CN107737616B - A kind of viscosity test micro-fluidic chip and production method based on the driving of PDMS positive pressure - Google Patents
A kind of viscosity test micro-fluidic chip and production method based on the driving of PDMS positive pressure Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
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Abstract
It is a kind of based on PDMS positive pressure driving viscosity test micro-fluidic chip and production method belong to micro-fluidic field.The present invention compares testing liquid and a kind of normal fluid of known-viscosity to measure its viscosity indirectly.PDMS positive pressure gas source is connected by leakproofness hose with micro-fluidic chip air inlet, to carry out positive pressure deflation driving two kinds of liquid flowing in fluid channel respectively, it is flowed in fluid channel using PDMS positive pressure driving liquid, the standard sample liquid of testing liquid and known-viscosity is compared, to measure its viscosity indirectly, specially utilize the graduated scale measurement length that two kinds of liquid is flowed through in fluid channel in the same time, according to the length that standard sample liquid and testing liquid flow through, the viscosity of testing liquid is calculated.Reagent consumption of the present invention is few, small in size, is convenient for carrying, and the testing time is relatively short.It is at low cost, it is reusable.PDMS is relatively cheap, can be inflated and be encapsulated again after the driving gas source use of PDMS positive pressure so that measurement next time uses.
Description
Technical field
The present invention relates to a kind of micro-fluidic chips and production method for viscosity test, and in particular to a kind of to utilize PDMS
Molten gas characteristic realizes the viscosity test micro-fluidic chip of positive pressure driving, belongs to microfluidic art.
Background technique
Viscosity is the ability for indicating fluid flowing or with flow tendency when and resisting its irreversible transformation, is measured in fluid
One physical quantity of portion's flow resistance size.Monitoring to viscosity is essential in many basic industries researchs and medicine
One work.
In food and drug manufacturing, the measurement to viscosity is the key factor examined the quality of the production.In medical diagnosis
Aspect, abnormal plasma viscosity are often related with the diseases such as diabetes, hypertension.The viscosity of other body fluid, such as synovial fluid and urine
It is also the factor of the certain diseases of prediction.
The method of measurement fluid viscosity mainly has rotary process, vibratory drilling method and falling ball method etc. at present.With these viscosimeters into
It needs to consume a large amount of reagent when row viscosity measurement, the testing time is also relatively long.And required hardware device is more, structure
Complexity, it is expensive.Often equipment is also huger for the higher viscosimeter of precision, operates also more complicated.For these problems country
Outer many scholars study, and propose some viscosity determining procedures based on microflow control technique.Such as: Zuoyan Han et al.
A kind of negative pressure driving viscosity test micro-fluidic chip (A PDMS based on the molten gas characteristic of PDMS was devised in 2007
viscometer for microliter Newtonian fluid[J].Journal of Micromechanics&
Microengineering,2007,17(9):1828.).X Tang et al. has advanced optimized negative pressure driving viscosity in 2011
Measure micro-fluidic chip (A PDMS viscometer for assaying endoglucanase activity. [J]
.Analyst,2011,136(6):1222.).However this device has more harsh requirement to the time of test, needs PDMS
Negative pressure driving source is tested immediately after being ready to, and there is the disadvantages of being stored inconveniently, driving force is small.
Summary of the invention
It is an object of the invention to using micro-fluidic chip reagent consumption is small, the testing time is short, small in size and operation
The advantages that simple.Micro-fluidic chip and PDMS positive pressure driving gas source are combined, proposed a kind of based on the driving of PDMS positive pressure
Viscosity test micro-fluidic chip.Its working principle is that: it is flowed in fluid channel using PDMS positive pressure driving liquid, by testing liquid
It compares with a kind of standard sample liquid of known-viscosity, to measure its viscosity indirectly, is specially measured using graduated scale in same time
The length that interior two kinds of liquid is flowed through in fluid channel can be calculated according to the length that standard sample liquid and testing liquid flow through
The viscosity of testing liquid.
In order to achieve the above object, the present invention adopts the following technical scheme:
The viscosity test micro-fluidic chip of PDMS positive pressure driving, including micro-fluidic upper chip 1, substrate of glass 11 and PDMS are just
Pressure driving gas source 16；Wherein, micro-fluidic upper chip 1 includes to standard inlet 13, prepare liquid inlet 17, titer liquid outlet
12, prepare liquid liquid outlet 18, air inlet 14, prepare liquid storage microcavity body 8, titer storage microcavity body 3, the storage of prepare liquid waste liquid
Microcavity body 6, titer waste liquid storage microcavity body 5, gas introduce microcavity body 10 and gas introducing fluid channel I 2, titer are micro-
Runner 4, prepare liquid fluid channel 7, gas introduce fluid channel II 9, graduated scale I 30, graduated scale II 33；
The titer inlet 13, prepare liquid inlet 17, titer liquid outlet 12, prepare liquid liquid outlet 18 and air inlet
Mouth 14 runs through micro-fluidic upper chip 1；
The titer storage microcavity body 3, prepare liquid stores microcavity body 8, is the circular cavity knot on micro-fluidic upper chip 1
Structure is connected with titer inlet 13, prepare liquid inlet 17 respectively, passes through titer fluid channel 4 and prepare liquid respectively
Fluid channel 7 stores microcavity body 5 with titer waste liquid and prepare liquid waste liquid storage microcavity body 6 is connected；
The titer waste liquid storage microcavity body 5 and prepare liquid waste liquid store microcavity body 6, are on micro-fluidic upper chip 1
Circular cavity structure is connected with titer liquid outlet 12 and prepare liquid liquid outlet 18 respectively, passes through titer miniflow respectively
Road 4 and prepare liquid fluid channel 7 are connected with titer storage microcavity body 3 and prepare liquid storage microcavity body 8；
The gas introduces microcavity body 10, is the cavity body structure on micro-fluidic upper chip 1, is connected with air inlet 14
It is logical, fluid channel I 2 is introduced by gas and gas introduces fluid channel II 9 and stores microcavity body 3 and prepare liquid storage with titer respectively
Microcavity body 8 is deposited to be connected；
The titer fluid channel 4 stores microcavity body 3 by titer and is connected with titer inlet 13, passes through titer
Waste liquid storage microcavity body 5 is connected with titer liquid outlet 12；
The prepare liquid fluid channel 7 stores microcavity body 8 by prepare liquid and is connected with prepare liquid inlet 17, passes through prepare liquid
Waste liquid storage microcavity body 6 is connected with prepare liquid liquid outlet 18；
The gas introduces the connection titer of fluid channel I 2 storage microcavity body 3 and gas introduces microcavity body 10；
The gas introduces fluid channel II 9 and stores microcavity body 8 and gas introducing microcavity body 10 by prepare liquid；
The titer inlet 13 and prepare liquid inlet 17, titer liquid outlet 12 and prepare liquid liquid outlet 18 with into
Port 14 is round hole；
The graduated scale I 30 is arranged in micro-fluidic 1 surface of upper chip along prepare liquid fluid channel 7, stores in prepare liquid waste liquid
Between microcavity body 6 and prepare liquid storage microcavity body 8；
The graduated scale II 33 is arranged in micro-fluidic 1 surface of upper chip along titer fluid channel 4, stores in titer micro-
Between cavity 3 and titer waste liquid storage microcavity body 5；
The titer storage microcavity body 3 and prepare liquid store microcavity body 8, and diameter is equal, and value is 300 μm -2000 μm,
Deep equality, value are 20 μm -200 μm；
The titer waste liquid storage microcavity body 5 and prepare liquid waste liquid store microcavity body 6, and diameter is equal, and value is 300 μ
M-2000 μm, deep equality, value is 20 μm -200 μm；
It is 0.5cm-2cm that the gas, which introduces 10 length value of microcavity body, and width value is 0.5cm-1cm, depth value
It is 20 μm -200 μm；
The gas introduces fluid channel I 2 and gas introduces fluid channel II 9, and the equal value of two channel depths is equal, value
It is 20 μm -200 μm, the equal value of two channel widths is equal, and value is 50 μm -200 μm, and the equal value of two channel lengths is equal,
Value is 0.5cm-2cm；
The titer fluid channel 4 and prepare liquid fluid channel 7, two channel depths are equal, and value is 20 μm -200 μm, two ditches
Road width is equal, and value is 20 μm -200 μm, and the equal value of two channel lengths is equal, value 5cm-15cm；
Titer storage microcavity body 3 and prepare liquid store microcavity body 8, inside fill liquid, respectively viscosity
Known normal fluid and testing liquid, and microcavity body 8 is stored full of entire titer storage microcavity body 3 and prepare liquid；
The PDMS positive pressure drives gas source 16, including air-tight bottle 27, inner flow passage 29, PDMS26, sealing-plug with holes 32；
The air-tight bottle 27, volume value are 3ml-15ml；
The inner flow passage 29 is circular flow channel, value 0.3mm-2mm, highly for through PDMS26；
The PDMS positive pressure driving gas source 16 is connected with micro-fluidic chip 1 by leakproofness hose 15, and wherein leakproofness is soft
Pipe caliber value is 0.5mm-2mm.
It is specific as follows such as attached drawing 5 the present invention is based on the micro-fluidic chip working principle of PDMS positive pressure driving viscosity test:
Testing liquid and a kind of normal fluid of known-viscosity are compared to measure its viscosity indirectly.By PDMS positive pressure gas source
Sealing cover 31 is opened, and is connected by leakproofness hose 15 with micro-fluidic chip air inlet 14, drives two to carry out positive pressure and deflate
The kind liquid flowing in fluid channel respectively is flowed using PDMS positive pressure driving liquid in fluid channel, by testing liquid and one
The standard sample liquid comparison of kind of known-viscosity specially utilizes graduated scale measurement in the same time two to measure its viscosity indirectly
The length that kind liquid is flowed through in fluid channel can calculate to be measured according to the length that standard sample liquid and testing liquid flow through
The viscosity of liquid.
The present invention can obtain following beneficial effect and feature:
1) reagent consumption is few, small in size, is convenient for carrying, and the testing time is relatively short.
2) at low cost, it is reusable.PDMS is relatively cheap, can be beaten again after the driving gas source use of PDMS positive pressure
Gas simultaneously encapsulates so that measurement next time uses；
3) easy to use, it operates relatively simple.It is inflated to PDMS and or so several months can be stored after encapsulation process and made
Used time only opens air-tight bottle and directly passes through leakproofness hose to be connected with micro-fluidic chip.
Detailed description of the invention
Fig. 1: overall appearance view of the present invention；
Fig. 2: micro-fluidic chip decomposition view of the present invention；
Fig. 3: the micro-fluidic upper chip outside drawing of the present invention；
Fig. 4: the micro-fluidic upper chip micro-channel structure figure of the present invention；
Fig. 5: working principle diagram of the present invention；
Fig. 6: micro-fluidic upper chip Shooting Technique (one) procedure chart one of the present invention；
Fig. 7: micro-fluidic upper chip Shooting Technique (one) procedure chart two of the present invention；
Fig. 8: micro-fluidic upper chip Shooting Technique (one) procedure chart three of the present invention；
Fig. 9: micro-fluidic upper chip Shooting Technique (one) procedure chart four of the present invention；
Figure 10: micro-fluidic upper chip Shooting Technique (one) procedure chart five of the present invention；
Figure 11: micro-fluidic upper chip Shooting Technique (one) procedure chart six of the present invention；
Figure 12: micro-fluidic upper chip Shooting Technique (one) procedure chart seven of the present invention；
Figure 13: PDMS gas source work cross-sectional view of the present invention；
Figure 14: PDMS gas source of the present invention seals cross-sectional view；
In figure: 1. micro-fluidic upper chips, 2. gases introduce fluid channel I, and 3. titers store microcavity body, 4. titer miniflows
Road, 5. titer waste liquids store microcavity body, and 6. prepare liquid waste liquids store microcavity body, 7. prepare liquid fluid channels, the storage of 8. prepare liquids
Microcavity body, 9. gases introduce fluid channel II, and 10. gases introduce microcavity body, 11. substrate of glass, 12. titer liquid outlets, 13. marks
Quasi- liquid inlet, 14. air inlets, 15. leakproofness hoses, 16.PDMS gas source, 17. prepare liquid inlets, 18. prepare liquids go out liquid
Mouthful, 19. titers, 20. prepare liquids, 21. silicon chips, 22.SU-8 glue, 23. mask plates, 24.SU-8 sealing rubber die, 25. rectangular channels
Mold, 26.PDMS, 27. air-tight bottles, 28. core models, 29. microchannels, 30. graduated scale I, 31. sealing covers, 32. sealing-plugs with holes,
33. graduated scale II.
Specific embodiment
The present invention is based on the viscosity test facture of microchip method of PDMS positive pressure driving, embodiments
Micro-fluidic upper chip 1 in the present invention makes formpiston, dimethyl silicone polymer using SU-8 type negative photoresist
(PDMS) Shooting Technique processing and fabricating, concrete technology flow process are as follows:
(a) attached drawing 6 are selected silicon chip 21 to be used as substrate, are cleaned with deionized water, and the drying glue platform for being 110 DEG C in temperature
Upper drying；
(b) attached drawing 7, one layer of SU-8 glue 22 of spin coating on silicon chip 21, bondline thickness be 50 μm -250 μm, using hot plate into
Row front baking, first at 65 DEG C of temperature drying time 35min, then at 95 DEG C of temperature drying time 30-90min (with bondline thickness
Correlation, thickness is bigger, and drying time is longer), then natural cooling, solidifies SU-8 glue 22, and the SU-8 glue 22 is negativity light
Photoresist；
(c) mask plate 23 is placed 22 surface of SU-8 glue after hardening, carries out ultraviolet exposure, exposure by attached drawing 8
Time 40s-150s；
(d) processing after SU-8 glue 22 exposes, is warmed, first the drying time at 65 DEG C of temperature in attached drawing 9 after carrying out on hot plate
25min, then drying time 10-30min (related to bondline thickness, thickness is bigger, and drying time is longer) at 95 DEG C of temperature, so
Natural cooling afterwards leaves the SU-8 sealing rubber die 24 of protrusion after ultrasonic development, cleaning on silicon chip 21；
(e) silicon chip 21 with SU-8 sealing rubber die 24 is placed on square identical with 21 size of silicon chip by attached drawing 10-11
In shape groove mould 25, it is poured PDMS, is heating and curing at 120 DEG C of temperature；
(f) attached drawing 12 remove the PDMS after solidification from silicon chip 21, obtain micro-fluidic upper chip 1, are beaten using ultrasound
Hole method, processed on micro-fluidic upper chip 1 titer inlet 13 and prepare liquid inlet 17, titer liquid outlet 12 and
Prepare liquid liquid outlet 18 and air inlet 14.
Above-mentioned have titer inlet 13, prepare liquid inlet 17, the titer processed of the present invention stores microcavity body
3, titer waste liquid storage microcavity body 5, prepare liquid waste liquid storage microcavity body 6, prepare liquid storage microcavity body 8, gas introduce microcavity
Body 10, gas introduce fluid channel I 2, titer fluid channel 4, prepare liquid fluid channel 7, gas and introduce fluid channel II 9, titer
The micro-fluidic upper chip 1 of liquid outlet 12 and prepare liquid liquid outlet 18 and air inlet 14, substrate of glass 11, graduated scale I 30, scale
Ruler II 33 is packaged using the method for bonding or bonding, and the viscosity test micro-fluidic chip based on the driving of PDMS positive pressure is made.
Positive pressure of the present invention drives gas source production method, embodiment
(a) air-tight bottle 27 is cleaned with deionized water, and is dried on the drying glue platform that temperature is 110 DEG C；
(b) PDMS26 is poured into air-tight bottle 27, and is inserted into a core model 28 in air-tight bottle center and is put into drying in oven, temperature
Degree is 90 DEG C.
(c) core model 28 is extracted from PDMS26, forms channel 29, be put into air accumulator and inflated by air compressor, it
After be sealed, when needing to carry out viscosity measurement, open sealing cover 31 simultaneously microchannel is connected with leakproofness hose 15.
The above are a preferred embodiment of the present invention, but the contents of the present invention are not limited solely to this.
Claims (2)
1. a kind of viscosity test micro-fluidic chip based on the driving of PDMS positive pressure, it is characterised in that:
Gas source is driven including micro-fluidic upper chip, substrate of glass and PDMS positive pressure；Wherein, micro-fluidic upper chip include to standard into
Liquid mouth, prepare liquid inlet, titer liquid outlet, prepare liquid liquid outlet, air inlet, prepare liquid storage microcavity body, titer storage
It deposits microcavity body, prepare liquid waste liquid storage microcavity body, titer waste liquid storage microcavity body, gas and introduces microcavity body and gas introducing
Fluid channel I, titer fluid channel, prepare liquid fluid channel, gas introduce fluid channel II, graduated scale I, graduated scale II；
The titer inlet, prepare liquid inlet, titer liquid outlet, prepare liquid liquid outlet and air inlet are through micro-fluidic
Upper chip；
Titer storage microcavity body, prepare liquid store microcavity body, respectively with titer inlet, prepare liquid inlet phase
Connection stores microcavity body by titer fluid channel and prepare liquid fluid channel and titer waste liquid respectively and prepare liquid waste liquid is stored
Microcavity body is connected；
Titer waste liquid storage microcavity body and prepare liquid waste liquid store microcavity body, respectively with titer liquid outlet and to be measured
Liquid liquid outlet is connected, and stores microcavity body by titer fluid channel and prepare liquid fluid channel and titer respectively and prepare liquid is store
Microcavity body is deposited to be connected；
The gas introduces microcavity body, is the cavity body structure on micro-fluidic upper chip, is connected with air inlet, passes through gas
It introduces fluid channel I and gas introduces fluid channel II and is connected respectively with titer storage microcavity body and prepare liquid storage microcavity body；
The titer fluid channel stores microcavity body by titer and is connected with titer inlet, is stored by titer waste liquid
Microcavity body is connected with titer liquid outlet；
The prepare liquid fluid channel stores microcavity body by prepare liquid and is connected with prepare liquid inlet, is stored by prepare liquid waste liquid
Microcavity body is connected with prepare liquid liquid outlet；
The gas introduces fluid channel I connection titer storage microcavity body and gas introduces microcavity body；
The gas introduces fluid channel II and stores microcavity body and gas introducing microcavity body by prepare liquid；
The graduated scale I is arranged in micro-fluidic upper chip surface along prepare liquid fluid channel, prepare liquid waste liquid store microcavity body and
Prepare liquid is stored between microcavity body；
The graduated scale II is arranged in micro-fluidic upper chip surface along titer fluid channel, stores microcavity body and standard in titer
Liquid waste liquid is stored between microcavity body；
The titer storage microcavity body and prepare liquid store microcavity body, and diameter is equal, and value is 300 μm -2000 μm, depth phase
It is 20 μm -200 μm Deng, value；
The titer waste liquid storage microcavity body and prepare liquid waste liquid store microcavity body, and diameter is equal, and value is 300 μm of -2000 μ
M, deep equality, value are 20 μm -200 μm；
It is 0.5cm-2cm that the gas, which introduces microcavity body length value, and width value is 0.5cm-1cm, depth value is 20 μm-
200μm；
The gas introduces fluid channel I and gas introduces fluid channel II, and two channel depths are equal, and value is 20 μm -200 μm, and two
Channel width is equal, and value is 50 μm -200 μm, and two channel lengths are equal, value 0.5cm-2cm；
The titer fluid channel and prepare liquid fluid channel, two channel depths are equal, and value is 20 μm -200 μm, two channel widths
Equal, value is 20 μm -200 μm, and two channel lengths are equal, value 5cm-15cm；
Titer storage microcavity body and prepare liquid store microcavity body, inside fill liquid, respectively known to viscosity
Normal fluid and testing liquid, and microcavity body is stored full of entire titer storage microcavity body and prepare liquid；
The PDMS positive pressure drives gas source, including air-tight bottle, inner flow passage, PDMS and sealing-plug with holes；
The PDMS positive pressure driving gas source is connected with micro-fluidic chip by leakproofness hose.
2. the method for application chip as described in claim 1, it is characterised in that:
PDMS positive pressure gas source sealing cover is opened, is connected by leakproofness hose with micro-fluidic chip air inlet, to carry out just
It presses gas drive and moves the flowing in fluid channel respectively of two kinds of liquid, flowed in fluid channel using PDMS positive pressure driving liquid, it will
The standard sample liquid of testing liquid and a kind of known-viscosity compares, using graduated scale measurement in the same time two kinds of liquid in miniflow
The length flowed through in road calculates the viscosity of testing liquid according to the length that standard sample liquid and testing liquid flow through.
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| CN110496657B (en) * | 2019-09-11 | 2022-04-22 | 苏州大学 | Microfluidic chip capable of forming liquid metal droplets and preparation method thereof |
| CN113324875B (en) * | 2021-05-14 | 2023-02-28 | 大连海事大学 | Photoresist type liquid viscosity measuring device |
| CN115436227A (en) * | 2022-10-11 | 2022-12-06 | 山东大学 | Micro-fluidic chip and method suitable for measuring viscosity of micro-upgrading liquid sample |
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