and produce.
- 10. the preparation technology of the anaesthetic of the treatment Amenorrhea as described in claim 1,2,3,4,5,6 or 7, it is characterised in that：It will state Bulk drug is put into liquid nitrogen frozen pulverizer, and it is -110 DEG C to crush temperature, and constant temperature is ground into the superfine powder of 200 mesh, is well mixed, Dispense and produce.
- 11. the preparation technology of the anaesthetic of the treatment Amenorrhea as described in claim 1,2,3,4,5,6 or 7, it is characterised in that：By institute State bulk drug and bilayer tablet is made, 1.8- Cineoles or betel nut or Amomum cardamomum or tsaoko or galangal or dimension life will be contained Inner layer piece major ingredient of the plain C bulk drug as double-layer tablets, remaining component are the major ingredient of the outer-skin sheet of double-layer tablets.
- 12. the anaesthetic of the treatment Amenorrhea as described in claim 1,2,3,4,5,6 or 7, it is characterised in that：In the anaesthetic is used as Take anthelmintic and be applied to clinic.
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| CN109813814A (en) * | 2019-01-21 | 2019-05-28 | 中国人民解放军第四军医大学 | Application of the phenylalanine metabolic alterations in cerebral ischemia/reperfusion injury degree evaluation |
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| CN102068650A (en) * | 2009-11-23 | 2011-05-25 | 史海霞 | Chinese herbal medicine for treatment of dysmenorrhea |
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2017
- 2017-10-21 CN CN201710988650.5A patent/CN107744578A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102068650A (en) * | 2009-11-23 | 2011-05-25 | 史海霞 | Chinese herbal medicine for treatment of dysmenorrhea |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109813814A (en) * | 2019-01-21 | 2019-05-28 | 中国人民解放军第四军医大学 | Application of the phenylalanine metabolic alterations in cerebral ischemia/reperfusion injury degree evaluation |
| CN109813814B (en) * | 2019-01-21 | 2022-03-15 | 中国人民解放军第四军医大学 | Application of phenylalanine metabolism change in evaluation of cerebral ischemia/reperfusion injury degree |
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