CN107737219A - 一种治疗股骨痛的中药组合物及其制备方法 - Google Patents
一种治疗股骨痛的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗股骨痛的中药组合物及其制备方法。该中药组合物是由以下原料制备而成:黑老虎、伸筋草、肿节风、两面针、海风藤、苏木、黄姜、三叉苦、接骨木、鸡血藤、小千金、白芷、薄荷油、九龙根。该中药组合物具有补肾强筋、祛风除湿、舒经通络、活血止痛的作用,对股骨痛有较好疗效。
Description
技术领域
本发明涉及中药领域,具体涉及一种治疗股骨痛的中药组合物及其制备方法。
背景技术
股骨头就是支撑身体上半部分的两根骨头,具体位置在骨盆下方,骨盆那里一边一个髋臼,两个股骨头正好和髋臼配合,起到支撑上体的作用。如果从外面看就是在臀部的后下方。股骨是人体最重要的骨骼,股骨头更为重要,人的直立行走、活动、劳动都依靠股骨头的支撑作用。所以股骨头也是最容易受伤的部位。
股骨头疾病最常见的就是股骨头坏死。股骨头坏死即股骨头缺血性坏死,又称无菌性股骨头坏死。早期症状是疼痛,疼痛可为间歇性或持续性,行走活动后加重,有时为休息痛。疼痛多为针刺样、钝痛或酸痛不适等,常向腹股沟区,大腿内侧,臀后侧和膝内侧放射,并有该区麻木感。渐渐会出现间歇性跛行,最后如果不注意,导致股骨头塌陷,很容易致残。
发明内容
本发明的目的是提供一种治疗股骨痛的中药组合物;
本发明的另一目的是提供一种治疗股骨痛的中药组合物制备方法。
本发明的目的是通过下列的技术方案实现的:
本发明所述的治疗股骨痛的中药组合物,它是由包括如下重量份的原料制备而成的:
黑老虎5-20份、伸筋草3-15份、肿节风5-20份、两面针20-40份、海风藤5-20份、苏木15-30份、黄姜5-20份、三叉苦15-30份、接骨木5-20份、鸡血藤5-20份、小千金15-30份、白芷20-40份、薄荷油5-20份、九龙根5-20份。
优选地,是由包括如下重量份的原料制备而成的:
黑老虎10-15份、伸筋草5-10份、肿节风10-15份、两面针25-35份、海风藤10-15份、苏木20-25份、黄姜10-15份、三叉苦20-25份、接骨木10-15份、鸡血藤10-15份、小千金20-25份、白芷25-35份、薄荷油10-15份、九龙根10-15份。
更优的,是由包括如下重量份的原料制备而成的:
黑老虎12份、伸筋草8份、肿节风12份、两面针30份、海风藤12份、苏木23份、黄姜12份、三叉苦23份、接骨木12份、鸡血藤12份、小千金23份、白芷30份、薄荷油12份、九龙根12份。
以下是本发明中药组合物的药材来源:
黑老虎,为五味子科植物冷饭团Kadsura coccinea(Lem.)A.C.Smith[K.chinensisHance ex Benth;K.hainanensisMerr.]的根及蔓茎。。辛;微苦;性温。行气活血,消肿止痛。用于风湿痹痛,胃痛,痛经,产后积瘀,跌打损伤肿痛。
海风藤,为胡椒科植物风藤Piper kadsura (Choisy)0hwi的干燥藤茎。味辛、苦,性微温。归肝经。祛风湿,通经络,止痹痛。用于风寒湿痹,肢节疼痛,筋脉拘挛,屈伸不利。
伸筋草,为石松科植物石松Lycopodium jaPonicum Thunb.的干燥全草。味苦、微辛,性温。归肝、脾、肾经。有祛风除湿,舒筋活络的功效。用于关节酸痛,屈伸不利。
肿节风,为金粟兰科植物草珊瑚的干燥全株。苦、辛、平。归心、肝经。抗菌消炎凉血清热解毒,祛风通络,活血散结。用于肺炎、阑尾炎、蜂窝组织炎属热毒壅盛证候者;以及风湿痹痛、跌扑损伤、肿瘤的辅助治疗。
两面针,为芸香科植物两面针Zanthorμlum nitidum(Roxb.)DC.的干燥根。味苦、辛,性平。归肝、胃经。活血化瘀,行气止痛,祛风通络,解毒消肿。用于跌扑损伤,胃痛,牙痛,风湿痹痛,毒蛇咬伤;外治烧烫伤。
苏木,,为豆科苏木属植物苏木的干燥心材。甘;咸;辛凉。归心;肝;胃;脾经;活血祛瘀,消肿定痛。如妇人血滞经闭,痛经,产后瘀阻心腹痛,产后血晕,痈肿,跌打损伤,破伤风。
三叉苦,芸香科吴茱萸属植物三叉苦Evodia lepta (Spreng.) Merr.,以根及叶入药。苦,寒。清热解毒、祛风除湿。治咽喉肿痛、风湿骨痛、疟疾、黄疸、湿疹、皮炎、跌打损伤及虫蛇咬伤等症。
黄姜,薯蓣科薯蓣属植物盾叶薯蓣,以根状茎入药。甘、苦,凉。解毒消肿。用于痈疖早期未破溃,皮肤急性化脓性感染,软组织损伤,蜂螫虫咬。
接骨木,忍冬科接骨木属植物接骨木Sambucus williamsii Hance,以全株入药。甘、苦,平。归肝经。接骨续筋,活血止痛,祛风利湿。用于骨折,跌打损伤,风湿性关节炎,痛风,大骨节病,急、慢性肾炎;外用治创伤出血。
九龙根,为豆科植物龙须藤的根。甘苦,温。祛风湿,行血气。治跌打损伤,风湿骨痛,心胃气痛。
小千金,卫矛科小千金Euonymus aculeatus Hemsl.,以根入药。辛、微涩,温。祛风除湿,舒筋活络。治风湿疼痛,脚转筋。
鸡血藤,为豆科植物密花豆(大血藤、血风藤、三叶鸡血藤、九层风)Spatholobussuberectus Dunn 的干燥藤茎。苦、甘,温。归肝、肾经。补血,活血,通络。用于月经不调,血虚萎黄,麻木瘫痪,风湿痹痛。
白芷,为伞型科植物白芷Angelica dahurica (Fisch.ex Hoffm.) Benth. etHook.f.或杭白芷Angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f.var.formosana(Boiss.)Shan et Yuan 的干燥根。辛,温。归胃、大肠、肺经。散风除湿,通窍止痛,消肿排脓。用于感冒头痛,眉棱骨痛,鼻塞,鼻渊,牙痛,白带,疮疡肿痛。
薄荷油,为唇形科植物薄荷或家薄荷的鲜茎叶经蒸馏而得的芳香油。辛,凉,无毒。疏风,清热。治外感风热,头痛目赤,咽痛,齿痛,皮肤风痒。
本发明的另一方面是提供了本发明中药组合物的活性成分的制备方法,该方法是采用采用水提或40-80%体积百分浓度的乙醇提取制备而成。具体制备方法如下:
方案一:取全部全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,滤过,滤液浓缩至70-80℃时相对密度为1.15-1.20的清膏,即得活性成分。
方案二:取全部全部药材,混合后用40-80%乙醇回流提取2-3次,每次乙醇用量为药材总量的4-10倍,提取时间为1-4小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.15-1.20的清膏,即得活性成分。
方案三:取全部全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,滤过,滤液浓缩至70-80℃时相对密度为1.15-1.20的清膏,加入乙醇,使含醇量为40-70%,静置12-24小时,滤过,滤液浓缩至70-80℃时相对密度为1.10-1.25的浸膏,即得活性成分。
本发明所述的治疗股骨痛的中药,还可以与医药学上可接受的载体配合,制成各种口服制剂,如片剂、胶囊剂、口服液、糖浆剂、合剂等。
本发明的药学上可接受的载体包括但不限于以下:
口服制剂:
稀释剂:淀粉、糖粉、乳糖、糊精、微晶纤维素、无机盐、糖醇类等。
润湿剂与粘合剂:纯化水、乙醇、明胶、聚乙二醇、纤维素衍生物等。
崩解剂:淀粉、羧甲基淀粉钠、纤维素衍生物、交联聚维酮等。
润滑剂:硬脂酸镁、微粉硅胶、滑石粉、聚乙二醇等。
助溶剂:水、乙醇、甘油、丙二醇、液状石蜡、植物油等。
矫味剂:蔗糖、单糖、芳香剂等。
防腐剂:苯甲酸、山梨酸、甲酯、乙酯、丙酯等。
方法1:片剂
取方案一至方案三所得活性成分之一,加入片剂常用辅料,按常规生产方法制备得本发明片剂。
上述片剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
方法1:胶囊剂
取方案一至方案三所得活性成分之一,加入胶囊剂常用辅料,按常规生产方法制备得本发明胶囊剂。
上述胶囊剂常用辅料包括稀释剂、润湿剂、粘合剂、崩解剂、润滑剂之一或全部。
方法3:糖浆剂
取方案一至方案三所得活性成分之一,加入糖浆剂常用辅料,按常规生产方法制备得本发明糖浆剂。
上述糖浆剂常用辅料包括矫味剂、防腐剂、助溶剂之一或全部。
方法4:合剂
取方案一至方案三所得活性成分之一,加入合剂常用辅料,按常规生产方法制备得本发明合剂。
上述合剂常用辅料包括矫味剂、防腐剂之一或全部。
方法5:口服液
取方案一至方案三所得活性成分之一,溶解后净化、浓缩,加入口服液常用辅料,按常规生产方法制备得本发明口服液。
上述口服液常用辅料包括矫味剂、防腐剂、助溶剂之一或全部。
本申请人在研究传统中医辨证治疗的基础上参考现代药理研究成果,经过多年的试验,将多种配方进行筛选,找到了能有效治疗股骨痛的中药配方。
本发明所公开的中药组合物有效成分是由黑老虎、伸筋草、肿节风、两面针、海风藤、苏木、黄姜、三叉苦、接骨木、鸡血藤、小千金、白芷、薄荷油、九龙根制备而成。全方相互协同,具有补肾强筋、祛风除湿、舒经通络、活血止痛的作用,对股骨痛有较好疗效。
本发明提供的一种治疗股骨痛的中药组合物具有以下优点:
1、本发明提供的组合物制剂安全有效,具有补肾强筋、祛风除湿、舒经通络、活血止痛的作用,对股骨痛有较好疗效。
2、经临床试验证明,患者经本发明所述中药组合物治疗后,股骨痛患者的临床症状有明显改善,有效率达94.2%。
3、本发明提供的中药组合物制剂,配方科学合理,工艺简单,口感好,成本低。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是,本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明,本发明中的乙醇量的百分数是体积百分数,v/v表示溶液的体积比。
实施例1 口服液
黑老虎0.5kg、伸筋草0.3kg、肿节风0.5kg、两面针2kg、海风藤0.5kg、苏木1.5kg、黄姜0.5kg、三叉苦1.5kg、接骨木0.5kg、鸡血藤0.5kg、小千金1.5kg、白芷2kg、薄荷油0.5kg、九龙根0.5kg。取全部药材,加水提取2次,两次加水量分别为药材总重量的10倍、8倍,两次提取时间分别为2小时、1小时,合并提取液,滤过,滤液浓缩至80℃时相对密度为1.10的浸膏,在浸膏中加入辅料甘露醇、山梨酸、水搅拌均匀,分装,制得口服液。
实施例2 片剂
黑老虎2kg、伸筋草1.5kg、肿节风2kg、两面针4kg、海风藤2kg、苏木3kg、黄姜2kg、三叉苦3kg、接骨木2kg、鸡血藤2kg、小千金3kg、白芷4kg、薄荷油2kg、九龙根2kg。取全部药材,用40%乙醇回流提取3次,每次乙醇用量分别为药材总量的10倍、8倍、4倍,提取时间分别3小时、2小时、1小时,合并提取液,过滤,滤液浓缩60℃时相对密度为1.25的浸膏,加入辅料淀粉、乙醇、滑石粉,制得片剂。
实施例3 颗粒剂
黑老虎1kg、伸筋草0.5kg、肿节风1kg、两面针2.5kg、海风藤1kg、苏木2kg、黄姜1kg、三叉苦2kg、接骨木1kg、鸡血藤1kg、小千金2kg、白芷2.5kg、薄荷油1kg、九龙根1kg。取全部药材,加水提取3次,三次加水量分别相当于药材总重量的12倍、8倍、6倍,每次提取时间分别3小时、2小时、1小时,合并提取液,滤过,滤液浓缩至70℃时相对密度为1.20的清膏,加入乙醇,使含醇量为40%,静置24小时,滤过,滤液浓缩至滤液浓缩至70℃时相对密度为1.10的浸膏,加入淀粉、糊精,制粒、干燥、整粒即得。
实施例4 胶囊剂
黑老虎1.5kg、伸筋草1kg、肿节风1.5kg、两面针3.5kg、海风藤1.5kg、苏木2.5kg、黄姜1.5kg、三叉苦2.5kg、接骨木1.5kg、鸡血藤1.5kg、小千金2.5kg、白芷3.5kg、薄荷油1.5kg、九龙根1.5kg。取全部药材,用乙醇回流提取2次,每次乙醇浓度分别为80%、60%,每次乙醇用量分别为药材总量的10倍、8倍,提取时间分别为4小时、3小时,合并提取液,过滤,滤液浓缩至80℃时相对密度为1.10的浸膏,在浸膏中加入辅料淀粉、乙醇、糊精、硬脂酸镁,按常规方法制成胶囊剂。
实施例5 片剂
黑老虎1.2kg、伸筋草0.8kg、肿节风1.2kg、两面针3kg、海风藤1.2kg、苏木2.3kg、黄姜1.2kg、三叉苦2.3kg、接骨木1.2kg、鸡血藤1.2kg、小千金2.3kg、白芷3kg、薄荷油1.2kg、九龙根1.2kg。取全部药材,三次加水量分别为药材总重量的12倍、8倍、6倍,三次提取时间分别为3小时、2小时、1小时,合并提取液,滤过,滤液浓缩至70℃时相对密度为1.25的清膏,加入辅料淀粉、乙醇、滑石粉,制得片剂。
实施例6 颗粒剂
黑老虎1.5kg、伸筋草0.6kg、肿节风1kg、两面针2.8kg、海风藤1.4kg、苏木2.8kg、黄姜1.6kg、三叉苦2kg、接骨木1.8kg、鸡血藤1.2kg、小千金2.8kg、白芷3.3kg、薄荷油1kg、九龙根0.6kg、牛大力2.5kg、五指山参2kg。取全部药材,每次加水量分别相当于药材总重量的12倍、10倍,每次提取时间分别为3小时、2小时,合并提取液,滤过,滤液浓缩至80℃下相对密度为1.05的清膏,加入乙醇,使含醇量为70%,静置12小时,滤过,滤液浓缩至70℃时相对密度为1.25的浸膏,加入淀粉、糊精,制粒、干燥、整粒即得。
实施例7 糖浆剂
黑老虎0.8kg、伸筋草0.4kg、肿节风0.6kg、两面针2.3kg、海风藤0.8kg、苏木1.8kg、黄姜0.6kg、三叉苦2.6kg、接骨木0.7kg、鸡血藤1.5kg、小千金2.8kg、白芷3.2kg、薄荷油1.8kg、九龙根0.8kg。取全部药材,两次加水量分别为药材总重量的10倍、8倍,两次提取时间分别为2小时、1小时,合并提取液,滤过,滤液浓缩至80℃时相对密度为1.10的浸膏。在浸膏中加入糖浆剂辅料蔗糖、山梨酸、水搅拌均匀,制得糖浆剂。
实施例8 合剂
黑老虎1.6kg、伸筋草0.6kg、肿节风1.7kg、两面针3.5kg、海风藤1.7kg、苏木2.8kg、黄姜0.8kg、三叉苦2kg、接骨木1.6kg、鸡血藤1.4kg、小千金3kg、白芷2.4kg、薄荷油0.6kg、九龙根1.8kg。取全部药材,三次加水量分别相当于药材总重量的12倍、8倍、6倍,每次提取时间分别3小时、2小时、1小时,合并提取液,滤过,滤液浓缩至总重量为药材总重量的3倍,灌装,加入合剂辅料蔗糖、乙酯、水、山梨酸搅拌均匀,制得合剂。
实施例9
本发明实施例4所制备的胶囊剂,给予股骨痛患者口服,每次2粒,每日3次,临床数据如下:
病症类别 | 病症例数 | 病程 | 治疗时间 | 有效人数 | 总有效率 |
股骨痛 | 86 | 5天-10个月 | 20-30天 | 81人 | 94.2% |
实施例10
金xx,男,46岁,右侧股骨头酸痛一年多,不动时没什么感觉,走路时疼的厉害。给予本发明实施例7治疗,10天后疼痛大为改善,继续服用一个月,疼痛基本消失。
虽然,上文中已经用一般性说明、具体实施方式及试验,对本发明作了详尽的描述,但在本发明基础上,可以对之作一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
Claims (8)
1.一种治疗股骨痛的中药组合物,其特征在于它是由包括以下重量份的原料制成的:
黑老虎5-20份、伸筋草3-15份、肿节风5-20份、两面针20-40份、海风藤5-20份、苏木15-30份、黄姜5-20份、三叉苦15-30份、接骨木5-20份、鸡血藤5-20份、小千金15-30份、白芷20-40份、薄荷油5-20份、九龙根5-20份。
2.如权利要求1所述的治疗股骨痛的中药组合物,其特征在于它是由包括以下重量份的原料制成的:
黑老虎10-15份、伸筋草5-10份、肿节风10-15份、两面针25-35份、海风藤10-15份、苏木20-25份、黄姜10-15份、三叉苦20-25份、接骨木10-15份、鸡血藤10-15份、小千金20-25份、白芷25-35份、薄荷油10-15份、九龙根10-15份、。
3.如权利要求1所述的治疗股骨痛的中药组合物,其特征在于它是由包括以下重量份的原料制成的:
黑老虎12份、伸筋草8份、肿节风12份、两面针30份、海风藤12份、苏木23份、黄姜12份、三叉苦23份、接骨木12份、鸡血藤12份、小千金23份、白芷30份、薄荷油12份、九龙根12份。
4.如权利要求1-3任一项所述的治疗股骨痛的中药组合物,其特征在于它的活性成分是采用水提或40-80%体积百分浓度的乙醇提取制备而成。
5.如权利要求4所述的治疗股骨痛的中药组合物,其特征在于它的活性成分是通过以下方法制备而成的:取全部全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,滤过,滤液浓缩至70-80℃时相对密度为1.15-1.20的清膏,即得活性成分。
6.如权利要求4所述的治疗股骨痛的中药组合物,其特征在于它的活性成分是通过以下方法制备而成的:取全部全部药材,混合后用40-80%乙醇回流提取2-3次,每次乙醇用量为药材总量的4-10倍,提取时间为1-4小时,合并提取液,过滤,滤液浓缩至70-80℃时相对密度为1.15-1.20的清膏,即得活性成分。
7.如权利要求4所述的治疗股骨痛的的中药组合物,其特征在于它的活性成分是通过以下方法制备而成的:取全部全部药材,混合后加水提取2-3次,每次加水量相当于药材总重量的6-12倍,每次提取时间为1-3小时,合并提取液,滤过,滤液浓缩至70-80℃时相对密度为1.15-1.20的清膏,加入乙醇,使含醇量为40-70%,静置12-24小时,滤过,滤液浓缩至70-80℃时相对密度为1.10-1.25的浸膏,即得活性成分。
8.一种治疗股骨痛的中药组合物,由权利要求1-3中任一项所述的治疗股骨痛的中药组合物与医药学上可接受的载体配合制备而成。
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