CN107711850A - A kind of complex composition and bactericide of the lactams of ketoxime containing isolonglifolene and Flutriafol - Google Patents

A kind of complex composition and bactericide of the lactams of ketoxime containing isolonglifolene and Flutriafol Download PDF

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CN107711850A
CN107711850A CN201711218328.0A CN201711218328A CN107711850A CN 107711850 A CN107711850 A CN 107711850A CN 201711218328 A CN201711218328 A CN 201711218328A CN 107711850 A CN107711850 A CN 107711850A
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flutriafol
lactams
isolonglifolene
ketoxime
complex composition
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谭贵友
蓝丽红
赵钟兴
雷声波
韦秋平
韦翠庆
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/46—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom rings with more than six members

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
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  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention discloses a kind of complex composition and preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol.The complex composition is made up of isolonglifolene ketoxime lactams and Flutriafol；Wherein, the weight of isolonglifolene ketoxime lactams acyl bacterium and Flutriafol ratio is (20~1):(1~40), complex composition of the invention account for the weight percentage of bactericide as 0.1% 90%.The complex composition of the present invention can effectively prevent and treat various bacterial diseases such as citrus bacterial canker disease, cucumber bacterial angular leaf spot etc., while can prevent and treat fungal disease such as downy mildew of garpe.The complex composition of the present invention has obvious synergistic function, and preventive effect is high, reduces the usage amount of medicament, reduces cost accounting, while delays the resistance to the action of a drug.

Description

A kind of complex composition and bactericide of the lactams of ketoxime containing isolonglifolene and Flutriafol
Technical field
The present invention relates to technical field of pesticide, the compounding of the more particularly to a kind of lactams of ketoxime containing isolonglifolene and Flutriafol Composition and bactericide.
Background technology
The resistance problem of agricultural pests is a global problem.With the continuity of disease chemical prevention, Pesticide use The increase of amount and not scientifical use agricultural chemicals, the resistance getting worse of germ, the germ species for producing resistance are on the increase.Especially It is bacterial disease, resistance level is high, and resistance development speed is fast.
As people constantly strengthen the consciousness of environmental protection and social sustainable development, especially 21 century, from plant New natural drug is found and excavated in resource applied to medical science or agriculturally, has become countries in the world important subject. It is increasingly difficult to using traditional bactericide of the synthetic method synthesis with excellent activity, and this bactericide that is synthesized is past It is past that there is certain toxicity, the resistance to the action of a drug and pollution environment etc., for example the agricultural chemicals such as DDT, BHC organochlorine is due to environmental disruption Property it is relatively strong and be gradually backed out market or be eliminated.Therefore, researching and developing and formulate the newtype drug with autonomous property right turns into medicine Learn the focus with Pesticide Science research.Oximido ether compound tool has been widely used, for example as bactericide, antifungal agent, weeding Agent etc., and there is hypotoxicity, low-residual, high activity, widely attract the research interest of research-on-research.Recently, people Find 1,2,3,4,5,6- hexahydros -1,1,5,5- tetramethyl -7H-2,4 α-methanonaphthalene -7- ketone (Isolongifolenone) is to suppressing Junket ammonia enzyme and anti-breast cancer have preferably activity, and Isolongifolenone is highly effective to prevention tick and bite by mosquitos, effect Fruit is better than traditional Metadelphene.
Flutriafol has efficient, wide spectrum, safer bactericidal action, has preferable bactericidal action to bacterium, fungi etc.. But because its long-time uses, alone its prevents and treats crop disease, and prevention effect is undesirable, and disease also generates certain anti-medicine to it Property.Therefore, it is necessary to develop a kind of pesticide complex composition efficiently, less toxic, environmentally friendly.
Isolonglifolene ketoxime lactam structure formula is as follows:
The step of preparation process of the compound：Using Isolongifolenone as raw material, different come into leaves is synthesized by addition elimination reaction Ketenes oxime, then acyl in described isolonglifolene ketoxime should be prepared by the progress Beckmann rearrangement reactions of isolonglifolene ketoxime Amine.
The content of the invention
Applicant further study show that, show isolonglifolene ketoxime lactams to bacterial disease by substantial amounts of experiment It is respectively provided with preferable prevention effect and inhibitory action.Bacterium such as staphylococcus aureus, ETEC, pneumonia gram can be suppressed The primary Salmonella of thunder, proteus vulgaris and pseudomonas aeruginosa and fungi Ru Aspergillus, Exserohilum turcicum, corn line it is withered, fragrant Any of several broadleaf plants lotus lattice bacterium, banana anthrax etc.；Superior insecticidal action is shown to insect pests such as aphid and planthoppers.The compound has height Effect, wide spectrum, it is safe to use the characteristics of, be with exploitation for large tonnage product potential quality bactericide.Acute toxicity and environment poison Property experiment show that isolonglifolene ketoxime lactams belongs to low toxicity compounds, there are good market prospects.
However, a kind of appearance of new drug, if long-term single use, is all inevitably generated resistance, Isolongifolenone This new type bactericide of oxime lactams is no exception, and single dose uses, and its preventing and treating to pest and disease damage is also difficult to obtain its optimum efficiency. Therefore, it is to improve the effect of preventing and treating crop disease by isolonglifolene ketoxime lactams and Flutriafol compounding by compounding channel, and The effective way of delaying drug resistance development.
In view of this, the purpose of the present invention solves above-mentioned technical problem, there is provided a kind of lactams of ketoxime containing isolonglifolene with The complex composition of Flutriafol, the complex composition have obvious synergistic function relative to single dose, reduce the use of agricultural chemicals Dose, while delay the resistance to the action of a drug of the pathogen to isolonglifolene ketoxime lactams and Flutriafol.
To realize above-mentioned purpose, use following technical scheme of the invention：
A kind of complex composition of the lactams of ketoxime containing isolonglifolene and Flutriafol, the complex composition is by Isolongifolenone Oxime lactams and Flutriafol composition；Described isolonglifolene ketoxime lactams and the weight ratio of Flutriafol are (20~1):(1~ 40)。
In order to ensure that complex composition has more preferable preventive effect and a synergistic effect, in above-described ketoxime containing isolonglifolene The complex composition of acid amides and Flutriafol, preferably, described isolonglifolene ketoxime lactams and the weight ratio of Flutriafol are (5~1):(1~20).
The present invention also provides a kind of preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol, and said preparation book will be described above Complex composition and agricultural chemicals on acceptable adjuvant, be prepared into preventing and treating crop disease bactericide.
In order to ensure that bactericide has more preferable preventive effect, the system of the lactams of ketoxime containing isolonglifolene and Flutriafol described above Agent, preferably, the weight percentage that the complex composition accounts for above-mentioned bactericide is 0.1%-90%.
The preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol described above, it is preferable that the complex composition accounts for The weight percentage for stating bactericide is 1%-80%.
The preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol described above, it is highly preferred that the complex composition accounts for The weight percentage of above-mentioned bactericide is 5%-60%.
In order to meet different the needs of using, bactericide of the present invention can be made into a variety of formulations, preferably, at this In the offer embodiment of invention, the formulation of bactericide is suspending agent, wettable powder, water dispersible granules, suspension seed-coating agent or Granula.It is not limited only to formulation provided by the invention.
In order to preferably play the bactericidal effect of complex composition, the bactericide is except including compounded combination beyond the region of objective existence, going back Including acceptable adjuvant on agricultural chemicals.Wherein adjuvant is a kind of and mixture of auxiliary agent in filler and solvent.
The auxiliary agent is surfactant, wetting dispersing agent, thickener, binding agent, disintegrant, film forming agent.If necessary plus Enter other conventional functionality auxiliary agents such as antifreezing agent, thickener, stabilizer, defoamer.
Filler is in white carbon, clay, bentonite, kaolin, diatomite, soil powder, montmorillonite, humic acid, urea It is one or more of.
Solvent is water.
Surfactant used, which is selected from polyoxyethylene sorbitan fatty acid ester series, includes T-60, T-80, T-85；Fat Fat alcohol APEO JFC；OP series includes OP-10, OP-15, OP-18, OP-20 for condensation compound of alkyl phenol and epoxy ethane； NPE series includes NP-10, NP-15, NP-18, NP-20；Styrylphenol formaldehyde polyether series include 33#、34#、36#、37#；Three phenethyl phenol polyethenoxy ether 601#, 604#, 605#；Double phenethyl phenol polyethenoxy ether 606#.
Wetting dispersing agent is selected from diisobutyl sodium naphthalene sulfonate (abbreviation pull open powder), lauryl sodium sulfate (K12), methylene Double bitter edible plant sodium sulfonates (abbreviation NNO), acrylic acid and propionamide copolymer (abbreviation DA), dispersing agent MF are (referred to as MF), Sodium Polyacrylate (abbreviation DC), desugar and the sodium lignin sulfonate (abbreviation M-9) being classified, the lignin of desugar condensation and modification Sodium sulfonate (abbreviation M-10), poly carboxylic acid derivative (abbreviation CF), sodium lignin sulfonate (abbreviation M-14).
Thickener includes xanthans, aluminium-magnesium silicate, Arabic gum, pectin.
The one kind of binding agent in ethyl cellulose, methylcellulose, starch.
Disintegrant includes sodium phosphate, sodium chloride, potassium sulfate, potassium chloride, potassium phosphate, sodium carbonate, ammonium chloride, ammonium sulfate, carbon Sour potassium, sodium sulphate, potassium dihydrogen phosphate.
Film forming agent includes Sodium Polyacrylate, pectin, polyvinylpyrrolidone, methylcellulose, animal glue.
Antifreezing agent includes ethylene glycol, isopropanol, glycerine, propane diols, urea.
Complex composition provided by the invention, suitable for preventing and treating crop bacterium venereal disease evil and/or bacterial disease.
Crop bacterium venereal disease evil such as bacterial leaf streak of rice and bacterial leaf spot, soft rot of cabbage, citrus bacterial canker disease, peach bacterium Bacterial wilt, canker of tomato, the bacterial wilt of ginger such as bacterial angular leaf spot, the tomato peanuts such as property shothole disease, cucumber watermelon etc..
Crop fungal disease such as downy mildew of garpe, downy mildew of cucurbits, mango anthracnose, pepper anthracnose, melon withered Disease, citrus scab, Chinese cabbage downy mildew, black leg of beet, melon samping off, leaf spot of peanut, peanut root rot, the black shin of tobacco Disease etc..
Complex composition provided by the invention can also prevent and treat crop part Disease, such as tomato virus disease, watermelon disease Viral disease, pepper virus disease, tobacco mosaic disease etc..
Bactericide of the present invention can be applied by commonsense method, such as add water spray cauline leaf process, can also root Portion fills and applied, and can also dress seed or seed pelleting uses.
The complex composition and preparation of the present invention has the advantages that：
1st, complex composition and its preparation of the invention have obvious synergistic function relative to single dose.
2nd, wide sterilization spectrum, multiple diseases are respectively provided with good prevention effect.
3rd, the lasting period is grown.14 days prevention effects are up to more than 77% after second of medicine.
4th, delay the service life of new medicament isolonglifolene ketoxime lactams, reduce the development cost of new medicament.
5th, dosage is few, and residual is low, meets the trace standard of pesticide, ecological, environmental protective.
Embodiment
The present invention is illustrated with the following example, but is not limited the scope of the invention.It is used in the present invention different to come into leaves Ketenes oxime lactams active compound is provided by Guangxi National Univ., and other active compounds used and preparation are purchased in market.Wherein active component Isolonglifolene ketoxime lactams and Flutriafol.
Preparation embodiment：
For unification, it is adjuvant used all using abbreviation or commercial disignation that embodiment is prepared below.
First, the preparation of suspending agent
Surfactant, antifreezing agent, thickener, surfactant, water are mixed, are well mixed through high speed shear, successively Isolonglifolene ketoxime lactams, Flutriafol are added, abrading-ball 2~3 hours in ball crusher, the suspension of bactericide of the present invention is made Agent.
2nd, the preparation of wettable powder
Isolonglifolene ketoxime lactams, Flutriafol, wetting dispersing agent, white carbon, filler are well mixed, through air-flow crushing After machine crushes, 30min is stirred, obtains the wettable powder of bactericide of the present invention.
3rd, the preparation of water dispersible granules
Isolonglifolene ketoxime lactams, Flutriafol, wetting dispersing agent, white carbon, disintegrant, binding agent, filler are mixed Uniformly, after airslide disintegrating mill crushes, 30min is stirred, through mediating, rear add in fluidized-bed granulation dryer is granulated, done It is dry, obtain the water dispersible granules of bactericide of the present invention.
4th, the preparation of suspension seed-coating agent
Isolonglifolene ketoxime lactams and Flutriafol are passed through into air-flow crushing, add surfactant, film forming agent, thickener, Antifreezing agent and water be thoroughly mixed after after, put into sand mill in proportion and grind 2 times, until the grain fineness of suspension reaches D50 is 2-3 μm, 8 μm of D90 ＜, produce the suspension seed-coating agent of bactericide of the present invention.
5th, the preparation of granule
The component of each embodiment in table is uniformly mixed, air-flow crushing, add suitable quantity of water and then mediate, the mixture of gained It is granulated, is drying to obtain the granule of bactericide of the present invention.
Toxicity Determination：
Following indoor biometricses experiment calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Toxicity index TI (B)=(standard agent A EC50The EC of ÷ B agent50×100
Actual toxicity index ATI (AB)=(A EC50÷ AB EC50)×100
Percentage+TI (B) × B percentages in mixture of theoretical toxicity index TTI (AB)=TI (the A) × A in mixture Number
Survey toxicity index (ATI)=(standard agent EC50÷ reagent agents EC50)×100
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed B percentage composition in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI) ÷ mixtures theoretical toxicity index (TTI)] × 100
Evaluation criterion is：Co-toxicity coefficient >=120 show as synergistic effect；Co-toxicity coefficient≤80 show as antagonism；80< Co-toxicity coefficient<120 show as summation action.
Toxicity Determination embodiment one：
Experiment reference《Pesticide bioassay technology》(old spring chief editor, publishing house of Beijing Agricultural University publish) and《Agriculture Bioassay test criterion NY/T1156.2-2006 in coyote hole》.This experiment uses inhibition zone method.On aseptic operating platform, by NA Culture medium is poured on NA flat boards, after drying, takes 0.1ml citrus processing bacteria suspension to be equably applied to NA flat boards with spreading rod On.After drying, punched with diameter 7mm card punch in flat board center, then take 100 μ l decoctions in aperture.Each concentration 5 Repeat.To add the processing of sterilized water in aperture as blank control.28 ± 0.5 DEG C of insulating box sterile culture is placed on after processing, Taken out after 2d.Use crossing method to measure the antibacterial circle diameter (in units of millimeter) of each processing respectively, and calculate inhibition zone Average value, the inhibiting rate of diameter.Statistical analysis is carried out with DPS data processing softwares, calculates the EC of each medicament50, then by Sun Yun Abundant method calculates co-toxicity coefficient (CTC).
Toxicity test is the results detailed in Table 1.
The joint toxicity measuring result of the isolonglifolene ketoxime lactams of table 1 and Flutriafol compounding preventing and treating citrus bacterial canker disease
From the data of measurement result table 1, isolonglifolene ketoxime lactams and Flutriafol are by weight in (20~1):(1 ~40) CTC of compounding preventing and treating citrus bacterial canker disease reaches more than 120 in the range of, shows obvious synergistic effect.Especially It is that weight ratio is in (5~1):Compounded in the range of (1~20), for the CTC respectively handled more than 150, synergy is especially pronounced.
Toxicity Determination embodiment two：
It is 10 by bacteria suspension concentration8cfu·mL-1Pathogen adds 0.5mL in each diameter 9cm sterilizes culture dish, then Pour into 15mL to be cooled in 45 DEG C of gravy peptone culture mediums, fully mix, solidification.At 3 of culture dish bottom marker equilateral triangle Away from the equidistant Angle Positions of center 2.5cm, Oxford cup (high 10mm, internal diameter 6mm) is prevented, the medicament that equivalent various concentrations are added dropwise is dilute Liquid is released, 7d is cultivated under 28 DEG C of constant temperature aseptic conditions, determines antibacterial circle diameter, and calculates the average value of antibacterial circle diameter, suppress Rate.Statistical analysis is carried out with DPS data processing softwares, calculates the EC of each medicament50, then calculate co-toxicity coefficient by the abundant methods of Sun Yun (CTC)。
Toxicity test is the results detailed in Table 2.
The joint toxicity measuring knot of the isolonglifolene ketoxime lactams of table 2 and Flutriafol compounding preventing and treating cucumber bacterial angular leaf spot
Fruit
From the data of measurement result table 2, isolonglifolene ketoxime lactams and Flutriafol are by weight in (20~1):(1 ~40) CTC of compounding preventing and treating cucumber bacterial angular leaf spot reaches more than 120 in the range of, shows obvious synergistic effect. Particularly, it is by weight (5~1):Compounded in the range of (1~20), for the CTC respectively handled more than 150, synergy is particularly aobvious Write.
Toxicity Determination embodiment three：
Prepare pathogeny blade, lower blade back side Pseudoperonospora cubensis sporangiums are washed with 4 DEG C of distillations, being made into suspension, (concentration is Every milliliter 1 × 105~1 × 107Individual sporangium).Medicament mother liquor is diluted to corresponding concentration with the 0.05% Tween 80 aqueous solution, Uniformly spray and cultivated in prior to the plant leaf two sides of 4~6 leaf periods to whole wettings, 4 repetitions are often handled, if with clearly The processing that water sprays is blank control, after dispenser 24h, Fresh spores capsule suspension spray is inoculated in into vacuum side of blade, daily Each 12h alternatings of continuous illumination/dark, temperature is 17 DEG C~22 DEG C, and relative humidity is cultivated under conditions of being more than 90%.Work as blank The control incidence of disease reaches more than 50% time stage investigation incidence, disease index and preventive effect is calculated, according to each drug concentration pair Numerical value and corresponding preventive effect niqueMin make regression analysis, calculate the EC of lattice medicament50, and according to the common poison of the abundant method calculating mixtures of Sun Yun Coefficient.
Toxicity test is the results detailed in Table 3.
The isolonglifolene ketoxime lactams of table 3 and the joint toxicity measuring result of Flutriafol compounding preventing and treating downy mildew of garpe
From the data of measurement result table 3, isolonglifolene ketoxime lactams and Flutriafol are by weight (20~1):(1 ~40) CTC of compounding preventing and treating downy mildew of garpe reaches more than 120 in the range of, shows obvious synergistic effect.Especially It is that weight ratio is (5~1):Compounded in the range of (1~20), for the CTC respectively handled more than 150, synergy is especially pronounced.
Crop field test examples
In order to clear and definite isolonglifolene ketoxime lactams and Flutriafol it is alone with it is mixed when it is bacillary to citrus bacterial canker disease, cucumber The prevention effect of the bacterial disease such as angular leaf spot and downy mildew of garpe, different regions have been carried out largely present invention applicant at home Field test.
The isolonglifolene ketoxime lactams wettable powders of CK1 20% are made by oneself
The Flutriafol wettable powders of CK2 30% are purchased in market
Prevent and treat citrus bacterial canker disease field efficacy experiment one：
Test method：According to《Pesticide field efficacy medicine test criterion (GB/T17980.103-2004)》Provide application method, First time spray pesticide before blooming is seen in the beginning, second of spray pesticide after disease occurs.Dispenser twice, each handles cell altogether Area is into 3 plants of age fruit tree, number of repetition 4 times.Record spraying times and each dispenser date and fruit tree breeding time.
Investigation method：According to《Pesticide field efficacy medicine test criterion (GB/T17980.103-2004)》Provide investigation method, 7d after second of dispenser, 14d investigate each cell two plants, and every plant by the sampling of 5 points of all directions, 10 fruits of every investigation And whole blades on two tips, calculate preventing and treating preventive effect.
Leaf (fruit) stage division：
0 grade：There is scab 1~5 per leaf (fruit)；
3 grades：There is scab 6~10 per leaf (fruit)；
5 grades：There is scab 11~15 per leaf (fruit)；
7 grades：There is scab 15~20 per leaf (fruit)；
9 grades：There is scab more than 21 per leaf (fruit)；
Field control effectiveness test result refers to table 4.
Table 4 prevents and treats the field control effectiveness test result of citrus bacterial canker disease
From test of pesticide effectiveness result table 4：When preventing citrus bacterial canker disease, isolonglifolene ketoxime lactams+Flutriafol with Single dose isolonglifolene ketoxime lactams or Flutriafol are compared, in the case where active ingredient dosage is identical or even less, different length The 7d of leaf ketenes oxime lactams+Flutriafol preventing and treating citrus bacterial canker disease preventive effect (active ingredient dosage 20g/667m2) obvious Preventive effect higher than the preventive effect of single dose, and 14d remains to reach more than 78%, lasting period length.
Prevent and treat cucumber bacterial angular leaf spot field control effectiveness test two：
Test method：According to《Pesticide field efficacy medicine test criterion (GB/T17980.110-2004)》Provide application method, Beginning first time spray pesticide when seeing scab, second of spray pesticide after 10d.Twice, each plot area that handles is for dispenser altogether 20m2, number of repetition 4 times.
Investigation method：According to《Pesticide field efficacy medicine test criterion (GB/T17980.110-2004)》Provide investigation method, For open country per the 5 points of samplings of cell diagonal, every is investigated 3 plants, investigates whole blades, whole blade is accounted for every leaf spot lesion area Area percentage is classified.Calculate disease index and preventive effect effect.
Stage division：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6%~10% of whole leaf area；
5 grades：Lesion area accounts for the 11%~20% of whole leaf area；
7 grades：Lesion area accounts for the 21%~50% of whole leaf area；
9 grades：Lesion area accounts for more than the 51% of whole leaf area.
Field control effectiveness test result refers to table 5.
Table 5 prevents and treats the field control effectiveness test result of cucumber bacterial angular leaf spot
From test of pesticide effectiveness result table 5：In prevention cucumber bacterial angular leaf spot, isolonglifolene ketoxime lactams+powder azoles Alcohol is compared with single dose isolonglifolene ketoxime lactams or Flutriafol, in the case where active ingredient dosage is identical or even less, 7d preventive effects (the active ingredient dosage 10g/ of isolonglifolene ketoxime lactams+Flutriafol preventing and treating cucumber bacterial angular leaf spot 667m2) obviously higher than the preventive effect of single dose, and 14d preventive effect remains to reach more than 81.27%, lasting period length.
Prevent and treat downy mildew of garpe field control effectiveness test three：
Test method：According to《Pesticide field efficacy medicine test criterion (GB/T17980.122-2004)》Provide application method, The first time spray pesticide when blade begins to see morbidity, second of spray pesticide after 10d.Dispenser is twice, each to handle cell face altogether Product is 10 plants of open country, number of repetition 4 times.
Investigation method：According to《Pesticide field efficacy medicine test criterion (GB/T17980.122-2004)》Provide investigation method, Pumping is newly climing then to each cell random searching 10 by 7d after second of dispenser, 14d, investigates whole blades from top to bottom, presses Following stage division records the sick numbers of sheets and total number of sheets at different levels, calculates disease index and preventing and treating preventive effect.
Stage division：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6%~25% of whole leaf area；
5 grades：Lesion area accounts for the 26%~50% of whole leaf area；
7 grades：Lesion area accounts for the 51%~75% of whole leaf area；
9 grades：Lesion area accounts for more than the 76% of whole leaf area.
Field control effectiveness test result refers to table 6.
Table 6 prevents and treats the field control effectiveness test result of downy mildew of garpe
From test of pesticide effectiveness result table 6：In prevention downy mildew of garpe, isolonglifolene ketoxime lactams+Flutriafol and list Agent isolonglifolene ketoxime lactams or Flutriafol are compared, different to come into leaves in the case where active ingredient dosage is identical or even less Ketenes oxime lactams+Flutriafol preventing and treating downy mildew of garpe 7d preventive effect (active ingredient dosage 20g/667m2) obviously higher than The preventive effect of single dose, and 14d preventive effect remains to reach more than 80%, lasting period length.

Claims (9)

  1. A kind of 1. complex composition of lactams of ketoxime containing isolonglifolene and Flutriafol, it is characterised in that the complex composition It is made up of isolonglifolene ketoxime lactams and Flutriafol；Wherein the weight of isolonglifolene ketoxime lactams and Flutriafol ratio is (20 ~1):(1~40).
  2. 2. the complex composition of the lactams of ketoxime containing isolonglifolene according to claim 1 and Flutriafol, it is characterised in that The weight ratio of the isolonglifolene ketoxime lactams and Flutriafol is (5~1):(1~20).
  3. 3. the preparation of a kind of lactams of ketoxime containing isolonglifolene and Flutriafol, it is characterised in that by any one of claim 1~2 Acceptable adjuvant on described complex composition and agricultural chemicals, it is prepared into the bactericide of preventing and treating crop disease.
  4. 4. the preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol according to claim 3, it is characterised in that described answers The weight percentage that described bactericide is accounted for composition is 0.1%~90%.
  5. 5. the preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol according to claim 4, it is characterised in that described answers The weight percentage that described bactericide is accounted for composition is 1%~80%.
  6. 6. the preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol according to claim 5, it is characterised in that compounded combination The weight percentage that thing accounts for described bactericide is 5%~60%.
  7. 7. the preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol according to claim 3-6 is any, it is characterised in that institute The formulation for stating bactericide is suspending agent, wettable powder, water dispersible granules, suspension seed-coating agent or granule.
  8. 8. the preparation of the lactams of ketoxime containing isolonglifolene and Flutriafol according to claim 3, it is characterised in that described agriculture Acceptable adjuvant is a kind of and mixture of auxiliary agent in filler and solvent on medicine.
  9. 9. if complex composition according to any one of claims 1 to 2 is in preventing and treating crop bacterium venereal disease evil and/or fungoid disease The application of evil aspect.
CN201711218328.0A 2017-11-28 2017-11-28 A kind of complex composition and bactericide of the lactams of ketoxime containing isolonglifolene and Flutriafol Pending CN107711850A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104521990A (en) * 2014-12-18 2015-04-22 广西田园生化股份有限公司 Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and flutriafol and bactericide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104521990A (en) * 2014-12-18 2015-04-22 广西田园生化股份有限公司 Compound composition containing 2-(p-fluorophenyl)-5-methanesulfonyl-1,3,4-oxadiazole and flutriafol and bactericide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WU ZHUANG等: "Design,Synthesis,and Bioassay of Novel Compounds of Isolongifolenone Oxime Derivatives", 《HELV. CHIM. ACTA》 *

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Application publication date: 20180223