CN107677836A - 微生物分析的设备和方法 - Google Patents

微生物分析的设备和方法 Download PDF

Info

Publication number
CN107677836A
CN107677836A CN201710950149.XA CN201710950149A CN107677836A CN 107677836 A CN107677836 A CN 107677836A CN 201710950149 A CN201710950149 A CN 201710950149A CN 107677836 A CN107677836 A CN 107677836A
Authority
CN
China
Prior art keywords
protein
sample
analysis method
analysis
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710950149.XA
Other languages
English (en)
Chinese (zh)
Inventor
小詹姆斯·L·斯蒂芬森
O·沃兹达科
R·格斯特
C·坎贝尔
I·D·贾丁
I·C·莫尔科利斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxoid Ltd
Original Assignee
Oxoid Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxoid Ltd filed Critical Oxoid Ltd
Publication of CN107677836A publication Critical patent/CN107677836A/zh
Pending legal-status Critical Current

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
    • G01N30/7233Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0036Step by step routines describing the handling of the data generated during a measurement
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/16Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165Electrospray ionisation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201710950149.XA 2012-05-01 2013-05-01 微生物分析的设备和方法 Pending CN107677836A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261687785P 2012-05-01 2012-05-01
US61/687,785 2012-05-01
US13/874,213 US9074236B2 (en) 2012-05-01 2013-04-30 Apparatus and methods for microbial identification by mass spectrometry
US13/874,213 2013-04-30
CN201380035676.8A CN104797939B (zh) 2012-05-01 2013-05-01 微生物分析的设备和方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380035676.8A Division CN104797939B (zh) 2012-05-01 2013-05-01 微生物分析的设备和方法

Publications (1)

Publication Number Publication Date
CN107677836A true CN107677836A (zh) 2018-02-09

Family

ID=48428681

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710950149.XA Pending CN107677836A (zh) 2012-05-01 2013-05-01 微生物分析的设备和方法
CN201380035676.8A Active CN104797939B (zh) 2012-05-01 2013-05-01 微生物分析的设备和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380035676.8A Active CN104797939B (zh) 2012-05-01 2013-05-01 微生物分析的设备和方法

Country Status (8)

Country Link
US (3) US9074236B2 (enExample)
EP (2) EP3290925B1 (enExample)
JP (2) JP6430369B2 (enExample)
CN (2) CN107677836A (enExample)
AU (1) AU2013256355B2 (enExample)
BR (1) BR112014027450A2 (enExample)
IN (1) IN2014DN09493A (enExample)
WO (1) WO2013166169A1 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3172865A1 (en) 2011-04-21 2012-10-26 Biomerieux Inc. Method of detecting at least one mechanism of resistance to carbapenems by mass spectrometry
US9074236B2 (en) * 2012-05-01 2015-07-07 Oxoid Limited Apparatus and methods for microbial identification by mass spectrometry
CN105518448B (zh) * 2013-09-04 2018-04-10 株式会社岛津制作所 色谱质谱分析用数据处理装置
JP6238069B2 (ja) * 2014-03-20 2017-11-29 株式会社島津製作所 微生物の識別方法
EP3779454A1 (en) 2014-07-18 2021-02-17 Thermo Finnigan LLC Methods for mass spectrometry of mixtures of proteins or polypeptides using proton transfer reaction
FR3024903A1 (fr) * 2014-08-14 2016-02-19 Biomerieux Sa Procede de quantification d'au moins un groupe de microorganismes par spectrometrie de masse
EP3256847A4 (en) * 2015-02-11 2018-10-10 DH Technologies Development Pte. Ltd. Rapid detection of microbial resistance to lactam antibiotics by lc-ms/ms
EP3268978A1 (en) 2015-03-12 2018-01-17 Thermo Finnigan LLC Methods for data-dependent mass spectrometry of mixed biomolecular analytes
CN106404474B (zh) * 2015-12-25 2018-03-06 首都医科大学附属北京同仁医院 丝状真菌质谱鉴定蛋白提取技术
EP3193352A1 (en) 2016-01-14 2017-07-19 Thermo Finnigan LLC Methods for mass spectrometric based characterization of biological molecules
EP3460481B1 (en) 2016-01-14 2020-09-02 Thermo Finnigan LLC Methods for top-down multiplexed mass spectral analysis of mixtures of proteins or polypeptides
WO2017127733A1 (en) 2016-01-20 2017-07-27 Thermo Finnigan Llc Rapid mass spectrometry methods for antimicrobial susceptibility testing using top-down mass spectrometry
CN109313161B (zh) * 2016-03-31 2021-05-07 株式会社岛津制作所 微生物的识别方法
US11137406B2 (en) 2016-03-31 2021-10-05 Shimadzu Corporation Method for discriminating microorganism
US9960027B2 (en) 2016-05-25 2018-05-01 Thermo Finnigan Llc Analyzing a complex sample by MS/MS using isotopically-labeled standards
FI20165634A7 (fi) * 2016-08-25 2018-02-26 Thermo Fisher Scientific Oy Laite ja menetelmät mikro-organismien identifioimiseksi häiritsevästä matriisista
US10369521B2 (en) 2016-10-07 2019-08-06 Thermo Finnigan Llc System and method for real-time isotope identification
KR102124688B1 (ko) * 2017-01-19 2020-06-18 주식회사 아스타 Tof 질량 분석 데이터 처리 장치 및 방법
US10539569B2 (en) * 2017-01-19 2020-01-21 Asta Corporation Apparatus and method for processing data of time-of-flight mass spectrometry
CN110352354B (zh) 2017-02-28 2024-05-10 沃特世科技公司 用于分析完整蛋白质、抗体、抗体亚基和抗体药物缀合物的装置和方法
EP3615760A2 (en) * 2017-04-28 2020-03-04 Lutron Technology Company LLC Window treatment mounting bracket
JP2020521958A (ja) * 2017-05-22 2020-07-27 ベックマン コールター, インコーポレイテッド 複数の検出能力を有する統合試料処理システム
US11143637B2 (en) * 2017-08-07 2021-10-12 Agency For Science, Technology And Research Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (LC-MS) data
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
JP7105049B2 (ja) * 2017-10-02 2022-07-22 日本電子株式会社 質量分析データ処理装置、及び質量分析データ処理方法
KR20190054921A (ko) * 2017-11-14 2019-05-22 주식회사 노스퀘스트 항생제 변형을 유도하는 내성균에 대한 질량분석법 검사 장치 및 방법
CN108761084B (zh) * 2018-05-23 2020-06-02 同济大学 一种完整n-糖蛋白一级结构全面鉴定方法
CA3099674A1 (en) * 2018-05-25 2019-11-28 Qvella Corporation Methods and compositions for the selective lysis of blood cells and separation of microbial cells
DE102018114028A1 (de) * 2018-06-12 2019-12-12 Bundesrepublik Deutschland (Robert Koch-Institut) Probenpräparation für proteomische Untersuchungen
US11249089B2 (en) * 2018-12-12 2022-02-15 Regeneron Pharmaceuticals, Inc. System and method of analysis of a protein using liquid chromatography-mass spectrometry
US12287339B2 (en) * 2019-04-03 2025-04-29 Shimadzu Corporation Analysis method, microorganism identification method, and testing method
US11879897B2 (en) * 2019-05-30 2024-01-23 Thermo Finnigan Llc Operating a mass spectrometer utilizing mass spectral database search
FR3103197B1 (fr) 2019-11-15 2024-08-30 Biomerieux Sa Determination par spectrometrie de masse de la sensibilite ou de la resistance de bacteries a un antibiotique
FR3106414B1 (fr) * 2020-01-17 2021-12-24 Centre Nat Rech Scient Procédé d’identification et de caractérisation d’une population microbienne par spectrométrie de masse
RU2739758C1 (ru) * 2020-03-05 2020-12-28 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Способ идентификации Candida spp. и других дрожжеподобных грибов из положительной гемокультуры методом матричной лазерной десорбционной ионизационной времяпролетной масс-спектрометрии (MALDI-TOF MS) у больных с инфекцией кровотока
CN111524549B (zh) * 2020-03-31 2023-04-25 中国科学院计算技术研究所 一种基于离子索引的整体蛋白质鉴定方法
JP7579353B2 (ja) 2020-04-06 2024-11-07 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 重症急性呼吸器症候群(sars)における疾患進行を予後診断するためのプロアドレノメデュリン
CN115136009A (zh) 2020-04-09 2022-09-30 B.R.A.H.M.S有限公司 用于呼吸道感染诊断的生物标志物
WO2021263123A1 (en) * 2020-06-26 2021-12-30 Thermo Fisher Scientific Oy Rapid mass spectrometric methods for identifying microbes and antibiotic resistance proteins
JP7347378B2 (ja) * 2020-09-03 2023-09-20 株式会社島津製作所 質量分析データ表示処理装置
US20230410947A1 (en) 2020-10-06 2023-12-21 Thermo Fisher Scientific Oy Systems and methods for rapid microbial identification
US11721538B2 (en) * 2020-11-17 2023-08-08 Thermo Finnigan Llc Feeding real time search results of chimeric MS2 spectra into the dynamic exclusion list
JP7686961B2 (ja) * 2020-12-15 2025-06-03 株式会社島津製作所 分析用試料の調製方法及び質量分析方法
CN114200044A (zh) * 2021-12-01 2022-03-18 中国林业科学研究院林业研究所 一种基于uhplc-esi-qtof-ms/ms的五倍子单宁成分的鉴定方法
US20250327816A1 (en) 2021-12-13 2025-10-23 UNIVERSITé LAVAL Biomarkers for the prediction of preterm birth
KR102879427B1 (ko) * 2022-01-12 2025-11-03 영남대학교 산학협력단 바이오-에어로졸 및 이산화탄소 간의 연관성 분석 시스템
CN114609228B (zh) * 2022-03-08 2024-11-19 西湖大学 一种适用于舌苔样本的高通量蛋白提取方法
US12322583B2 (en) * 2022-05-20 2025-06-03 Sapient Bioanalytics, Llc Extracting mass spectrometry data using mass and retention time windows
CN115902065B (zh) * 2022-12-07 2024-08-20 中国检验检疫科学研究院 一种植物油中甘油三酯产生的非挥发性衍生物的检测方法
WO2025062975A1 (ja) * 2023-09-19 2025-03-27 株式会社島津製作所 前処理方法、分析方法、プログラムおよび分析システム
FR3157434A1 (fr) * 2023-12-26 2025-06-27 Commissariat à l'Energie Atomique et aux Energies Alternatives Procédé de détermination d’une résistance d’un microorganisme à l’égard d’un antimicrobien.
CN117491536B (zh) * 2023-12-29 2024-03-12 中国林业科学研究院林产化学工业研究所 一种prc-apmp工艺制浆废水的微生物毒性物质鉴定方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003098190A2 (en) * 2002-05-20 2003-11-27 Purdue Research Foundation Protein identification from protein product ion spectra
CN101363056A (zh) * 2008-09-11 2009-02-11 浙江大学 一种高通量微生物鉴定方法
WO2011006911A2 (en) * 2009-07-16 2011-01-20 Bruker Daltonik Gmbh Mass spectrometric diagnosis of septicemia
WO2011045544A2 (fr) * 2009-10-15 2011-04-21 bioMérieux Procede de caracterisation d'au moins un microorganisme par spectrometrie de masse

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617852D0 (en) * 1996-08-27 1996-10-09 Univ Manchester Metropolitan Micro-organism identification
US6296771B1 (en) 1999-04-02 2001-10-02 Symyx Technologies, Inc. Parallel high-performance liquid chromatography with serial injection
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US20030068825A1 (en) 2001-07-13 2003-04-10 Washburn Michael P. System and method of determining proteomic differences
US20030141253A1 (en) 2001-12-07 2003-07-31 Bihan Thierry Le Apparatus for efficient liquid chromatography/mass spectrometry processing
US20030124539A1 (en) 2001-12-21 2003-07-03 Affymetrix, Inc. A Corporation Organized Under The Laws Of The State Of Delaware High throughput resequencing and variation detection using high density microarrays
WO2006089103A1 (en) 2005-02-18 2006-08-24 Kalypsys, Inc. Automated evaluation of target samples in a high performance analysis system
CN101034087B (zh) * 2006-03-10 2011-08-31 中国科学院沈阳应用生态研究所 多环芳烃污染土壤中原位降解菌及生物修复能力鉴定方法
DE102007058516B4 (de) 2007-11-23 2017-08-10 Bruker Daltonik Gmbh Identifizierung von Erregern in Körperflüssigkeiten
WO2009134120A1 (en) 2008-04-29 2009-11-05 Erasmus University Medical Center Rotterdam Mass spectrometric analysis of small molecule analytes
US8160819B2 (en) 2008-08-22 2012-04-17 The United States Of America, As Represented By The Secretary Of Agriculture Rapid identification of proteins and their corresponding source organisms by gas phase fragmentation and identification of protein biomarkers
US8224581B1 (en) * 2009-06-18 2012-07-17 The United States Of America As Represented By The Secretary Of The Army Methods for detection and identification of cell type
SG10201601174XA (en) 2010-10-29 2016-03-30 Thermo Fisher Scientific Oy Automated System For Sample Preparation And Analysis
US9074236B2 (en) 2012-05-01 2015-07-07 Oxoid Limited Apparatus and methods for microbial identification by mass spectrometry

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003098190A2 (en) * 2002-05-20 2003-11-27 Purdue Research Foundation Protein identification from protein product ion spectra
CN101363056A (zh) * 2008-09-11 2009-02-11 浙江大学 一种高通量微生物鉴定方法
WO2011006911A2 (en) * 2009-07-16 2011-01-20 Bruker Daltonik Gmbh Mass spectrometric diagnosis of septicemia
WO2011045544A2 (fr) * 2009-10-15 2011-04-21 bioMérieux Procede de caracterisation d'au moins un microorganisme par spectrometrie de masse

Also Published As

Publication number Publication date
AU2013256355B2 (en) 2018-11-29
JP2015521035A (ja) 2015-07-27
JP6668415B2 (ja) 2020-03-18
JP2018183140A (ja) 2018-11-22
US9074236B2 (en) 2015-07-07
CN104797939B (zh) 2017-11-21
BR112014027450A2 (pt) 2017-06-27
US20190006161A9 (en) 2019-01-03
US20140051113A1 (en) 2014-02-20
AU2013256355A1 (en) 2014-11-27
WO2013166169A1 (en) 2013-11-07
EP3290925B1 (en) 2023-04-12
EP3290925A1 (en) 2018-03-07
EP2845011A1 (en) 2015-03-11
EP2845011B1 (en) 2017-12-27
CN104797939A (zh) 2015-07-22
JP6430369B2 (ja) 2018-11-28
IN2014DN09493A (enExample) 2015-07-17
US20180233340A1 (en) 2018-08-16
US20150255261A1 (en) 2015-09-10
US10157734B2 (en) 2018-12-18

Similar Documents

Publication Publication Date Title
CN107677836A (zh) 微生物分析的设备和方法
Demirev et al. Top-down proteomics for rapid identification of intact microorganisms
US20220050090A1 (en) Mass spectrometry assay method for detection and quantitation of microbiota related metabolites
Matysiak et al. Shotgun proteome analysis of honeybee venom using targeted enrichment strategies
Shevchenko et al. Nanoelectrospray tandem mass spectrometry and sequence similarity searching for identification of proteins from organisms with unknown genomes
JP2021073450A (ja) 質量分析によるタモキシフェンおよびその代謝産物の定量化
Wither et al. Mass spectrometry‐based bottom‐up proteomics: Sample preparation, LC‐MS/MS analysis, and database query strategies
Lay Jr et al. Rapid identification of bacteria based on spectral patterns using MALDI-TOFMS
CN105486796A (zh) 一种瓜果类水果中544种农药残留lc-q-tof/ms侦测技术
Dycka et al. Rapid and efficient protein enzymatic digestion: an experimental comparison
Ho et al. Investigating the effects of protein patterns on microorganism identification by high-performance liquid chromatography–mass spectrometry and protein database searches
Velichko et al. Classification and identification tasks in microbiology: mass spectrometric methods coming to the aid
Sun et al. Efficient enrichment and identification of phosphopeptides by cerium oxide using on‐plate matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometric analysis
Theel Matrix-assisted laser desorption ionization-time of flight mass spectrometry for the identification of bacterial and fungal isolates
CN105675703A (zh) 一种食用菌中544种农药残留lc-q-tof/ms侦测技术
Alomostafa Mass spectrometry-based Methods for the Identification of Bacteria: A Systematic Review
Vinci et al. Determination of biogenic amines in wines by HPLC-UV and LC-ESI-MS: A comparative study
Prabhakar Liquid Chromatography-Mass Spectrometry (LCMS): An Advanced Tool for the Microbial Proteomics Analysis
CN105486797A (zh) 一种芽菜类蔬菜中544种农药残留lc-q-tof/ms侦测技术
Triest et al. Proof-of-concept study of a new LC-ESI-MS/MS-based assay to identify Aspergillus spp. in artificially mixed samples using species/genus-specific proteotypic peptides
CN114137124A (zh) 一种对蛋白进行快速肽图分析的方法
Huang Identification and validation of protein biomarkers for invasive aspergillosis; development of surface-induced dissociation device and paper spray ionization source for protein complex studies
Kim et al. Data Collection and Analysis
Dugas Matrix-assisted laser desorption/ionization mass spectrometry for the analysis of collected bioaerosols
CN105606748A (zh) 一种热带和亚热带水果中544种农药残留lc-q-tof/ms侦测技术

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180209

RJ01 Rejection of invention patent application after publication