CN207012993U - A kind of micro-fluidic chip for particle analysis - Google Patents

A kind of micro-fluidic chip for particle analysis Download PDF

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Publication number
CN207012993U
CN207012993U CN201720922017.1U CN201720922017U CN207012993U CN 207012993 U CN207012993 U CN 207012993U CN 201720922017 U CN201720922017 U CN 201720922017U CN 207012993 U CN207012993 U CN 207012993U
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China
Prior art keywords
core plate
microchannel
micro
electrode pair
fluidic chip
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CN201720922017.1U
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Chinese (zh)
Inventor
游璠
王小英
周树民
李芳芳
陈雪亮
郭嘉杰
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Shenzhen Zhongke Intelligent Technology Co Ltd
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Shenzhen Zhongke Intelligent Technology Co Ltd
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Abstract

The utility model embodiment discloses a kind of micro-fluidic chip for particle analysis.The micro-fluidic chip includes:Four layers of core plate, respectively the first core plate, the second core plate, the 3rd core plate and the 4th core plate;There is inlet opening on the first core plate;There is the first microchannel in the second core plate, the 3rd core plate and the 4th core plate, inlet opening communicates with the first microchannel;There is the second microchannel on the 4th core plate, the second microchannel is communicated with the first microchannel by filter bores, and filter bores are on the 3rd core plate;There is the 3rd microchannel on the second core plate, the 3rd microchannel is communicated with the second microchannel by instrument connection, and instrument connection is on the 3rd core plate;There is first electrode pair at instrument connection both ends, pass through voltage pulse signal caused by instrument connection for detecting particle.The micro-fluidic chip that the present embodiment provides can improve the convenience of particle analysis, and reduce the cost of particle analysis.

Description

A kind of micro-fluidic chip for particle analysis
Technical field
The utility model embodiment is related to particle analysis technical field, more particularly to a kind of for the micro-fluidic of particle analysis Chip.
Background technology
At present, counted and during size measurement in fine particle in liquid, it is general using classical Kurt impedance Method.The general principle of Kurt impedance method is the cell or particle to suspend in the electrolytic solution, when passing through aperture with electrolyte, Because instead of the electrolyte of same volume, two electrode resistances inside and outside aperture pipeline are caused to occur instantaneously in the circuit of constant current design Change, and potential pulse is generated, the size and number of pulse signal are directly proportional to the size and number of particle.
In the prior art, it is general particle to be counted using Kurt electric impedance analyzer and size measurement, but it is traditional Kurt electric impedance analyzer it is bulky, it is expensive.
Utility model content
The utility model embodiment provides a kind of micro-fluidic chip for particle analysis, to improve the facility of particle analysis Property, and reduce the cost of particle analysis.
In a first aspect, the utility model embodiment provides a kind of micro-fluidic chip for particle analysis, this is micro-fluidic Chip includes:Four layers of core plate, respectively the first core plate, the second core plate, the 3rd core plate and the 4th core plate;
There is inlet opening on first core plate;Have the in second core plate, the 3rd core plate and the 4th core plate One microchannel, the inlet opening communicate with first microchannel;There is the second microchannel on the 4th core plate, Second microchannel is communicated with first microchannel by filter bores, and the filter bores are on the 3rd core plate; There is the 3rd microchannel on second core plate, the 3rd microchannel passes through instrument connection with second microchannel Communicate, the instrument connection is on the 3rd core plate;There is first electrode pair at the instrument connection both ends, for detecting particle warp Cross voltage pulse signal caused by the instrument connection, it is micro- that two electrodes of the first electrode pair are respectively placed in described second In circulation road and the 3rd microchannel;
There is suction through hole on first core plate, second core plate and the 3rd core plate, set for vacuumizing The standby air aspirated by the suction through hole in micro-fluidic chip in microchannel, the suction through hole and the 3rd miniflow Passage communicates.
Further, the first electrode pair is connected with host computer, when the first electrode is to detecting that voltage pulse is believed Number when, the voltage pulse signal is sent to the host computer, so as to the host computer to the voltage pulse signal carry out Analyzing and processing.
Further, there is the 4th microchannel, the 4th microchannel and the suction on the 4th core plate Through hole communicates;4th microchannel terminates hole by liquid with the 3rd microchannel and communicated, and the liquid terminates hole On the 3rd core plate.
Further, terminate hole in the liquid has second electrode pair with the position that the 3rd microchannel communicates, For flowing to the second electrode pair when liquid, when the second electrode is to after electrical connection, vacuumizes and set described in PC control Standby to stop suction, the second electrode is to being positioned in the 3rd microchannel.
Further, also there is the 3rd electrode pair at the instrument connection both ends, for flowing to the 3rd electrode when liquid It is right, when after the 3rd electrode pair electrical connection, constant driving voltage, the 3rd electrode pair are provided for the instrument connection both ends Two electrodes be respectively placed in second microchannel and the 3rd microchannel.
Further, also having at the instrument connection both ends has the 4th electrode pair, for flowing through the 4th electricity when liquid Extremely right, when the 4th electrode pair electrically connects, instruction host computer starts gathered data, two electrodes point of the 4th electrode pair It is not positioned in second microchannel and the 3rd microchannel.
Further, in addition to the 5th core plate, below the 4th core plate, for as first microchannel With the bottom surface of second microchannel.
Further, in first core plate, second core plate, the 3rd core plate, the 4th core plate and described Also there are aligned through holes on 5th core plate, for be aligned assemble first core plate, second core plate, the 3rd core plate, 4th core plate and the 5th core plate.
Further, fixed between adjacent core plate by pressure sensitive adhesive or instant glue assembling.
The micro-fluidic chip for particle analysis that the utility model embodiment provides, including four layers of core plate, respectively the One core plate, the second core plate, the 3rd core plate and the 4th core plate;There is inlet opening on the first core plate;In the second core plate, the 3rd core plate With there is the first microchannel in the 4th core plate, inlet opening communicates with the first microchannel;It is micro- with second on the 4th core plate Circulation road, the second microchannel are communicated with the first microchannel by filter bores, and filter bores are on the 3rd core plate;In the second core plate Upper to have the 3rd microchannel, the 3rd microchannel is communicated with the second microchannel by instrument connection, and instrument connection is in the 3rd core plate On;There is first electrode pair at instrument connection both ends, pass through voltage pulse signal caused by instrument connection for detecting particle; There is suction through hole on one core plate, the second core plate and the 3rd core plate, it is micro-fluidic by aspirating through hole suction for vaccum-pumping equipment Air in chip in microchannel, suction through hole communicate with the 3rd microchannel.When vaccum-pumping equipment is aspirated by suction hole In micro-fluidic chip during air in microchannel, liquid enters the first microchannel by inlet opening, then by filter bores Into the second microchannel, the 3rd microchannel is subsequently entered by instrument connection, when liquid passes through instrument connection, test can be made The first electrode at hole both ends is to electrical connection, and when there is particle to pass through instrument connection in liquid, first electrode is to detecting voltage pulse Signal, first electrode is to voltage pulse signal is sent to host computer after digital-to-analogue conversion, so that host computer is believed voltage pulse Number analyzed and processed, so as to realize the analysis to particle in liquid.Based on Kurt general principle design system in the present embodiment The micro-fluidic chip of work, has a multi-layer coreboard, liquid can in the passage of each layer core plate horizontal longitudinal flow, without complexity The supplementary means such as sheath Flow Technique are that the function of particle analysis can be achieved, and improve the convenience of particle analysis, while reduce particle point The cost of analysis.
Brief description of the drawings
Fig. 1 is a kind of structural representation of micro-fluidic chip for particle analysis in the utility model embodiment one;
Fig. 2 is the positive and negative structural representation of the 3rd core plate in the micro-fluidic chip in the utility model embodiment two;
Fig. 3 is a kind of flow chart of particle analysis method in the utility model embodiment three.
Embodiment
The utility model is described in further detail with reference to the accompanying drawings and examples.It is understood that herein Described specific embodiment is used only for explaining the utility model, rather than to restriction of the present utility model.Further need exist for It is bright, for the ease of description, the part related to the utility model rather than entire infrastructure are illustrate only in accompanying drawing.
Embodiment one
Fig. 1 is a kind of structural representation for micro-fluidic chip for particle analysis that the utility model embodiment one provides Figure.The present embodiment is applicable to the situation of the analysis carried out to the particle in liquid, as shown in figure 1, the micro-fluidic chip includes Four layers of core plate, respectively the first core plate 110, the second core plate 120, the 3rd core plate 130 and the 4th core plate 140.In the present embodiment, four Layer core plate stacks successively, in order to preferably show the internal structure of every layer of core plate, enters four layers of core plate expansion respectively in Fig. 1 Row displaying.
There is inlet opening 11 on the first core plate 110.In the second core plate 120, the 3rd core plate 130 and the 4th core plate 140 With the first microchannel 21, inlet opening 11 communicates with the first microchannel 21.On the 4th core plate 140 there is the second miniflow to lead to Road 22, the second microchannel 22 are communicated with the first microchannel 21 by filter bores 12, and filter bores 12 are on the 3rd core plate 130. There is the 3rd microchannel 23 on the second core plate 120, the 3rd microchannel 23 and the second microchannel 22 pass through instrument connection 13 Communicate, instrument connection 13 is 130 on the 3rd core plate.There is first electrode pair at the both ends of instrument connection 23, for detecting particle by surveying Voltage pulse signal caused by prospect hole, it is micro- that two electrodes of first electrode pair are respectively placed in the second microchannel 22 and the 3rd In circulation road 23.There is suction through hole 14 on the first core plate 110, the second core plate 120 and the 3rd core plate 130, for vacuumizing Equipment aspirates through hole 14 and the 3rd microchannel phase by aspirating the air in the suction micro-fluidic chip of through hole 14 in microchannel Logical 23.
Wherein, the material of core plate can be high molecular polymer, such as polymethyl methacrylate (Polymethyl Methacrylate, PMMA) or cyclic olefine copolymer (Cyclo Olefin Coplymer, COC).The thickness of core plate can be with Any thickness between 50-300um.First microchannel 21 is by the second core plate 120, the 3rd core plate 130 and the 4th core plate 140 Passage in these three core plates stacks what is formed, and to increase the depth of the first microchannel 21, the first microchannel 21 is second The length of core plate 120 is more than the length in the 3rd core plate 130 and the 4th core plate.The form of filter bores 12 can be the shape of hole array Formula, effect are to filter out the larger impurity of volume in liquid and each composition in liquid is fully mixed.Install at the both ends of instrument connection 13 There is first electrode pair, when liquid flow to first electrode pair, first electrode can detect instrument connection 13 in real time to electrically connecting The magnitude of voltage at both ends.When the particle (such as haemocyte, cancer cell, bacterium) in liquid passes through instrument connection 13, particle is being tested Substitute the liquid of same volume in hole 13, cause the first electrode at the both ends of instrument connection 13 that transient change occurs to electrode resistance, from And produce voltage pulse signal.Vaccum-pumping equipment can be vavuum pump, after vaccum-pumping equipment is connected with pump-line, pass through suction The air in microchannel in micro-fluidic chip is aspirated in hole 14, so that liquid is entered in a subtle way under suction function by inlet opening 11 In the microchannel of fluidic chip.
Under this application scene, the principle that micro-fluidic chip carries out particle analysis can be that vaccum-pumping equipment passes through suction hole In 14 suction micro-fluidic chips during air in microchannel, sample to be tested liquid under suction function by inlet opening 11 first Into the first microchannel 21 in the 4th core plate 140, liquid continues to enter passage from inlet opening 11 under suction function, With the increase of liquid, liquid gradually reaches filter bores 12, and filter bores 12 fall the larger contaminant filter of volume in liquid.Liquid Reached by filter bores 12 in the second microchannel 22, flow to instrument connection 13 always in the second microchannel 22, work as liquid When reaching the first electrode pair at instrument connection 13 both ends, for first electrode to producing electrical connection, first electrode pair after electrical connection can be with Particle passes through voltage pulse signal caused by instrument connection 13 in detection liquid.Liquid is micro- into the 3rd after instrument connection 13 In circulation road 23.The effect of 3rd microchannel 23 is after passing liquid through instrument connection 13, can also continue to flow in microchannel It is dynamic, it is ensured that a certain amount of liquid passes through instrument connection 13.
Preferably, first electrode pair is connected with host computer, when first electrode is to detecting voltage pulse signal, by voltage Pulse signal is sent after digital-to-analogue conversion to host computer, so that host computer analyzes and processes to voltage pulse signal.Host computer By the size of analysis voltage pulse signal and count the number of voltage pulse signal, determine in liquid the size of particle volume and The number of particle is included in liquid.Wherein, digital-to-analogue conversion with first electrode to the mainboard being connected by completing.
Preferably, as shown in figure 1, there is the 4th microchannel 24 on the 4th core plate 140, the 4th microchannel 24 is with taking out Through hole 14 is inhaled to communicate;4th microchannel 24 terminates hole 15 by liquid with the 3rd microchannel 23 and communicated, and liquid terminates hole 15 On the 3rd core plate.The effect of 4th microchannel 24 is to prevent liquid from flowing out micro-fluidic chip, avoids liquid to other devices Pollute.
Preferably, terminate hole 15 in liquid has second electrode pair with the position that the 3rd microchannel 23 communicates, for working as Liquid flow to second electrode pair, and when second electrode is to after electrical connection, PC control vaccum-pumping equipment stops suction, second electrode To being positioned in the 3rd miniflow logical 23.Under this application scene, second electrode pair is connected with host computer, when liquid flow to second electrode After making second electrode to electrically connecting, upper computer detection to electrically connecting, is then sent out to second electrode to vaccum-pumping equipment The instruction for stopping aspirating is sent, control vaccum-pumping equipment stops the air in suction micro-fluidic chip, now in micro-fluidic chip Negative pressure disappears, and liquid no longer enters in micro-fluidic chip from inlet opening 11, and liquid stops flow forward.Advantage of this is that from The amount of liquid that dynamic control enters in micro-fluidic chip.
Preferably, the micro-fluidic chip also includes the 5th core plate 150, positioned at the lower section of the 4th core plate 140, for as first The bottom surface of the microchannel 22 of microchannel 21 and second.In the present embodiment, the microchannel on every layer of core plate is by this layer of core The passage and the levels core plate adjacent with this layer of core plate that positive and negative communicates on plate surround what is formed.Optionally, suction hole is set On the 5th core plate 150, communicated with the 4th microchannel 24, i.e., vaccum-pumping equipment is taken out by the suction hole on the 5th core plate 150 Inhale air in micro-fluidic chip.
Preferably, as shown in figure 1, in the first core plate 110, the second core plate 120, the 3rd core plate 130, the and of the 4th core plate 140 Also there are aligned through holes 16, for being directed at the first core plate 110 of assembling, the second core plate 120, the 3rd core plate on 5th core plate 150 130th, the 4th core plate 140 and the 5th core plate 150.
Preferably, fixed between adjacent core plate by pressure sensitive adhesive or instant glue assembling.Wherein, pressure sensitive adhesive can be elastomeric-type Pressure sensitive adhesive, resin pressure sensitive adhesive or two liquid mixed hardening glue etc..
The micro-fluidic chip for particle analysis that the present embodiment provides, including four layers of core plate, respectively the first core plate, the Two core plates, the 3rd core plate and the 4th core plate;There is inlet opening on the first core plate;In the second core plate, the 3rd core plate and the 4th core There is the first microchannel in plate, inlet opening communicates with the first microchannel;There is the second microchannel on the 4th core plate, the Two microchannels are communicated with the first microchannel by filter bores, and filter bores are on the 3rd core plate;Have the on the second core plate Three microchannels, the 3rd microchannel are communicated with the second microchannel by instrument connection, and instrument connection is on the 3rd core plate;Testing Hole both ends have first electrode pair, pass through voltage pulse signal caused by instrument connection for detecting particle;In the first core plate, There is suction through hole on two core plates and the 3rd core plate, miniflow in micro-fluidic chip is aspirated by aspirating through hole for vaccum-pumping equipment Air in passage, suction through hole communicate with the 3rd microchannel.When vaccum-pumping equipment aspirates micro-fluidic chip by suction hole During air in middle microchannel, liquid enters the first microchannel by inlet opening, and it is micro- then to enter second by filter bores Circulation road, the 3rd microchannel is subsequently entered by instrument connection, when liquid passes through instrument connection, the of instrument connection both ends can be made One electrode pair electrically connects, and when there is particle to pass through instrument connection in liquid, first electrode is to detecting voltage pulse signal, the first electricity Extremely to voltage pulse signal is sent to host computer after digital-to-analogue conversion, so that host computer is carried out at analysis to voltage pulse signal Reason, so as to realize the analysis to particle in liquid.The micro-fluidic core designed and produced in the present embodiment based on Kurt general principle Piece, has a multi-layer coreboard, liquid can in the passage of each layer core plate horizontal longitudinal flow, the sheath Flow Technique without complexity etc. it is auxiliary Assistant's section is that the function of particle analysis can be achieved, and improves the convenience of particle analysis, while reduce the cost of particle analysis.
Embodiment two
Fig. 2 is the positive and negative structural representation of the 3rd core plate in the micro-fluidic chip that the utility model embodiment two provides. Based on above-described embodiment, as shown in Fig. 2 the 3rd core plate includes front 131 and reverse side 132, installed at the both ends of instrument connection 13 There is first electrode to 1/2, terminating hole 15 and the position that the 3rd microchannel 23 communicates in liquid has second electrode to 7/8, the Two electrode pairs 7/8 are positioned over the end of the 3rd microchannel 23.Preferably, also there is the 3rd electrode pair 3/ at the both ends of instrument connection 13 4, for flowing to the 3rd electrode pair 3/4 when liquid, when after the electrical connection of the 3rd electrode pair 3/4, provided for the both ends of instrument connection 13 constant Driving voltage, two electrodes of the 3rd electrode pair 3/4 are respectively placed in the second microchannel 22 and the 3rd microchannel 23. Also having at the both ends of instrument connection 13 has the 4th electrode pair 5/6, for flowing through the 4th electrode pair 5/6, the 4th electrode pair 5/6 when liquid During electrical connection, instruction host computer starts gathered data, and two electrodes of the 4th electrode pair 5/6 are respectively placed in the second microchannel 22 and the 3rd in microchannel 23.As shown in Fig. 2 the electrode block of electrode 1,3 and 5 is positioned in the 3rd microchannel 23, electrode 2nd, 4 and 6 electrode block is positioned in the second microchannel 22.Optionally, electrode 3 and 5 can share an electrode, or electrode 4 An electrode can be shared with 6.
Under this application scene, liquid covers the electrode block of electrode 6,4 and 2 successively in the second microchannel 22 first, so Liquid, which flows through instrument connection 13 and entered after the 3rd microchannel 23, afterwards covers the electrode block of electrode 1,3 and 5, and first electrode is to 1/2, the Three electrode pairs 3/4 and the 4th electrode pair 5/6 electrically connect successively.It is instrument connection 13 after 3rd electrode pair 3/4 electrically connects Both ends provide constant driving voltage.After 4th electrode pair 5/6 electrically connects, host computer gathered data is indicated.
The technical scheme of the present embodiment, by installing multiple electrodes pair, and first electrode pair and the 3rd at instrument connection both ends Electrode pair is connected with host computer respectively, so that micro-fluidic chip realizes the function to particle analysis.
Embodiment three
Fig. 3 is a kind of flow chart for particle analysis method that the utility model embodiment two provides.This method is using above-mentioned Micro-fluidic chip described in embodiment performs, as shown in figure 3, this method includes:
Step 310, when vaccum-pumping equipment aspirates the air in micro-fluidic chip in microchannel by suction hole, liquid Entered by inlet opening in the microchannel in micro-fluidic chip.
Step 320, when liquid flow to the first electrode pair at instrument connection both ends, first electrode is to electrical connection.
Step 330, when there is particle to pass through instrument connection in liquid, first electrode is to detecting voltage pulse signal.
Step 340, first electrode is to voltage pulse signal is sent to host computer, so as to host computer pair after digital-to-analogue conversion Voltage pulse signal is analyzed and processed.
Specifically, when vaccum-pumping equipment aspirates the air in micro-fluidic chip in microchannel by suction hole, liquid First microchannel is entered by inlet opening, then enters the second microchannel by filter bores, is subsequently entered by instrument connection Enter the 3rd microchannel, when liquid passes through instrument connection, the first electrode at instrument connection both ends can be made to electrical connection, when having in liquid When particle passes through instrument connection, first electrode to detecting voltage pulse signal, first electrode to by voltage pulse signal through digital-to-analogue Sent after conversion to host computer, so that host computer analyzes and processes to voltage pulse signal, so as to realize to particle in liquid Analysis.
Pay attention to, above are only preferred embodiment of the present utility model and institute's application technology principle.Those skilled in the art's meeting Understand, the utility model is not limited to specific embodiment described here, can carried out for a person skilled in the art various bright Aobvious change, readjust and substitute without departing from the scope of protection of the utility model.Therefore, although passing through above example The utility model is described in further detail, but the utility model is not limited only to above example, is not departing from In the case that the utility model is conceived, other more equivalent embodiments can also be included, and the scope of the utility model is by appended Right determine.

Claims (9)

  1. A kind of 1. micro-fluidic chip for particle analysis, it is characterised in that including:Four layers of core plate, respectively the first core plate, Two core plates, the 3rd core plate and the 4th core plate;
    There is inlet opening on first core plate;It is micro- with first in second core plate, the 3rd core plate and the 4th core plate Circulation road, the inlet opening communicate with first microchannel;There is the second microchannel on the 4th core plate, it is described Second microchannel is communicated with first microchannel by filter bores, and the filter bores are on the 3rd core plate;Institute Stating has the 3rd microchannel on the second core plate, the 3rd microchannel passes through instrument connection phase with second microchannel Logical, the instrument connection is on the 3rd core plate;There is first electrode pair at the instrument connection both ends, pass through for detecting particle Voltage pulse signal caused by the instrument connection, two electrodes of the first electrode pair are respectively placed in second miniflow In passage and the 3rd microchannel;
    There is suction through hole on first core plate, second core plate and the 3rd core plate, lead to for vaccum-pumping equipment Cross the air in microchannel, the suction through hole and the 3rd microchannel in the suction through hole suction micro-fluidic chip Communicate.
  2. 2. the micro-fluidic chip according to claim 1 for particle analysis, it is characterised in that the first electrode pair with Host computer is connected, and when the first electrode is to detecting voltage pulse signal, the voltage pulse signal is turned through digital-to-analogue A/D Sent after changing to the host computer, so that the host computer analyzes and processes to the voltage pulse signal.
  3. 3. the micro-fluidic chip according to claim 1 for particle analysis, it is characterised in that on the 4th core plate With the 4th microchannel, the 4th microchannel communicates with the suction through hole;4th microchannel and described the Three microchannels terminate hole by liquid and communicated, and the liquid terminates hole on the 3rd core plate.
  4. 4. the micro-fluidic chip according to claim 3 for particle analysis, it is characterised in that terminate hole in the liquid The position communicated with the 3rd microchannel has second electrode pair, described for flowing to the second electrode pair when liquid When second electrode is to after electrical connection, vaccum-pumping equipment described in PC control stops suction, and the second electrode is to being positioned over State in the 3rd microchannel.
  5. 5. the micro-fluidic chip according to claim 1 for particle analysis, it is characterised in that at the instrument connection both ends Also there is the 3rd electrode pair, be described when after the 3rd electrode pair electrical connection for flowing to the 3rd electrode pair when liquid Instrument connection both ends provide constant driving voltage, and two electrodes of the 3rd electrode pair are respectively placed in second miniflow and led to In road and the 3rd microchannel.
  6. 6. the micro-fluidic chip according to claim 1 for particle analysis, it is characterised in that at the instrument connection both ends Also there is the 4th electrode pair, for flowing through the 4th electrode pair when liquid, during the 4th electrode pair electrical connection, in instruction Position machine starts gathered data, and two electrodes of the 4th electrode pair are respectively placed in second microchannel and the described 3rd In microchannel.
  7. 7. the micro-fluidic chip according to claim 1 for particle analysis, it is characterised in that also including the 5th core plate, Below the 4th core plate, for the bottom surface as first microchannel and second microchannel.
  8. 8. the micro-fluidic chip according to claim 7 for particle analysis, it is characterised in that first core plate, Also there are aligned through holes on second core plate, the 3rd core plate, the 4th core plate and the 5th core plate, for being aligned Assemble first core plate, second core plate, the 3rd core plate, the 4th core plate and the 5th core plate.
  9. 9. the micro-fluidic chip according to claim 7 for particle analysis, it is characterised in that pass through pressure between adjacent core plate Quick glue or instant glue assembling is fixed.
CN201720922017.1U 2017-07-27 2017-07-27 A kind of micro-fluidic chip for particle analysis Withdrawn - After Issue CN207012993U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107213930A (en) * 2017-07-27 2017-09-29 深圳中科芯海智能科技有限公司 A kind of micro-fluidic chip and particle analysis method for particle analysis
CN108507910A (en) * 2018-03-16 2018-09-07 中国科学院大学 A kind of microfluidic chip devices of detection Atmospheric particulates

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107213930A (en) * 2017-07-27 2017-09-29 深圳中科芯海智能科技有限公司 A kind of micro-fluidic chip and particle analysis method for particle analysis
CN107213930B (en) * 2017-07-27 2022-12-20 深圳中科芯海智能科技有限公司 Microfluidic chip for particle analysis and particle analysis method
CN108507910A (en) * 2018-03-16 2018-09-07 中国科学院大学 A kind of microfluidic chip devices of detection Atmospheric particulates

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