CN108507910A - A kind of microfluidic chip devices of detection Atmospheric particulates - Google Patents
A kind of microfluidic chip devices of detection Atmospheric particulates Download PDFInfo
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- CN108507910A CN108507910A CN201810218637.6A CN201810218637A CN108507910A CN 108507910 A CN108507910 A CN 108507910A CN 201810218637 A CN201810218637 A CN 201810218637A CN 108507910 A CN108507910 A CN 108507910A
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- 238000001514 detection method Methods 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 45
- 239000002245 particle Substances 0.000 claims abstract description 18
- 238000005259 measurement Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 23
- 230000008569 process Effects 0.000 claims description 12
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000010586 diagram Methods 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 4
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 4
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 230000002572 peristaltic effect Effects 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 229920001486 SU-8 photoresist Polymers 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000001259 photo etching Methods 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 239000013618 particulate matter Substances 0.000 abstract description 12
- 230000005540 biological transmission Effects 0.000 abstract description 3
- 239000003792 electrolyte Substances 0.000 abstract description 2
- 239000008151 electrolyte solution Substances 0.000 abstract description 2
- 239000011859 microparticle Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 238000005070 sampling Methods 0.000 description 5
- 230000008859 change Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008277 atmospheric particulate matter Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1029—Particle size
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Abstract
The invention discloses a kind of methods measuring Atmospheric particulates by micro-fluidic chip based on electrical sensing zone method, entitled " a kind of microfluidic chip devices of detection Atmospheric particulates ", collected Atmospheric particulates are put into electrolyte solution, since Atmospheric particulates replace the electrolyte of same volume, cause the increase of resistance in hole, measure the current signal of particulate matter via in real time using constant voltage circuit, obtained number of pulses corresponds to the number and size of particulate matter with amplitude respectively.There is quantitative relationships between the resistance pulse signal and the size of particulate matter.The present invention is based on micro-fluidic chips therefore can realize portable, online, real-time, quantitative, continuous measure；High certainty of measurement, background noise are small；Micro runner device is portable, of low cost；Equipped with wireless launcher, data transmission is easier；It can obtain the geometric topology information of particle.
Description
Technical field
The present invention relates to a kind of methods measuring Atmospheric particulates by micro-fluidic chip based on electrical sensing zone, more particularly to
It is a kind of based on electrical sensing zone can realize it is portable, online, real-time, quantitative, continuous measure Atmospheric Grains grain size, quantity device
And method, belong to environmental protection, chemical, biological medicine, medical instruments field.
Background technology
Expanding economy brings the raising of living standards of the people, and strong promotes the development of society, but passes through simultaneously
The problems such as Ji development also brings increasing environmental pollution.Especially Atmospheric Particulate Matter has seriously threatened the strong of the mankind
Health.Atmospheric particulates are the general names of various solid-states present in air and liquid particles shape substance, and particle size range is about 0.1-
100 microns, the methods for detecting Atmospheric particulates at present are more, and the equipment of independent detection is also more, generally for air
Grain object carries out analysis and needs to detect the ingredient type and its quality of certain elements present in particulate matter gross mass and particulate matter.
Detection gimmick is detected using independent equipment used at present, not only with high costs, while operating also inconvenience, more
Add and is difficult to realize portable on-line continuous detection.
A kind of existing method proposes a kind of method by measuring the non-quantitative measurment Atmospheric particulates of resistance variations, claims
For electrical sensing zone counting method.Its main technical procedures is：Collected Atmospheric particulates are put into electrolyte solution, particle is worked as
Object when micro-fluidic chip detection hole by, since Atmospheric particulates replace the electrolyte of same volume, causing the increasing of resistance in hole
Add, measures the current signal of particulate matter via in real time using constant voltage circuit, obtained number of pulses and amplitude corresponding respectively
The number and size of grain object.There is following quantitative relationships between the resistance pulse signal and the size of particulate matter:
（1）
Wherein:ρ e are the conductivity of conducting liquid；D is the nominal size of particulate matter；D is the diameter of aperture.It can be according to formula (1)
It can get the size of microparticle by the resistance change measured.In general, using the measurable microparticle size of the method in 1-
In 1000 micron ranges, therefore measurement scale is a micron order of magnitude.(the Atmospheric particulates in the case where granule density is relatively low
Detection process meets this condition), a resistance pulse signal can be generated when flowing through aperture due to each microparticle,
The method also has recorded the quantity information of particulate matter, in other words, can measure the concentration of particulate matter in the solution.Therefore electrical sensing zone
Method is a kind of method of the size and concentration of particulate matter in quantitative measurment conducting liquid.
According in patent background technology of the present invention to described in the prior art, in the prior art, carry out Atmospheric particulates into
When row detection, generally requires two kinds of independent equipment and be detected, it is cumbersome there are of high cost；And it is provided by the invention
Atmospheric particulates detection device carries out the integration of multiple functions, simplifies operation invention content to reduce cost.
Invention content
The purpose of the present invention is in view of the drawbacks of the prior art, provide it is a kind of detection particulate in air concentration device and
Method is based on electrical sensing zone method principle, can quantify the size and concentration of the particulate matter in detection liquid, to meet in air
The demand of grain analyte detection.Method proposed by the present invention mainly utilizes electrical sensing zone method principle.
To achieve the above object, the present invention provides a kind of micro-fluidic chip dresses using the detection of electrical sensing zone method principle
It sets, the schematic diagram of micro-structure is as shown in Figure 1, realize the system of micro-structure using the photoetching process of standard in micro flow control chip device
Make, described device includes：
1, silicon chip is base material, and SU-8 photoresists, exposure, development make pipe mould；
2, by PDMS, curing agent with 20:1 mass ratio mixing, is cast on pipe mould after bubble removing, and 90 DEG C are heating and curing 1
Hour, make pipeline micro-structure；
3, the PDMS on mold is removed, entrance and exit duct and two ducts for being inserted into electrode are got with perforating needle.
4, the strong conjunction of adherend and microscopic slide that will accomplish fluently duct, completes the making of micro-fluidic chip chip.
5, PM2.5 particles are dissolved in conducting liquid injection micro flow control chip device；
6, pump is connected with the micro-fluidic chip channel.
Further, further include automatic injection pump, conducting liquid is injected into the mixing chamber.
Further, the micro-fluidic chip intermediate channel width is 30 μm.
Further, the pump is peristaltic pump or vacuum pump.
Technical method of the method proposed by the present invention based on electrical sensing zone method principle is also referred to as electrical pulse method or electric induction
Technology mainly measures particle size and quantity with conducting liquid using microparticle by the pulse signal formed when electrical sensing zone
（Or frequency）.There are particles in conduction liquid, when particle passes through aperture, due to the conductivity difference between particle and conduction liquid,
The voltage between electrode can be caused to change a lot, form pulse signal, which can reflect the size and number of particle.
Since micro runner device electrical sensing zone aperture is 30 μm, the particle in aperture 1/50 can be accurately measured, so measuring airborne particulate
Object can have degree of precision.
The present invention is built upon on electrical sensing zone method principle art, is completed in conjunction with microchannel technology, is had following excellent
Gesture：
（1）It is portable, online, real-time, quantitative, continuous to measure；
（2）High certainty of measurement, background noise are small；
（3）Micro runner device is portable, of low cost；
（4）Equipped with wireless launcher, data transmission is easier.
（5）It can obtain the geometric topology information of particle
Description of the drawings
Fig. 1 is micro fluidic device structural schematic diagram proposed by the present invention.
Fig. 2 is a kind of flow chart for the method detecting air particle using electrical sensing zone method of the present invention
Specific implementation mode
Below by drawings and examples, technical scheme of the present invention will be described in further detail.
For this purpose, following condition should be met in measurement process where the present invention:
, measure sampling process must be real-time, continuous, i.e., be compatible with process:
, must make measurement liquid after taking certain measure have comparable conductivity:
Fig. 1 is the schematic diagram of present invention microparticle detection device compatible with process, as shown, the present invention specifically includes:Sample introduction
First 8, injection port 1, outlet 2, first electrode 3, second electrode 4, first passage 6, second channel 5, cylindrical measuring holes 7
With wireless receiving module 9.
In measurement process, testing liquid pumping system is opened, conducting liquid is opened and system is added, opening resistor signal is surveyed
Amount system, you can realize the online, real-time, continuous of microparticle, quantitative measurment in testing liquid.
Fig. 2 is a kind of flow chart for the method detecting air particle using electrical sensing zone method of the present invention, as shown, this
Invention specifically comprises the following steps：
Step 101, sampling head is placed in region to be measured, the shape of sampling head inlet is toroidal, collects testing liquid；
Step 102, the other end of sampling head is connect by pipeline with cylindrical measuring holes；First duct and cylindrical measured hole
Road is connected, and the first hole trace interpolation enters first electrode；
Specifically, this step is optional step can omit the step if testing liquid conductivity is sufficiently high；Such as testing liquid electricity
Conductance is relatively low, be not enough to obtain measure resistance pulse signal, then use automatic injection pump by conducting liquid in real time, be continuously injected into
It is sufficiently mixed into the mixing chamber in step, and by convection mechanism and the testing liquid containing microparticle, so that liquid has
There is uniform conductivity value.
Step 103, the input end of cylindrical measuring holes connects airflow line, and airflow line connects peristaltic pump or vacuum
Pump；
Step 104, the second duct is connected with cylindrical measuring holes, second electrode is put in the second duct, in first electrode
Alternating current is passed through between second electrode.
An airflow line is connected on the sealing plug on the open end of test tube specifically, measuring, and is arranged on a passage compacted
Dynamic pump or vacuum pump or other liquid pumping devices, to realize the purpose of continuous sampling.Rest part is according to electrical sensing zone method meter
Number principle is realized and completes measurement process.
Therefore, present invention microparticle detection device compatible with process and method have the following advantages that：
（1）It is portable, online, real-time, quantitative, continuous to measure；
（2）High certainty of measurement, background noise are small；
（3）Micro runner device is portable, of low cost；
（4）Equipped with wireless launcher, data transmission is easier；
（5）It can obtain the geometric topology information of particle.
Claims (11)
1. a kind of microfluidic chip devices of detection Atmospheric particulates, which is characterized in that described device includes:Purpose is for existing
The defect for having technology provides a kind of device and method of detection atmosphere particle concentration, is based on electrical sensing zone method, can quantify and detect
The size and concentration of Atmospheric particulates in liquid, to meet the needs of being detected to Atmospheric Grains, side proposed by the present invention
Method mainly utilizes electrical sensing zone method.
2. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, it is characterised in that
Including microfluidic device, the schematic diagram of micro-structure is as shown in Figure 1, the photoetching process using standard realizes micro- knot in microfluidic device
The making of structure, described device include：
S1, silicon chip are base material, and SU-8 photoresists, exposure, development make pipe mould；
S2, by PDMS, curing agent with 20:1 mass ratio mixing, is cast on pipe mould after bubble removing, and 90 DEG C are heating and curing 1
Hour, make pipeline micro-structure；
PDMS on S3, stripping mold gets entrance and exit duct and two holes for being inserted into platinum electrode with perforating needle
Road；
S4, the strong conjunction of adherend and microscopic slide that will accomplish fluently duct, complete the making of micro-fluid chip；
S5, PM2.5 particle are dissolved in conducting liquid injection microfluidic device；
S6, pump are connected with the microfluidic channel；
S7, further include automatic injection pump, conducting liquid is injected into the duct；
S8, the microfluid intermediate channel width are 30 μm；
S9, the pump are peristaltic pump or vacuum pump.
3. the micro flow control chip device as described in claim 1 for carrying out multi-functional detection to single particle matter, which is characterized in that
The substrate (1) is glass substrate or silicon-based substrates.
4. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, which is characterized in that
The section in the duct is square-section or circular cross-section.
5. by the micro flow control chip device that Atmospheric particulates are carried out with multi-functional detection described in claim l, which is characterized in that
The inlet channels are the square groove of square-section or the semi-circular recesses of semi-circular cross-section.
6. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, which is characterized in that
It can be connected with air harvester, realize continuous, real-time, the on-line measurement Atmospheric particulates compatible with process.
7. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, which is characterized in that
It is portable small and exquisite, multi-parameter easily can be carried out to the Atmospheric particulates in field in the case where being not suitable for large-scale instrument and being tested
Detection.
8. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, which is characterized in that
Wireless transmitter is installed, it can be achieved that being remotely detected to Atmospheric particulates.
9. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, which is characterized in that
Detection process is smaller by external interference, and detection signal background interference is small, and detection data is closer to the truth.
10. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, feature exist
In, it is short by duct time of measuring described in S3, show that data time is short.
11. the micro flow control chip device as described in claim 1 that Atmospheric particulates are carried out with multi-functional detection, feature exist
In manufacturing technology is ripe, and material is cheap, and assembling is simple, is suitable for a variety of measuring environments（Such as field）.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810218637.6A CN108507910A (en) | 2018-03-16 | 2018-03-16 | A kind of microfluidic chip devices of detection Atmospheric particulates |
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Cited By (4)
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| CN109569753A (en) * | 2018-12-29 | 2019-04-05 | 北京工业大学 | A kind of micro-fluidic chip lane device of PM2.5 powder collection and experimental observation |
| CN109852542A (en) * | 2018-12-18 | 2019-06-07 | 北京化工大学 | A kind of micro-fluidic chip and its processing method for unicellular impedance flow cytometer detection |
| CN110227565A (en) * | 2019-06-25 | 2019-09-13 | 京东方科技集团股份有限公司 | Micro-fluidic device and production method, biomolecule amount detection method and system |
| CN110553956A (en) * | 2019-09-27 | 2019-12-10 | 东莞东阳光医疗智能器件研发有限公司 | impedance pulse particle detection device, detection system and detection method |
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