CN107709351A - 细胞毒性t细胞表位肽及其用途 - Google Patents

细胞毒性t细胞表位肽及其用途 Download PDF

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Publication number
CN107709351A
CN107709351A CN201580080723.XA CN201580080723A CN107709351A CN 107709351 A CN107709351 A CN 107709351A CN 201580080723 A CN201580080723 A CN 201580080723A CN 107709351 A CN107709351 A CN 107709351A
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cell
ctl
ebv
peptide
hla
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Chinese (zh)
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李栋梁
大鹰弘纪
中野绘
中野一绘
田路真悟
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Medical and Biological Laboratories Co Ltd
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Medical and Biological Laboratories Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838Viral antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201580080723.XA 2015-06-17 2015-06-17 细胞毒性t细胞表位肽及其用途 Pending CN107709351A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2015/067469 WO2016203577A1 (ja) 2015-06-17 2015-06-17 細胞傷害性t細胞エピトープペプチド及びその用途

Publications (1)

Publication Number Publication Date
CN107709351A true CN107709351A (zh) 2018-02-16

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CN201580080723.XA Pending CN107709351A (zh) 2015-06-17 2015-06-17 细胞毒性t细胞表位肽及其用途

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JP (1) JPWO2016203577A1 (ja)
CN (1) CN107709351A (ja)
TW (1) TW201708248A (ja)
WO (1) WO2016203577A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109294983A (zh) * 2018-09-30 2019-02-01 北京鼎成肽源生物技术有限公司 一种lff2细胞
CN110007071A (zh) * 2019-04-01 2019-07-12 河南省生物工程技术研究中心有限公司 一种ckap4标记抗体-荧光微球复合物的制备方法及其应用
CN110054663A (zh) * 2019-04-01 2019-07-26 河南省生物工程技术研究中心有限公司 Ckap4抗原表位肽、抗原、单克隆抗体及其应用和ckap4检测试纸条
CN110638787A (zh) * 2019-07-31 2020-01-03 中山大学 一种防治鼻咽癌的亚单位纳米疫苗及其制备方法
CN113419067A (zh) * 2021-05-26 2021-09-21 广州医科大学 一种用于评估造血干细胞移植病人cmv感染后免疫状态的多肽组合物以及检测试剂盒

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108997481B (zh) * 2017-06-07 2022-06-03 中国科学院广州生物医药与健康研究院 源自于lmp1的抗原短肽
JP7364237B2 (ja) 2017-08-10 2023-10-18 グッド ティー セルズ、 インコーポレイテッド 癌治療のためのt細胞の活性化方法
WO2019054409A1 (ja) * 2017-09-12 2019-03-21 国立大学法人北海道大学 Hlaタンパク質に相互作用する物質のスクリーニング方法及びスクリーニング用キット
CN113597430A (zh) * 2019-02-08 2021-11-02 古德T细胞有限公司 激活t细胞用于癌症治疗的方法
US20230210902A1 (en) * 2020-05-11 2023-07-06 Board Of Regents, The University Of Texas System Sars-cov-2-specific t cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009105152A2 (en) * 2008-01-31 2009-08-27 University Of Massachusetts Medical School Virus-like particles as vaccines for paramyxovirus
US20090305324A1 (en) * 2005-10-28 2009-12-10 Medical And Biological Laboratories Co., Ltd Cytotoxic t-cell epitope peptides that specifically attack epstein-barr virus-infected cells and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090305324A1 (en) * 2005-10-28 2009-12-10 Medical And Biological Laboratories Co., Ltd Cytotoxic t-cell epitope peptides that specifically attack epstein-barr virus-infected cells and uses thereof
WO2009105152A2 (en) * 2008-01-31 2009-08-27 University Of Massachusetts Medical School Virus-like particles as vaccines for paramyxovirus

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAO Y. N. ET AL: "Integrating transcriptome profiling and in silico pathway analysis toward reduction of therapeutic dimensionality in nasopharyngeal carcinoma", 《CANCER RESEARCH》 *
CHEUNG W. H. ET AL: "Conjugation of Latent Membrane Protein (LMP)-2 Epitope to Gold Nanoparticles as Highly Immunogenic Multiple Antigenic Peptides for Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses in Vitro", 《BIOCONJUGATE CHEM.》 *
LI S. X. ET AL: "Prognostic Significance of Cytoskeleton-Associated Membrane Protein 4 and Its Palmitoyl Acyltransferase DHHC2 in Hepatocellular Carcinoma", 《CANCER》 *
MURRAY R. J. ET AL: "Epstein-Barr Virus-Specific Cytotoxic T-Cell Recognition of Transfectants Expressing the Virus-Coded Latent Membrane Protein LMP", 《JOURNAL OF VIROLOGY》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109294983A (zh) * 2018-09-30 2019-02-01 北京鼎成肽源生物技术有限公司 一种lff2细胞
CN110007071A (zh) * 2019-04-01 2019-07-12 河南省生物工程技术研究中心有限公司 一种ckap4标记抗体-荧光微球复合物的制备方法及其应用
CN110054663A (zh) * 2019-04-01 2019-07-26 河南省生物工程技术研究中心有限公司 Ckap4抗原表位肽、抗原、单克隆抗体及其应用和ckap4检测试纸条
CN110054663B (zh) * 2019-04-01 2023-10-03 河南省生物工程技术研究中心 Ckap4抗原表位肽、抗原、单克隆抗体及其应用和ckap4检测试纸条
CN110638787A (zh) * 2019-07-31 2020-01-03 中山大学 一种防治鼻咽癌的亚单位纳米疫苗及其制备方法
CN110638787B (zh) * 2019-07-31 2021-11-05 中山大学 一种防治鼻咽癌的亚单位纳米疫苗及其制备方法
CN113419067A (zh) * 2021-05-26 2021-09-21 广州医科大学 一种用于评估造血干细胞移植病人cmv感染后免疫状态的多肽组合物以及检测试剂盒

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TW201708248A (zh) 2017-03-01
WO2016203577A1 (ja) 2016-12-22

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Application publication date: 20180216