CN101843675A - Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and preparation process thereof - Google Patents
Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and preparation process thereof Download PDFInfo
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- CN101843675A CN101843675A CN 201010209603 CN201010209603A CN101843675A CN 101843675 A CN101843675 A CN 101843675A CN 201010209603 CN201010209603 CN 201010209603 CN 201010209603 A CN201010209603 A CN 201010209603A CN 101843675 A CN101843675 A CN 101843675A
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Abstract
The invention discloses a Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and a preparation process thereof. The Chinese medicament is prepared by taking ephedra herb, siberian cocklour fruits, biond magnolia flowers, cortex moutan radicis, fineleaf schizonepeta herb and divaricate saposhnikovia roots as raw materials, extracting volatile oil, performing decoction and filtration, subjecting filtrate to concentration and alcohol precipitation, filtering and concentrating the obtained product into liquid extract and mixing volatile oil with the liquid extract well. The Chinese medicament has definite therapeutic effect on allergic rhinitis, cold rhinobyon, and has no nose irritation, allergy or other adverse effect in the using process, and small side effect, so that patients easily accept the Chinese medicament.
Description
Technical field
The present invention relates to a kind of Chinese Traditional Medicines and preparation technology thereof, the Chinese medicine and the preparation technology thereof of specifically a kind of treatment of allergic rhinitis, acute and chronic rhinitis.
Background technology
Allergic rhinitis (traditional Chinese medical science claims " allergic rhinitis ") and acute and chronic rhinitis are the commonly encountered diseases frequently-occurring disease, many clinically at present with antiallergic, antihistaminic and vasoconstrictor nose dropping treatment, severe patient is the oral or topical application with glucocorticoid then, be medicine mainly with Western medicine such as adrenocortical hormone and furan fiber crops elements, though certain curative effect is arranged, untoward reaction is comparatively common, and a lot of patients can not tolerate, normal abort treatment, thus comparatively powerful knock-on caused.Chinese medicine also has the prescription of some treatment allergic rhinitis, rhinitis, as application number is that 200710138949.8 application for a patent for invention discloses " a kind of decoction medicine and preparation method for the treatment of chronic one-way rhinitis ", it restrains the Radix Astragali with 13-15, and Herba Schizonepetae, Radix Scutellariae, the Rhizoma Atractylodis Macrocephalae, each 8-10 gram of Radix Saposhnikoviae are made for raw material.But existing Chinese medicine preparation mostly is decoction, and the decoction onset is slow, uses inconvenience, and particularly to the treatment of " allergic rhinitis ", the course of disease is long, and the course of treatment is long, and patient is difficult to stand.
Summary of the invention
Technical problem to be solved by this invention is to propose a kind of determined curative effect, in the use side effect little, a kind of Chinese medicine and preparation technology thereof who is used for the treatment of allergic rhinitis, acute and chronic rhinitis that patient takes like a shot.
For solving the problems of the technologies described above, a kind of Chinese medicine that is used for the treatment of allergic rhinitis, acute and chronic rhinitis of the present invention is raw material with Herba Ephedrae, Fructus Xanthii, Flos Magnoliae, Cortex Moutan, Herba Schizonepetae and Radix Saposhnikoviae, concentrates precipitate with ethanol through volatile oil extraction, decoction filtering, filtrate and refilters and be condensed into fluid extract, make after with volatile oil and fluid extract mixing.
Above-mentioned a kind of Chinese medicine that is used for the treatment of allergic rhinitis, acute and chronic rhinitis, it adopts outer dropping liquid dosage form, makes the outer dropping liquid of 1000ml need be with the quality of described each raw material: Herba Ephedrae 182g, Fructus Xanthii 182g, Flos Magnoliae 182g, Cortex Moutan 272g, Radix Saposhnikoviae 91g, Herba Schizonepetae 91g.
A kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, it comprises the steps: I, Herba Ephedrae, Fructus Xanthii, Flos Magnoliae, Cortex Moutan, Herba Schizonepetae and Radix Saposhnikoviae are mixed the back with water vapour distillation volatile oil and collection Aromatic water, and is standby; II, the medicinal residues of above-mentioned Six-element Chinese medicine after extracting are decocted with water 2 times, filter, merge filtrate, it is concentrated into relative density 1.35 (50 ℃); Add ethanol in III, the filtrate after described concentrating, make the alcohol amount that contains of filtrate reach 70% volumetric concentration; IV, with above-mentioned pure filtrate cold preservation 24 hours that contain, filter, reclaim ethanol, filtrate is concentrated into the fluid extract of relative density 1.08-1.11 (25 ℃), standby; V, get above-mentioned volatile oil and fluid extract mixing, make corresponding drug form.
A kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, the medicine of making adopts outer dropping liquid dosage form, it is to get described volatile oil and fluid extract mixed liquor the V stage to add phosphate buffer, antiseptic, accent PH and make, making the 1000ml dropping liquid need be with the quality of described each raw material: Herba Ephedrae 182g, Fructus Xanthii 182g, Flos Magnoliae 182g, Cortex Moutan 272g, Radix Saposhnikoviae 91g, Herba Schizonepetae 91g.
A kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, the time of water vapour distillation volatile oil is 1～5 hour.
A kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, the time of water vapour distillation volatile oil is 4 hours.
A kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, when medicinal residues were decocted with water 2 times, each amount of water was 10 times of medicinal residues quality, decocts 1 hour at every turn.
The present invention is owing to adopted technique scheme, and Herba Ephedrae acrid in the mouth wherein, little hardship, warm in nature are returned lung, bladder footpath, the merit of tool diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Fructus Xanthii acrid in the mouth, hardship, temperature is returned the lung footpath, has the effect of diffusing rheumatism, clearing the nasal passage.Flos Magnoliae nature and flavor suffering, temperature is returned lung footpath, stomach warp, the merit of tool dispersing wind and cold, clearing the nasal passage.The Cortex Moutan nature and flavor are arduous, cold, the merit of tool clearing away heat and cooling blood and Xue Xiao More.Herba Schizonepetae nature and flavor suffering, temperature, tool is delivered the merit of dispeling the wind.Radix Saposhnikoviae acrid in the mouth warm in nature is gone into bladder, lung, spleen channel, and tool is delivered and dispeled the wind, the function of removing dampness to relieve pain.The present invention is monarch with the Herba Ephedrae that Xin Wenxuan looses, and merit is arrogated to oneself " it is obstructed to control stuffy nose, good and foul smells do not hear "; With the Cortex Moutan that Xin Hanqing lets out, the Flos Magnoliae of hot temperature expelling heat from the exterior, Fructus Xanthii, helping Herba Ephedrae is minister, and wherein Cortex Moutan specially in " rush down the volt fire, broken knot holds ", matches with Herba Ephedrae, and hot a surname dredges and reaches then same merit, and warm cold expelling rushes down then and coordinates.Flos Magnoliae, Fructus Xanthii are longer than the dispelling wind heresy, clearing the nasal passage, and with the Herba Ephedrae mutual reinforcement between, then effect is more outstanding.Be assistant more with Herba Schizonepetae, Radix Saposhnikoviae, dispelling wind for relieving itching; And the hot cold Cortex Moutan and the diffusing medicine of suffering temperature a surname of multi-flavor share, and have the using corrigent effect again, and then temperature is loose system; Flos Magnoliae, Fructus Xanthii are because of specially in going into the key stuffy nose relieving, so the merit of messenger drug is arranged again.All medicines match, and make medicine of the present invention have the effect of a surname's clearing the nasal passage, dispelling wind for relieving itching, the turbid tears of removing.Clinical verification 50 routine allergic rhinitis, cold nasal obstruction patient, wherein 16 routine allergic rhinitis patients treat with this investigational agent, and effective percentage is 98.5% as a result; 15 example cold nasal obstruction patients are that 80.0%, 19 routine cold nasal obstruction patient treats with the furan fiber crops with this investigational agent treatment, effective percentage, and effective percentage is 52.6%, between these two groups evident difference P＜0.01 is arranged relatively.Therefore, Chinese medicine of the present invention has definite curative effect to allergic rhinitis, cold nasal obstruction, does not in use see side effect such as nose stimulation and anaphylaxis, and patient takes like a shot.
The specific embodiment
A kind of allergic rhinitis, acute and chronic rhinitis Chinese medicine of being used for the treatment of, it adopts following steps to make:
I, with the 182g Herba Ephedrae, the 182g Fructus Xanthii, 182g Flos Magnoliae, 272g Cortex Moutan, Radix Saposhnikoviae 91g, Herba Schizonepetae 91g mix the back with water vapour distillation volatile oil 4 hours, collect Aromatic water 300ml, and be standby;
II, the medicinal residues of above-mentioned Six-element Chinese medicine after extracting are decocted with water 2 times, each amount of water is 10 times of medicinal residues quality, decocts 1 hour at every turn, filters, and merges filtrate, and it is concentrated into relative density 1.35 (50 ℃);
Add ethanol in III, the filtrate after concentrating, make the alcohol amount that contains of filtrate reach 70% volumetric concentration;
IV, with above-mentioned pure filtrate cold preservation 24 hours that contain, filter, reclaim ethanol, filtrate is concentrated into the fluid extract of relative density 1.08-1.11 (25 ℃ of surveys), standby;
V, get above-mentioned volatile oil and fluid extract mixing;
VI, the mixed liquor of getting above-mentioned volatile oil and fluid extract add phosphate buffer, antiseptic, accent PH and make outer dropping liquid 1000ml.Wherein, adding phosphate buffer, antiseptic, accent PH is the conventional means in the outer dropping liquid preparation process, repeats no more herein
In the technology of the present invention, because of prescription Six-element raw material of Chinese medicine not all has the characteristics of volatile ingredient, wherein volatile oil of Flos Magnoliae, Fructus Xanthii and Aromatic water play key effect in tcm prescription.Cortex Moutan contains and has volatile active ingredient paeonol, can volatilize with steam, and is almost insoluble in the water.Also all in volatile ingredient, therefore we are when effective component extracting for the main component of Radix Saposhnikoviae, Herba Schizonepetae, and the extraction of volatile oil and Aromatic water is an important step.Active ingredient ephedrine in the Herba Ephedrae is soluble in water, and the flavonoid composition also can be water-soluble in the Fructus Xanthii, and considers the chemical change in the Chinese medicine soup decoction process, extracts volatile component earlier so adopt, and decocts then 2 times, merges the skill of preparation.
Simultaneously, after technology of the present invention was tested, screening drew following preferable process conditions:
(1), about the volatile oil content of Flos Magnoliae, Herba Schizonepetae medical material, 05 edition one one of Chinese Pharmacopoeia has all been made regulation, wherein Flos Magnoliae must not be less than 1.0% (ml/g), Herba Schizonepetae must not be less than 0.50% (ml/g).Because distillation time is very big to the influence of the oil yield of medical material, so the applicant extracts the volatile oil of medical material and done experiment, and the result is presented at and receives oil mass and proportional relation of time in 1-5 hour, reaches 99.48% in 4 hours.
(2), the Aromatic water collecting amount is selected.Paeonol in Cortex Moutan dissolubility in hot water is big, folds the particle water crystal after the water-cooled, therefore collects Aromatic water when collecting volatile oil, to reach the purpose of preserving paeonol.Show according to the result, collect the Aromatic water of 300ml and go up substantially near more than 90% of paeonol total amount.
(3), the decocting process conditions is preferred.Decocting technology is occupied critical role in whole process conditions, ephedrine is water-soluble, thus with ephedrine as the composition index that is just becoming in the design.The employing acid-dye colorimetry is measured.Select L9 (34) orthogonal table experiment arrangement for use, result's demonstration adds 10 times in water, decocts 1 hour, and decocting 2 times is preferred plan.
(4) selection of precipitate with ethanol condition.Because it is tighter that the clarity of nasal drop requires, therefore adopt the method for precipitate with ethanol as decontamination, reduce the loss as far as possible for guaranteeing active ingredient, and in conjunction with the preparation stability requirement, we select the precipitate with ethanol condition.Selection result shows that the ethanol precipitation condition of volume content 70% is better.
The dosage form of medicine of the present invention also can adopt capsule, soft capsule, granule, tablet, mixture, oral liquid, pill, drop pill, nasal drop, receptible dosage form on the pharmaceuticss such as nasal spray.
We have filtered out this external dropping liquid in conjunction with clinical and experiment, and clinical verification 50 examples contrast the obviously good and latter of curative effect with contrast medicine " the furan fiber crops are plain ".
Claims (7)
1. Chinese medicine that is used for the treatment of allergic rhinitis, acute and chronic rhinitis, it is characterized in that, it is a raw material with Herba Ephedrae, Fructus Xanthii, Flos Magnoliae, Cortex Moutan, Herba Schizonepetae and Radix Saposhnikoviae, concentrates precipitate with ethanol through volatile oil extraction, decoction filtering, filtrate and refilters and be condensed into fluid extract, make after with volatile oil and fluid extract mixing.
2. a kind of Chinese medicine that is used for the treatment of allergic rhinitis, acute and chronic rhinitis as claimed in claim 1, it is characterized in that, it adopts outer dropping liquid dosage form, making the outer dropping liquid of 1000ml need be with the quality of described each raw material: Herba Ephedrae 182g, Fructus Xanthii 182g, Flos Magnoliae 182g, Cortex Moutan 272g, Radix Saposhnikoviae 91g, Herba Schizonepetae 91g.
3. preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, it is characterized in that, it comprises the steps: I, Herba Ephedrae, Fructus Xanthii, Flos Magnoliae, Cortex Moutan, Herba Schizonepetae and Radix Saposhnikoviae are mixed the back with water vapour distillation volatile oil and collection Aromatic water, and is standby; II, the medicinal residues of above-mentioned Six-element Chinese medicine after extracting are decocted with water 2 times, filter, merge filtrate, it is concentrated into relative density 1.35 under 50 ℃ of temperature conditions; Add ethanol in III, the filtrate after described concentrating, make the alcohol amount that contains of filtrate reach 70% volumetric concentration; IV, with above-mentioned pure filtrate cold preservation 24 hours that contain, filter, reclaim ethanol, filtrate is concentrated into the fluid extract of relative density 1.08-1.11 under 25 ℃ of temperature conditions, standby; V, get above-mentioned volatile oil and fluid extract mixing, make corresponding drug form.
4. a kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine as claimed in claim 3, it is characterized in that, the medicine of making adopts outer dropping liquid dosage form, it is to get described volatile oil and fluid extract mixed liquor the V stage to add phosphate buffer, antiseptic, accent PH and make, and makes the 1000ml dropping liquid and need be with the quality of described each raw material: Herba Ephedrae 182g, Fructus Xanthii 182g, Flos Magnoliae 182g, Cortex Moutan 272g, Radix Saposhnikoviae 91g, Herba Schizonepetae 91g.
5. as claim 3 or 4 described a kind of preparation technologies that are used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, it is characterized in that the time of water vapour distillation volatile oil is 1～5 hour.
6. a kind of preparation technology who is used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine as claimed in claim 5 is characterized in that it is characterized in that, the time of water vapour distillation volatile oil is 4 hours.
7. as claim 3 or 4 described a kind of preparation technologies that are used for the treatment of allergic rhinitis, acute and chronic rhinitis Chinese medicine, it is characterized in that when medicinal residues were decocted with water 2 times, each amount of water was 10 times of medicinal residues quality, decocts 1 hour at every turn.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010209603 CN101843675A (en) | 2010-06-21 | 2010-06-21 | Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and preparation process thereof |
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| CN 201010209603 CN101843675A (en) | 2010-06-21 | 2010-06-21 | Chinese medicament for treating allergic rhinitis and acute/chronic rhinitis, and preparation process thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698074A (en) * | 2012-04-18 | 2012-10-03 | 王桂琴 | Traditional Chinese medicine composition for treating allergic rhinitis |
| CN107744558A (en) * | 2017-10-25 | 2018-03-02 | 李力强 | A kind of Chinese medicine for treating rhinitis composition and preparation method thereof |
| CN108619241A (en) * | 2018-06-20 | 2018-10-09 | 刘永利 | Antiallergic multifunction invisible mask |
| CN111450194A (en) * | 2020-04-27 | 2020-07-28 | 滕居爱 | Effective rhinitis external treatment powder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104506A (en) * | 1993-04-03 | 1995-07-05 | 北京医科大学人民医院 | Oral medicine for curing rhinitis |
-
2010
- 2010-06-21 CN CN 201010209603 patent/CN101843675A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104506A (en) * | 1993-04-03 | 1995-07-05 | 北京医科大学人民医院 | Oral medicine for curing rhinitis |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698074A (en) * | 2012-04-18 | 2012-10-03 | 王桂琴 | Traditional Chinese medicine composition for treating allergic rhinitis |
| CN102698074B (en) * | 2012-04-18 | 2014-07-09 | 王桂琴 | Traditional Chinese medicine composition for treating allergic rhinitis |
| CN107744558A (en) * | 2017-10-25 | 2018-03-02 | 李力强 | A kind of Chinese medicine for treating rhinitis composition and preparation method thereof |
| CN108619241A (en) * | 2018-06-20 | 2018-10-09 | 刘永利 | Antiallergic multifunction invisible mask |
| CN111450194A (en) * | 2020-04-27 | 2020-07-28 | 滕居爱 | Effective rhinitis external treatment powder |
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Application publication date: 20100929 |