CN107744558A - A kind of Chinese medicine for treating rhinitis composition and preparation method thereof - Google Patents
A kind of Chinese medicine for treating rhinitis composition and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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Abstract
The present invention relates to a kind of Chinese medicine for treating rhinitis composition, it includes the component of following parts by weight, 5 10 parts of 30 45 parts of the achene of Siberian cocklebur, 30 45 parts of the flower bud of lily magnolia, 10 20 parts of balloonflower root, 5 10 parts of peppermint, 10 15 parts of schizonepeta, 5 15 parts of Chinese juniper, 5 15 parts of storax, 38 parts of pearl, 8 15 parts of moutan bark, 5 10 parts of nine inner bright, 8 15 parts of ligusticum sinense oliver, 5 10 parts of rattletop and Chinese yam.Present invention also offers the preparation method of a kind of Chinese medicine for treating rhinitis composition, and for each raw material components are ground into 300 mesh, then with after vapours hot smoking 30 minutes, with gauze wrapped, the gauze for being enclosed with traditional Chinese medicinal components is placed in the interlayer in mouth mask.The present invention has no toxic side effect, without the hardship by the difficult clothes of medicine soup；Pass through the volatile matter of nasal cavity Sucked medicine component, you can, it is time saving to save trouble；By test, the present invention has the effect of fine to acute and allergic rhinitis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and specifically, it is related to a kind of Chinese medicine for treating rhinitis composition and its system
Preparation Method.
Background technology
Rhinitis is a kind of common disease in life, and due to very common, many people are not to be concerned about very much, if too late with rhinitis
When go treat life to us and had significant effect with work, and can also cause some serious complication, endanger pole
Greatly.Though western medicine rhinitis can obtain certain curative effect at present, built on the sand and there is larger side effect, traditional Chinese medicine takes effect
Slowly, patient takes poor taste.
The content of the invention
It is an object of the invention to provide a kind of quick, the Chinese medicine composition for the treatment rhinitis having no side effect and its preparation side
Method.
To achieve the above object, the Chinese medicine composition of present invention treatment rhinitis, which includes it, includes the component of following parts by weight,
Achene of Siberian cocklebur 30-45 parts, flower bud of lily magnolia 30-45 parts, balloonflower root 10-20 parts, peppermint 5-10 parts, schizonepeta 10-15 parts, Chinese juniper 5-15 parts, Su He
Fragrant 5-15 parts, pearl 3-8 parts, moutan bark 8-15 parts, nine inner bright 5-10 parts, ligusticum sinense oliver 8-15 parts, rattletop 5-10 parts and Chinese yam 5-10
Part.
Further, it includes the component of following parts by weight, achene of Siberian cocklebur 35-40 parts, flower bud of lily magnolia 35-40 parts, balloonflower root 13-18
In part, peppermint 6-8 parts, schizonepeta 11-14 parts, Chinese juniper 6-10 parts, storax 6-10 parts, pearl 4-7 parts, moutan bark 9-13 parts, nine
Bright 6-9 parts, ligusticum sinense oliver 9-13 parts, rattletop 6-9 parts and Chinese yam 6-8 parts.
Further, it include 37 parts of the component achene of Siberian cocklebur of following parts by weight, 36 parts of the flower bud of lily magnolia, 15 parts of balloonflower root, 7 parts of peppermint,
13 parts of schizonepeta, 8 parts of Chinese juniper, 6 parts of storax, 5 parts of pearl, 10 parts of moutan bark, 7 parts of nine inner bright, 10 parts of ligusticum sinense oliver, 8 parts of rattletop and mountain
7 parts of medicine.
Present invention also offers the preparation method of a kind of Chinese medicine for treating rhinitis composition, for by the achene of Siberian cocklebur, the flower bud of lily magnolia, tangerine
It is ground to after stalk, peppermint, schizonepeta, Chinese juniper, storax, pearl, moutan bark, nine inner bright, ligusticum sinense oliver, rattletop and Chinese yam are well mixed
300 mesh, then with after vapours hot smoking 30 minutes, with gauze wrapped, the gauze for being enclosed with traditional Chinese medicinal components is placed in mouth mask
In interlayer.
Good effect of the present invention is as follows：
The present invention uses Chinese medicine composition, has no toxic side effect, without the hardship by the difficult clothes of medicine soup；Pass through nasal cavity Sucked medicine component
Volatile matter, you can, it is time saving to save trouble without decocting medicine soup；By test, the present invention has good treatment to acute and allergic rhinitis
Effect.
Embodiment
The embodiment 1-5 of table 1 component table
Embodiment 1-5 preparation methods are as follows：
By the achene of Siberian cocklebur, the flower bud of lily magnolia, balloonflower root, peppermint, schizonepeta, Chinese juniper, storax, pearl, moutan bark, nine inner bright, ligusticum sinense oliver, rattletop and mountain
Medicine is ground to 300 mesh, then with after 90-120 DEG C of vapours hot smoking 30 minutes, with gauze wrapped, will be enclosed with traditional Chinese medicinal components
Gauze place mouth mask in interlayer in.
Curative effect counts
Random selection mechanism, which is received, examines patient 160, age 14-75 year, man 84, female 76, is picked out according to patient requests
Treatment group and control group, two groups of patients are in the general information no significant difference such as sex, age and course of disease（P ＞ 0.05）.
Treatment group：After the processing of 1 each component of embodiment, with gauze wrapped, the gauze for being enclosed with traditional Chinese medicinal components is prevented
In interlayer in mouth mask.Respectively wear 30 minutes in afternoon in the morning, also upper new drug before every morning wears.
Control group：The oral Cefprozil dispersible table of patient（Producer：Baiyunshan Pharmaceutical General Factory；Lot number：Chinese medicines quasi-word
H200514）7.5mg/kg, 2 times/day.
Treatment group and control group are treated 10 days respectively.
Criterion of therapeutical effect（1）Cure：After treatment, the clinical symptoms of patient（Have a running nose, nasal obstruction, headache）It is wholly absent, nose
Mucous membrane is without exception in X-ray film display cavity without congested swelling；（2）It is effective：After treatment, the clinical symptoms of patient occasionally have generation, nose
Mild swelling be present in mucous membrane；（3）It is invalid：After treatment, the clinical symptoms of patient are unchanged or aggravate.Treatment is total effectively to be included controlling
More with it is effective.
The treatment group of table 2 and the statistical result of control group
From statistics, present invention treatment total effective rate is higher.
Mouse sensitization model
Experimental animal：SD rats 60 (cleaning grade animal), the body weight 250 of male and female half and half
—300g.In 25~28 DEG C of temperature, the feeding room raising of humidity 40% one 50%.Feeding room avoids anaphylactogen from existing, and fits
Answering property starts formal experiment after raising l weeks.It is randomly divided into Normal group, model group and treatment group.Every group of lO is only.
It is prepared by AR rat models：
（1）Basic sensitization,
With OVA 0.3mg, Al (OH) 300mg adds physiological saline 1ml and suspension, rat abdominal cavity note is made for model group and treatment group
Penetrate, 1 time every other day, totally 8 times.Normal group substitutes OVA suspensions with normal saline, and method and steps is same as above.
（2）It is intranasal to excite model group and treatment group since the 16th day with 5%OVA normal saline solution collunariums.Per side
50ml, continuous 10 days to strengthen sensitization.Decision model success after, the next day instill same concentrations OVA solution, to maintain sensitization.
Normal group is replaced with physiological saline.Method is same as above.
Treatment group is matched the achene of Siberian cocklebur, the flower bud of lily magnolia, balloonflower root, peppermint, schizonepeta, Chinese juniper, Su He by embodiment 1 after model success
Perfume, pearl, moutan bark, nine inner bright, ligusticum sinense oliver, rattletop and Chinese yam are ground to 300 mesh, then with after vapours hot smoking 30 minutes, use
Gauze wrapped, the gauze of traditional Chinese medicinal components will be enclosed with（Traditional Chinese medicinal components containing 5g）In interlayer in anti-placement mouth mask, treatment is fixed on
On the nose of group mouse, removed daily after fixed 10min.Normal group is same as above with physiological saline alternatives to medication, method.Observation
And the sneeze number of record unit time (30min) interior rat.
Test structure：
Since first sensitization 7 days, the mouse of model group and treatment group is intranasal to excite obvious increase sneezing number.Scratch nose number
Then start to dramatically increase in the 14th day anaphylactogen part sensitization.Model group and treatment group's nose sneeze, scratch nose number significantly more than just
Normal control group.The SERUM IgE content average value of three groups of mouse is as shown in table 3.
3 three groups of SERUM IgE contents of table
Model group rats SERUM IgE content is significantly higher than Normal group (P<0.05).Treatment group's IgE contents and model group ratio
Compared with the statistically significant (P of difference<0.05).
The serum IL -4 of three groups of mouse, IL5 content average values are as shown in table 3.
3 three groups of serum ILs -4 of table, IL-5 content average values
Model group mice serum IL-4, IL-5 content is significantly higher than Normal group (P<
0.05).Treatment group's IL-4, IL-5 content is compared with model group, the statistically significant (P of difference<0.05).
The present invention uses Chinese medicine composition, and late result is stable, alleviates and even cures acute or allergic rhinitis, avoids
The side effect of Western medicine.Experimental result shows that the present invention can reduce IL4, IL-5 content in AR rat plasmas, has suppression Th2 thin
The effect of born of the same parents' subgroup strong response, the secreting function for suppressing Th2 cells reduce IL 1, IL-5 content, suppress EOS hair
Educate, activate, infiltrating and the release of inflammatory mediator, so as to mitigate schneiderian membrance inflammation, mitigating AR symptom or slow down AR breaking-out, with
Reach treatment AR purpose.
The foregoing description of the disclosed embodiments, professional and technical personnel in the field are enable to realize or using the present invention.
A variety of modifications to these embodiments will be apparent for those skilled in the art, as defined herein
General Principle can be realized in other embodiments in the case where not departing from the spirit or scope of patent of the present invention.Therefore, originally
Invention is not intended to be limited to the embodiments shown herein, and is to fit to and principles disclosed herein and features of novelty
Consistent most wide scope.
Claims (4)
1. a kind of Chinese medicine for treating rhinitis composition, it is characterised in that：It includes the component of following parts by weight, achene of Siberian cocklebur 30-45
Part, flower bud of lily magnolia 30-45 parts, balloonflower root 10-20 parts, peppermint 5-10 parts, schizonepeta 10-15 parts, Chinese juniper 5-15 parts, storax 5-15 parts, treasure
Pearl 3-8 parts, moutan bark 8-15 parts, nine inner bright 5-10 parts, ligusticum sinense oliver 8-15 parts, rattletop 5-10 parts and Chinese yam 5-10 parts.
2. a kind of Chinese medicine for treating rhinitis composition according to claim 1, it is characterised in that：It includes following parts by weight
Component, achene of Siberian cocklebur 35-40 parts, flower bud of lily magnolia 35-40 parts, balloonflower root 13-18 parts, peppermint 6-8 parts, schizonepeta 11-14 parts, Chinese juniper 6-10
Part, storax 6-10 parts, pearl 4-7 parts, moutan bark 9-13 parts, nine inner bright 6-9 parts, ligusticum sinense oliver 9-13 parts, rattletop 6-9 parts and Chinese yam
6-8 parts.
3. a kind of Chinese medicine for treating rhinitis composition according to claim 2, it is characterised in that：It includes following parts by weight
37 parts of the component achene of Siberian cocklebur, 36 parts of the flower bud of lily magnolia, 15 parts of balloonflower root, 7 parts of peppermint, 13 parts of schizonepeta, 8 parts of Chinese juniper, 6 parts of storax, pearl 5
Part, 10 parts of moutan bark, 7 parts of nine inner bright, 10 parts of ligusticum sinense oliver, 8 parts of rattletop and 7 parts of Chinese yam.
4. the preparation method of any described a kind of Chinese medicine for treating rhinitis compositions of claim 1-3, it is characterised in that：
By the achene of Siberian cocklebur, the flower bud of lily magnolia, balloonflower root, peppermint, schizonepeta, Chinese juniper, storax, pearl, moutan bark, nine inner bright, ligusticum sinense oliver, rattletop and mountain
300 mesh are ground to after medicine is well mixed, then with after 90-120 DEG C of vapours hot smoking 30 minutes, with gauze wrapped, will be wrapped up
The gauze for having traditional Chinese medicinal components is placed in the interlayer in mouth mask.
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| CN201711014805.1A CN107744558A (en) | 2017-10-25 | 2017-10-25 | A kind of Chinese medicine for treating rhinitis composition and preparation method thereof |
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| CN201711014805.1A CN107744558A (en) | 2017-10-25 | 2017-10-25 | A kind of Chinese medicine for treating rhinitis composition and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186829A (en) * | 2018-03-13 | 2018-06-22 | 广西中医药大学附属瑞康医院 | A kind of herbal composite for treating rhinitis chronic and preparation method thereof |
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| CN101843675A (en) * | 2010-06-21 | 2010-09-29 | 浙江泰利森药业有限公司 | Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and preparation process thereof |
| CN102366439A (en) * | 2011-10-16 | 2012-03-07 | 广东养美医药投资有限公司 | Self-heated traditional Chinese medicine emplastrum for treating chronic simple rhinitis |
| CN102727690A (en) * | 2012-07-23 | 2012-10-17 | 太仓市伟基生物科技有限公司 | Chinese medicinal snorted powder for preventing allergic rhinitis |
| CN106668160A (en) * | 2015-11-10 | 2017-05-17 | 顾立新 | External traditional Chinese medicinal prescription for treating chronic rhinitis |
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2017
- 2017-10-25 CN CN201711014805.1A patent/CN107744558A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843675A (en) * | 2010-06-21 | 2010-09-29 | 浙江泰利森药业有限公司 | Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and preparation process thereof |
| CN102366439A (en) * | 2011-10-16 | 2012-03-07 | 广东养美医药投资有限公司 | Self-heated traditional Chinese medicine emplastrum for treating chronic simple rhinitis |
| CN102727690A (en) * | 2012-07-23 | 2012-10-17 | 太仓市伟基生物科技有限公司 | Chinese medicinal snorted powder for preventing allergic rhinitis |
| CN106668160A (en) * | 2015-11-10 | 2017-05-17 | 顾立新 | External traditional Chinese medicinal prescription for treating chronic rhinitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186829A (en) * | 2018-03-13 | 2018-06-22 | 广西中医药大学附属瑞康医院 | A kind of herbal composite for treating rhinitis chronic and preparation method thereof |
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