CN101199826A - Patch of carsick-prevention containing hindu datura flower component - Google Patents
Patch of carsick-prevention containing hindu datura flower component Download PDFInfo
- Publication number
- CN101199826A CN101199826A CNA2006101302983A CN200610130298A CN101199826A CN 101199826 A CN101199826 A CN 101199826A CN A2006101302983 A CNA2006101302983 A CN A2006101302983A CN 200610130298 A CN200610130298 A CN 200610130298A CN 101199826 A CN101199826 A CN 101199826A
- Authority
- CN
- China
- Prior art keywords
- extractum
- layer
- flos daturae
- plaster
- patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The utility model discloses a datura-flower-alkali anti-carsickness plaster for preventing and treating carsickness, belonging to the medical preparation derived from the traditional herbs. The plaster of the invention consists of a medicine-containing mucilage layer, a protective layer and a backing memebrane layer. The proportion by weight of the medication ingredients of the plaster is: in the extract: the ratio of datura flower to ginger is 1 to 2; in the medicine-containing mucilage layer, extract 8-12, menthence 1-3, pressure sensitive adhesive 30-45, propylene glycol 5-15, laurocapram 0-5. The invention can be prepared by the equipment and the method of making ordinary plasters in this industry. The plaster of the invention uses the natural plant as the raw material, so the side effect is small; the invention with a little material consumption and notable curative effect can exert the efficacy in short term after being used; the invention can treat the internal illness externally; the invention is easy to use and the patient can have free choice on when to stop or resume the treatment.
Description
Technical field
The present invention relates to treat nauseating, motion sickness or dizzy pharmaceutical preparation, specifically is a kind of patch that contains the control carsickness of Flos Daturae alkali composition.
Background technology
Motion sickness be motion sickness, motion sickness, air-sickness and because waving of causing of a variety of causes, jolt, the general designation of associated diseases such as rotation, accelerated motion.Primary disease is everlasting by bus, navigation, flight and other operations take place after several minutes to a few hours.Feel epigastric discomfort at the beginning, existingly feel sick, pale complexion, be in a cold sweat dizzy, spirit depressing is arranged immediately, salivation increases and vomit.Can there be blood pressure drops to breathe dark and slow, nystagmus.Serious vomiting causes that power and water separates the matter disorder.Symptom generally disappears in tens of minutes and several hours after out of service or deceleration or alleviates.After also being arranged, just recovers gradually lasting a couple of days, and with lethargy, myasthenia of limbs.Rerun or accelerated motion after, symptom can occur again once again.But after repeatedly falling ill, symptom instead can alleviate, and even takes place.
General carsick medicine is oral, because the existence of peak valley phenomenon, side effect is apparent in view.And after having broken away from carsick seasick environment, carsick transference cure, medicine is also in action.People's action is affected, has therefore occurred the patch of percutaneous dosing now.
Patch is compared with oral carsick medicine, and the advantage on many application performances is arranged.1. can avoid " first pass effect " of drug metabolism liver, thereby reduce the toxic and side effects of medicine human body.2. can remove the influence that oral drugs are subjected to intestines and stomach dilution and effective consumption from.3. overcome " peak valley phenomenon " of oral administration blood drug level, reduced administration number of times and dosage, so relieving side effects.4. constant speed continues release, can keep stable effective treatment blood drug level for a long time, has reached the long-acting slow-release effect.
Chinese patent CN1056772C disclosed " the carsick subsides and carsick agent " is that the compound type externally applied transdermal pastes cave agent and water preparation.The drug storage layer and the mucigel that contain medicament in backing layer one side of impermeability.Medicament component and consumption are as follows: weight %, Borneolum Syntheticum 1-10, Rhizoma Zingiberis Recens 20-70, Flos Daturae 10-40, Styrax 4-15, Moschus 0.01-2, Radix Aristolochiae 4-15.Stickup or wiping utilize drug fragrant to keep away dirty characteristics on the acupuncture point, realize prevention, carsick, airsick, the seasick purpose of treatment.
This patent has good effect to the control motion sickness.But this prescription medical material is wide in variety, makes trouble, need place the flexible package of pastille in the center fixed of base material, and labor efficiency is low.
Summary of the invention
Many at existing prescription traditional Chinese medicinal materials assortment in the above-mentioned prior art, make the problem that bothers, it is simple that the present invention releases a kind of prescription, makes easily, is convenient to the Flos Daturae alkali Carsickness patch of large-scale production.
Flos Daturae alkali Carsickness patch involved in the present invention is by following conceptual design.
The weight part ratio of its drug component is as follows: extractum: Flos Daturae: Rhizoma Zingiberis Recens is 1: 2; Medicine layer: extractum 8-20, Oleum menthae 1-3, pressure sensitive adhesive 30-45, propylene glycol 5-15, azone 0-5.
The weight part ratio of drug component is as follows: extractum: Flos Daturae: Rhizoma Zingiberis Recens is 1: 2; Medicine layer: extractum 10, Oleum menthae 1, pressure sensitive adhesive 35, propylene glycol 10, azone 1.
Its preparation method mainly may further comprise the steps:
A. in the Flos Daturae of above ratio with chopping, the Rhizoma Zingiberis Recens ethanol extraction of section is condensed into extractum;
B. take by weighing extractum, Oleum menthae, propylene glycol, azone in above ratio and join in the pressure sensitive adhesive, stirring makes the pastille rubber cement;
C. after coating machine coating, drying, by the product of cutting, screening, quality inspection, packing system.
Patch of the present invention can be cut into different shape.
Flos Daturae is the dried floral of datura metel and datura innoxia, and feeble QI is smelly, and the acrid in the mouth hardship is warm in nature.Poisonous, level land cough-relieving is arranged, narcotic analgesic, the spasmolytic function of only jerking.Cure mainly asthma and cough, wrist abdomen cold type of pain, rheumatic arthralgia, epilepsy, infantile convulsion, surgical anesthesia.Its main effective ingredient is scopolamine, hyoscyamine and atropine.This product and amount are different to have inhibition or excited effect to nervus centralis.Low dose of decreased heart rate, heavy dose of fresh green of accelerating.Higher concentration has the effect that stagnates of antiarrhythmic effect and nonspecific calcium channel group, can suppress the generation of Angiotensin II, microcirculation improvement, and antioxidation and remove free radical, excited respiratory center plays when being used to anaesthetize that the table temperature raises and body temperature descends.Also have mydriasis in addition and regulate paralysis, suppress multiple glandular secretion, the effect of relaxing smooth muscle.Can also the induce dna damage.Modern clinical because treatment chronic bronchitis, ankylosing spondylitis and ophthalmologic examination.
The present invention adopts effect and the Rhizoma Zingiberis Recens prescription that utilizes Flos Daturae, and is simple, easy to make, reaches same effect.
Patch of the present invention is a raw material with the natural plants, and toxic and side effects is little; Material therefor is few, and is evident in efficacy, paste in the short time of back just can play a role, and inner disease outer treat, easy to use, can interrupt voluntarily at any time or resume treatment, the patient fully can be from line operate.Therefore be subjected to patient's welcome especially.
The specific embodiment
Below in conjunction with embodiment the present invention is explained.The present invention can make of equipment, the method for the common making patch of the industry.As coating process, extrusion process or spray processing, below with the coating process example only, preparation process of the present invention is described.
Among the following embodiment, used raw material is commercially available pharmaceutical grade.
Take by weighing the chopping of 10kg Flos Daturae, the section of 20kg Rhizoma Zingiberis Recens is inserted in the percolation jar, the ethanol extraction with 75%, and the extracting solution concentrating under reduced pressure becomes extractum.
Take by weighing extractum 2g, Oleum menthae 0.2g, propylene glycol 2g, azone 0.2g joins in the acrylate pressure-sensitive adhesive, is stirred well to evenly, promptly gets the rubber cement of pastille.
Be coated on the polyester film with the rubber cement of coating machine pastille.After the oven dry, carry out the paper substrate protecting film of release treatment on compound, obtained the medicine plaster that contains of three-decker.Be cut into 50 of the disks of diameter 2cm, become finished product through quality inspection, packing.
Using method:
The patient that motion sickness is arranged, at riding public transportation means preceding 15 minutes, paster is attached to ear after, arrive destination after, descended the vehicles to take off.
The present invention is through too much people's use, and effect is remarkable, behind the paster of the invention that loses money in a business, carsick phenomenon does not take place by bus again.
Claims (3)
1. the anti-corona traffic allowance agent of Flos Daturae alkali is made of pastille adhesive-layer, protective layer and backing layer, and it is characterized in that the weight part ratio of the drug component of patch is as follows: in the extractum: Flos Daturae: Rhizoma Zingiberis Recens is 1: 2; Pastille adhesive-layer: extractum 8-12, Oleum menthae 1-3, pressure sensitive adhesive 30-45, propylene glycol 5-15, azone 0-5.
Its preparation method mainly may further comprise the steps:
A. in the Flos Daturae of above ratio with chopping, the Rhizoma Zingiberis Recens ethanol extraction of section is condensed into extractum; B. take by weighing extractum, Oleum menthae, propylene glycol, azone in above ratio and join in the pressure sensitive adhesive, stirring makes the pastille rubber cement; C. after coating machine coating, drying, by the product of cutting, screening, quality inspection, packing system.
2. the anti-corona traffic allowance agent of Flos Daturae according to claim 1 is characterized in that the weight part ratio of the drug component of patch is as follows: extractum: Flos Daturae: Rhizoma Zingiberis Recens is 1: 2; Medicine layer: extractum 10, Oleum menthae 1, pressure sensitive adhesive 35, propylene glycol 10, azone 1.
3. the anti-corona traffic allowance agent of Flos Daturae according to claim 1 is characterized in that, extracts used ethanol and be 75% ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302983A CN101199826A (en) | 2006-12-15 | 2006-12-15 | Patch of carsick-prevention containing hindu datura flower component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302983A CN101199826A (en) | 2006-12-15 | 2006-12-15 | Patch of carsick-prevention containing hindu datura flower component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101199826A true CN101199826A (en) | 2008-06-18 |
Family
ID=39515310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101302983A Pending CN101199826A (en) | 2006-12-15 | 2006-12-15 | Patch of carsick-prevention containing hindu datura flower component |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101199826A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069475A (en) * | 2014-07-22 | 2014-10-01 | 四川省乐至贵均卫生材料有限公司 | Car sickness resistant external patch and preparation method |
| CN108704082A (en) * | 2018-09-05 | 2018-10-26 | 安徽德信佳生物医药有限公司 | A kind of datura flower carsickness-proof oral solution |
| CN110214998A (en) * | 2019-04-24 | 2019-09-10 | 四川省乐至贵均卫生材料有限公司 | A kind of Anti-carsickness mask |
-
2006
- 2006-12-15 CN CNA2006101302983A patent/CN101199826A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104069475A (en) * | 2014-07-22 | 2014-10-01 | 四川省乐至贵均卫生材料有限公司 | Car sickness resistant external patch and preparation method |
| CN108704082A (en) * | 2018-09-05 | 2018-10-26 | 安徽德信佳生物医药有限公司 | A kind of datura flower carsickness-proof oral solution |
| CN110214998A (en) * | 2019-04-24 | 2019-09-10 | 四川省乐至贵均卫生材料有限公司 | A kind of Anti-carsickness mask |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105287837B (en) | A kind of compound Chinese medicinal preparation and preparation method thereof for treating hemorrhoid | |
| CN104922248A (en) | Antibacterial and anti-inflammatory Chinese herbal compound gel and preparation method thereof | |
| CN102178810B (en) | Chinese medicinal paste film for treating skin ulcer and preparation method thereof | |
| CN101199826A (en) | Patch of carsick-prevention containing hindu datura flower component | |
| CN101564520B (en) | Plastic umbilical plaster for external use, preparation method thereof, plastic infantile diarrhea umbilical plaster and preparation method thereof | |
| EP3884942B1 (en) | Use of bulleyaconitine a for treating skin disorders | |
| CN102178811B (en) | Medicament for treating skin ulcer and preparation method thereof | |
| CN108379461B (en) | Graphene blood pressure lowering patch and preparation method thereof | |
| CN102204963B (en) | Composite armadillidium vulgare extract and preparation method and application thereof to pain relieving medicaments | |
| CN101066298B (en) | Chinese medicine powder for treating portacaval mucositis | |
| CN114177160A (en) | Foot patch for treating dental ulcer and preparation method thereof | |
| CN101337026A (en) | External medicine composition for treating gout | |
| CN113144061A (en) | Cough-relieving traditional Chinese medicine external preparation and preparation method thereof | |
| CN101703492B (en) | Tetrahydropalmatine transdermal patch and preparation method thereof | |
| RU2058152C1 (en) | Agent for chronic prostatitis treatment | |
| CN111419952B (en) | Traditional Chinese medicine composition with hemostatic and analgesic effects and preparation method and application thereof | |
| CN106729631A (en) | Treat the externally applied spray of intractable skin ulcer | |
| CN101683376A (en) | Patch for treating toothache and method for producing the same | |
| CN101991616B (en) | Traditional Chinese medicine composite for coronary heart disease and angina pectoris and preparation method thereof | |
| CN106177874A (en) | A kind of patche treating cough with asthma and preparation method thereof | |
| CN101721437A (en) | Medicine composition used for treating chronic pharyngitis and preparation method thereof | |
| CN106267134A (en) | A kind of anti-inflammatory analgesic Chinese medicine composition and preparation method thereof | |
| CN101085069A (en) | Medicine for curing beriberi | |
| CN1057926C (en) | Medicinal composition for curing gastrointestinal disease | |
| CN104547044A (en) | Medicinal composition for preventing and treating upper respiratory inflammation and preparation and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080618 |