CN105687779A - 一种止咳喘颗粒及其制备方法 - Google Patents
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Abstract
本发明属于中药制剂的制备领域,具体涉及一种止咳喘颗粒及其制备方法,原料药组成按重量份计包括:桃根20-30份、黄瓜籽20-40份、葡萄籽粉25-35份、菠菜籽粉25-35份、枸杞叶15-25份、知母20-30份、西兰花15-25份、金银花15-20份、铁皮石斛15-26份、紫菜10-20份、满山红10-25份、甘草12-16份、桔梗12-16份、蔗糖2-4份、糊精1-3份。本发明所提供的止咳喘颗粒,不仅具有去燥湿化痰、疏散风热,生津、止咳平喘等功效,还具有润肠通便、提高免疫力、抗过敏等的作用,主要用于咳嗽多、气喘、咽喉肿瘤、肺热痰郁、痰黄粘稠等症状,本发明安全可靠、无毒副作用。
Description
技术领域
本发明属于中药制剂的制备领域,具体涉及一种止咳喘颗粒及其制备方法。
背景技术
咳嗽是一种呼吸道常见的突发性症状,咳嗽由气管、支气管粘膜或胸膜受炎症、异物、物理或化学性刺激等引起。咳嗽分外感、内伤两大类:
外感多由风、寒、燥、热等邪侵入肺部所致,痰多稀薄、鼻塞、流涕、舌苔薄白者,属风寒,治疗宜疏风、散热、宣肺;燥邪犯肺,则干咳无痰、鼻燥、咽干、苔薄黄,治疗宜清肺润燥为主。
内伤多由痰湿、肝火及肺虚所致,痰湿兼痰多白粘、胸闷、苔腻、脉滑、治疗宜健脾、燥湿、化痰;肝火犯肺可见气逆作咳、面红、胁痛、脉弦数,治疗宜清肺、平肝、降火、肺虚如咳嗽少痰、或痰粘不易咯出、消瘦、内热、升火为阴虚,治疗宜滋阴、清火、润肺,如咳嗽无力、气短神倦、言语音低等为气虚,治疗宜益气、培脾、补肺为主。
发明内容
本发明的目的在于提供一种止咳喘颗粒及其制备方法,本发明所提供的止咳喘颗粒,不仅具有去燥湿化痰、疏散风热,生津、止咳平喘等功效,还具有润肠通便、提高免疫力、抗过敏等的作用,主要用于咳嗽多、气喘、咽喉肿瘤、肺热痰郁、痰黄粘稠等症状,本发明安全可靠、无毒副作用。
为实现上述目的,本发明采用如下技术方案:
一种止咳喘颗粒,原料药组成按重量份计包括:桃根20-30份、黄瓜籽20-40份、葡萄籽粉25-35份、菠菜籽粉25-35份、枸杞叶15-25份、知母20-30份、西兰花15-25份、金银花15-20份、铁皮石斛15-26份、紫菜10-20份、满山红10-25份、甘草12-16份、桔梗12-16份、蔗糖2-4份、糊精1-3份。
优选的,原料药组成按重量份计包括:桃根25份、黄瓜籽30份、葡萄籽粉30份、菠菜籽粉30份、枸杞叶20份、知母25份、西兰花20份、金银花18份、铁皮石斛21份、紫菜16份、满山红20份、甘草14份、桔梗14份、蔗糖3份、糊精2份。
止咳喘颗粒的制备方法,所述方法包括如下:
1)满山红加6倍重量水50℃浸泡4h,加热蒸馏待无挥发油馏出,收集挥发油,将残渣于提取罐内加适量乙醇至含醇量为40%,回流提取2.5h,收集提取液,过滤,滤液回收乙醇,在80℃浓缩至相对密度1.02-1.07,得到满山红醇提浓缩液,备用;
2)铁皮石斛加入9-10倍重量饮用水,90-100℃煎煮3-4h,过滤,药渣备用,滤液浓缩至相对密度为1.1-1.25;
3)桃根、枸杞叶、知母、西兰花、金银花、紫菜、黄瓜籽、甘草、桔梗混合加8倍重量的水煎煮2h,收集煎煮液,药渣再加6倍重量水煎煮1h,收集煎煮液,合并两次煎煮液,药渣备用;
4)将步骤2)、步骤3)的药渣与葡萄籽粉、菠菜籽粉混合,加入2-3倍重量饮用水煎煮3遍,每次1.5h,过滤,合并滤液,浓缩至相对密度为1.15~1.25;
5)将满山红醇提浓缩液、步骤2)滤液、步骤3)滤液与步骤4)的滤液混合均匀,80℃浓缩至相对密度为1.30~1.35的稠膏;将稠膏加入蔗糖与糊精,制粒、干燥,整粒,分装,即得。
葡萄籽粉和菠菜籽粉是分别取葡萄籽和菠菜籽经过常规步骤干燥粉碎获得。
桃根,清热利湿,活血止痛;消痈肿。主黄疸;吐血;衄血;经闭;痈肿;痔疮;风湿痹痛;跌打劳伤疼痛;腰痛;痧气腹痛。
黄瓜籽的主要成分为:多种游离氨基酸(其中丙醇二酸在人体有减肥和预防冠心病的功效)和维生素、木糖、果糖、以及芸香甙、异槲皮甙、精氨酸的葡萄糖甙等甙类、胡萝卜素及其它对人体有益的矿物质、硫胺素、核黄素。
葡萄籽含丰富的原花青素,后者被誉为“天然的护肤品”,能抗氧化、抗过敏、延缓皮肤衰老,兼有抑制血小板聚集和动脉粥样硬化形成的作用。
菠菜籽粉经常服用可以预防肺部疾病。主要功效养肺、治疗肺结核、哮喘、咳嗽、清理肺部疾病等,与黄瓜籽粉同服效果更佳。
枸杞叶功效主治:补肝益肾,生津止渴,祛风除湿,活血化瘀。治虚劳发热,烦渴,目赤昏痛,障翳夜盲,崩漏带下,热毒疮肿。
知母的干燥根状茎为著名中药,性苦寒,有滋阴降火、润燥滑肠、利大小便之效。属清热下火药,主治:温热病、高热烦渴、咳嗽气喘、燥咳、便秘、骨蒸潮热、虚烦不眠、消渴淋浊。
西兰花营养丰富,含蛋白质、糖、脂肪、维生素和胡萝卜素,营养成份位居同类蔬菜之首。西兰花可以有效降低乳腺癌、直肠癌、胃癌、心脏病和中风的发病率,还有杀菌和防止感染的功效。
紫菜富含蛋白质和碘、磷、钙等。供食用和药用,具有化痰软坚、清热利水、补肾养心的功效。
金银花自古被誉为清热解毒的良药。它性甘寒气芳香,甘寒清热而不伤胃,芳香透达又可祛邪。金银花既能宣散风热,还善清解血毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症,均效果显著。
铁皮石斛,性味功效:味甘,性微寒。生津养胃;滋阴清热;润肺益肾;明目强腰。
甘草补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
满山红具有止咳,祛疾等功效,治慢性支气管炎,咳嗽。
本发明的优点在于:本发明各药配伍,不仅可以主治咳嗽气喘、去燥湿化痰、疏散风热等由咳嗽引起的症状,还具有提高免疫力等功效,达到了标本兼治的效果和治愈疾病的预期目的,同时本发明药物的剂型利于吸收,食用方便、安全、无毒副作用,治愈率也高、无残留,同时原料低廉,工艺简便可行,是一种良好的治疗咳嗽气喘的中药制剂。
具体实施方式
一种止咳喘颗粒,原料药组成按重量份计包括:桃根20-30份、黄瓜籽20-40份、葡萄籽粉25-35份、菠菜籽粉25-35份、枸杞叶15-25份、知母20-30份、西兰花15-25份、金银花15-20份、铁皮石斛15-26份、紫菜10-20份、满山红10-25份、甘草12-16份、桔梗12-16份、蔗糖2-4份、糊精1-3份。
优选的,原料药组成按重量份计包括:桃根25份、黄瓜籽30份、葡萄籽粉30份、菠菜籽粉30份、枸杞叶20份、知母25份、西兰花20份、金银花18份、铁皮石斛21份、紫菜16份、满山红20份、甘草14份、桔梗14份、蔗糖3份、糊精2份。
止咳喘颗粒的制备方法,所述方法包括如下:
1)满山红加6倍重量水50℃浸泡4h,加热蒸馏待无挥发油馏出,收集挥发油,将残渣于提取罐内加适量乙醇至含醇量为40%,回流提取2.5h,收集提取液,过滤,滤液回收乙醇,在80℃浓缩至相对密度1.02-1.07,得到满山红醇提浓缩液,备用;
2)铁皮石斛加入9-10倍重量饮用水,90-100℃煎煮3-4h,过滤,药渣备用,滤液浓缩至相对密度为1.1-1.25;
3)桃根、枸杞叶、知母、西兰花、金银花、紫菜、黄瓜籽、甘草、桔梗混合加8倍重量的水煎煮2h,收集煎煮液,药渣再加6倍重量水煎煮1h,收集煎煮液,合并两次煎煮液,药渣备用;
4)将步骤2)、步骤3)的药渣与葡萄籽粉、菠菜籽粉混合,加入2-3倍重量饮用水煎煮3遍,每次1.5h,过滤,合并滤液,浓缩至相对密度为1.15~1.25;
5)将满山红醇提浓缩液、步骤2)滤液、步骤3)滤液与步骤4)的滤液混合均匀,80℃浓缩至相对密度为1.30~1.35的稠膏;将稠膏加入蔗糖与糊精,制粒、干燥,整粒,分装,即得。
实施例1
一种止咳喘颗粒,原料药组成按重量份计包括:桃根25份、黄瓜籽30份、葡萄籽粉30份、菠菜籽粉30份、枸杞叶20份、知母25份、西兰花20份、金银花18份、铁皮石斛21份、紫菜16份、满山红20份、甘草14份、桔梗14份、蔗糖3份、糊精2份。
止咳喘颗粒的制备方法,所述方法包括如下:
1)满山红加6倍重量水50℃浸泡4h,加热蒸馏待无挥发油馏出,收集挥发油,将残渣于提取罐内加适量乙醇至含醇量为40%,回流提取2.5h,收集提取液,过滤,滤液回收乙醇,在80℃浓缩至相对密度1.05,得到满山红醇提浓缩液,备用;
2)铁皮石斛加入9倍重量饮用水,100℃煎煮3h,过滤,药渣备用,滤液浓缩至相对密度为1.2;
3)桃根、枸杞叶、知母、西兰花、金银花、紫菜、黄瓜籽、甘草、桔梗混合加8倍重量的水煎煮2h,收集煎煮液,药渣再加6倍重量水煎煮1h,收集煎煮液,合并两次煎煮液,药渣备用;
4)将步骤2)、步骤3)的药渣与葡萄籽粉、菠菜籽粉混合,加入2倍重量饮用水煎煮3遍,每次1.5h,过滤,合并滤液,浓缩至相对密度为1.2;
5)将满山红醇提浓缩液、步骤2)滤液、步骤3)滤液与步骤4)的滤液混合均匀,80℃浓缩至相对密度为1.33的稠膏;将稠膏加入蔗糖与糊精,制粒、干燥,整粒,分装,即得。
实施例2
一种止咳喘颗粒,原料药组成按重量份计包括:桃根20份、黄瓜籽20份、葡萄籽粉25份、菠菜籽粉25份、枸杞叶15份、知母20份、西兰花15份、金银花15份、铁皮石斛15份、紫菜10份、满山红10份、甘草12份、桔梗12份、蔗糖2份、糊精1份。
止咳喘颗粒的制备方法,所述方法包括如下:
1)满山红加6倍重量水50℃浸泡4h,加热蒸馏待无挥发油馏出,收集挥发油,将残渣于提取罐内加适量乙醇至含醇量为40%,回流提取2.5h,收集提取液,过滤,滤液回收乙醇,在80℃浓缩至相对密度1.02,得到满山红醇提浓缩液,备用;
2)铁皮石斛加入9倍重量饮用水,90℃煎煮4h,过滤,药渣备用,滤液浓缩至相对密度为1.1;
3)桃根、枸杞叶、知母、西兰花、金银花、紫菜、黄瓜籽、甘草、桔梗混合加8倍重量的水煎煮2h,收集煎煮液,药渣再加6倍重量水煎煮1h,收集煎煮液,合并两次煎煮液,药渣备用;
4)将步骤2)、步骤3)的药渣与葡萄籽粉、菠菜籽粉混合,加入2倍重量饮用水煎煮3遍,每次1.5h,过滤,合并滤液,浓缩至相对密度为1.15;
5)将满山红醇提浓缩液、步骤2)滤液、步骤3)滤液与步骤4)的滤液混合均匀,80℃浓缩至相对密度为1.30的稠膏;将稠膏加入蔗糖与糊精,制粒、干燥,整粒,分装,即得。
实施例3
一种止咳喘颗粒,原料药组成按重量份计包括:桃根30份、黄瓜籽40份、葡萄籽粉35份、菠菜籽粉35份、枸杞叶25份、知母30份、西兰花25份、金银花20份、铁皮石斛26份、紫菜20份、满山红25份、甘草16份、桔梗16份、蔗糖4份、糊精3份。
止咳喘颗粒的制备方法,所述方法包括如下:
1)满山红加6倍重量水50℃浸泡4h,加热蒸馏待无挥发油馏出,收集挥发油,将残渣于提取罐内加适量乙醇至含醇量为40%,回流提取2.5h,收集提取液,过滤,滤液回收乙醇,在80℃浓缩至相对密度1.07,得到满山红醇提浓缩液,备用;
2)铁皮石斛加入10倍重量饮用水,100℃煎煮4h,过滤,药渣备用,滤液浓缩至相对密度为1.25;
3)桃根、枸杞叶、知母、西兰花、金银花、紫菜、黄瓜籽、甘草、桔梗混合加8倍重量的水煎煮2h,收集煎煮液,药渣再加6倍重量水煎煮1h,收集煎煮液,合并两次煎煮液,药渣备用;
4)将步骤2)、步骤3)的药渣与葡萄籽粉、菠菜籽粉混合,加入3倍重量饮用水煎煮3遍,每次1.5h,过滤,合并滤液,浓缩至相对密度为1.25;
5)将满山红醇提浓缩液、步骤2)滤液、步骤3)滤液与步骤4)的滤液混合均匀,80℃浓缩至相对密度为1.35的稠膏。将稠膏加入蔗糖与糊精,制粒、干燥,整粒,分装,即得。
临床资料
一般资料:患者300例,其中男162例,女138例,年龄6~53岁,发病2~4d。
诊断标准:参照全国防治感冒科研协作座谈会制定(1978年5月24日)的“感冒诊断要点防治效果判断标准(草案)”中有关规定。感冒系指病毒引起的急性上呼吸道感染,临床表现,以局部症状为主,全身症状可有或不明显,①局部症状:流涕,喷嚏,鼻塞有时咳嗽,咽痛,声嘶,流泪;②全身症状:全身不适,畏寒发热,头痛头昏,四肢腰背酸痛;③血象:白细胞多为正常或减少。
治疗方法:口服实施例1制备的中药制剂,每日三次,每次10ml,饭后服用。三天后观察疗效。
疗效标准:参照《实用中西医结合诊断治疗学》即:判定疗效时以发病在24h以内治疗者为统计对象;显效:服用24h内,全身症状及局部主要症状如发热、流涕等消失或基本消退;有效:服药24~48h内全身及局部主要症状如发热、流涕等消失或基本消失,高热患者(39℃以上)在24h内体温下降2℃以上,并不再回升者;无效:不符合以上标准者,均为无效。
治疗结果:300例患者中,显效:245例,有效:53例,无效2例,总有效率99.99%。
以上所述仅为本发明的较佳实施例,凡依本发明申请专利范围所做的均等变化与修饰,皆应属本发明的涵盖范围。
Claims (3)
1.一种止咳喘颗粒,其特征在于:原料药组成按重量份计包括:桃根20-30份、黄瓜籽20-40份、葡萄籽粉25-35份、菠菜籽粉25-35份、枸杞叶15-25份、知母20-30份、西兰花15-25份、金银花15-20份、铁皮石斛15-26份、紫菜10-20份、满山红10-25份、甘草12-16份、桔梗12-16份、蔗糖2-4份、糊精1-3份。
2.根据权利要求1所述的止咳喘颗粒,其特征在于:原料药组成按重量份计包括:桃根25份、黄瓜籽30份、葡萄籽粉30份、菠菜籽粉30份、枸杞叶20份、知母25份、西兰花20份、金银花18份、铁皮石斛21份、紫菜16份、满山红20份、甘草14份、桔梗14份、蔗糖3份、糊精2份。
3.一种如权利要求1所述的止咳喘颗粒的制备方法,其特征在于:所述方法包括如下:
1)满山红加6倍重量水50℃浸泡4h,加热蒸馏待无挥发油馏出,收集挥发油,将残渣于提取罐内加适量乙醇至含醇量为40%,回流提取2.5h,收集提取液,过滤,滤液回收乙醇,在80℃浓缩至相对密度1.02-1.07,得到满山红醇提浓缩液,备用;
2)铁皮石斛加入9-10倍重量饮用水,90-100℃煎煮3-4h,过滤,药渣备用,滤液浓缩至相对密度为1.1-1.25;
3)桃根、枸杞叶、知母、西兰花、金银花、紫菜、黄瓜籽、甘草、桔梗混合加8倍重量的水煎煮2h,收集煎煮液,药渣再加6倍重量水煎煮1h,收集煎煮液,合并两次煎煮液,药渣备用;
4)将步骤2)、步骤3)的药渣与葡萄籽粉、菠菜籽粉混合,加入2-3倍重量饮用水煎煮3遍,每次1.5h,过滤,合并滤液,浓缩至相对密度为1.15~1.25;
5)将满山红醇提浓缩液、步骤2)滤液、步骤3)滤液与步骤4)的滤液混合均匀,80℃浓缩至相对密度为1.30~1.35的稠膏;将稠膏加入蔗糖与糊精,制粒、干燥,整粒,分装,即得。
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