CN107737616A - A kind of viscosity test micro-fluidic chip and preparation method based on the driving of PDMS malleations - Google Patents
A kind of viscosity test micro-fluidic chip and preparation method based on the driving of PDMS malleations Download PDFInfo
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- CN107737616A CN107737616A CN201710870419.6A CN201710870419A CN107737616A CN 107737616 A CN107737616 A CN 107737616A CN 201710870419 A CN201710870419 A CN 201710870419A CN 107737616 A CN107737616 A CN 107737616A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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Abstract
A kind of viscosity test micro-fluidic chip and preparation method based on the driving of PDMS malleations belong to micro-fluidic field.The present invention contrasts testing liquid and a kind of normal fluid of known-viscosity to measure its viscosity indirectly.PDMS malleations source of the gas is connected by sealing flexible pipe with micro-fluidic chip air inlet, so as to carry out malleation deflation driving two kinds of liquid flowing in fluid channel respectively, flowed using PDMS malleations driving liquid in fluid channel, the standard sample liquid of testing liquid and known-viscosity is contrasted, to measure its viscosity indirectly, specially utilize the graduated scale measurement length that two kinds of liquid is flowed through in fluid channel in same time, the length flowed through according to standard sample liquid and testing liquid, calculate the viscosity of testing liquid.Reagent consumption of the present invention is few, small volume, is convenient for carrying, and the testing time is relatively short.Cost is low, repeats and utilizes.PDMS is relatively cheap, can again be inflated and encapsulated after the driving source of the gas use of PDMS malleations so that measurement next time uses.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip and preparation method for viscosity test, and in particular to one kind utilizes PDMS
Molten gas characteristic realizes the viscosity test micro-fluidic chip of malleation driving, belongs to microfluidic art.
Background technology
Viscosity is the ability for representing flow of fluid or its irreversible transformation being resisted when having flow tendency, is weighed in fluid
One physical quantity of portion's flow resistance size.Monitoring to viscosity is essential in many basic industries researchs and medical science
One work.
In food and medicine manufacturing, the measurement to viscosity is the key factor examined the quality of the production.In medical diagnosis
Aspect, abnormal plasma viscosity are often relevant with the disease such as diabetes, hypertension.The viscosity of other body fluid, such as synovial fluid and urine
And the factor of some diseases of prediction.
The method of measurement fluid viscosity mainly has rotary process, vibratory drilling method and falling ball method etc. at present.Entered with these viscosimeters
Need to consume substantial amounts of reagent during row viscosity measurement, the testing time is also relatively long.And required hardware device is more, structure
Complexity, it is expensive.Often equipment is also huger for the higher viscosimeter of precision, and operation is also more complicated.It is domestic for these problems
Outer many scholars are studied, it is proposed that some viscosity determining procedures based on microflow control technique.Such as：Zuoyan Han et al.
A kind of negative pressure driving viscosity test micro-fluidic chip (A PDMS based on the molten gas characteristics of PDMS were devised in 2007
viscometer for microliter Newtonian fluid[J].Journal of Micromechanics&
Microengineering,2007,17(9):1828.).X Tang et al. further optimized negative pressure driving viscosity in 2011
Measure micro-fluidic chip (A PDMS viscometer for assaying endoglucanase activity. [J]
.Analyst,2011, 136(6):1222.).But this device have more harsh requirement to the time of test, it is necessary to
PDMS negative pressure driving sources are tested immediately after being ready to, and the shortcomings of being stored inconveniently, driving force is small be present.
The content of the invention
It is an object of the invention to using micro-fluidic chip reagent consumption is small, the testing time is short, small volume and operation
The advantages that simple.Micro-fluidic chip and PDMS malleations driving source of the gas are combined, proposed a kind of based on the driving of PDMS malleations
Viscosity test micro-fluidic chip.Its operation principle is：Flowed using PDMS malleations driving liquid in fluid channel, by testing liquid
Contrast with a kind of standard sample liquid of known-viscosity, to measure its viscosity indirectly, specially measured using graduated scale in same time
The length that interior two kinds of liquid is flowed through in fluid channel, the length flowed through according to standard sample liquid and testing liquid, can be calculated
The viscosity of testing liquid.
In order to achieve the above object, the present invention adopts the following technical scheme that：
The viscosity test micro-fluidic chip of PDMS malleations driving, including micro-fluidic upper chip 1, substrate of glass 11 and PDMS
Malleation drives source of the gas 16；Wherein, micro-fluidic upper chip 1 includes treating that standard inlet 13, prepare liquid inlet 17, titer go out liquid
Mouth 12, prepare liquid liquid outlet 18, air inlet 14, prepare liquid storage microcavity body 8, titer storage microcavity body 3, the storage of prepare liquid waste liquid
Deposit microcavity body 6, titer waste liquid storage microcavity body 5, gas introduces microcavity body 10 and gas introduces fluid channel I 2, titer
Fluid channel 4, prepare liquid fluid channel 7, gas introduce fluid channel II 9, graduated scale I 30, graduated scale II 33；
The titer inlet 13, prepare liquid inlet 17, titer liquid outlet 12, prepare liquid liquid outlet 18 and air inlet
Mouth 14 runs through micro-fluidic upper chip 1；
The titer storage microcavity body 3, prepare liquid storage microcavity body 8, are the circular cavity knot on micro-fluidic upper chip 1
Structure, it is connected with titer inlet 13, prepare liquid inlet 17 respectively, passes through titer fluid channel 4 and prepare liquid respectively
Fluid channel 7 is connected with titer waste liquid storage microcavity body 5 and prepare liquid waste liquid storage microcavity body 6；
The titer waste liquid storage microcavity body 5 and prepare liquid waste liquid storage microcavity body 6, are on micro-fluidic upper chip 1
Circular cavity structure, it is connected with titer liquid outlet 12 and prepare liquid liquid outlet 18 respectively, passes through titer miniflow respectively
Road 4 and prepare liquid fluid channel 7 are connected with titer storage microcavity body 3 and prepare liquid storage microcavity body 8；
The gas introduces microcavity body 10, is the cavity body structure on micro-fluidic upper chip 1, it is connected with air inlet 14
It is logical, fluid channel I 2 is introduced by gas and gas introduces fluid channel II 9 and stores microcavity body 3 and prepare liquid storage with titer respectively
Microcavity body 8 is deposited to be connected；
The titer fluid channel 4 is stored microcavity body 3 by titer and is connected with titer inlet 13, passes through titer
Waste liquid storage microcavity body 5 is connected with titer liquid outlet 12；
The prepare liquid fluid channel 7 is stored microcavity body 8 by prepare liquid and is connected with prepare liquid inlet 17, passes through prepare liquid
Waste liquid storage microcavity body 6 is connected with prepare liquid liquid outlet 18；
The gas introduces fluid channel I 2 and connects titer storage microcavity body 3 and gas introducing microcavity body 10；
The gas introduces fluid channel II 9 and stores microcavity body 8 and gas introducing microcavity body 10 by prepare liquid；
The titer inlet 13 and prepare liquid inlet 17, titer liquid outlet 12 and prepare liquid liquid outlet 18 are with entering
Gas port 14 is circular port；
The graduated scale I 30 is arranged in the micro-fluidic surface of upper chip 1 along prepare liquid fluid channel 7, is stored in prepare liquid waste liquid
Between microcavity body 6 and prepare liquid storage microcavity body 8；
The graduated scale II 33 is arranged in the micro-fluidic surface of upper chip 1 along titer fluid channel 4, is stored in titer micro-
Between cavity 3 and titer waste liquid storage microcavity body 5；
The titer storage microcavity body 3 and prepare liquid storage microcavity body 8, diameter is equal, and value is 300 μm -2000 μm,
Deep equality, value are 20 μm -200 μm；
The titer waste liquid storage microcavity body 5 and prepare liquid waste liquid storage microcavity body 6, diameter is equal, and value is 300 μ
M-2000 μm, deep equality, value is 20 μm -200 μm；
It is 0.5cm-2cm that the gas, which introduces the length value of microcavity body 10, and width value is 0.5cm-1cm, depth value
For 20 μm -200 μm；
The gas introduces fluid channel I 2 and gas introduces fluid channel II 9, and the equal value of two channel depths is equal, value
For 20 μm -200 μm, the equal value of two channel widths is equal, and value is 50 μm -200 μm, and the equal value of two channel lengths is equal,
Value is 0.5cm-2cm；
The titer fluid channel 4 and prepare liquid fluid channel 7, two channel depths are equal, and value is 20 μm -200 μm, two ditches
Road width is equal, and value is 20 μm -200 μm, and the equal value of two channel depths is equal, and value is 50 μm of -200 μm of two channel lengths
Equal value is equal, value 5cm-15cm；
The titer storage microcavity body 3 and prepare liquid storage microcavity body 8, its internal equal liquid filling body, respectively viscosity
Known normal fluid and testing liquid, and full of whole titer storage microcavity body 3 and prepare liquid storage microcavity body 8；
The PDMS malleations drive source of the gas 16, including air-tight bottle 27, inner flow passage 29, PDMS26, sealing-plug with holes 32；
The air-tight bottle 27, volume value are 3ml-15ml；
The inner flow passage 29, is circular flow channel, value 0.3mm-2mm, highly for through PDMS26；
The PDMS malleations driving source of the gas 16 is connected with micro-fluidic chip 1 by sealing flexible pipe 15, and wherein sealing is soft
Pipe caliber value is 0.5mm-2mm.
Micro-fluidic chip operation principle of the present invention based on PDMS malleations driving viscosity test, it is specific as follows such as accompanying drawing 5：
Testing liquid and a kind of normal fluid of known-viscosity are contrasted to measure its viscosity indirectly.By PDMS malleation sources of the gas
Closure 31 is opened, and is connected by sealing flexible pipe 15 with micro-fluidic chip air inlet 14, so as to carry out malleation deflation driving two
The kind liquid flowing in fluid channel respectively, flowed using PDMS malleations driving liquid in fluid channel, by testing liquid and one
The standard sample liquid contrast of kind known-viscosity, to measure its viscosity indirectly, specially using graduated scale measurement two in same time
The length that kind liquid is flowed through in fluid channel, the length flowed through according to standard sample liquid and testing liquid, can be calculated to be measured
The viscosity of liquid.
The present invention can obtain following beneficial effect and feature：
1) reagent consumption is few, small volume, is convenient for carrying, and the testing time is relatively short.
2) cost is low, repeats and utilizes.PDMS is relatively cheap, can be beaten again after the driving source of the gas use of PDMS malleations
Gas is simultaneously encapsulated so that measurement next time uses；
3) easy to use, operation is relatively simple.PDMS is inflated and or so several months can be stored after encapsulation process and is made
Used time only opens air-tight bottle and is directly connected by sealing flexible pipe with micro-fluidic chip.
Brief description of the drawings
Fig. 1：Overall appearance view of the present invention；
Fig. 2：Micro-fluidic chip decomposition view of the present invention；
Fig. 3：The micro-fluidic upper chip outside drawing of the present invention；
Fig. 4：The micro-fluidic upper chip micro-channel structure figure of the present invention；
Fig. 5：Fundamental diagram of the present invention；
Fig. 6：Micro-fluidic upper chip Shooting Technique (one) procedure chart one of the present invention；
Fig. 7：Micro-fluidic upper chip Shooting Technique (one) procedure chart two of the present invention；
Fig. 8：Micro-fluidic upper chip Shooting Technique (one) procedure chart three of the present invention；
Fig. 9：Micro-fluidic upper chip Shooting Technique (one) procedure chart four of the present invention；
Figure 10：Micro-fluidic upper chip Shooting Technique (one) procedure chart five of the present invention；
Figure 11：Micro-fluidic upper chip Shooting Technique (one) procedure chart six of the present invention；
Figure 12：Micro-fluidic upper chip Shooting Technique (one) procedure chart seven of the present invention；
Figure 13：PDMS sources of the gas work sectional view of the present invention；
Figure 14：PDMS sources of the gas of the present invention seal sectional view；
In figure：1. micro-fluidic upper chip, 2. gases introduce fluid channel I, 3. titers storage microcavity body, 4. titer miniflows
Road, 5. titer waste liquids storage microcavity body, 6. prepare liquid waste liquids storage microcavity body, 7. prepare liquid fluid channels, the storage of 8. prepare liquids
Microcavity body, 9. gases introduce fluid channel II, and 10. gases introduce microcavity body, 11. substrate of glass, 12. titer liquid outlets, 13. marks
Quasi- liquid inlet, 14. air inlets, 15. sealing flexible pipes, 16.PDMS sources of the gas, 17. prepare liquid inlets, 18. prepare liquids go out liquid
Mouthful, 19. prepare liquids, 20. titers, 21. silicon chips, 22.SU-8 glue, 23. mask plates, 24.SU-8 sealing rubber dies, 25. rectangular channels
Mould, 26.PDMS, 27. air-tight bottles, 28. cores, 29. microchannels, 30. graduated scale I, 31. closures, 32. sealing-plugs with holes,
33 and graduated scale II.
Embodiment
Viscosity test facture of microchip method of the present invention based on the driving of PDMS malleations, embodiment
Micro-fluidic upper chip 1 in the present invention, formpiston, dimethyl silicone polymer are made using SU-8 types negative photoresist
(PDMS) Shooting Technique processing and fabricating, concrete technology flow process are as follows：
(a) accompanying drawing 6, substrate is used as from silicon chip 21, is cleaned with deionized water, and in the drying glue platform that temperature is 110 DEG C
Upper drying；
(b) accompanying drawing 7, one layer of SU-8 glue 22 of spin coating on silicon chip 21, bondline thickness are 50 μm -250 μm, are entered using hot plate
Row front baking, the first drying time 35min at 65 DEG C of temperature, then at 95 DEG C of temperature drying time 30-90min (with bondline thickness
Correlation, thickness is bigger, and drying time is longer), then natural cooling, solidifies SU-8 glue 22, and described SU-8 glue 22 is negativity
Photoresist；
(c) accompanying drawing 8, mask plate 23 is placed into the surface of SU-8 glue 22 after hardening, carries out ultraviolet exposure, exposure
Time 40s-150s；
(d) accompanying drawing 9, after SU-8 glue 22 exposes, processing is warmed after being carried out on hot plate, elder generation's drying time at 65 DEG C of temperature
25min, then the drying time 10-30min (related to bondline thickness, thickness is bigger, and drying time is longer) at 95 DEG C of temperature, so
Natural cooling afterwards, after ultrasonic development, cleaning, the SU-8 sealing rubber dies 24 of projection are left on silicon chip 21；
(e) accompanying drawing 10-11, the silicon chip 21 with SU-8 sealing rubber dies 24 is placed on and the size identical square of silicon chip 21
In shape groove mould 25, PDMS is poured into a mould, is heating and curing at 120 DEG C of temperature；
(f) accompanying drawing 12, the PDMS after solidification is peeled off from silicon chip 21, obtains micro-fluidic upper chip 1, beaten using ultrasound
Hole method, processed on micro-fluidic on chip 1 titer inlet 13 and prepare liquid inlet 17, titer liquid outlet 12 and
Prepare liquid liquid outlet 18 and air inlet 14.
Above-mentioned carry titer inlet 13, prepare liquid inlet 17, the titer processed of the present invention stores microcavity body
3rd, titer waste liquid storage microcavity body 5, prepare liquid waste liquid storage microcavity body 6, prepare liquid storage microcavity body 8, gas introduce microcavity
Body 10, gas introduce fluid channel I 2, titer fluid channel 4, prepare liquid fluid channel 7, gas and introduce fluid channel II 9, titer
Micro-fluidic upper chip 1, substrate of glass 11, graduated scale I 30, the scale of liquid outlet 12 and prepare liquid liquid outlet 18 and air inlet 14
Chi II 33 is packaged using the method for bonding or bonding, and the viscosity test micro-fluidic chip based on the driving of PDMS malleations is made.
Malleation driving gas source preparation method of the present invention, embodiment
(a) air-tight bottle 27 is cleaned with deionized water, and dried on the drying glue platform that temperature is 110 DEG C；
(b) PDMS26 is poured into air-tight bottle 27, and drying in oven is put into one core 28 of air-tight bottle center insertion, temperature
Spend for 90 DEG C.
(c) core 28 is extracted from PDMS26, forms passage 29, be put into air accumulator and inflated by air compressor, it
After sealed, wait need carry out viscosity measurement when, open closure 31 simultaneously microchannel is connected with sealing flexible pipe 15.
It is above a preferred embodiment of the present invention, but present disclosure is not limited solely to this.
Claims (2)
- A kind of 1. viscosity test micro-fluidic chip based on the driving of PDMS malleations, it is characterised in that：Source of the gas is driven including micro-fluidic upper chip, substrate of glass and PDMS malleations；Wherein, micro-fluidic upper chip includes treating that standard is entered Liquid mouth, prepare liquid inlet, titer liquid outlet, prepare liquid liquid outlet, air inlet, prepare liquid storage microcavity body, titer storage Deposit microcavity body, prepare liquid waste liquid storage microcavity body, titer waste liquid storage microcavity body, gas and introduce microcavity body and gas introducing Fluid channel I, titer fluid channel, prepare liquid fluid channel, gas introduce fluid channel II, graduated scale I, graduated scale II；The titer inlet, prepare liquid inlet, titer liquid outlet, prepare liquid liquid outlet and air inlet are through micro-fluidic Upper chip；Titer storage microcavity body, prepare liquid storage microcavity body, its respectively with titer inlet, prepare liquid inlet phase Connection, microcavity body and the storage of prepare liquid waste liquid are stored with titer waste liquid by titer fluid channel and prepare liquid fluid channel respectively Microcavity body phase connects；Titer waste liquid storage microcavity body and prepare liquid waste liquid storage microcavity body, its respectively with titer liquid outlet and to be measured Liquid liquid outlet is connected, and stores microcavity body and prepare liquid storage with titer by titer fluid channel and prepare liquid fluid channel respectively Deposit the connection of microcavity body phase；The gas introduces microcavity body, is the cavity body structure on micro-fluidic upper chip, it is connected with air inlet, passes through gas Introduce fluid channel I and gas introduces fluid channel II and connected respectively with titer storage microcavity body and prepare liquid storage microcavity body phase；The titer fluid channel is stored microcavity body by titer and is connected with titer inlet, is stored by titer waste liquid Microcavity body is connected with titer liquid outlet；The prepare liquid fluid channel is stored microcavity body by prepare liquid and is connected with prepare liquid inlet, is stored by prepare liquid waste liquid Microcavity body is connected with prepare liquid liquid outlet；The gas introduces fluid channel I connections titer storage microcavity body and introduces microcavity body with gas；The gas introduces fluid channel II and stores microcavity body and gas introducing microcavity body by prepare liquid；The graduated scale I is arranged in micro-fluidic upper chip surface along prepare liquid fluid channel, prepare liquid waste liquid store microcavity body and Between prepare liquid storage microcavity body；The graduated scale II is arranged in micro-fluidic upper chip surface along titer fluid channel, and microcavity body and standard are stored in titer Between liquid waste liquid storage microcavity body；The titer storage microcavity body and prepare liquid storage microcavity body, diameter is equal, and value is 300 μm -2000 μm, depth phase It it is 20 μm -200 μm Deng, value；Titer waste liquid storage microcavity body and prepare liquid waste liquid the storage microcavity body, diameter is equal, and value is 300 μm of -2000 μ M, deep equality, value are 20 μm -200 μm；It is 0.5cm-2cm that the gas, which introduces microcavity body length value, and width value is 0.5cm-1cm, depth value for 20 μm- 200μm；The gas introduces fluid channel I and gas introduces fluid channel II, and two channel depths are equal, and value is 20 μm -200 μm, and two Channel width is equal, and value is 50 μm -200 μm, and two channel lengths are equal, value 0.5cm-2cm；The titer fluid channel and prepare liquid fluid channel, two channel depths are equal, and value is 20 μm -200 μm, two channel widths Equal, value is 20 μm -200 μm, and two channel depths are equal, and value is that 50 μm of -200 μm of two channel lengths are equal, and value is 5cm-15cm；The titer storage microcavity body and prepare liquid storage microcavity body, its internal equal liquid filling body, respectively known to viscosity Normal fluid and testing liquid, and full of whole titer storage microcavity body and prepare liquid storage microcavity body；The PDMS malleations drive source of the gas, including air-tight bottle, inner flow passage, PDMS and sealing-plug with holes；The PDMS malleations driving source of the gas is connected with micro-fluidic chip by sealing flexible pipe.
- 2. the method for application chip as claimed in claim 1, it is characterised in that：PDMS malleation sources of the gas closure is opened, is connected by sealing flexible pipe with micro-fluidic chip air inlet, so as to carry out just Press gas drive and move the flowing in fluid channel respectively of two kinds of liquid, flowed using PDMS malleations driving liquid in fluid channel, will The standard sample liquid of testing liquid and a kind of known-viscosity contrasts, using graduated scale measurement in same time two kinds of liquid in miniflow The length flowed through in road, the length flowed through according to standard sample liquid and testing liquid, calculate the viscosity of testing liquid.
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| CN113324875A (en) * | 2021-05-14 | 2021-08-31 | 大连海事大学 | Photoresist type liquid viscosity measuring device |
| CN115436227A (en) * | 2022-10-11 | 2022-12-06 | 山东大学 | Micro-fluidic chip and method suitable for measuring viscosity of micro-upgrading liquid sample |
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| CN110496657A (en) * | 2019-09-11 | 2019-11-26 | 苏州大学 | A kind of micro-fluidic chip and preparation method thereof forming liquid metal droplet |
| CN110496657B (en) * | 2019-09-11 | 2022-04-22 | 苏州大学 | Microfluidic chip capable of forming liquid metal droplets and preparation method thereof |
| CN113324875A (en) * | 2021-05-14 | 2021-08-31 | 大连海事大学 | Photoresist type liquid viscosity measuring device |
| CN113324875B (en) * | 2021-05-14 | 2023-02-28 | 大连海事大学 | Photoresist type liquid viscosity measuring device |
| CN115436227A (en) * | 2022-10-11 | 2022-12-06 | 山东大学 | Micro-fluidic chip and method suitable for measuring viscosity of micro-upgrading liquid sample |
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